Aliases for BMP1 Gene
External Ids for BMP1 Gene
Previous HGNC Symbols for BMP1 Gene
Previous GeneCards Identifiers for BMP1 Gene
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
GeneCards Summary for BMP1 Gene
BMP1 (Bone Morphogenetic Protein 1) is a Protein Coding gene. Diseases associated with BMP1 include Osteogenesis Imperfecta, Type Xiii and High Bone Mass Osteogenesis Imperfecta. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and growth factor activity. An important paralog of this gene is TLL2.
UniProtKB/Swiss-Prot for BMP1 Gene
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.