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Aliases for BLACE Gene

Subcategory (RNA class) for BLACE Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for BLACE Gene

  • B Cell Acute Lymphoblastic Leukemia Expressed 2 3
  • B-Cell Acute Lymphoblastic Leukemia Expressed 5

External Ids for BLACE Gene

Previous GeneCards Identifiers for BLACE Gene

  • GC00U901009
  • GC07U901528
  • GC07M154842
  • GC07M155149

Summaries for BLACE Gene

GeneCards Summary for BLACE Gene

BLACE (B Cell Acute Lymphoblastic Leukemia Expressed) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for BLACE Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLACE Gene

Genomics for BLACE Gene

GeneHancer (GH) Regulatory Elements for BLACE Gene

Promoters and enhancers for BLACE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I155344 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12.4 +22.9 22949 1.5 HDGF SIN3A ZNF2 GLIS2 ARID2 ZNF143 ATF7 RUNX3 ZNF263 REST GC07P155346 INSIG1 BLACE RBM33 LOC105375591 LOC105375592
GH07I155740 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.7 -373.9 -373926 3.2 BACH1 EBF1 BATF IRF4 RELA NFATC1 NFE2 ETV6 IKZF2 BCLAF1 EN2 ENSG00000236544 BLACE RBM33 PAXIP1-AS2 PIR49030 LOC100506302
GH07I155471 Enhancer 1 VISTA ENCODE 10 -104.3 -104299 1.8 MAZ ZSCAN4 ZBTB8A ZIC2 GLIS2 POLR2A GLIS1 ZNF341 ZNF600 TCF7L2 ENSG00000227365 CNPY1 BLACE EN2
GH07I155190 Enhancer 0.9 ENCODE dbSUPER 10.3 +177.2 177168 0.2 CTCF LEF1 RB1 RAD21 CCNT2 CC2D1A E2F1 CTBP1 ARID2 SMC3 BLACE ENSG00000217825 RN7SKP280
GH07I155189 Enhancer 0.8 ENCODE dbSUPER 11.1 +178.4 178370 0.5 CEBPB CEBPG RAD21 ATF4 JUND ATF3 HMBOX1 HNF4A ATF7 TRIM24 BLACE ENSG00000217825 RN7SKP280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BLACE on UCSC Golden Path with GeneCards custom track

Genomic Locations for BLACE Gene

Genomic Locations for BLACE Gene
chr7:155,356,985-155,367,934
(GRCh38/hg38)
Size:
10,950 bases
Orientation:
Minus strand
chr7:155,149,680-155,160,629
(GRCh37/hg19)

Genomic View for BLACE Gene

Genes around BLACE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLACE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLACE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLACE Gene

Proteins for BLACE Gene

  • Protein details for BLACE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D250-BLACE_HUMAN
    Recommended name:
    B-cell acute lymphoblastic leukemia-expressed protein
    Protein Accession:
    A4D250

    Protein attributes for BLACE Gene

    Size:
    179 amino acids
    Molecular mass:
    19503 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AY166699; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

neXtProt entry for BLACE Gene

Post-translational modifications for BLACE Gene

No Post-translational modifications

Other Protein References for BLACE Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for BLACE Gene

Domains & Families for BLACE Gene

Gene Families for BLACE Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BLACE Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLACE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BLACE: view

No data available for UniProtKB/Swiss-Prot for BLACE Gene

Function for BLACE Gene

Phenotypes From GWAS Catalog for BLACE Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BLACE Gene

Localization for BLACE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLACE gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BLACE Gene

Pathways & Interactions for BLACE Gene

SuperPathways for BLACE Gene

No Data Available

Interacting Proteins for BLACE Gene

Gene Ontology (GO) - Biological Process for BLACE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BLACE Gene

Drugs & Compounds for BLACE Gene

No Compound Related Data Available

Transcripts for BLACE Gene

mRNA/cDNA for BLACE Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BLACE Gene

No ASD Table

Relevant External Links for BLACE Gene

GeneLoc Exon Structure for
BLACE
ECgene alternative splicing isoforms for
BLACE

Expression for BLACE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLACE Gene

mRNA differential expression in normal tissues according to GTEx for BLACE Gene

This gene is overexpressed in Testis (x20.4), Whole Blood (x11.3), Fallopian Tube (x10.7), and Brain - Cerebellum (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of BLACE Gene:

BLACE

SOURCE GeneReport for Unigene cluster for BLACE Gene:

Hs.521326
genes like me logo Genes that share expression patterns with BLACE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLACE Gene

Orthologs for BLACE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLACE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BLACE 34
  • 98 (a)
OneToOne
Species where no ortholog for BLACE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BLACE Gene

ENSEMBL:
Gene Tree for BLACE (if available)
TreeFam:
Gene Tree for BLACE (if available)

Paralogs for BLACE Gene

No data available for Paralogs for BLACE Gene

Variants for BLACE Gene

Sequence variations from dbSNP and Humsavar for BLACE Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000166031 -- 155,369,244(-) C/T upstream_transcript_variant
rs1000344043 -- 155,361,481(-) A/G intron_variant
rs1000619496 -- 155,366,463(-) A/G intron_variant
rs1000623028 -- 155,368,905(-) C/G/T upstream_transcript_variant
rs1000796622 -- 155,357,341(-) A/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BLACE Gene

Variant ID Type Subtype PubMed ID
nsv824408 CNV gain 20364138
nsv479653 CNV novel sequence insertion 20440878
nsv479558 CNV novel sequence insertion 20440878
nsv479205 CNV novel sequence insertion 20440878
nsv478993 CNV novel sequence insertion 20440878
nsv473947 CNV novel sequence insertion 20440878
nsv473675 CNV novel sequence insertion 20440878
nsv472044 CNV novel sequence insertion 20440878

Variation tolerance for BLACE Gene

Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BLACE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLACE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLACE Gene

Disorders for BLACE Gene

Additional Disease Information for BLACE

No disorders were found for BLACE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BLACE Gene

Publications for BLACE Gene

  1. A gene expressed exclusively in acute B lymphoblastic leukemias. (PMID: 14667812) Vialle-Castellano A … van Baren N (Genomics 2004) 2 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58

Products for BLACE Gene

Sources for BLACE Gene

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