Aliases for BMP15 Gene
External Ids for BMP15 Gene
Previous GeneCards Identifiers for BMP15 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
GeneCards Summary for BMP15 Gene
BMP15 (Bone Morphogenetic Protein 15) is a Protein Coding gene. Diseases associated with BMP15 include Ovarian Dysgenesis 2 and 46,Xx Sex Reversal 1. Among its related pathways are Akt Signaling and Ovarian steroidogenesis. Gene Ontology (GO) annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is GDF9.
UniProtKB/Swiss-Prot for BMP15 Gene
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.