This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevate... See more...

Aliases for BIRC7 Gene

Aliases for BIRC7 Gene

  • Baculoviral IAP Repeat Containing 7 2 3 5
  • Melanoma Inhibitor Of Apoptosis Protein 2 3 4
  • Kidney Inhibitor Of Apoptosis Protein 2 3 4
  • ML-IAP 2 3 4
  • RNF50 2 3 4
  • KIAP 2 3 4
  • Baculoviral IAP Repeat-Containing Protein 7 3 4
  • RING-Type E3 Ubiquitin Transferase BIRC7 3 4
  • RING Finger Protein 50 3 4
  • Livin 2 4
  • LIVIN 3 4
  • MLIAP 3 4
  • Baculoviral IAP Repeat-Containing 7 2
  • Livin Inhibitor-Of-Apoptosis 2
  • Livin Inhibitor Of Apoptosis 3
  • EC 2.3.2.27 4
  • BIRC7 5
  • Mliap 2

External Ids for BIRC7 Gene

Previous GeneCards Identifiers for BIRC7 Gene

  • GC20P061744
  • GC20P062546
  • GC20P062593
  • GC20P061337
  • GC20P061867
  • GC20P058592

Summaries for BIRC7 Gene

Entrez Gene Summary for BIRC7 Gene

  • This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]

CIViC Summary for BIRC7 Gene

  • BIRC7 encodes the protein Livin which is a member of the inhibitor of apoptosis protein (IAP) family. Livin consists of a single baculoviral IAP repeat domain (BIR) and a RING domian at the C-terminus. The protein inhibits apoptosis by inhibiting proteolytic activation of capsases. Overexpression of Livin has been observed in a variety of cancers including lung, colon, and prostate compared to most normal adult tissues and has been proposed as a putative therapeutic target.

GeneCards Summary for BIRC7 Gene

BIRC7 (Baculoviral IAP Repeat Containing 7) is a Protein Coding gene. Diseases associated with BIRC7 include Lung Cancer and Melanoma. Among its related pathways are Small cell lung cancer and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is BIRC2.

UniProtKB/Swiss-Prot Summary for BIRC7 Gene

  • Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.

Gene Wiki entry for BIRC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BIRC7 Gene

Genomics for BIRC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BIRC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BIRC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BIRC7

Top Transcription factor binding sites by QIAGEN in the BIRC7 gene promoter:
  • HNF-4alpha1
  • HNF-4alpha2
  • N-Myc

Genomic Locations for BIRC7 Gene

Latest Assembly
chr20:63,235,883-63,240,495
(GRCh38/hg38)
Size:
4,613 bases
Orientation:
Plus strand

Previous Assembly
chr20:61,867,257-61,871,847
(GRCh37/hg19 by Entrez Gene)
Size:
4,591 bases
Orientation:
Plus strand

chr20:61,867,235-61,871,859
(GRCh37/hg19 by Ensembl)
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for BIRC7 Gene

Genes around BIRC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC7 Gene

Proteins for BIRC7 Gene

  • Protein details for BIRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CA5-BIRC7_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 7
    Protein Accession:
    Q96CA5
    Secondary Accessions:
    • Q9BQV0
    • Q9H2A8
    • Q9HAP7

    Protein attributes for BIRC7 Gene

    Size:
    298 amino acids
    Molecular mass:
    32798 Da
    Quaternary structure:
    • Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain.

    Three dimensional structures from OCA and Proteopedia for BIRC7 Gene

    Alternative splice isoforms for BIRC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC7 Gene

Post-translational modifications for BIRC7 Gene

  • Autoubiquitinated and undergoes proteasome-mediated degradation.
  • The truncated protein (tLivin) not only loses its anti-apoptotic effect but also acquires a pro-apoptotic effect.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIRC7 Gene

No data available for DME Specific Peptides for BIRC7 Gene

Domains & Families for BIRC7 Gene

Gene Families for BIRC7 Gene

Protein Domains for BIRC7 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • Baculovirus inhibitor of apoptosis protein repeat (BIR)

Suggested Antigen Peptide Sequences for BIRC7 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 50 (BIRC7_HUMAN)
  • Baculoviral IAP repeat-containing 7 (Q6R308_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96CA5

UniProtKB/Swiss-Prot:

BIRC7_HUMAN :
  • The RING domain is essential for autoubiquitination.
  • Belongs to the IAP family.
Domain:
  • The RING domain is essential for autoubiquitination.
Family:
  • Belongs to the IAP family.
genes like me logo Genes that share domains with BIRC7: view

Function for BIRC7 Gene

Molecular function for BIRC7 Gene

UniProtKB/Swiss-Prot Function:
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:16729033};.

Enzyme Numbers (IUBMB) for BIRC7 Gene

Phenotypes From GWAS Catalog for BIRC7 Gene

Gene Ontology (GO) - Molecular Function for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16729033
GO:0004869 cysteine-type endopeptidase inhibitor activity TAS 21617971
GO:0005515 protein binding IPI 11024045
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding NAS 11801603
genes like me logo Genes that share ontologies with BIRC7: view
genes like me logo Genes that share phenotypes with BIRC7: view

Animal Models for BIRC7 Gene

MGI Knock Outs for BIRC7:

Animal Models for research

  • Taconic Biosciences Mouse Models for BIRC7

miRNA for BIRC7 Gene

miRTarBase miRNAs that target BIRC7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIRC7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC7 Gene

Localization for BIRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC7 Gene

Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus. the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIRC7 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
cytoskeleton 4
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (4)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 17294084
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 17294084
GO:0005794 Golgi apparatus IEA,IDA 17294084
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with BIRC7: view

Pathways & Interactions for BIRC7 Gene

genes like me logo Genes that share pathways with BIRC7: view

Pathways by source for BIRC7 Gene

1 R&D Systems pathway for BIRC7 Gene
1 Cell Signaling Technology pathway for BIRC7 Gene

SIGNOR curated interactions for BIRC7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for BIRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002088 lens development in camera-type eye IEA --
GO:0006915 apoptotic process IEA --
GO:0007257 activation of JUN kinase activity NAS 11865055
GO:0010466 negative regulation of peptidase activity IEA --
GO:0016567 protein ubiquitination IDA 16729033
genes like me logo Genes that share ontologies with BIRC7: view

Drugs & Compounds for BIRC7 Gene

(7) Drugs for BIRC7 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GDC-0152 Investigational Pharma IAP antagonist,potent amd samll-molecule 0
LCL161 Pharma Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist 0
AT-406 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0

(3) Additional Compounds for BIRC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for BIRC7 Gene

Compound Action Cas Number
LCL161 Antagonist of IAPs inhibitor 1005342-46-0
genes like me logo Genes that share compounds with BIRC7: view

Drug products for research

Transcripts for BIRC7 Gene

mRNA/cDNA for BIRC7 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIRC7

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for BIRC7 Gene

GeneLoc Exon Structure for
BIRC7

Expression for BIRC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BIRC7 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC7 Gene

This gene is overexpressed in Nerve - Tibial (x28.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BIRC7

SOURCE GeneReport for Unigene cluster for BIRC7 Gene:

Hs.256126

mRNA Expression by UniProt/SwissProt for BIRC7 Gene:

Q96CA5-BIRC7_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for BIRC7 Gene

  • Skin(4.7)
  • Kidney(4.5)
  • Intestine(2.6)
  • Lymph node(2.6)
  • Nervous system(2.3)
  • Pancreas(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with BIRC7: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIRC7 Gene

Orthologs for BIRC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BIRC7 29 30
  • 93.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BIRC7 29 30
  • 78.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Birc7 29 16 30
  • 76.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BIRC7 29 30
  • 73.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BIRC7 30
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BIRC7 30
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BIRC7 30
  • 26 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BIRC7 30
  • 25 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XLX 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.3444 29
Zebrafish
(Danio rerio)
Actinopterygii birc7 30
  • 29 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta th 30
  • 18 (a)
ManyToMany
Iap2 30
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 62 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
-- 30
  • 26 (a)
ManyToMany
-- 30
  • 23 (a)
ManyToMany
-- 30
  • 23 (a)
ManyToMany
-- 30
  • 13 (a)
ManyToMany
-- 30
  • 7 (a)
ManyToMany
-- 30
  • 5 (a)
ManyToMany
Species where no ortholog for BIRC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BIRC7 Gene

ENSEMBL:
Gene Tree for BIRC7 (if available)
TreeFam:
Gene Tree for BIRC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BIRC7: view image
Alliance of Genome Resources:
Additional Orthologs for BIRC7

Paralogs for BIRC7 Gene

Paralogs for BIRC7 Gene

(4) SIMAP similar genes for BIRC7 Gene using alignment to 3 proteins:

  • BIRC7_HUMAN
  • A8MTF4_HUMAN
  • Q6R308_HUMAN
genes like me logo Genes that share paralogs with BIRC7: view

Variants for BIRC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BIRC7 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs11908302 Benign: not provided 63,239,194(+) C/T
NM_139317.3(BIRC7):c.610C>T (p.Pro204Ser)
MISSENSE
rs6011693 Benign: not provided 63,238,597(+) C/G
NM_139317.3(BIRC7):c.560C>G (p.Ala187Gly)
MISSENSE
rs1077019 -- p.Glu223Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BIRC7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BIRC7 Gene

Variant ID Type Subtype PubMed ID
dgv519n27 CNV loss 19166990
dgv520n27 CNV loss 19166990
dgv7664n54 CNV loss 21841781
dgv7665n54 CNV loss 21841781
esv3893360 CNV loss 25118596
nsv3446 CNV deletion 18451855
nsv470560 CNV loss 18288195
nsv517648 CNV loss 19592680
nsv518905 CNV loss 19592680
nsv522880 CNV loss 19592680
nsv525279 CNV loss 19592680
nsv586559 CNV gain 21841781
nsv586562 CNV gain 21841781
nsv586563 CNV loss 21841781
nsv819591 CNV gain 19587683
nsv820146 CNV gain 19587683
nsv834031 CNV loss 17160897
nsv834032 CNV loss 17160897
nsv953306 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for BIRC7 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIRC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIRC7
Leiden Open Variation Database (LOVD)
BIRC7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC7 Gene

Disorders for BIRC7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BIRC7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
melanoma
  • malignant melanoma
renal cell carcinoma, nonpapillary
  • rcc
microphthalmia
  • microphthalmos
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search BIRC7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BIRC7

genes like me logo Genes that share disorders with BIRC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC7 Gene

Publications for BIRC7 Gene

  1. Livin, a novel inhibitor of apoptosis protein family member. (PMID: 11024045) Kasof GM … Gomes BC (The Journal of biological chemistry 2001) 2 3 4 22
  2. KIAP, a novel member of the inhibitor of apoptosis protein family. (PMID: 11162435) Lin JH … Morser J (Biochemical and biophysical research communications 2000) 2 3 4 22
  3. Challenge and promise: roles for Livin in progression and therapy of cancer. (PMID: 19074843) Wang L … Shan B (Molecular cancer therapeutics 2008) 3 4 22
  4. Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. (PMID: 17294084) Nachmias B … Ben-Yehuda D (Apoptosis : an international journal on programmed cell death 2007) 3 4 22
  5. Manipulation of NK cytotoxicity by the IAP family member Livin. (PMID: 18034418) Nachmias B … Mandelboim O (European journal of immunology 2007) 3 4 22

Products for BIRC7 Gene

Sources for BIRC7 Gene