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This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include Mantle Cell Lymphoma and Erythroplakia. Among its related pathways are Transcriptional misregulation in cancer and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is COMMD3-BMI1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15386022 |
GO:0008270 | zinc ion binding | IDA | 16714294 |
GO:0046872 | metal ion binding | IEA | -- |
GO:0071535 | RING-like zinc finger domain binding | IPI | 16714294 |
GO:1990841 | promoter-specific chromatin binding | IBA,IDA | 24623306 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IDA | 16714294 |
GO:0005634 | nucleus | IEA,IDA | 9367786 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cellular Senescence (REACTOME) | ||
2 | SUMOylation |
.95
|
|
3 | Metabolism of proteins | ||
4 | Chromatin Regulation / Acetylation | ||
5 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA,IMP | 19636380 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0006342 | chromatin silencing | IBA | 21873635 |
GO:0007379 | segment specification | TAS | -- |
GO:0010468 | regulation of gene expression | IMP | 17420273 |
Compound | Action | Cas Number |
---|---|---|
PTC-209 | Bmi-1 inhibitor,cell-permeable and small-molecule | 315704-66-6 |
PTC209 HBr | BMI-1 inhibitor | 1217022-63-3 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
BMI1 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | BMI1 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | BMI1 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Bmi1 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | BMI1 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | bmi1b 31 |
|
ManyToMany | |
bmi1a 30 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Psc 31 32 |
|
ManyToMany | |
Su(z)2 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1002n54 | CNV | loss | 21841781 |
dgv1003n54 | CNV | loss | 21841781 |
dgv136n67 | CNV | gain | 20364138 |
dgv137n67 | CNV | gain | 20364138 |
esv27808 | CNV | gain | 19812545 |
nsv1069031 | CNV | deletion | 25765185 |
nsv1143626 | CNV | deletion | 24896259 |
nsv550207 | CNV | loss | 21841781 |
nsv825300 | CNV | gain | 20364138 |
nsv951254 | CNV | duplication | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mantle cell lymphoma |
|
|
erythroplakia |
|
|
brain cancer |
|
|
bone cancer |
|
|
leukemia |
|