Aliases for BIRC6 Gene
External Ids for BIRC6 Gene
Previous GeneCards Identifiers for BIRC6 Gene
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
GeneCards Summary for BIRC6 Gene
BIRC6 (Baculoviral IAP Repeat Containing 6) is a Protein Coding gene. Diseases associated with BIRC6 include Brain Cancer. Among its related pathways are Apoptosis and Autophagy and Nanomaterial induced apoptosis. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is NAIP.
UniProtKB/Swiss-Prot Summary for BIRC6 Gene
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.