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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homo... See more...
Aliases for BMP5 Gene
External Ids for BMP5 Gene
- HGNC: 1072
- Entrez Gene: 653
- Ensembl: ENSG00000112175
- OMIM: 112265
- UniProtKB: P22003
Previous GeneCards Identifiers for BMP5 Gene
- GC06M055622
- GC06M055667
- GC06M055455
Summaries for BMP5 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
GeneCards Summary for BMP5 Gene
BMP5 (Bone Morphogenetic Protein 5) is a Protein Coding gene. Diseases associated with BMP5 include Osteoarthritis and Keshan Disease. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is BMP7.
UniProtKB/Swiss-Prot Summary for BMP5 Gene
-
Induces cartilage and bone formation.
Additional gene information for BMP5 Gene
- HGNC(1072)
- Entrez Gene(653)
- Ensembl(ENSG00000112175)
- OMIM(112265)
- UniProtKB(P22003)
- Open Targets Platform(ENSG00000112175)
- Search for BMP5 at DataMed
- Search for BMP5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BMP5 Gene
Genomics for BMP5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BMP5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J055867 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | +3.6 | 3577 | 8.3 | SP1 BACH1 STAT3 RELA POLR2A TCF12 IKZF2 TRIM22 ZNF561 EED | BMP5 piR-46002-485 HMGCLL1 | |
| GH06J055898 | Enhancer | 0.5 | Ensembl | 12.1 | -23.0 | -23011 | 0.4 | SP1 CEBPB JUN JUND EP300 FOSL2 TCF7L2 | BMP5 piR-54764-556 COL21A1 | |
| GH06J055913 | Enhancer | 0.5 | Ensembl | 11.3 | -38.1 | -38111 | 1 | BHLHE40 GATA3 SIN3A FEZF1 PRDM6 CTBP1 BCL6B PKNOX1 | BMP5 COL21A1 piR-36393-448 piR-43107-262 | |
| GH06J055755 | Enhancer | 0.9 | Ensembl ENCODE | 4.8 | +117.9 | 117899 | 4.3 | CEBPG CREB1 TARDBP FOXA1 CEBPA ATF7 CEBPB BRCA1 CTBP1 FOS | BMP5 piR-46002-485 HMGCLL1 | |
| GH06J055916 | Enhancer | 0.3 | Ensembl | 11.3 | -40.8 | -40811 | 0.8 | JUN JUND | BMP5 piR-36393-448 piR-43107-262 COL21A1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BMP5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BMP5
- Top Transcription factor binding sites by QIAGEN in the BMP5 gene promoter:
-
- AML1a
- c-Fos
- c-Jun
- En-1
- HFH-1
- Nkx2-2
- Nkx2-5
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for BMP5 Gene
Genomic Locations for BMP5 Gene
- chr6:55,753,653-55,875,590
- (GRCh38/hg38)
- Size:
- 121,938 bases
- Orientation:
- Minus strand
- chr6:55,618,443-55,740,375
- (GRCh37/hg19)
- Size:
- 121,933 bases
- Orientation:
- Minus strand
Genomic View for BMP5 Gene
Genes around BMP5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.1 by HGNC
- 6p12.1 by Entrez Gene
- 6p12.1 by Ensembl
BMP5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BMP5 Gene
Proteins for BMP5 Gene
-
Protein details for BMP5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22003-BMP5_HUMAN
- Recommended name:
- Bone morphogenetic protein 5
- Protein Accession:
- P22003
- B4E0Y4
- Q9H547
- Q9NTM5
Protein attributes for BMP5 Gene
- Size:
- 454 amino acids
- Molecular mass:
- 51737 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Protein Expression for BMP5 Gene
Post-translational modifications for BMP5 Gene
Other Protein References for BMP5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BMP5 Antibody
- G Biosciences Immunotag™ BMP5 Antibody
- NSJ Bioreagents BMP5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for BMP5
- Novus Biologicals Antibodies for BMP5
-
Abcam antibodies for BMP5
- Invitrogen Antibodies for BMP5 (AFLGC-Bmp5)
- antibodies-online: Show 36 available BMP5 Antibodies ranked by validation data
- Compare Top BMP5 Antibodies
-
Recommended
- 91 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 FACS Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
-
Boster Bio Antibodies for BMP5
-
Santa Cruz Biotechnology (SCBT) Antibodies for BMP5
Protein Products
- RayBiotech Recombinant Human BMP-5
-
OriGene Purified Proteins for BMP5
- Search Origene for MassSpec and Protein Over-expression Lysates for BMP5
- Origene Custom Protein Services for BMP5
- Sino Biological Recombinant Proteins for BMP5
- Sino Biological Cell Lysates for BMP5
- ProSpec Recombinant Proteins for BMP5
-
Signalway Proteins for BMP5
-
ProSci Proteins for BMP5
-
Abcam proteins for BMP5
No data available for DME Specific Peptides for BMP5 Gene
Domains & Families for BMP5 Gene
Gene Families for BMP5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for BMP5 Gene
- InterPro:
- Blocks:
-
- Transforming growth factor beta (TGFb), N-terminal
- Transforming growth factor beta (TGFb)
- Growth factor cystine knot superfamily signature
- ProtoNet:
Suggested Antigen Peptide Sequences for BMP5 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ59222, highly similar to Bone morphogenetic protein 5 (B4E0Y4_HUMAN)
- Bone morphogenetic protein 5 (BMP5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P22003- Family:
-
- Belongs to the TGF-beta family.
Function for BMP5 Gene
Molecular function for BMP5 Gene
- UniProtKB/Swiss-Prot Function:
- Induces cartilage and bone formation.
- GENATLAS Biochemistry:
- bone morphogenetic protein 5 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),mouse short-ear (se) homolog
Phenotypes From GWAS Catalog for BMP5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IBA | 21873635 |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0070700 | BMP receptor binding | IDA | 7811286 |
Phenotypes for BMP5 Gene
- MGI mutant phenotypes for BMP5:
-
inferred from 21 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for BMP5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMP5 - Select products 50% OFF >
- * BMP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMP5
miRNA for BMP5 Gene
- miRTarBase miRNAs that target BMP5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMP5
- Browse OriGene Inhibitory RNA Products For BMP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP5
Clone Products
- Applied Biological Materials (abm): Clones for BMP5 - Select products 50% OFF >
- * BMP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BMP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMP5
Cell Line Products
-
Horizon Cell Lines for BMP5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMP5 Gene
Localization for BMP5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BMP5 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA,ISS | -- |
| GO:0031982 | vesicle | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BMP5 Gene
Pathways & Interactions for BMP5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
Pathways by source for BMP5 Gene
3 KEGG pathways for BMP5 Gene
1 R&D Systems pathway for BMP5 Gene
71 Qiagen pathways for BMP5 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for BMP5 Gene
Selected Interacting proteins:
P22003-BMP5_HUMAN
ENSP00000359866
for BMP5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BMP5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA,NAS | 2263636 |
| GO:0001503 | ossification | IEA | -- |
| GO:0003272 | endocardial cushion formation | ISS | -- |
| GO:0003323 | type B pancreatic cell development | IDA | 11865031 |
| GO:0003344 | pericardium morphogenesis | ISS | -- |
No data available for SIGNOR curated interactions for BMP5 Gene
Drugs & Compounds for BMP5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Escitalopram | Approved | Pharma | 0 |
Transcripts for BMP5 Gene
mRNA/cDNA for BMP5 Gene
- 3 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370830 3970 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMP5 - Select products 50% OFF >
- * BMP5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMP5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMP5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMP5
- Browse OriGene Inhibitory RNA Products For BMP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP5
Clone Products
- Applied Biological Materials (abm): Clones for BMP5 - Select products 50% OFF >
- * BMP5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BMP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMP5
Relevant External Links for BMP5 Gene
- GeneLoc Exon Structure for
- BMP5
Expression for BMP5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Ameloblasts Dental Enamel
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Mature Choroid Plexus Cells Choroid Plexus
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Heart (Cardiovascular System)
- Cardiomyocyte Progenitor Cells Myocardium
- Pre-myocardial Cells Cardiogenic Mesoderm
- Cardiac Crescent Cells Cardiac Crescent
- Cardiomyocyte-like progenitor cells(Uosaki H et. al. 2011)
-
Bone (Muscoskeletal System)
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Endochondral Preosteoblasts Autopod Perichondrium
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Choroid Plexus Progenitor Cells Choroid Plexus
- Inner Cell Mass (Early Embryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
- NULL (Uncategorized)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Spinal Cord (Nervous System)
- Preganglionic Motor Neurons Preganglionic Column
-
Neurons
- Preganglionic Motor Neurons Preganglionic Column
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Pre-myocardial Cells Cardiogenic Mesoderm
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
- Neural Tube (Nervous System)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesoderm (Gastrulation Derivatives)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for BMP5 Gene
This gene is overexpressed in Bladder (x8.3), Lung (x7.4), and Prostate (x4.1).
This gene is overexpressed in Heart (68.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BMP5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BMP5
SOURCE GeneReport for Unigene cluster for BMP5 Gene:
Hs.296648mRNA Expression by UniProt/SwissProt for BMP5 Gene:
P22003-BMP5_HUMAN
Tissue specificity:
Expressed in the lung and liver.
Evidence on tissue expression from TISSUES for BMP5 Gene
- Bone(4.4)
- Lung(4.4)
- Spleen(4.2)
- Muscle(2.1)
- Nervous system(2.1)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for BMP5
-
OriGene qPCR primer pairs and template standards for BMP5
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BMP5 Gene
Orthologs for BMP5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BMP5 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BMP5 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BMP5 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BMP5 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BMP5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bmp5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bmp5 30 |
|
||
| Chicken (Gallus gallus) |
Aves | BMP5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BMP5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bmp5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bmp5 30 31 |
|
OneToOne | |
| zgc64230 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | gbb 32 |
|
|
|
| scw 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | dbl-1 32 |
|
|
- Species where no ortholog for BMP5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for BMP5 Gene
- ENSEMBL:
- Gene Tree for BMP5 (if available)
- TreeFam:
- Gene Tree for BMP5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BMP5: view image
Paralogs for BMP5 Gene
Paralogs for BMP5 Gene
(7) SIMAP similar genes for BMP5 Gene using alignment to 3 proteins:
- BMP5_HUMAN
- B4E0Y4_HUMAN
- M9VUD0_HUMAN
Variants for BMP5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BMP5 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708435 | Benign: not provided | 55,760,493(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 709824 | Benign: not provided | 55,874,504(-) | T/C | MISSENSE_VARIANT | |
| 714767 | Benign: not provided | 55,819,713(-) | A/G | MISSENSE_VARIANT | |
| 735236 | Benign: not provided | 55,759,124(-) | T/TACACAC | INTRON_VARIANT | |
| rs35124644 | - | p.Asn121Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5966n100 | CNV | gain | 25217958 |
| esv2665663 | CNV | deletion | 23128226 |
| esv3571078 | CNV | loss | 25503493 |
| esv3609078 | CNV | loss | 21293372 |
| esv3609079 | CNV | loss | 21293372 |
| nsv1032684 | CNV | loss | 25217958 |
| nsv1034037 | CNV | gain | 25217958 |
| nsv603164 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.76;
47.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BMP5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP5 Gene
Disorders for BMP5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| osteoarthritis |
|
|
| keshan disease |
|
|
| epileptic encephalopathy, childhood-onset |
|
|
| renal artery atheroma |
|
|
| nephrosclerosis |
|
|
Search BMP5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BMP5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BMP5 Gene
Publications for BMP5 Gene
- Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. (PMID: 20021689) Wilkins JM … Loughlin J (BMC medical genetics 2009) 3 23 41
- Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. (PMID: 11580864) Beck HN … Lein PJ (BMC neuroscience 2001) 2 3 23
- A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PMID: 1427904) Hahn GV … Kaplan FS (Genomics 1992) 2 3 23
- Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PMID: 2263636) Celeste AJ … Wozney JM (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for BMP5 Gene
- View all 9 R&D Systems BMP5 (BMP-5) Products
- View all R&D Systems BMP5 (BMP-5) Proteins and Enzymes
- View all 6 R&D Systems BMP5 (BMP-5) Primary Antibodies
- View all R&D Systems BMP5 (BMP-5) ELISAs
- View all R&D Systems BMP5 (BMP-5) cDNA Clones
- Learn more about R&D Systems custom BMP5 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for BMP5
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- OriGene Purified Proteins for BMP5
- Search Origene for MassSpec and Protein Over-expression Lysates for BMP5
- Origene Custom Protein Services for BMP5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMP5
- Browse OriGene Inhibitory RNA Products For BMP5
- OriGene qPCR primer pairs for BMP5
- OriGene qPCR primer pairs and template standards for BMP5
- OriGene CRISPR knockouts for BMP5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BMP5
- Sino Biological Human cDNA Clone for BMP5
- Sino Biological Recombinant Proteins for BMP5
- Sino Biological Cell Lysates for BMP5
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for BMP5
- Novus Biologicals ELISA Kits for BMP5
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- VectorBuilder Custom and pre-made DNA vectors for BMP5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BMP5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BMP5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BMP5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BMP5
- antibodies-online: Show 36 available BMP5 Antibodies ranked by validation data
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- 37 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- antibodies-online: Show 39 available BMP5 Elisa Kits ranked by validation data
- Compare Top BMP5 Elisa Kits
- antibodies-online: Show 27 available BMP5 Proteins ranked by validation data
- Compare Top BMP5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BMP5
- Search Santa Cruz Biotechnology (SCBT) for BMP5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BMP5
- Search for BMP5 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for BMP5
- Horizon Cell Lines for BMP5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMP5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BMP5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP5
Sources for BMP5 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
- (8) Gene Wiki
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- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
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- (30) HomoloGene
- (31) PanEnsembl
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- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (112) MedlinePlus
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- (115) NCBI Bookshelf
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
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- (151) miR2Disease
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- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB