Aliases for BLVRA Gene
External Ids for BLVRA Gene
Previous HGNC Symbols for BLVRA Gene
Previous GeneCards Identifiers for BLVRA Gene
The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for BLVRA Gene
BLVRA (Biliverdin Reductase A) is a Protein Coding gene. Diseases associated with BLVRA include Hyperbiliverdinemia and Cholestasis. Among its related pathways are IL-10 Pathway and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and biliverdin reductase activity. An important paralog of this gene is DHDH.
UniProtKB/Swiss-Prot Summary for BLVRA Gene
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.