Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BIVM Gene

Aliases for BIVM Gene

  • Basic, Immunoglobulin-Like Variable Motif Containing 2 3 5

External Ids for BIVM Gene

Previous GeneCards Identifiers for BIVM Gene

  • GC13P101819
  • GC13P097838
  • GC13P102288
  • GC13P101149
  • GC13P102249
  • GC13P103451
  • GC13P084043

Summaries for BIVM Gene

GeneCards Summary for BIVM Gene

BIVM (Basic, Immunoglobulin-Like Variable Motif Containing) is a Protein Coding gene.

Additional gene information for BIVM Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIVM Gene

Genomics for BIVM Gene

GeneHancer (GH) Regulatory Elements for BIVM Gene

Promoters and enhancers for BIVM Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I102798 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558.8 +0.8 779 3.7 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 BIVM BIVM-ERCC5 KDELC1 METTL21EP GC13M102806
GH13I102844 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.6 +47.5 47451 3.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ERCC5 BIVM TEX30 METTL21EP TPP2 CCDC168 LINC00283 METTL21C GC13P102835 GC13M102871
GH13I102830 Enhancer 1 ENCODE dbSUPER 12.7 +32.0 31956 1.2 ELF3 FOXA2 MLX ARID4B DMAP1 ZNF48 RAD21 RARA THAP11 MIXL1 BIVM ERCC5 TEX30 LINC00283 GC13P102835 RNY5P8 BIVM-ERCC5
GH13I102606 Enhancer 0.8 dbSUPER 10.7 -192.5 -192528 0.7 HDAC1 PKNOX1 ATF1 ARNT TCF12 GATA2 ATF7 CREM SMAD5 CEBPB BIVM ERCC5 LINC00283 CCDC168 METTL21C TPP2 GC13P102663
GH13I102760 Promoter 0.5 EPDnew 11 -40.0 -39966 0.1 CCDC168 LOC105370337 BIVM ERCC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BIVM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BIVM gene promoter:

Genomic Locations for BIVM Gene

Genomic Locations for BIVM Gene
42,490 bases
Plus strand

Genomic View for BIVM Gene

Genes around BIVM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIVM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIVM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIVM Gene

Proteins for BIVM Gene

  • Protein details for BIVM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic immunoglobulin-like variable motif-containing protein
    Protein Accession:
    Secondary Accessions:
    • Q2M1J2
    • Q9NXM4

    Protein attributes for BIVM Gene

    503 amino acids
    Molecular mass:
    56774 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH51813.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90986.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BIVM Gene


neXtProt entry for BIVM Gene

Post-translational modifications for BIVM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIVM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIVM Gene

Domains & Families for BIVM Gene

Gene Families for BIVM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BIVM Gene


Suggested Antigen Peptide Sequences for BIVM Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BIVM family.
  • Belongs to the BIVM family.
genes like me logo Genes that share domains with BIVM: view

Function for BIVM Gene

Phenotypes for BIVM Gene

GenomeRNAi human phenotypes for BIVM:
genes like me logo Genes that share phenotypes with BIVM: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BIVM Gene

Localization for BIVM Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIVM Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIVM gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BIVM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BIVM: view

Pathways & Interactions for BIVM Gene

No Data Available

Interacting Proteins for BIVM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q86UB2-BIVM_HUMAN ENSP00000257336 for BIVM Gene via IID STRING

Gene Ontology (GO) - Biological Process for BIVM Gene


No data available for Pathways by source and SIGNOR curated interactions for BIVM Gene

Drugs & Compounds for BIVM Gene

No Compound Related Data Available

Transcripts for BIVM Gene

Unigene Clusters for BIVM Gene

Basic, immunoglobulin-like variable motif containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIVM Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^
SP1: - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - -
SP13: - - - - -
SP14: - - -
SP15: - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - - - - - - -

ExUns: 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: - -
SP6: -

Relevant External Links for BIVM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BIVM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIVM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BIVM Gene

This gene is overexpressed in Urine (54.6) and Fetal heart (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BIVM Gene

Protein tissue co-expression partners for BIVM Gene

NURSA nuclear receptor signaling pathways regulating expression of BIVM Gene:


SOURCE GeneReport for Unigene cluster for BIVM Gene:


mRNA Expression by UniProt/SwissProt for BIVM Gene:

Tissue specificity: Widely expressed. Expressed at higher level in spleen, ovary, small intestine, colon, peripheral blood leukocytes and liver. Also expressed in testis, ovary, aorta, appendix, trachea, pituitary gland, bladder, uterus, spinal cord, salivary gland, stomach, mammary gland and bone marrow. Weakly or not expressed in fetal spleen, adult thymus and certain cancer cell lines.

Evidence on tissue expression from TISSUES for BIVM Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with BIVM: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIVM Gene

Orthologs for BIVM Gene

This gene was present in the common ancestor of chordates.

Orthologs for BIVM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BIVM 33
  • 99.14 (n)
(Canis familiaris)
Mammalia BIVM 33
  • 93.8 (n)
(Bos Taurus)
Mammalia BIVM 33
  • 90.9 (n)
(Ornithorhynchus anatinus)
Mammalia BIVM 34
  • 88 (a)
(Rattus norvegicus)
Mammalia LOC102548228 33
  • 87.38 (n)
(Mus musculus)
Mammalia Bivm 33 16 34
  • 87.12 (n)
(Monodelphis domestica)
Mammalia BIVM 34
  • 86 (a)
(Gallus gallus)
Aves BIVM 33 34
  • 76.58 (n)
(Anolis carolinensis)
Reptilia BIVM 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bivm 33
  • 69.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia bivm-A-prov 33
(Danio rerio)
Actinopterygii bivm 33 34
  • 55 (a)
Species where no ortholog for BIVM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIVM Gene

Gene Tree for BIVM (if available)
Gene Tree for BIVM (if available)

Paralogs for BIVM Gene

(1) SIMAP similar genes for BIVM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BIVM: view

No data available for Paralogs for BIVM Gene

Variants for BIVM Gene

Sequence variations from dbSNP and Humsavar for BIVM Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000029057 -- 102,820,969(+) G/A intron_variant
rs1000041867 -- 102,826,496(+) CTAACT/CT intron_variant
rs1000055182 -- 102,833,537(+) G/C intron_variant
rs1000108280 -- 102,840,564(+) G/T 3_prime_UTR_variant
rs1000152944 -- 102,797,996(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BIVM Gene

Variant ID Type Subtype PubMed ID
nsv1048497 CNV gain 25217958
nsv562981 CNV gain 21841781

Variation tolerance for BIVM Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIVM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIVM Gene

Disorders for BIVM Gene

Additional Disease Information for BIVM

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BIVM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIVM Gene

Publications for BIVM Gene

  1. BIVM, a novel gene widely distributed among deuterostomes, shares a core sequence with an unusual gene in Giardia lamblia. (PMID: 12036287) Yoder JA … Litman GW (Genomics 2002) 2 3 4 58
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. (PMID: 23580065) Pieragostino D … Del Boccio P (Molecular bioSystems 2013) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for BIVM Gene

Sources for BIVM Gene

Loading form....