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Aliases for BLNK Gene

Aliases for BLNK Gene

  • B Cell Linker 2 3 5
  • B-Cell Adapter Containing A SH2 Domain Protein 2 3 4
  • Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD 2 3
  • Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa 3 4
  • B-Cell Adapter Containing A Src Homology 2 Domain Protein 3 4
  • B Cell Adaptor Containing SH2 Domain 2 3
  • Cytoplasmic Adapter Protein 3 4
  • B-Cell Linker Protein 3 4
  • B-Cell Activation 2 3
  • SLP-65 3 4
  • SLP65 3 4
  • BASH 3 4
  • BLNK-S 3
  • AGM4 3
  • LY57 3
  • Bca 3

External Ids for BLNK Gene

Previous GeneCards Identifiers for BLNK Gene

  • GC10M096844
  • GC10M097184
  • GC10M098082
  • GC10M097616
  • GC10M097941
  • GC10M091579

Summaries for BLNK Gene

Entrez Gene Summary for BLNK Gene

  • This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for BLNK Gene

BLNK (B Cell Linker) is a Protein Coding gene. Diseases associated with BLNK include Agammaglobulinemia 4, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is LCP2.

UniProtKB/Swiss-Prot for BLNK Gene

  • Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Gene Wiki entry for BLNK Gene

Additional gene information for BLNK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLNK Gene

Genomics for BLNK Gene

GeneHancer (GH) Regulatory Elements for BLNK Gene

Promoters and enhancers for BLNK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096266 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 623.3 +0.8 847 8.4 SP1 NKRF POLR2A ZNF687 RELA CREM MLLT1 ZBED1 IKZF1 CREB1 BLNK DNTT TCTN3 CCNJ ZNF518A GC10M096216 GC10M096095
GH10J096304 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 -34.2 -34226 3.2 EBF1 DNTT ENSG00000229418 BLNK OPALIN CCNJ ZNF518A CC2D2B GC10M096095
GH10J096242 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.4 +27.9 27890 3.8 ZNF687 RELA SP1 CREM MLLT1 ZBED1 IKZF1 IKZF2 TRIM22 CBFB BLNK OPALIN CC2D2B GC10M096216 GC10M096200 GC10M096095
GH10J096286 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 10.6 -17.3 -17349 5.2 SP1 ELF3 CEBPG ZNF384 ZNF687 RELA PPARG HNF1A CREM ZNF644 BLNK OPALIN RNU6-271P TLL2 DNTT GC10M096095
GH10J096238 Enhancer 0.8 Ensembl dbSUPER 16.1 +32.5 32486 1.8 NFIB CTBP1 HES1 RUNX3 ZNF217 DPF2 GATAD2B GATA3 JUND TCF7L2 BLNK OPALIN GC10M096216 GC10M096200 GC10M096095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BLNK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BLNK gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • IRF-2
  • Olf-1
  • p53
  • Pax-4a
  • RREB-1

Genomic Locations for BLNK Gene

Genomic Locations for BLNK Gene
chr10:96,191,699-96,271,587
(GRCh38/hg38)
Size:
79,889 bases
Orientation:
Minus strand
chr10:97,951,455-98,031,344
(GRCh37/hg19)
Size:
79,890 bases
Orientation:
Minus strand

Genomic View for BLNK Gene

Genes around BLNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLNK Gene

Proteins for BLNK Gene

  • Protein details for BLNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV28-BLNK_HUMAN
    Recommended name:
    B-cell linker protein
    Protein Accession:
    Q8WV28
    Secondary Accessions:
    • O75498
    • O75499
    • Q2MD49

    Protein attributes for BLNK Gene

    Size:
    456 amino acids
    Molecular mass:
    50466 Da
    Quaternary structure:
    • Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A. Interacts (via SH2 domain) with SYK; phosphorylated and activated by SYK. Interacts with SCIMP.

    Alternative splice isoforms for BLNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BLNK Gene

Post-translational modifications for BLNK Gene

  • Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BLNK Gene

Domains & Families for BLNK Gene

Gene Families for BLNK Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BLNK Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BLNK Gene

GenScript: Design optimal peptide antigens:
  • Src homology 2 domain-containing leukocyte protein of 65 kDa (BLNK_HUMAN)
  • B-cell linker protein (Q2MD39_HUMAN)
  • B-cell linker protein (Q2MD40_HUMAN)
  • B-cell linker protein (Q2MD42_HUMAN)
  • B-cell linker protein (Q2MD44_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLNK: view

No data available for UniProtKB/Swiss-Prot for BLNK Gene

Function for BLNK Gene

Molecular function for BLNK Gene

UniProtKB/Swiss-Prot Function:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Phenotypes From GWAS Catalog for BLNK Gene

Gene Ontology (GO) - Molecular Function for BLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS 9697839
GO:0005070 SH3/SH2 adaptor activity IDA,IBA 9697839
GO:0005515 protein binding IPI 16912232
genes like me logo Genes that share ontologies with BLNK: view
genes like me logo Genes that share phenotypes with BLNK: view

Human Phenotype Ontology for BLNK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BLNK Gene

MGI Knock Outs for BLNK:

Animal Model Products

CRISPR Products

miRNA for BLNK Gene

miRTarBase miRNAs that target BLNK

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BLNK

Clone Products

  • Applied Biological Materials (abm): Clones for BLNK - Now 50% OFF >
  • * BLNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * BLNK tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for BLNK

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BLNK Gene

Localization for BLNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLNK Gene

Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLNK gene
Compartment Confidence
plasma membrane 4
cytosol 4
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with BLNK: view

Pathways & Interactions for BLNK Gene

genes like me logo Genes that share pathways with BLNK: view

SIGNOR curated interactions for BLNK Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BLNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9697839
GO:0006959 humoral immune response TAS 9697839
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0009967 positive regulation of signal transduction IEA --
GO:0030183 B cell differentiation NAS 10583958
genes like me logo Genes that share ontologies with BLNK: view

Drugs & Compounds for BLNK Gene

(3) Drugs for BLNK Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,4-Dithiothreitol Experimental Pharma Target 0

(2) Additional Compounds for BLNK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BLNK: view

Transcripts for BLNK Gene

Unigene Clusters for BLNK Gene

B-cell linker:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BLNK

Clone Products

  • Applied Biological Materials (abm): Clones for BLNK - Now 50% OFF >
  • * BLNK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * BLNK tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for BLNK

Alternative Splicing Database (ASD) splice patterns (SP) for BLNK Gene

No ASD Table

Relevant External Links for BLNK Gene

GeneLoc Exon Structure for
BLNK
ECgene alternative splicing isoforms for
BLNK

Expression for BLNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BLNK Gene

This gene is overexpressed in Spleen (x5.3), Liver (x4.4), and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for BLNK Gene

This gene is overexpressed in Blymphocyte (37.8), Peripheral blood mononuclear cells (11.6), Cerebrospinal fluid (10.8), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BLNK Gene



Protein tissue co-expression partners for BLNK Gene

NURSA nuclear receptor signaling pathways regulating expression of BLNK Gene:

BLNK

SOURCE GeneReport for Unigene cluster for BLNK Gene:

Hs.665244

mRNA Expression by UniProt/SwissProt for BLNK Gene:

Q8WV28-BLNK_HUMAN
Tissue specificity: Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.

Evidence on tissue expression from TISSUES for BLNK Gene

  • Blood(3.2)
  • Lymph node(2.9)
  • Spleen(2.2)
  • Intestine(2.1)
  • Urine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for BLNK Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • outer ear
  • sinus
  • skull
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with BLNK: view

Orthologs for BLNK Gene

This gene was present in the common ancestor of chordates.

Orthologs for BLNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLNK 35 34
  • 99.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BLNK 35 34
  • 88.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BLNK 35 34
  • 87.98 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Blnk 17 35 34
  • 83.41 (n)
rat
(Rattus norvegicus)
Mammalia Blnk 34
  • 83.41 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BLNK 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves BLNK 35 34
  • 69.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BLNK 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia blnk 34
  • 57.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398328 34
zebrafish
(Danio rerio)
Actinopterygii blnk 35 34
  • 57.49 (n)
OneToOne
Species where no ortholog for BLNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BLNK Gene

ENSEMBL:
Gene Tree for BLNK (if available)
TreeFam:
Gene Tree for BLNK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BLNK: view image

Paralogs for BLNK Gene

Paralogs for BLNK Gene

(1) SIMAP similar genes for BLNK Gene using alignment to 3 proteins:

  • BLNK_HUMAN
  • F5GXS1_HUMAN
  • K7EKR2_HUMAN
genes like me logo Genes that share paralogs with BLNK: view

Variants for BLNK Gene

Sequence variations from dbSNP and Humsavar for BLNK Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs11540858 benign, Agammaglobulinemia 4, autosomal recessive 96,247,049(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs12261820 benign, Agammaglobulinemia 4, autosomal recessive 96,230,803(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs143109144 uncertain-significance, Agammaglobulinemia 4, autosomal recessive 96,247,009(-) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs144266674 uncertain-significance, likely-benign, not provided, Agammaglobulinemia 4, autosomal recessive 96,204,068(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs144903484 benign, Agammaglobulinemia 4, autosomal recessive 96,227,509(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BLNK Gene

Variant ID Type Subtype PubMed ID
dgv29n17 CNV loss 16327808
esv2661927 CNV deletion 23128226
esv2739762 CNV deletion 23290073
esv2739773 CNV deletion 23290073
nsv1110852 OTHER inversion 24896259
nsv1121460 CNV deletion 24896259
nsv1152730 CNV deletion 26484159
nsv831947 CNV gain+loss 17160897
nsv831949 CNV gain 17160897

Variation tolerance for BLNK Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BLNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLNK
Human Gene Mutation Database (HGMD)
BLNK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLNK Gene

Disorders for BLNK Gene

MalaCards: The human disease database

(7) MalaCards diseases for BLNK Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 4, autosomal recessive
  • agm4
agammaglobulinemia, non-bruton type
  • autosomal agammaglobulinemia
agammaglobulinemia
  • hypogammaglobulinemia
b cell linker protein deficiency
  • b-cell linker protein deficiency
congenital hypogammaglobulinemia
  • congenital hypogammaglobulinaemia
- elite association - COSMIC cancer census association via MalaCards
Search BLNK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BLNK_HUMAN
  • Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:10583958}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for BLNK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BLNK: view

No data available for Genatlas for BLNK Gene

Publications for BLNK Gene

  1. BLNK: a central linker protein in B cell activation. (PMID: 9697839) Fu C … Chan AC (Immunity 1998) 2 3 4 23 58
  2. Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. (PMID: 16912232) Grabbe A … Wienands J (Blood 2006) 3 4 23 58
  3. Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. (PMID: 15270728) Taguchi T … Fujimoto J (Immunology 2004) 3 4 23 58
  4. An essential role for BLNK in human B cell development. (PMID: 10583958) Minegishi Y … Conley ME (Science (New York, N.Y.) 1999) 2 3 4 58
  5. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P … Brdicka T (Molecular and cellular biology 2011) 3 4 58

Products for BLNK Gene

Sources for BLNK Gene

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