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Aliases for BLCAP Gene

Aliases for BLCAP Gene

  • BLCAP, Apoptosis Inducing Factor 2 3
  • Bladder Cancer Associated Protein 2 3 5
  • BC10 3 4
  • Bladder Cancer Related Protein (10kD) 3
  • Bladder Cancer-Associated Protein 3
  • Bladder Cancer 10 KDa Protein 4
  • Bc10 4

External Ids for BLCAP Gene

Previous GeneCards Identifiers for BLCAP Gene

  • GC20M035874
  • GC20M036784
  • GC20M036831
  • GC20M035579
  • GC20M036130
  • GC20M032881

Summaries for BLCAP Gene

Entrez Gene Summary for BLCAP Gene

  • This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]

GeneCards Summary for BLCAP Gene

BLCAP (BLCAP, Apoptosis Inducing Factor) is a Protein Coding gene. Diseases associated with BLCAP include Bladder Cancer.

UniProtKB/Swiss-Prot for BLCAP Gene

  • May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Wiki entry for BLCAP Gene

Additional gene information for BLCAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLCAP Gene

Genomics for BLCAP Gene

GeneHancer (GH) Regulatory Elements for BLCAP Gene

Promoters and enhancers for BLCAP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J037516 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.3 +5.3 5326 13.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 SSRP1 GLIS1 BLCAP NNAT RALGAPB RBL1 TTI1 LINC00489 ENSG00000201811 SNHG17 SOGA1 LOC100419562
GH20J037534 Enhancer 1.1 Ensembl ENCODE 7.6 -6.8 -6815 0.8 HDGF PKNOX1 RB1 MLX ARID4B ZSCAN9 RAD21 RFX5 ZNF614 ARID2 BLCAP PPIAP3 LINC01746
GH20J036830 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +694.1 694112 7.4 HDGF PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 IRF4 POLR2B ZNF143 NDRG3 BLCAP RBL1 DSN1 SOGA1 GC20P036795
GH20J036841 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.6 +682.1 682130 9.6 IRF4 ZNF121 GLIS2 ZNF207 FOS ATF7 RUNX3 JUNB ZNF518A ZNF592 NDRG3 DSN1 BLCAP SOGA1 GC20P036795
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BLCAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BLCAP gene promoter:

Genomic Locations for BLCAP Gene

Genomic Locations for BLCAP Gene
35,460 bases
Minus strand

Genomic View for BLCAP Gene

Genes around BLCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLCAP Gene

Proteins for BLCAP Gene

  • Protein details for BLCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bladder cancer-associated protein
    Protein Accession:
    Secondary Accessions:
    • A2A2K7
    • O60629
    • Q9D3B5

    Protein attributes for BLCAP Gene

    87 amino acids
    Molecular mass:
    9876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BLCAP Gene

Post-translational modifications for BLCAP Gene

No Post-translational modifications

No data available for DME Specific Peptides for BLCAP Gene

Domains & Families for BLCAP Gene

Gene Families for BLCAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BLCAP Gene


Suggested Antigen Peptide Sequences for BLCAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BLCAP family.
  • Belongs to the BLCAP family.
genes like me logo Genes that share domains with BLCAP: view

Function for BLCAP Gene

Molecular function for BLCAP Gene

UniProtKB/Swiss-Prot Function:
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

Gene Ontology (GO) - Molecular Function for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with BLCAP: view
genes like me logo Genes that share phenotypes with BLCAP: view

Animal Model Products

CRISPR Products

miRNA for BLCAP Gene

miRTarBase miRNAs that target BLCAP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BLCAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BLCAP Gene

Localization for BLCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLCAP Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLCAP gene
Compartment Confidence
extracellular 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BLCAP: view

Pathways & Interactions for BLCAP Gene

SuperPathways for BLCAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for BLCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0030262 apoptotic nuclear changes IDA 17031575
genes like me logo Genes that share ontologies with BLCAP: view

No data available for Pathways by source and SIGNOR curated interactions for BLCAP Gene

Drugs & Compounds for BLCAP Gene

No Compound Related Data Available

Transcripts for BLCAP Gene

Unigene Clusters for BLCAP Gene

Bladder cancer associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BLCAP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLCAP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP3: - - - - -
SP4: - - -
SP5: - -

Relevant External Links for BLCAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BLCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLCAP Gene

mRNA differential expression in normal tissues according to GTEx for BLCAP Gene

This gene is overexpressed in Muscle - Skeletal (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of BLCAP Gene:


SOURCE GeneReport for Unigene cluster for BLCAP Gene:


mRNA Expression by UniProt/SwissProt for BLCAP Gene:

Tissue specificity: Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.

Evidence on tissue expression from TISSUES for BLCAP Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Intestine(4.4)
  • Kidney(2.8)
  • Muscle(2.5)
  • Pancreas(2.3)
  • Eye(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with BLCAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLCAP Gene

Orthologs for BLCAP Gene

This gene was present in the common ancestor of animals.

Orthologs for BLCAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BLCAP 34 33
  • 100 (n)
(Bos Taurus)
Mammalia BLCAP 34 33
  • 97.7 (n)
(Canis familiaris)
Mammalia BLCAP 34 33
  • 96.55 (n)
(Mus musculus)
Mammalia Blcap 16 34 33
  • 95.02 (n)
(Monodelphis domestica)
Mammalia BLCAP 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Blcap 33
  • 93.49 (n)
(Gallus gallus)
Aves BLCAP 34 33
  • 86.59 (n)
(Anolis carolinensis)
Reptilia BLCAP 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia blcap 33
  • 78.16 (n)
Str.634 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12525 33
(Danio rerio)
Actinopterygii blcap 34 33 33
  • 84.29 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5031 33
fruit fly
(Drosophila melanogaster)
Insecta bc10 34
  • 61 (a)
(Caenorhabditis elegans)
Secernentea Y73E7A.6 34
  • 40 (a)
Species where no ortholog for BLCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BLCAP Gene

Gene Tree for BLCAP (if available)
Gene Tree for BLCAP (if available)
Evolutionary constrained regions (ECRs) for BLCAP: view image

Paralogs for BLCAP Gene

No data available for Paralogs for BLCAP Gene

Variants for BLCAP Gene

Sequence variations from dbSNP and Humsavar for BLCAP Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000243615 -- 37,524,736(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000860076 -- 37,523,589(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000939691 -- 37,526,451(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000985219 -- 37,529,208(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BLCAP Gene

Variant ID Type Subtype PubMed ID
nsv1055206 CNV loss 25217958
nsv585962 CNV loss 21841781
nsv833968 CNV gain 17160897

Variation tolerance for BLCAP Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BLCAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLCAP Gene

Disorders for BLCAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for BLCAP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BLCAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BLCAP

genes like me logo Genes that share disorders with BLCAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BLCAP Gene

Publications for BLCAP Gene

  1. Human BLCAP transcript: new editing events in normal and cancerous tissues. (PMID: 19908260) Galeano F … Gallo A (International journal of cancer 2010) 3 4 22 58
  2. Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis. (PMID: 17031575) Yao J … Wu X (Molecular and cellular biochemistry 2007) 2 3 4 58
  3. Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma. (PMID: 16675915) Zuo Z … Wu X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2006) 3 4 22 58
  4. Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure. (PMID: 10197429) Gromova I … Celis JE (Electrophoresis 1999) 2 3 4 58
  5. BLCAP arrests G₁/S checkpoint and induces apoptosis through downregulation of pRb1 in HeLa cells. (PMID: 26986503) Zhao M … Wu X (Oncology reports 2016) 2 3 58

Products for BLCAP Gene

Sources for BLCAP Gene

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