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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
BMF (Bcl2 Modifying Factor) is a Protein Coding gene. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Androgen receptor signaling pathway.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 11546872 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001669 | acrosomal vesicle | IEA | -- |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016459 | myosin complex | IBA,ISS | 11546872 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of BH3-only proteins | ||
2 | Apoptotic execution phase |
.31
|
|
3 | MicroRNAs in cancer | ||
4 | MAPK Signaling: Oxidative Stress | ||
5 | Autophagy Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | TAS | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0010507 | negative regulation of autophagy | IDA | 23629966 |
GO:0031334 | positive regulation of protein complex assembly | ISS | -- |
GO:0034644 | cellular response to UV | IDA | 23629966 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BMF 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BMF 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BMF 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bmf 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Bmf 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BMF 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BMF 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BMF 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bmf 30 |
|
No disorders were found for BMF Gene.