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This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogen... See more...
Aliases for BMI1 Gene
Aliases for BMI1 Gene
External Ids for BMI1 Gene
- HGNC: 1066
- Entrez Gene: 648
- Ensembl: ENSG00000168283
- OMIM: 164831
- UniProtKB: P35226
Previous HGNC Symbols for BMI1 Gene
- PCGF4
Previous GeneCards Identifiers for BMI1 Gene
- GC10U990006
- GC10P022760
- GC10P022614
- GC10P022650
- GC10P022605
- GC10P022611
Summaries for BMI1 Gene
-
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for BMI1 Gene
BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include Mantle Cell Lymphoma and Erythroplakia. Among its related pathways are Transcriptional misregulation in cancer and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is COMMD3-BMI1.
UniProtKB/Swiss-Prot Summary for BMI1 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Additional gene information for BMI1 Gene
- HGNC(1066)
- Entrez Gene(648)
- Ensembl(ENSG00000168283)
- OMIM(164831)
- UniProtKB(P35226)
- Open Targets Platform(ENSG00000168283)
- Monarch Initiative
- Search for BMI1 at DataMed
- Search for BMI1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BMI1 Gene
Genomics for BMI1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BMI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BMI1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BMI1
- Top Transcription factor binding sites by QIAGEN in the BMI1 gene promoter:
-
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- POU3F2
- POU3F2 (N-Oct-5a)
- YY1
Genomic Locations for BMI1 Gene
Genomic Locations for BMI1 Gene
- chr10:22,321,099-22,331,484
- (GRCh38/hg38)
- Size:
- 10,386 bases
- Orientation:
- Plus strand
- chr10:22,610,139-22,620,414
- (GRCh37/hg19)
- Size:
- 10,276 bases
- Orientation:
- Plus strand
Genomic View for BMI1 Gene
Genes around BMI1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p12.2 by HGNC
- 10p12.2 by Entrez Gene
- 10p12.2 by Ensembl
BMI1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BMI1 Gene
Proteins for BMI1 Gene
-
Protein details for BMI1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35226-BMI1_HUMAN
- Recommended name:
- Polycomb complex protein BMI-1
- Protein Accession:
- P35226
- Q16030
- Q5T8Z3
- Q96F37
Protein attributes for BMI1 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 36949 Da
- Quaternary structure:
-
- Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:21772249, PubMed:25355358). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). Interacts with CBX7 and CBX8 (PubMed:19636380). Interacts with SPOP (PubMed:15897469). Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469). Interacts with E4F1 (PubMed:16882984). Interacts with PHC2 (PubMed:9121482, PubMed:9199346, PubMed:27827373).
- Miscellaneous:
-
- The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
Protein Expression for BMI1 Gene
Post-translational modifications for BMI1 Gene
- Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BMI1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for BMI1
-
Abcam antibodies for BMI1
- Invitrogen Antibodies for BMI1 (AFLGC-BMI1)
- antibodies-online: Show 87 available BMI1 Antibodies ranked by validation data
- Compare Top BMI1 Antibodies
-
Recommended
- 267 WB Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 ChIP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 2 ChIP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 53 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for BMI1
-
Santa Cruz Biotechnology (SCBT) Antibodies for BMI1
- Sino Biological Antibodies for BMI1
Protein Products
-
OriGene Purified Proteins for BMI1
- Search Origene for MassSpec and Protein Over-expression Lysates for BMI1
- Origene Custom Protein Services for BMI1
-
Abcam proteins for BMI1
Assay Products
No data available for DME Specific Peptides for BMI1 Gene
Domains & Families for BMI1 Gene
Gene Families for BMI1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for BMI1 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for BMI1 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 51 (BMI1_HUMAN)
- BMI1 polycomb ring finger oncogene (Q5T8Z2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BMI1 Gene
Function for BMI1 Gene
Molecular function for BMI1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
- GENATLAS Biochemistry:
- bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin
Phenotypes From GWAS Catalog for BMI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15386022 |
| GO:0008270 | zinc ion binding | IDA | 16714294 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0071535 | RING-like zinc finger domain binding | IPI | 16714294 |
| GO:1990841 | promoter-specific chromatin binding | IBA,IDA | 24623306 |
Phenotypes for BMI1 Gene
- GenomeRNAi human phenotypes for BMI1:
-
- no effect
- Increased cell death HMECs cells
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Decreased ionizing radiation sensitivity
- Increased cell death in HCT116 cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMI1 - Select products 50% OFF >
- * BMI1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
miRNA for BMI1 Gene
- miRTarBase miRNAs that target BMI1
-
- hsa-miR-200c-3p (MIRT000197)
- hsa-miR-16-5p (MIRT000266)
- hsa-miR-15a-5p (MIRT000280)
- hsa-miR-128-3p (MIRT004645)
- hsa-miR-302b-3p (MIRT005670)
- mmu-miR-200b-3p (MIRT005770)
- hsa-miR-203a-3p (MIRT006036)
- hsa-miR-708-5p (MIRT006139)
- hsa-miR-200b-3p (MIRT006165)
- hsa-miR-194-5p (MIRT007000)
- hsa-miR-218-5p (MIRT007258)
- mmu-miR-7b-5p (MIRT009427)
- hsa-let-7g-5p (MIRT024120)
- hsa-miR-33a-5p (MIRT028182)
- hsa-miR-106b-3p (MIRT038596)
- hsa-miR-27a-3p (MIRT050022)
- rno-miR-128-3p (MIRT053015)
- hsa-miR-544a (MIRT053511)
- hsa-miR-494-3p (MIRT053512)
- hsa-miR-495-3p (MIRT053513)
- hsa-miR-300 (MIRT053514)
- hsa-miR-30e-5p (MIRT053588)
- hsa-miR-302a-3p (MIRT053776)
- hsa-miR-183-5p (MIRT054143)
- hsa-miR-379-3p (MIRT177206)
- hsa-miR-380-3p (MIRT177207)
- hsa-miR-411-3p (MIRT177208)
- hsa-miR-4495 (MIRT177212)
- hsa-miR-559 (MIRT177226)
- hsa-miR-548b-5p (MIRT177228)
- hsa-miR-548a-5p (MIRT177229)
- hsa-miR-548c-5p (MIRT177230)
- hsa-miR-548d-5p (MIRT177231)
- hsa-miR-548j-5p (MIRT177232)
- hsa-miR-548n (MIRT177235)
- hsa-miR-548h-5p (MIRT177236)
- hsa-miR-548i (MIRT177237)
- hsa-miR-548w (MIRT177238)
- hsa-miR-548y (MIRT177239)
- hsa-miR-548o-5p (MIRT177240)
- hsa-miR-548ab (MIRT177241)
- hsa-miR-548ad-5p (MIRT177243)
- hsa-miR-548ae-5p (MIRT177244)
- hsa-miR-548ak (MIRT177245)
- hsa-miR-548am-5p (MIRT177246)
- hsa-miR-548ap-5p (MIRT177249)
- hsa-miR-548aq-5p (MIRT177250)
- hsa-miR-548ar-5p (MIRT177251)
- hsa-miR-548as-5p (MIRT177252)
- hsa-miR-548au-5p (MIRT177253)
- hsa-miR-548ay-5p (MIRT177256)
- hsa-miR-548bb-5p (MIRT177258)
- hsa-miR-580-5p (MIRT177295)
- hsa-miR-3120-3p (MIRT177298)
- hsa-miR-3942-5p (MIRT177299)
- hsa-miR-4703-5p (MIRT177300)
- hsa-miR-376c-3p (MIRT245244)
- hsa-miR-320a (MIRT262091)
- hsa-miR-586 (MIRT330296)
- hsa-miR-452-5p (MIRT437780)
- hsa-miR-487b-3p (MIRT437851)
- mmu-miR-200c-3p (MIRT438019)
- hsa-miR-548t-5p (MIRT560307)
- hsa-miR-548az-5p (MIRT560308)
- hsa-miR-153-5p (MIRT717182)
- hsa-miR-195-3p (MIRT717183)
- hsa-miR-16-2-3p (MIRT717184)
- hsa-miR-4666a-3p (MIRT717185)
- hsa-miR-338-5p (MIRT717186)
- hsa-miR-15a-3p (MIRT732884)
- hsa-miR-192-5p (MIRT732962)
- hsa-miR-21-5p (MIRT733326)
- hsa-miR-3622b-5p (MIRT733557)
- hsa-miR-200c-5p (MIRT734270)
- hsa-miR-128-1-5p (MIRT734515)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Clone Products
- Applied Biological Materials (abm): Clones for BMI1 - Select products 50% OFF >
- * BMI1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BMI1
- Addgene plasmids for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
Cell Line Products
-
Horizon Cell Lines for BMI1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMI1 Gene
Localization for BMI1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BMI1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear bodies (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 16714294 |
| GO:0005634 | nucleus | IEA,IDA | 9367786 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for BMI1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | MicroRNAs in cancer | ||
Pathways by source for BMI1 Gene
2 BioSystems pathways for BMI1 Gene
9 Reactome pathways for BMI1 Gene
3 KEGG pathways for BMI1 Gene
2 R&D Systems pathways for BMI1 Gene
1 Cell Signaling Technology pathway for BMI1 Gene
1 GeneTex pathway for BMI1 Gene
Interacting Proteins for BMI1 Gene
Selected Interacting proteins:
P35226-BMI1_HUMAN
ENSP00000365851
for BMI1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BMI1
SIGNOR curated interactions for BMI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA,IMP | 19636380 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006342 | chromatin silencing | IBA | 21873635 |
| GO:0007379 | segment specification | TAS | -- |
| GO:0010468 | regulation of gene expression | IMP | 17420273 |
Drugs & Compounds for BMI1 Gene
(2) ApexBio Compounds for BMI1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PTC-209 | Bmi-1 inhibitor,cell-permeable and small-molecule | 315704-66-6 |
| PTC209 HBr | BMI-1 inhibitor | 1217022-63-3 |
Transcripts for BMI1 Gene
mRNA/cDNA for BMI1 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376663 3540 nts (view in UCSC)
- ENST00000602523 748 nts (view in UCSC)
- ENST00000456675 550 nts (view in UCSC)
- ENST00000442508 536 nts (view in UCSC)
- ENST00000416820 406 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BMI1 - Select products 50% OFF >
- * BMI1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BMI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
-
Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Clone Products
- Applied Biological Materials (abm): Clones for BMI1 - Select products 50% OFF >
- * BMI1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BMI1
- Addgene plasmids for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - |
Relevant External Links for BMI1 Gene
- GeneLoc Exon Structure for
- BMI1
Expression for BMI1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
This gene is overexpressed in Plasma (28.0), Retina (9.1), and Blymphocyte (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BMI1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BMI1
SOURCE GeneReport for Unigene cluster for BMI1 Gene:
Hs.380403Evidence on tissue expression from TISSUES for BMI1 Gene
- Muscle(4.6)
- Blood(4.6)
- Nervous system(3.9)
- Intestine(3.3)
- Liver(3.1)
- Skin(3.1)
- Heart(3)
- Lung(3)
- Kidney(3)
- Bone marrow(3)
- Lymph node(3)
- Spleen(2.9)
- Pancreas(2.8)
- Stomach(2.7)
- Eye(2.4)
- Thyroid gland(2.4)
- Adrenal gland(2.1)
- Bone(2)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for BMI1
-
OriGene qPCR primer pairs and template standards for BMI1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BMI1 Gene
Orthologs for BMI1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
| BMI1 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | BMI1 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | BMI1 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Mouse (Mus musculus) |
Mammalia | Bmi1 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | BMI1 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | bmi1b 31 |
|
ManyToMany | |
| bmi1a 30 31 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Psc 31 32 |
|
ManyToMany | |
| Su(z)2 31 |
|
ManyToMany |
- Species where no ortholog for BMI1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BMI1 Gene
- ENSEMBL:
- Gene Tree for BMI1 (if available)
- TreeFam:
- Gene Tree for BMI1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BMI1: view image
Paralogs for BMI1 Gene
(19) SIMAP similar genes for BMI1 Gene using alignment to 5 proteins:
- BMI1_HUMAN
- Q5T8Z2_HUMAN
- Q5T8Z4_HUMAN
- Q5T8Z5_HUMAN
- Q5T8Z6_HUMAN
Variants for BMI1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1002n54 | CNV | loss | 21841781 |
| dgv1003n54 | CNV | loss | 21841781 |
| dgv136n67 | CNV | gain | 20364138 |
| dgv137n67 | CNV | gain | 20364138 |
| esv27808 | CNV | gain | 19812545 |
| nsv1069031 | CNV | deletion | 25765185 |
| nsv1143626 | CNV | deletion | 24896259 |
| nsv550207 | CNV | loss | 21841781 |
| nsv825300 | CNV | gain | 20364138 |
| nsv951254 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BMI1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMI1 Gene
Disorders for BMI1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mantle cell lymphoma |
|
|
| erythroplakia |
|
|
| brain cancer |
|
|
| bone cancer |
|
|
| leukemia |
|
Search BMI1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BMI1
No data available for UniProtKB/Swiss-Prot and Genatlas for BMI1 Gene
Publications for BMI1 Gene
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 23
- Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PMID: 16714294) Li Z … Xu RM (The Journal of biological chemistry 2006) 3 4 23
- Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PMID: 9121482) Gunster MJ … Otte AP (Molecular and cellular biology 1997) 3 4 23
- Characterization and chromosomal localization of the human proto-oncogene BMI-1. (PMID: 8268912) Alkema MJ … van Lohuizen M (Human molecular genetics 1993) 2 3 4
- BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization. (PMID: 27827373) Gray F … Cierpicki T (Nature communications 2016) 3 4
ExternalLinks
Products for BMI1 Gene
- Custom Antibody ServicesOriGene Antibodies for BMI1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BMI1
- Search Origene for MassSpec and Protein Over-expression Lysates for BMI1
- Origene Custom Protein Services for BMI1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BMI1
- Browse OriGene Inhibitory RNA Products For BMI1
- OriGene qPCR primer pairs for BMI1
- OriGene qPCR primer pairs and template standards for BMI1
- OriGene CRISPR knockouts for BMI1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BMI1
- Sino Biological Human cDNA Clone for BMI1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for BMI1
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BMI1
- Novus Biologicals proteins and lysates for BMI1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BMI1
- Abcam proteins for BMI1
- Find your target
- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for BMI1 (AFLGC-BMI1)
- ApexBio compounds for BMI1
- VectorBuilder Custom and pre-made DNA vectors for BMI1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BMI1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BMI1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BMI1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BMI1
- Addgene plasmids for BMI1
- antibodies-online: Show 87 available BMI1 Antibodies ranked by validation data
- Compare Top BMI1 Antibodies
- Recommended
- 267 WB Antibodies (anti-human)
- 12 IHC (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 2 ChIP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 120 WB Antibodies (anti-mouse)
- 2 ChIP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 53 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 13 available BMI1 Elisa Kits ranked by validation data
- Compare Top BMI1 Elisa Kits
- antibodies-online: Show 10 available BMI1 Proteins ranked by validation data
- Compare Top BMI1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BMI1
- Search Santa Cruz Biotechnology (SCBT) for BMI1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BMI1
- Custom Antibody ServicesProSci Antibodies for BMI1
- Search for BMI1 Proteins at ProSci
- Horizon Cell Lines for BMI1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BMI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BMI1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BMI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BMI1
Sources for BMI1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (43) HuGE
- (44) Atlas
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (89) antibodies-online
- (90) CYP
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- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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- (100) DGIdb
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- (103) SIGNOR
- (104) diseasecard
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