Aliases for BLACE Gene

Subcategory (RNA class) for BLACE Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for BLACE Gene

  • B Cell Acute Lymphoblastic Leukemia Expressed 2 3 5
  • BLACE 2 5 165
  • B-Cell Acute Lymphoblastic Leukemia-Expressed Protein 4
  • HSALNG0062567 164

External Ids for BLACE Gene

Previous GeneCards Identifiers for BLACE Gene

  • GC00U901009
  • GC07U901528
  • GC07M154842
  • GC07M155149

Summaries for BLACE Gene

GeneCards Summary for BLACE Gene

BLACE (B Cell Acute Lymphoblastic Leukemia Expressed) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for BLACE Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BLACE Gene

Genomics for BLACE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BLACE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J155368 Enhancer 0.3 Ensembl 600.7 -1.0 -967 0.6 POLR2A SMARCA4 BLACE piR-32677-456 piR-55654-485 ENSG00000273117 LOC105375593 HSALNG0062575 INSIG1 EN2
GH07J155366 Enhancer 0.2 Ensembl 600.7 +1.6 1633 0.2 BLACE piR-32677-456 piR-55654-485 LOC105375593 INSIG1 EN2
GH07J155344 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 12.5 +23.2 23182 0.9 CTCF IKZF1 BACH1 JUND LARP7 ZNF143 RELA ZNF24 REST RAD21 INSIG1 BLACE ENSG00000273117 LOC105375592 LOC105375593 EN2
GH07J155233 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 +133.6 133647 3.2 SP1 CTCF ZSCAN29 YY1 GABPA JUND ZFHX2 RAD21 ZNF18 ZNF687 lnc-PAXIP1-25 BLACE piR-30465-038 INSIG1 HTR5A
GH07J155471 Enhancer 1.1 VISTA Ensembl ENCODE 10 -104.3 -104342 1.8 ZIC2 ZSCAN4 POLR2A EZH2 ZNF600 ZNF341 TCF7L2 GLIS1 TRIM28 FOS ENSG00000227365 CNPY1 BLACE LOC107986863 HSALNG0062585 EN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BLACE on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for BLACE Gene

Genomic Locations for BLACE Gene
chr7:155,356,985-155,367,934
(GRCh38/hg38)
Size:
10,950 bases
Orientation:
Minus strand
chr7:155,149,680-155,160,629
(GRCh37/hg19)
Size:
10,950 bases
Orientation:
Minus strand

Genomic View for BLACE Gene

Genes around BLACE on UCSC Golden Path with GeneCards custom track
BLACE in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
BLACE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLACE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLACE Gene

Proteins for BLACE Gene

  • Protein details for BLACE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D250-BLACE_HUMAN
    Recommended name:
    B-cell acute lymphoblastic leukemia-expressed protein
    Protein Accession:
    A4D250

    Protein attributes for BLACE Gene

    Size:
    179 amino acids
    Molecular mass:
    19503 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AY166699; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for BLACE Gene

Post-translational modifications for BLACE Gene

No Post-translational modifications

No data available for DME Specific Peptides for BLACE Gene

Domains & Families for BLACE Gene

Gene Families for BLACE Gene

Protein Domains for BLACE Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BLACE Gene

GenScript: Design optimal peptide antigens:
  • B-cell acute lymphoblastic leukemia-expressed protein (BLACE_HUMAN)
genes like me logo Genes that share domains with BLACE: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BLACE Gene

Function for BLACE Gene

Phenotypes From GWAS Catalog for BLACE Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BLACE Gene

Localization for BLACE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLACE gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BLACE Gene

Pathways & Interactions for BLACE Gene

PathCards logo

SuperPathways for BLACE Gene

No Data Available

Gene Ontology (GO) - Biological Process for BLACE Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for BLACE Gene

Drugs & Compounds for BLACE Gene

No Compound Related Data Available

Transcripts for BLACE Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for BLACE Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000D621AC_9606 lncRNA 2456 2

Ensembl: ENST00000378120 (view in UCSC) ,

LNCipedia: BLACE:2,

URS000075DC13_9606 lncRNA 2452 2

HGNC: 20484,

RefSeq: NR_103545,

URS0000D6021F_9606 lncRNA 540 2

Ensembl: ENST00000616210 (view in UCSC) ,

LNCipedia: BLACE:4,

URS0000EA12AA_9606 lncRNA 2458 1

LncBook: HSALNT0289444,

URS0000D6E23D_9606 lncRNA 2452 1

LNCipedia: BLACE:5,

BLACE in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for BLACE Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLACE Gene

No ASD Table

Relevant External Links for BLACE Gene

GeneLoc Exon Structure for
BLACE

Expression for BLACE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BLACE Gene

mRNA differential expression in normal tissues according to GTEx for BLACE Gene

This gene is overexpressed in Testis (x20.4), Whole Blood (x11.3), Fallopian Tube (x10.7), and Brain - Cerebellum (x7.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BLACE

SOURCE GeneReport for Unigene cluster for BLACE Gene:

Hs.521326
genes like me logo Genes that share expression patterns with BLACE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLACE Gene

Orthologs for BLACE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BLACE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BLACE 31
  • 98 (a)
OneToOne
Species where no ortholog for BLACE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BLACE Gene

ENSEMBL:
Gene Tree for BLACE (if available)
TreeFam:
Gene Tree for BLACE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BLACE: view image

Paralogs for BLACE Gene

No data available for Paralogs for BLACE Gene

Variants for BLACE Gene

Additional dbSNP identifiers (rs#s) for BLACE Gene

Structural Variations from Database of Genomic Variants (DGV) for BLACE Gene

Variant ID Type Subtype PubMed ID
nsv472044 CNV novel sequence insertion 20440878
nsv473675 CNV novel sequence insertion 20440878
nsv473947 CNV novel sequence insertion 20440878
nsv478993 CNV novel sequence insertion 20440878
nsv479205 CNV novel sequence insertion 20440878
nsv479558 CNV novel sequence insertion 20440878
nsv479653 CNV novel sequence insertion 20440878
nsv824408 CNV gain 20364138

Variation tolerance for BLACE Gene

Gene Damage Index Score: 0.62; 13.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BLACE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BLACE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BLACE Gene

Disorders for BLACE Gene

No disorders were found for BLACE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BLACE Gene

Publications for BLACE Gene

  1. A gene expressed exclusively in acute B lymphoblastic leukemias. (PMID: 14667812) Vialle-Castellano A … van Baren N (Genomics 2004) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4

Products for BLACE Gene

Sources for BLACE Gene