External Ids for BMP10 Gene
Previous GeneCards Identifiers for BMP10 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]
GeneCards Summary for BMP10 Gene
BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include Juvenile Polyposis/Hereditary Hemorrhagic Telangiectasia Syndrome and Right Atrial Isomerism. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is GDF2.
UniProtKB/Swiss-Prot Summary for BMP10 Gene
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.