Aliases for BMP4 Gene
Aliases for BMP4 Gene
External Ids for BMP4 Gene
- HGNC: 1071
- Entrez Gene: 652
- Ensembl: ENSG00000125378
- OMIM: 112262
- UniProtKB: P12644
Previous HGNC Symbols for BMP4 Gene
- BMP2B
Previous GeneCards Identifiers for BMP4 Gene
- GC14M051739
- GC14M048212
- GC14M052406
- GC14M053486
- GC14M054416
- GC14M034579
Summaries for BMP4 Gene
-
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
GeneCards Summary for BMP4 Gene
BMP4 (Bone Morphogenetic Protein 4) is a Protein Coding gene. Diseases associated with BMP4 include Microphthalmia, Syndromic 6 and Orofacial Cleft 11. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is BMP2.
UniProtKB/Swiss-Prot for BMP4 Gene
-
Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
Additional gene information for BMP4 Gene
- Monarch Initiative
- Search for BMP4 at DataMed
- Search for BMP4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP4 Gene
Genomics for BMP4 Gene
GeneHancer (GH) Regulatory Elements for BMP4 Gene
Promoters and enhancers for BMP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BMP4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BMP4 gene promoter:
-
- Nkx2-5
Regulatory Element Products
Genomic Locations for BMP4 Gene
Genomic Locations for BMP4 Gene
- chr14:53,949,736-53,958,761
- (GRCh38/hg38)
- Size:
- 9,026 bases
- Orientation:
- Minus strand
- chr14:54,416,454-54,425,479
- (GRCh37/hg19)
- Size:
- 9,026 bases
- Orientation:
- Minus strand
Genomic View for BMP4 Gene
Genes around BMP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q22.2 by Entrez Gene
- 14q22.2 by HGNC
- 14q22.2 by Ensembl
BMP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BMP4 Gene
Proteins for BMP4 Gene
-
Protein details for BMP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12644-BMP4_HUMAN
- Recommended name:
- Bone morphogenetic protein 4
- Protein Accession:
- P12644
- Q9UM80
Protein attributes for BMP4 Gene
- Size:
- 408 amino acids
- Molecular mass:
- 46555 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (By similarity). Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Interacts with SOSTDC1. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).
Protein Expression for BMP4 Gene
Post-translational modifications for BMP4 Gene
Other Protein References for BMP4 Gene
Antibody Products
- R&D Systems Antibodies for BMP4 (BMP-4)
-
Custom Antibody ServicesOriGene Antibodies for BMP4
- Novus Biologicals Antibodies for BMP4
- Invitrogen Antibodies for BMP4
- antibodies-online: Search results for 278 available BMP4 Antibodies ranked by validation data
- Compare Top BMP4 Antibodies
-
Recommended
- 172 WB Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 49 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 85 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- GeneTex BMP4 Antibody for BMP4
-
Santa Cruz Biotechnology (SCBT) Antibodies for BMP4
- Sino Biological Antibodies for BMP4
Protein Products
- R&D Systems Proteins and Enzymes for BMP4 (BMP-4)
- R&D Systems Proteins and Enzymes for BMP4 (BMP-4/BMP-7 Heterodimer)
- Search Origene for MassSpec and Protein Over-expression Lysates for BMP4
- Origene Custom Protein Services for BMP4
- Sino Biological Cell Lysates for BMP4
- Sino Biological Recombinant Proteins for BMP4
- ProSpec Recombinant Proteins for BMP4
- GeneTex Proteins for BMP4
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for BMP4
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for BMP4 (BMP-4)
- Novus Biologicals ELISA Kits for BMP4
- antibodies-online: Search results for 122 available BMP4 Elisa Kits ranked by validation data
- Compare Top BMP4 Elisa Kits
-
Recommended
- 13 Chicken ELISA Kits
- 9 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
- 7 Goat ELISA Kits
- 2 Guinea Pig ELISA Kits
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 11 Pig (Porcine) ELISA Kits
- 11 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 3 Wild boar (Sus scrofa) ELISA Kits
No data available for DME Specific Peptides for BMP4 Gene
Domains & Families for BMP4 Gene
Gene Families for BMP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for BMP4 Gene
Suggested Antigen Peptide Sequences for BMP4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P12644- Family:
-
- Belongs to the TGF-beta family.
Function for BMP4 Gene
Molecular function for BMP4 Gene
- UniProtKB/Swiss-Prot Function:
- Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
- GENATLAS Biochemistry:
- bone morphogenetic protein 4 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),BMP4 expression under MSX2 control,inducing ventralizing signals inhibited by noggin,also inducing apoptosis and chondrogenesis in the chick limb bud,inhibited by FGF4,regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells
LifeMap Function Summary for BMP4 Gene
During embryonic development, BMP4 as signaling molecule is secreted from the following cells
- Head Mesenchyme
- Lung
- Bone
- Epiblast
- Trophoblast
- Hair
- Inner Cell Mass
- Ectoderm
- Lateral Plate Mesoderm
- Kidney
- Surface Ectoderm
- Primitive Streak
- Neural Tube
- Heart
- Tendon & Ligament
It affects the following cells:
- Neural Crest
-
Bone
- Chondrocytes (Vertebrae)
- Chondrocytes (Stylopod Epiphyseal End)
- Chondrocytes (Rib)
- Chondrocytes (Autopod Epiphyseal End)
- Chondrocytes (Zeugopod Epiphyseal End)
- Endochondral Preosteoblasts (Caudal Facial Endochondral Bones)
- Endochondral Preosteoblasts (Rostral Endochondral Facial Bones)
- Endochondral Preosteoblasts (Endochondral Facial Bones)
- Intramembranous Preosteoblasts (Membranous Facial Bones)
- Intramembranous Preosteoblasts (Rostral Skull Membranous Bones)
- Prechondrocytic Mesenchymal Cells (Spinous Process Of Vertebrae)
- Prechondrocytic Mesenchymal Cells (Dorsal Neural Arch)
- Lateral Plate Mesoderm
- Head Mesenchyme
- Tooth
- Lung
- Neural Tube
- Hypoblast
- Trophoblast
- Primitive Streak
- Hair
- Ectoderm
- Epiblast
- Eye
- Limb
- Somite
- Spinal Cord
- Brain
- Surface Ectoderm
- Lower Urinary Tract
- Kidney
BMP4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Placenta
- Pancreas
- Mesoderm
- Primitive Streak
- Endoderm
- Blood
- Heart
- Epithelial Cells
- Trophoblast
- Intermediate Mesoderm
- Brain
- Liver
- Lung
- Kidney
- Bone
- Cartilage
- Adipose
-
and also in
- Anterior foregut endoderm
- Beating cells
- Beta-like cells
- BMP4/EGF-induced cells
- BMP4-induced embryoid bodies
- BMP4-induced embryoid bodies
- BMP4-induced embryoid bodies
- BMP-induced cells
- Bone morphogenetic protein 4/ascorbic acid-induced cells
- Bone morphogenic protein-induced cells
- Cardiomyocyte precursor cells
- Cardiomyocyte-like cells
- Cartilage-like cells
- Definitive endoderm-like cells
- Early mesoderm cells
- Early proximal lung progenitors
- Embryoid bodies
- Embryoid bodies
- Embryoid bodies
- Embryoid bodies
- Embryoid bodies
- Embryoid Bodies
- Embryoid Bodies
- Endoderm progenitor-like cells
- Endoderm-like cells
- Endoderm-like cells
- Epithelial-like cells
- Hematopoietic progenitor cells
- Hepatoblasts
- Hepato-specified cells
- HyStem+BMP4-induced 7SMOO32 cells
- HyStem+BMP4-induced MEL2 cells
- Intermediate mesoderm-like cells
- Lateral plate mesoderm
- Mesoderm embryoid bodies
- Mesoderm precursors
- Mesodermal embryoid bodies
- Mesoderm-like cells
- Mesoderm-like cells
- Mesoderm-like cells
- Mesoderm-like cells
- Mixed hematopoietic progenitor cells
- Mixed hematopoietic progenitor cells
- Nkx2-1 induced endoderm
- Posterior intermediate mesoderm
- Posterior nascent mesoderm
- Posterior primitive streak cells
- Primitive Streak Mesendoderm cells
- Primitive streak-like cells
- RA/BMP4-induced cells
- Spheres
- Syncytiotrophoblast-like cells
- Thymic epithelial progenitor cells
- Trophoblast-like cells
- Vascular endothelial growth factor-induced cells
- Vascular progenitor cells
- VEGF-induced cells
- Ventral pharyngeal endoderm
Phenotypes From GWAS Catalog for BMP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 14749725 |
| GO:0005160 | transforming growth factor beta receptor binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 8413626 |
| GO:0008083 | growth factor activity | IEA | -- |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for BMP4 Gene
- MGI mutant phenotypes for BMP4:
-
inferred from 14 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for BMP4:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased circadian period length
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Increased cell number in S
- Increased transferrin (TF) endocytosis
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for BMP4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BMP4
-
CRISPR Products
-
OriGene CRISPR knockouts for BMP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP4
- genomics-online: gRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- Applied Biological Materials CRISPR for BMP4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMP4
- GenScript: Design CRISPR guide RNA sequences for BMP4
miRNA for BMP4 Gene
- miRTarBase miRNAs that target BMP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMP4
- Browse OriGene Inhibitory RNA Products For BMP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP4
- genomics-online: shRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
Clone Products
-
OriGene ORF clones in human for BMP4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BMP4
- VectorBuilder custom plasmid, inducible vectors for BMP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BMP4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BMP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMP4
- Applied Biological Materials Clones for BMP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BMP4 (BMP-4)
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BMP4 Gene
Localization for BMP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BMP4 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA,ISS | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BMP4 Gene
Pathways & Interactions for BMP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | PEDF Induced Signaling |
.61
|
.47
|
| 3 | GPCR Pathway |
.73
.62
|
.55
|
| 4 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for BMP4 Gene
10 BioSystems pathways for BMP4 Gene
3 Reactome pathways for BMP4 Gene
2 R&D Systems pathways for BMP4 Gene
74 Qiagen pathways for BMP4 Gene
1 Cell Signaling Technology pathway for BMP4 Gene
Interacting Proteins for BMP4 Gene
Selected Interacting proteins:
P12644-BMP4_HUMAN
ENSP00000245451
for BMP4 Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for BMP4
SIGNOR curated interactions for BMP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0000186 | activation of MAPKK activity | IDA | 17600318 |
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001503 | ossification | IEA | -- |
| GO:0001525 | angiogenesis | IEA | -- |
Drugs & Compounds for BMP4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for BMP4 Gene
mRNA/cDNA for BMP4 Gene
- (9) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (158) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000245451 1917 bps (uc001xao.6)
- ENST00000417573 1784 bps (uc010aoh.5)
- ENST00000558489 605 bps (uc059bqm.1)
- ENST00000558961 495 bps (uc059bqj.1)
- ENST00000558984 1705 bps (uc001xal.6)
Unigene Clusters for BMP4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BMP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP4
- genomics-online: gRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- Applied Biological Materials CRISPR for BMP4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMP4
- GenScript: Design CRISPR guide RNA sequences for BMP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMP4
- Browse OriGene Inhibitory RNA Products For BMP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP4
- genomics-online: shRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
Clone Products
-
OriGene ORF clones in human for BMP4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BMP4
- VectorBuilder custom plasmid, inducible vectors for BMP4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BMP4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BMP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMP4
- Applied Biological Materials Clones for BMP4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BMP4 (BMP-4)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | - |
Expression for BMP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
This gene is overexpressed in Tlymphocyte (40.5) and Heart (28.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BMP4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BMP4 Gene:
BMP4SOURCE GeneReport for Unigene cluster for BMP4 Gene:
Hs.68879mRNA Expression by UniProt/SwissProt for BMP4 Gene:
P12644-BMP4_HUMAN
Tissue specificity:
Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Evidence on tissue expression from TISSUES for BMP4 Gene
- Intestine(4.7)
- Bone(2.8)
- Muscle(2.8)
- Heart(2.7)
- Lung(2.4)
- Skin(2.3)
- Nervous system(2.3)
- Eye(2.2)
- Kidney(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BMP4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- inner ear
- jaw
- lip
- mandible
- maxilla
- middle ear
- mouth
- nose
- outer ear
- pharynx
- pituitary gland
- skull
Pelvis:
- testicle
- urinary bladder
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- peripheral nervous system
- skin
- spinal cord
Primer Products
-
OriGene qPCR primer pairs and template standards for BMP4
-
OriGene qPCR primer pairs for BMP4
- genomics-online: primer clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for BMP4 Gene
Orthologs for BMP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BMP4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BMP4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BMP4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bmp4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bmp4 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | BMP4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BMP4 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BMP4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bmp4 33 |
|
||
| Str.490 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | bmp4 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | dpp 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dbl-1 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for BMP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for BMP4 Gene
- ENSEMBL:
- Gene Tree for BMP4 (if available)
- TreeFam:
- Gene Tree for BMP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BMP4: view image
Paralogs for BMP4 Gene
Paralogs for BMP4 Gene
(12) SIMAP similar genes for BMP4 Gene using alignment to 8 proteins:
- BMP4_HUMAN
- H0YLW3_HUMAN
- H0YM53_HUMAN
- H0YMP9_HUMAN
- L8E8S7_HUMAN
- Q53XC5_HUMAN
- U3MVU6_HUMAN
- V9GYF1_HUMAN
Variants for BMP4 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121912765 | pathogenic, Microphthalmia syndromic 6, Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932] | 53,951,945(-) | T/C | coding_sequence_variant, missense_variant | |
| rs121912766 | pathogenic, Orofacial cleft 11, Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625] | 53,950,222(-) | G/A | coding_sequence_variant, missense_variant | |
| rs121912767 | pathogenic, Orofacial cleft 11, Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625] | 53,951,951(-) | G/C | coding_sequence_variant, missense_variant | |
| rs121912768 | pathogenic, Orofacial cleft 11, Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625] | 53,950,399(-) | C/A/T | coding_sequence_variant, missense_variant | |
| rs140085940 | uncertain-significance, Syndromic Microphthalmia, Dominant, Orofacial cleft, Cleft Lip +/- Cleft Palate, Autosomal Dominant, BMP4-Related Syndromic Microphthalmia | 53,949,883(-) | CT/ | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.75;
91.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BMP4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMP4 Gene
Disorders for BMP4 Gene
(34) MalaCards diseases for BMP4 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microphthalmia, syndromic 6 |
|
|
| orofacial cleft 11 |
|
|
| renal hypodysplasia/aplasia 3 |
|
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| fibrodysplasia ossificans progressiva |
|
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| cleft lip |
|
Search BMP4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BMP4_HUMAN- Microphthalmia, syndromic, 6 (MCOPS6) [MIM:607932]: A disease characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. {ECO:0000269 PubMed:18252212}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Non-syndromic orofacial cleft 11 (OFC11) [MIM:600625]: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. {ECO:0000269 PubMed:19249007}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for BMP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for BMP4 Gene
Publications for BMP4 Gene
- Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. (PMID: 7579580) Oida S … Sasaki S (DNA sequence : the journal of DNA sequencing and mapping 1995) 2 3 4 22 58
- Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. (PMID: 19249007) Suzuki S … Murray JC (American journal of human genetics 2009) 3 4 44 58
- A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population. (PMID: 19557432) Capasso M … Iolascon A (Journal of cancer research and clinical oncology 2009) 3 22 44 58
- Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. (PMID: 18252212) Bakrania P … Ragge NK (American journal of human genetics 2008) 3 4 22 58
- Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). (PMID: 12404109) Felder B … Koch MC (European journal of human genetics : EJHG 2002) 3 4 44 58
Products for BMP4 Gene
- R&D Systems Antibodies for BMP4 (BMP-4)
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- VectorBuilder custom plasmid, inducible vectors for BMP4
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BMP4
- antibodies-online: Search results for 278 available BMP4 Antibodies ranked by validation data
- Compare Top BMP4 Antibodies
- Recommended
- 172 WB Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 49 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 85 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
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- antibodies-online: Search results for 122 available BMP4 Elisa Kits ranked by validation data
- Compare Top BMP4 Elisa Kits
- Recommended
- 13 Chicken ELISA Kits
- 9 Cow (Bovine) ELISA Kits
- 7 Dog (Canine) ELISA Kits
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- 2 Guinea Pig ELISA Kits
- 34 Human ELISA Kits
- 3 Monkey ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 11 Pig (Porcine) ELISA Kits
- 11 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 3 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 75 available BMP4 Proteins ranked by validation data
- Compare Top BMP4 Proteins
- GeneTex BMP4 Antibody for BMP4
- GeneTex Proteins for BMP4
- Santa Cruz Biotechnology (SCBT) Antibodies for BMP4
- Search Santa Cruz Biotechnology (SCBT) for BMP4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BMP4
- Horizon Cell Lines for BMP4
- genomics-online: cdna clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- orf clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- genomics-online: gRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- genomics-online: primer clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- genomics-online: shRNA clones - Search results for 175 available BMP4 gene related products
- Overview of 175 available BMP4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or