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Aliases for BIRC8 Gene

Aliases for BIRC8 Gene

  • Baculoviral IAP Repeat Containing 8 2 3 5
  • Inhibitor Of Apoptosis-Like Protein 2 2 3 4
  • IAP-Like Protein 2 2 3 4
  • Testis-Specific Inhibitor Of Apoptosis 3 4
  • ILP-2 3 4
  • ILP2 3 4
  • Baculoviral IAP Repeat-Containing Protein 8 3
  • Baculoviral IAP Repeat-Containing 8 2
  • RNF136 3
  • HILP2 3

External Ids for BIRC8 Gene

Previous GeneCards Identifiers for BIRC8 Gene

  • GC19M054438
  • GC19M054154
  • GC19M058468
  • GC19M058484
  • GC19M053792
  • GC19M050113

Summaries for BIRC8 Gene

GeneCards Summary for BIRC8 Gene

BIRC8 (Baculoviral IAP Repeat Containing 8) is a Protein Coding gene. Among its related pathways are Apoptosis Modulation and Signaling and TNF Signaling (sino). Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and scaffold protein binding. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC8 Gene

  • Protects against apoptosis mediated by BAX.

Additional gene information for BIRC8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC8 Gene

Genomics for BIRC8 Gene

GeneHancer (GH) Regulatory Elements for BIRC8 Gene

Promoters and enhancers for BIRC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053037 Promoter/Enhancer 1 Ensembl ENCODE 10.4 +253.9 253925 1 POLR2A GABPB1 NR2C1 ZBTB33 ZBTB40 NR2C2 EZH2 ZNF702P ZNF347 ZNF160 ZNF677 VN1R2 BIRC8 ERVV-1
GH19I053019 Enhancer 0.4 ENCODE 10.6 +271.7 271723 0.1 CTCF RAD21 ZNF160 BIRC8 ZNF415 ZNF347 ZNF677 VN1R2 ERVV-1 ZNF702P
GH19I053016 Enhancer 0.4 ENCODE 10.6 +274.6 274603 0.2 CEBPB PRDM10 ZNF160 BIRC8 ZNF415 ZNF347 VN1R2 ZNF677 ERVV-1 ZNF702P
GH19I053787 Enhancer 0.6 FANTOM5 2.8 -496.3 -496318 0 NRF1 ZBTB11 ZBTB40 GTF2A2 DIDO1 GABPB1 TRIM24 CREM MGA ENSG00000269564 GC19P053928 GC19P053932 GC19P053940 GC19P053959 GC19P053967 MIR371A MIR371B MIR372 MIR373
GH19I053308 Enhancer 0.6 ENCODE 0.4 -17.0 -16957 0.2 CTCF ZNF654 USF1 BACH1 RAD21 ETS1 SP1 ZNF143 EZH2 FAM90A28P FAM90A27P VN1R2 ZNF677 ZNF347 BIRC8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BIRC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BIRC8 gene promoter:

Genomic Locations for BIRC8 Gene

Genomic Locations for BIRC8 Gene
2,026 bases
Minus strand

Genomic View for BIRC8 Gene

Genes around BIRC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC8 Gene

Proteins for BIRC8 Gene

  • Protein details for BIRC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Baculoviral IAP repeat-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q6IPY1
    • Q96RW5

    Protein attributes for BIRC8 Gene

    236 amino acids
    Molecular mass:
    27089 Da
    Quaternary structure:
    • Binds to caspase-9.

    Three dimensional structures from OCA and Proteopedia for BIRC8 Gene

neXtProt entry for BIRC8 Gene

Post-translational modifications for BIRC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIRC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIRC8 Gene

Domains & Families for BIRC8 Gene

Gene Families for BIRC8 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for BIRC8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IAP family.
  • Belongs to the IAP family.
genes like me logo Genes that share domains with BIRC8: view

Function for BIRC8 Gene

Molecular function for BIRC8 Gene

UniProtKB/Swiss-Prot Function:
Protects against apoptosis mediated by BAX.

Gene Ontology (GO) - Molecular Function for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BIRC8: view
genes like me logo Genes that share phenotypes with BIRC8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BIRC8 Gene

Localization for BIRC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIRC8 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with BIRC8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BIRC8 Gene

Pathways & Interactions for BIRC8 Gene

genes like me logo Genes that share pathways with BIRC8: view

Pathways by source for BIRC8 Gene

1 R&D Systems pathway for BIRC8 Gene

Gene Ontology (GO) - Biological Process for BIRC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway IBA --
GO:0090307 NOT mitotic spindle assembly IBA --
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA --
genes like me logo Genes that share ontologies with BIRC8: view

No data available for SIGNOR curated interactions for BIRC8 Gene

Drugs & Compounds for BIRC8 Gene

No Compound Related Data Available

Transcripts for BIRC8 Gene

mRNA/cDNA for BIRC8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BIRC8 Gene

Baculoviral IAP repeat containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC8 Gene

No ASD Table

Relevant External Links for BIRC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BIRC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIRC8 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC8 Gene

This gene is overexpressed in Testis (x52.8).

Protein differential expression in normal tissues from HIPED for BIRC8 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BIRC8 Gene

Protein tissue co-expression partners for BIRC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of BIRC8 Gene:


SOURCE GeneReport for Unigene cluster for BIRC8 Gene:


mRNA Expression by UniProt/SwissProt for BIRC8 Gene:

Tissue specificity: Testis specific in normal tissues.

Evidence on tissue expression from TISSUES for BIRC8 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with BIRC8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIRC8 Gene

Orthologs for BIRC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BIRC8 33
  • 98.59 (n)
(Mus musculus)
Mammalia Xiap 34
  • 37 (a)
(Bos Taurus)
Mammalia XIAP 34
  • 36 (a)
(Canis familiaris)
Mammalia BIRC4 34
  • 36 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
(Gallus gallus)
Aves IAP3 34
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 22 (a)
(Danio rerio)
Actinopterygii xiap 34
  • 18 (a)
birc4 33
fruit fly
(Drosophila melanogaster)
Insecta Iap2 34
  • 16 (a)
th 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
-- 34
  • 43 (a)
-- 34
  • 21 (a)
-- 34
  • 20 (a)
-- 34
  • 18 (a)
-- 34
  • 11 (a)
-- 34
  • 4 (a)
-- 34
Species where no ortholog for BIRC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC8 Gene

Gene Tree for BIRC8 (if available)
Gene Tree for BIRC8 (if available)

Paralogs for BIRC8 Gene

Paralogs for BIRC8 Gene

(2) SIMAP similar genes for BIRC8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BIRC8: view

Variants for BIRC8 Gene

Sequence variations from dbSNP and Humsavar for BIRC8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000423453 -- 53,292,130(-) G/C upstream_transcript_variant
rs1001094102 -- 53,291,968(-) A/C upstream_transcript_variant
rs1001242687 -- 53,292,866(-) G/A upstream_transcript_variant
rs1001289117 -- 53,289,479(-) A/C downstream_transcript_variant
rs1001944484 -- 53,289,157(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BIRC8 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv3644741 CNV gain 21293372
esv5629 OTHER inversion 19470904
esv6489 OTHER inversion 19470904
nsv1055773 CNV gain 25217958
nsv1078889 OTHER inversion 25765185
nsv1141887 OTHER inversion 24896259
nsv1153752 OTHER inversion 26484159
nsv817865 CNV gain 17921354

Variation tolerance for BIRC8 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIRC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC8 Gene

Disorders for BIRC8 Gene

Additional Disease Information for BIRC8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BIRC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIRC8 Gene

Publications for BIRC8 Gene

  1. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. (PMID: 11390657) Richter BW … Duckett CS (Molecular and cellular biology 2001) 2 3 4 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. (PMID: 15485395) Shin H … Salvesen GS (The Biochemical journal 2005) 3 4 58
  4. Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript. (PMID: 11597143) Lagacé M … Korneluk RG (Genomics 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BIRC8 Gene

Sources for BIRC8 Gene

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