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This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogen... See more...
Aliases for BMI1 Gene
Aliases for BMI1 Gene
External Ids for BMI1 Gene
- HGNC: 1066
- NCBI Entrez Gene: 648
- Ensembl: ENSG00000168283
- OMIM®: 164831
- UniProtKB/Swiss-Prot: P35226
Previous HGNC Symbols for BMI1 Gene
- PCGF4
Previous GeneCards Identifiers for BMI1 Gene
- GC10U990006
- GC10P022760
- GC10P022614
- GC10P022650
- GC10P022605
- GC10P022611
Summaries for BMI1 Gene
-
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for BMI1 Gene
BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include Mantle Cell Lymphoma and Erythroplakia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is COMMD3-BMI1.
UniProtKB/Swiss-Prot Summary for BMI1 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Additional gene information for BMI1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BMI1 Gene
Genomics for BMI1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BMI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BMI1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BMI1
- Top Transcription factor binding sites by QIAGEN in the BMI1 gene promoter:
-
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- POU3F2
- POU3F2 (N-Oct-5a)
- YY1
Genomic Locations for BMI1 Gene
Latest Assembly
- chr10:22,321,099-22,331,484
- (GRCh38/hg38)
- Size:
- 10,386 bases
- Orientation:
- Plus strand
Previous Assembly
- chr10:22,610,028-22,620,413
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 10,386 bases
- Orientation:
- Plus strand
Genomic View for BMI1 Gene
Genes around BMI1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.2 by HGNC
- 10p12.2 by Entrez Gene
- 10p12.2 by Ensembl
BMI1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BMI1 Gene
Proteins for BMI1 Gene
-
Protein details for BMI1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35226-BMI1_HUMAN
- Recommended name:
- Polycomb complex protein BMI-1
- Protein Accession:
- P35226
- Q16030
- Q5T8Z3
- Q96F37
Protein attributes for BMI1 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 36949 Da
- Quaternary structure:
-
- Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:21772249, PubMed:25355358). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). Interacts with CBX7 and CBX8 (PubMed:19636380). Interacts with SPOP (PubMed:15897469). Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469). Interacts with E4F1 (PubMed:16882984). Interacts with PHC2 (PubMed:9121482, PubMed:9199346, PubMed:27827373).
- Miscellaneous:
-
- The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
Protein Expression for BMI1 Gene
Post-translational modifications for BMI1 Gene
- Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BMI1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences BMI1 / PCGF4 Antibody and BMI1 / PCGF4 Monoclonal Antibody
- Novus Biologicals Antibodies for BMI1
-
Abcam antibodies for BMI1
- Invitrogen Antibodies for BMI1 (AFLGC-BMI1)
- antibodies-online: Show 87 available BMI1 Antibodies ranked by validation data
- Compare Top BMI1 Antibodies
-
Recommended
- 267 WB Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 ChIP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 2 ChIP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 53 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for BMI1
- BMI1 polycomb ring finger oncogene [13-052]
- BMI1 polycomb ring finger oncogene [13-080]
- BMI1 polycomb ring finger oncogene [3755]
- BMI1 polycomb ring finger oncogene [18-591]
- BMI1 polycomb ring finger oncogene [28-036]
- BMI1 polycomb ring finger oncogene [43-563]
- BMI1 polycomb ring finger oncogene [43-567]
- Polycomb complex protein BMI-1 [63-629]
- Polycomb complex protein BMI-1 [61-406]
-
Santa Cruz Biotechnology (SCBT) Antibodies for BMI1
- Sino Biological Antibodies for BMI1
Protein products for research
-
OriGene Purified Proteins for BMI1
- Search Origene for MassSpec and Protein Over-expression Lysates for BMI1
- Origene Custom Protein Services for BMI1
-
Abcam proteins for BMI1
Assay products for research
No data available for DME Specific Peptides for BMI1 Gene
Domains & Families for BMI1 Gene
Gene Families for BMI1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for BMI1 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
Suggested Antigen Peptide Sequences for BMI1 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 51 (BMI1_HUMAN)
- BMI1 polycomb ring finger oncogene (Q5T8Z2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BMI1 Gene
Function for BMI1 Gene
Molecular function for BMI1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
- GENATLAS Biochemistry:
- bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin
Phenotypes From GWAS Catalog for BMI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15386022 |
| GO:0008270 | zinc ion binding | IDA | 16714294 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0071535 | RING-like zinc finger domain binding | IPI | 16714294 |
| GO:1990841 | promoter-specific chromatin binding | IBA,IDA | 24623306 |
Phenotypes for BMI1 Gene
- GenomeRNAi human phenotypes for BMI1:
-
- Increased G1 DNA content
- no effect
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased ionizing radiation sensitivity
- Increased cell death HMECs cells
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death in HCT116 cells
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BMI1 - Starting at $85 >
- * BMI1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BMI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
miRNA for BMI1 Gene
- miRTarBase miRNAs that target BMI1
-
- hsa-miR-200c-3p (MIRT000197)
- hsa-miR-16-5p (MIRT000266)
- hsa-miR-15a-5p (MIRT000280)
- hsa-miR-128-3p (MIRT004645)
- hsa-miR-302b-3p (MIRT005670)
- mmu-miR-200b-3p (MIRT005770)
- hsa-miR-203a-3p (MIRT006036)
- hsa-miR-708-5p (MIRT006139)
- hsa-miR-200b-3p (MIRT006165)
- hsa-miR-194-5p (MIRT007000)
- hsa-miR-218-5p (MIRT007258)
- mmu-miR-7b-5p (MIRT009427)
- hsa-let-7g-5p (MIRT024120)
- hsa-miR-33a-5p (MIRT028182)
- hsa-miR-106b-3p (MIRT038596)
- hsa-miR-27a-3p (MIRT050022)
- rno-miR-128-3p (MIRT053015)
- hsa-miR-544a (MIRT053511)
- hsa-miR-494-3p (MIRT053512)
- hsa-miR-495-3p (MIRT053513)
- hsa-miR-300 (MIRT053514)
- hsa-miR-30e-5p (MIRT053588)
- hsa-miR-302a-3p (MIRT053776)
- hsa-miR-183-5p (MIRT054143)
- hsa-miR-379-3p (MIRT177206)
- hsa-miR-380-3p (MIRT177207)
- hsa-miR-411-3p (MIRT177208)
- hsa-miR-4495 (MIRT177212)
- hsa-miR-559 (MIRT177226)
- hsa-miR-548b-5p (MIRT177228)
- hsa-miR-548a-5p (MIRT177229)
- hsa-miR-548c-5p (MIRT177230)
- hsa-miR-548d-5p (MIRT177231)
- hsa-miR-548j-5p (MIRT177232)
- hsa-miR-548n (MIRT177235)
- hsa-miR-548h-5p (MIRT177236)
- hsa-miR-548i (MIRT177237)
- hsa-miR-548w (MIRT177238)
- hsa-miR-548y (MIRT177239)
- hsa-miR-548o-5p (MIRT177240)
- hsa-miR-548ab (MIRT177241)
- hsa-miR-548ad-5p (MIRT177243)
- hsa-miR-548ae-5p (MIRT177244)
- hsa-miR-548ak (MIRT177245)
- hsa-miR-548am-5p (MIRT177246)
- hsa-miR-548ap-5p (MIRT177249)
- hsa-miR-548aq-5p (MIRT177250)
- hsa-miR-548ar-5p (MIRT177251)
- hsa-miR-548as-5p (MIRT177252)
- hsa-miR-548au-5p (MIRT177253)
- hsa-miR-548ay-5p (MIRT177256)
- hsa-miR-548bb-5p (MIRT177258)
- hsa-miR-580-5p (MIRT177295)
- hsa-miR-3120-3p (MIRT177298)
- hsa-miR-3942-5p (MIRT177299)
- hsa-miR-4703-5p (MIRT177300)
- hsa-miR-376c-3p (MIRT245244)
- hsa-miR-320a (MIRT262091)
- hsa-miR-586 (MIRT330296)
- hsa-miR-452-5p (MIRT437780)
- hsa-miR-487b-3p (MIRT437851)
- mmu-miR-200c-3p (MIRT438019)
- hsa-miR-548t-5p (MIRT560307)
- hsa-miR-548az-5p (MIRT560308)
- hsa-miR-153-5p (MIRT717182)
- hsa-miR-195-3p (MIRT717183)
- hsa-miR-16-2-3p (MIRT717184)
- hsa-miR-4666a-3p (MIRT717185)
- hsa-miR-338-5p (MIRT717186)
- hsa-miR-15a-3p (MIRT732884)
- hsa-miR-192-5p (MIRT732962)
- hsa-miR-21-5p (MIRT733326)
- hsa-miR-3622b-5p (MIRT733557)
- hsa-miR-200c-5p (MIRT734270)
- hsa-miR-128-1-5p (MIRT734515)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Clone products for research
- Applied Biological Materials (abm): Clones for BMI1 - Starting at $45 >
- * BMI1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for BMI1
- Addgene plasmids for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
Cell Lines for research
-
Horizon Cell Lines for BMI1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMI1 Gene
Localization for BMI1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BMI1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear bodies (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 16714294 |
| GO:0005634 | nucleus | IEA,IDA | 9367786 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for BMI1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for BMI1 Gene
2 BioSystems pathways for BMI1 Gene
9 Reactome pathways for BMI1 Gene
3 KEGG pathways for BMI1 Gene
2 R&D Systems pathways for BMI1 Gene
1 Cell Signaling Technology pathway for BMI1 Gene
1 GeneTex pathway for BMI1 Gene
Interacting Proteins for BMI1 Gene
Selected Interacting proteins:
P35226-BMI1_HUMAN
ENSP00000365851
for BMI1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BMI1
SIGNOR curated interactions for BMI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006342 | chromatin silencing | IBA | 21873635 |
| GO:0007379 | segment specification | TAS | -- |
| GO:0010468 | regulation of gene expression | IMP | 17420273 |
Drugs & Compounds for BMI1 Gene
(2) ApexBio Compounds for BMI1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PTC-209 | Bmi-1 inhibitor,cell-permeable and small-molecule | 315704-66-6 |
| PTC209 HBr | BMI-1 inhibitor | 1217022-63-3 |
Transcripts for BMI1 Gene
mRNA/cDNA for BMI1 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376663 3540 nts (view in UCSC)
- ENST00000416820 406 nts (view in UCSC)
- ENST00000442508 536 nts (view in UCSC)
- ENST00000443519 552 nts (view in UCSC)
- ENST00000456675 550 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for BMI1 - Starting at $85 >
- * BMI1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for BMI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Clone products for research
- Applied Biological Materials (abm): Clones for BMI1 - Starting at $45 >
- * BMI1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for BMI1
- Addgene plasmids for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - |
Relevant External Links for BMI1 Gene
- GeneLoc Exon Structure for
- BMI1
Expression for BMI1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
This gene is overexpressed in Plasma (28.0), Retina (9.1), and Blymphocyte (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BMI1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BMI1
SOURCE GeneReport for Unigene cluster for BMI1 Gene:
Hs.380403Evidence on tissue expression from TISSUES for BMI1 Gene
- Muscle(4.6)
- Blood(4.5)
- Nervous system(3.8)
- Intestine(3.1)
- Liver(2.9)
- Lung(2.9)
- Heart(2.9)
- Kidney(2.8)
- Skin(2.8)
- Bone marrow(2.8)
- Spleen(2.8)
- Lymph node(2.8)
- Pancreas(2.6)
- Stomach(2.5)
- Thyroid gland(2.2)
- Eye(2.2)
- Adrenal gland(2)
Primer products for research
-
OriGene qPCR primer pairs for BMI1
-
OriGene qPCR primer pairs and template standards for BMI1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BMI1 Gene
Orthologs for BMI1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 30 |
|
OneToMany | |
| BMI1 29 |
|
||||
| Cow (Bos Taurus) |
Mammalia | BMI1 30 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | BMI1 30 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Bmi1 30 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | BMI1 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | bmi1b 30 |
|
ManyToMany | |
| bmi1a 29 30 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Psc 30 31 |
|
ManyToMany | |
| Su(z)2 30 |
|
ManyToMany |
- Species where no ortholog for BMI1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BMI1 Gene
- ENSEMBL:
- Gene Tree for BMI1 (if available)
- TreeFam:
- Gene Tree for BMI1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BMI1: view image
- Alliance of Genome Resources:
- Additional Orthologs for BMI1
Paralogs for BMI1 Gene
(19) SIMAP similar genes for BMI1 Gene using alignment to 5 proteins:
- BMI1_HUMAN
- Q5T8Z2_HUMAN
- Q5T8Z4_HUMAN
- Q5T8Z5_HUMAN
- Q5T8Z6_HUMAN
Variants for BMI1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BMI1 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 931408 | Uncertain Significance: See cases | 22,326,561(+) |
T/G NM_005180.9(BMI1):c.112T>G (p.Phe38Val) |
MISSENSE | |
| rs142568869 | Benign: not provided | 22,326,571(+) |
G/A NM_005180.9(BMI1):c.112+10G>A |
INTRON | |
| rs545089539 | Likely Benign: not provided | 22,328,706(+) |
C/T NM_005180.9(BMI1):c.570+8C>T |
INTRON | |
| rs1042059 | -- |
p.Cys18Tyr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1002n54 | CNV | loss | 21841781 |
| dgv1003n54 | CNV | loss | 21841781 |
| dgv136n67 | CNV | gain | 20364138 |
| dgv137n67 | CNV | gain | 20364138 |
| esv27808 | CNV | gain | 19812545 |
| nsv1069031 | CNV | deletion | 25765185 |
| nsv1143626 | CNV | deletion | 24896259 |
| nsv550207 | CNV | loss | 21841781 |
| nsv825300 | CNV | gain | 20364138 |
| nsv951254 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BMI1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMI1 Gene
Disorders for BMI1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mantle cell lymphoma |
|
|
| erythroplakia |
|
|
| leukemia |
|
|
| brain cancer |
|
|
| bone cancer |
|
|
Search BMI1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BMI1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BMI1 Gene
Publications for BMI1 Gene
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 22
- Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PMID: 16714294) Li Z … Xu RM (The Journal of biological chemistry 2006) 3 4 22
- Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PMID: 9121482) Gunster MJ … Otte AP (Molecular and cellular biology 1997) 3 4 22
- Characterization and chromosomal localization of the human proto-oncogene BMI-1. (PMID: 8268912) Alkema MJ … van Lohuizen M (Human molecular genetics 1993) 2 3 4
- BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. (PMID: 27827373) Gray F … Cierpicki T (Nature communications 2016) 3 4
ExternalLinks
Products for BMI1 Gene
- Custom Antibody ServicesOriGene Antibodies for BMI1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BMI1
- Search Origene for MassSpec and Protein Over-expression Lysates for BMI1
- Origene Custom Protein Services for BMI1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- OriGene qPCR primer pairs for BMI1
- OriGene qPCR primer pairs and template standards for BMI1
- OriGene CRISPR knockouts for BMI1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BMI1
- Sino Biological Human cDNA Clone for BMI1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for BMI1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BMI1
- Novus Biologicals proteins and lysates for BMI1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BMI1
- Abcam proteins for BMI1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for BMI1 (AFLGC-BMI1)
- ApexBio compounds for BMI1
- VectorBuilder Custom and pre-made DNA vectors for BMI1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BMI1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BMI1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BMI1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BMI1
- Addgene plasmids for BMI1
- antibodies-online: Show 87 available BMI1 Antibodies ranked by validation data
- Compare Top BMI1 Antibodies
- Recommended
- 267 WB Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 ChIP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 2 ChIP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 53 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 13 available BMI1 Elisa Kits ranked by validation data
- Compare Top BMI1 Elisa Kits
- antibodies-online: Show 10 available BMI1 Proteins ranked by validation data
- Compare Top BMI1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BMI1
- Search Santa Cruz Biotechnology (SCBT) for BMI1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
- Custom Antibody ServicesProSci Antibodies for BMI1
- BMI1 polycomb ring finger oncogene [13-052]
- BMI1 polycomb ring finger oncogene [13-080]
- BMI1 polycomb ring finger oncogene [3755]
- BMI1 polycomb ring finger oncogene [18-591]
- BMI1 polycomb ring finger oncogene [28-036]
- BMI1 polycomb ring finger oncogene [43-563]
- BMI1 polycomb ring finger oncogene [43-567]
- Polycomb complex protein BMI-1 [63-629]
- Polycomb complex protein BMI-1 [61-406]
- Search for BMI1 Proteins at ProSci
- Horizon Cell Lines for BMI1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Sources for BMI1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources