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Aliases for BMP2K Gene

Aliases for BMP2K Gene

  • BMP2 Inducible Kinase 2 3 5
  • BIKE 3 4
  • BMP-2-Inducible Protein Kinase 3
  • EC 4
  • HRIHFB2017 3
  • BIKe 4

External Ids for BMP2K Gene

Previous GeneCards Identifiers for BMP2K Gene

  • GC04P080090
  • GC04P080155
  • GC04P080054
  • GC04P079916
  • GC04P079697
  • GC04P075443

Summaries for BMP2K Gene

Entrez Gene Summary for BMP2K Gene

  • This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP2K Gene

BMP2K (BMP2 Inducible Kinase) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AAK1.

UniProtKB/Swiss-Prot for BMP2K Gene

  • May be involved in osteoblast differentiation.

Gene Wiki entry for BMP2K Gene

Additional gene information for BMP2K Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP2K Gene

Genomics for BMP2K Gene

GeneHancer (GH) Regulatory Elements for BMP2K Gene

Promoters and enhancers for BMP2K Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J078774 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 654.8 +1.0 1021 6.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B BMP2K ENSG00000260278 PAQR3 LOC105377299
GH04J078872 Promoter 0.5 EPDnew 650.2 +96.0 95970 0.1 BMP2K RN7SL127P GC04M078827
GH04J078691 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.8 -83.2 -83237 4 HDGF PKNOX1 SMAD1 ARNT ZNF766 CBX5 E2F8 FOS REST ZNF592 BMP2K CNOT6L LINC00989 SERBP1P5 OR7E94P ENSG00000200998 RPS21P3 GC04P078707 HIGD1AP13
GH04J078616 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 24.7 -159.9 -159897 0.8 HDAC1 PKNOX1 ATF1 ZBTB40 CHAMP1 ZNF766 CREM ZNF592 MEF2D MTA1 BMP2K RPS21P3 GC04M078633 ENSG00000200998 ANXA3
GH04J078621 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -149.7 -149655 10.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT YBX1 POLR2B ZNF766 E2F8 FOS BMP2K CNOT6L RPS21P3 LINC01094 LINC01088 ENSG00000200998 GC04M078633 ANXA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BMP2K on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BMP2K gene promoter:

Genomic Locations for BMP2K Gene

Genomic Locations for BMP2K Gene
140,031 bases
Plus strand

Genomic View for BMP2K Gene

Genes around BMP2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP2K Gene

Proteins for BMP2K Gene

  • Protein details for BMP2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BMP-2-inducible protein kinase
    Protein Accession:
    Secondary Accessions:
    • O94791
    • Q4W5H2
    • Q8IYF2
    • Q8N2G7
    • Q8NHG9
    • Q9NTG8

    Protein attributes for BMP2K Gene

    1161 amino acids
    Molecular mass:
    129172 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BMP2K Gene

    Alternative splice isoforms for BMP2K Gene


neXtProt entry for BMP2K Gene

Post-translational modifications for BMP2K Gene

No data available for DME Specific Peptides for BMP2K Gene

Domains & Families for BMP2K Gene

Gene Families for BMP2K Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for BMP2K Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with BMP2K: view

Function for BMP2K Gene

Molecular function for BMP2K Gene

UniProtKB/Swiss-Prot Function:
May be involved in osteoblast differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for BMP2K Gene

Phenotypes From GWAS Catalog for BMP2K Gene

Gene Ontology (GO) - Molecular Function for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with BMP2K: view
genes like me logo Genes that share phenotypes with BMP2K: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP2K

Clone Products

  • Addgene plasmids for BMP2K

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMP2K Gene

Localization for BMP2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP2K Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BMP2K gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IBA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with BMP2K: view

Pathways & Interactions for BMP2K Gene

genes like me logo Genes that share pathways with BMP2K: view

Pathways by source for BMP2K Gene

1 KEGG pathway for BMP2K Gene

Gene Ontology (GO) - Biological Process for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA --
GO:0016310 phosphorylation IEA --
GO:0030100 regulation of endocytosis IBA --
GO:0030500 regulation of bone mineralization IBA,IEA --
GO:0045747 positive regulation of Notch signaling pathway IBA --
genes like me logo Genes that share ontologies with BMP2K: view

No data available for SIGNOR curated interactions for BMP2K Gene

Drugs & Compounds for BMP2K Gene

(2) Drugs for BMP2K Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for BMP2K Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with BMP2K: view

Transcripts for BMP2K Gene

Unigene Clusters for BMP2K Gene

BMP2 inducible kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMP2K

Clone Products

  • Addgene plasmids for BMP2K

Alternative Splicing Database (ASD) splice patterns (SP) for BMP2K Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for BMP2K Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP2K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BMP2K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BMP2K Gene

This gene is overexpressed in Brain (41.3) and Serum (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BMP2K Gene

NURSA nuclear receptor signaling pathways regulating expression of BMP2K Gene:


SOURCE GeneReport for Unigene cluster for BMP2K Gene:


Evidence on tissue expression from TISSUES for BMP2K Gene

  • Thyroid gland(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with BMP2K: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BMP2K Gene

Orthologs for BMP2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BMP2K Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BMP2K 34 33
  • 99.31 (n)
(Canis familiaris)
Mammalia BMP2K 34 33
  • 90.76 (n)
(Bos Taurus)
Mammalia BMP2K 34 33
  • 86.01 (n)
(Mus musculus)
Mammalia Bmp2k 16 34 33
  • 83.6 (n)
(Rattus norvegicus)
Mammalia Bmp2k 33
  • 83.22 (n)
(Monodelphis domestica)
Mammalia BMP2K 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia BMP2K 34
  • 71 (a)
(Gallus gallus)
Aves BMP2K 34 33
  • 80.02 (n)
(Anolis carolinensis)
Reptilia BMP2K 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp2k 33
  • 68.64 (n)
Str.14011 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9335 33
(Danio rerio)
Actinopterygii bmp2k 34 33
  • 68.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nak 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea sel-5 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARK1 34
  • 22 (a)
PRK1 34
  • 19 (a)
AKL1 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for BMP2K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP2K Gene

Gene Tree for BMP2K (if available)
Gene Tree for BMP2K (if available)
Evolutionary constrained regions (ECRs) for BMP2K: view image

Paralogs for BMP2K Gene

Paralogs for BMP2K Gene

(5) SIMAP similar genes for BMP2K Gene using alignment to 4 proteins:

  • H0Y9P1_HUMAN
  • K4DI97_HUMAN
  • Q4W5H2_HUMAN Pseudogenes for BMP2K Gene

genes like me logo Genes that share paralogs with BMP2K: view

Variants for BMP2K Gene

Sequence variations from dbSNP and Humsavar for BMP2K Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs770167074 A lung squamous cell carcinoma sample 78,826,060(+) G/A/C 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs138262352 benign, not specified 78,912,028(+) C/G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, stop_gained
rs1000008704 -- 78,784,129(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000066012 -- 78,831,199(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000075556 -- 78,790,661(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BMP2K Gene

Variant ID Type Subtype PubMed ID
dgv5329n100 CNV loss 25217958
esv26247 CNV loss 19812545
esv2727859 CNV deletion 23290073
esv3307766 CNV mobile element insertion 20981092
esv3438049 CNV insertion 20981092
esv3564123 CNV deletion 23714750
esv3575753 CNV gain 25503493
esv990407 CNV insertion 20482838
nsv1006026 CNV loss 25217958
nsv1073345 CNV deletion 25765185
nsv1145034 CNV deletion 24896259
nsv508291 CNV deletion 20534489
nsv594706 CNV gain+loss 21841781
nsv822627 CNV loss 20364138
nsv829979 CNV gain 17160897

Variation tolerance for BMP2K Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.80; 83.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BMP2K Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP2K Gene

Disorders for BMP2K Gene

Additional Disease Information for BMP2K

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BMP2K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BMP2K Gene

Publications for BMP2K Gene

  1. A novel genetic variant of BMP2K contributes to high myopia. (PMID: 19927351) Liu HP … Tsai FJ (Journal of clinical laboratory analysis 2009) 3 22 44 58
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for BMP2K Gene

  • Addgene plasmids for BMP2K

Sources for BMP2K Gene

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