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Aliases for BIRC6 Gene

Aliases for BIRC6 Gene

  • Baculoviral IAP Repeat Containing 6 2 3 5
  • Apollon 2 3 4
  • BIR Repeat-Containing Ubiquitin-Conjugating Enzyme 3 4
  • RING-Type E3 Ubiquitin Transferase BIRC6 3 4
  • BRUCE 3 4
  • Ubiquitin-Conjugating BIR-Domain Enzyme Apollon 3
  • Ubiquitin-Conjugating BIR Domain Enzyme Apollon 4
  • Baculoviral IAP Repeat-Containing Protein 6 3
  • Baculoviral IAP Repeat-Containing 6 2
  • EC 2.3.2.27 4
  • KIAA1289 4

External Ids for BIRC6 Gene

Previous GeneCards Identifiers for BIRC6 Gene

  • GC02P032525
  • GC02P032709
  • GC02P032556
  • GC02P032493
  • GC02P032435
  • GC02P032582
  • GC02P032320

Summaries for BIRC6 Gene

Entrez Gene Summary for BIRC6 Gene

  • This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIRC6 Gene

BIRC6 (Baculoviral IAP Repeat Containing 6) is a Protein Coding gene. Diseases associated with BIRC6 include Brain Cancer. Among its related pathways are Apoptosis Modulation and Signaling and Nanomaterial induced apoptosis. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2O.

UniProtKB/Swiss-Prot for BIRC6 Gene

  • Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Gene Wiki entry for BIRC6 Gene

Additional gene information for BIRC6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC6 Gene

Genomics for BIRC6 Gene

GeneHancer (GH) Regulatory Elements for BIRC6 Gene

Promoters and enhancers for BIRC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I032355 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 710 3.8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC02M032356 BIRC6 DDX50P1 TTC27
GH02I032164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 47 -190.7 -190720 3.7 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SLC30A6 ENSG00000272716 GC02M032166 BIRC6 DDX50P1 TTC27 RNU6-647P NLRC4 GC02P032156
GH02I032627 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.1 +271.0 270980 2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 ZNF207 TTC27 BIRC6 DDX50P1 SLC30A6 DPY30 GC02M032591
GH02I032277 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20 -78.9 -78891 2.1 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YIPF4 SLC30A6 BIRC6 TTC27 DDX50P1 RNU6-647P NLRC4 ENSG00000272754
GH02I032288 Enhancer 1.1 Ensembl ENCODE 29.2 -67.6 -67627 2.4 ELF3 ATF1 FOXA2 ARID4B THRB ZSCAN9 RARA SMARCC2 ATF7 FOS BIRC6 NLRC4 DDX50P1 TTC27 SLC30A6 YIPF4 RNU6-647P MIR558 ENSG00000272754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BIRC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BIRC6 gene promoter:

Genomic Locations for BIRC6 Gene

Genomic Locations for BIRC6 Gene
chr2:32,357,028-32,618,899
(GRCh38/hg38)
Size:
261,872 bases
Orientation:
Plus strand
chr2:32,582,096-32,843,966
(GRCh37/hg19)

Genomic View for BIRC6 Gene

Genes around BIRC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC6 Gene

Proteins for BIRC6 Gene

  • Protein details for BIRC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR09-BIRC6_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 6
    Protein Accession:
    Q9NR09
    Secondary Accessions:
    • Q9ULD1

    Protein attributes for BIRC6 Gene

    Size:
    4857 amino acids
    Molecular mass:
    530255 Da
    Quaternary structure:
    • Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.
    SequenceCaution:
    • Sequence=BAA86603.2; Type=Frameshift; Positions=2047; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BIRC6 Gene

neXtProt entry for BIRC6 Gene

Post-translational modifications for BIRC6 Gene

  • Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY.
  • Ubiquitination at Lys416, posLast=16431643, posLast=22652265, Lys2270, Lys2277, Lys2511, Lys3854, and posLast=40204020

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BIRC6 (BIRC6)
  • Abcam antibodies for BIRC6

No data available for DME Specific Peptides for BIRC6 Gene

Domains & Families for BIRC6 Gene

Gene Families for BIRC6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for BIRC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR09

UniProtKB/Swiss-Prot:

BIRC6_HUMAN :
  • The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.
  • In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Domain:
  • The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.
Family:
  • In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with BIRC6: view

Function for BIRC6 Gene

Molecular function for BIRC6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

Enzyme Numbers (IUBMB) for BIRC6 Gene

Phenotypes From GWAS Catalog for BIRC6 Gene

Gene Ontology (GO) - Molecular Function for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 15200957
GO:0004869 cysteine-type endopeptidase inhibitor activity IMP 15200957
GO:0005515 protein binding IPI 14765125
GO:0016740 transferase activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with BIRC6: view
genes like me logo Genes that share phenotypes with BIRC6: view

Animal Models for BIRC6 Gene

MGI Knock Outs for BIRC6:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC6 Gene

Localization for BIRC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC6 Gene

Golgi apparatus, trans-Golgi network membrane. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring. Note=Exhibits cell cycle-dependent localization. Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis. On the midbody, localizes to the midbody ring, also called Flemming body (PubMed:18329369). In interphase cells, localizes to the trans-Golgi network membrane and endosomes. During cytokinesis, a fraction moves to the midzone where it specifically arrives at the midbody ring. After abscission completion, travels with the midbody remnant into one daughter cell, and remains bound to it until a new midbody ring is formed during the next cell division (PubMed:18329369). {ECO:0000269 PubMed:18329369}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIRC6 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
endosome 5
cytosol 4
plasma membrane 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
  • Mitotic spindle (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 18329369
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IDA,IEA 18329369
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IDA 18329369
genes like me logo Genes that share ontologies with BIRC6: view

Pathways & Interactions for BIRC6 Gene

genes like me logo Genes that share pathways with BIRC6: view

Pathways by source for BIRC6 Gene

1 Cell Signaling Technology pathway for BIRC6 Gene
1 BioSystems pathway for BIRC6 Gene
1 R&D Systems pathway for BIRC6 Gene

SIGNOR curated interactions for BIRC6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for BIRC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEA --
GO:0006468 protein phosphorylation TAS 18329369
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with BIRC6: view

Drugs & Compounds for BIRC6 Gene

(7) Drugs for BIRC6 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0
AEG40826 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0
GDC0917 Pharma Antagonist Inhibitor of apoptosis proteins (IAPS) antagonist 0

(1) Additional Compounds for BIRC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with BIRC6: view

Transcripts for BIRC6 Gene

Unigene Clusters for BIRC6 Gene

Baculoviral IAP repeat containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

ExUns: 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55a · 55b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for BIRC6 Gene

GeneLoc Exon Structure for
BIRC6
ECgene alternative splicing isoforms for
BIRC6

Expression for BIRC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIRC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BIRC6 Gene

This gene is overexpressed in Heart (17.5), Bone (16.3), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BIRC6 Gene



Protein tissue co-expression partners for BIRC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BIRC6 Gene:

BIRC6

SOURCE GeneReport for Unigene cluster for BIRC6 Gene:

Hs.150107

mRNA Expression by UniProt/SwissProt for BIRC6 Gene:

Q9NR09-BIRC6_HUMAN
Tissue specificity: Expressed in brain cancer cells.

Evidence on tissue expression from TISSUES for BIRC6 Gene

  • Nervous system(4.7)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with BIRC6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIRC6 Gene

Orthologs for BIRC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BIRC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC6 33 34
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia BIRC6 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC6 33 34
  • 93.74 (n)
cow
(Bos Taurus)
Mammalia BIRC6 33 34
  • 93.53 (n)
rat
(Rattus norvegicus)
Mammalia Birc6 33
  • 89.7 (n)
mouse
(Mus musculus)
Mammalia Birc6 33 16 34
  • 89.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC6 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves BIRC6 33 34
  • 83.41 (n)
lizard
(Anolis carolinensis)
Reptilia BIRC6 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia birc6 33
  • 76.9 (n)
Str.10024 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32494 33
zebrafish
(Danio rerio)
Actinopterygii birc6 33 34
  • 71.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bruce 35 33 34
  • 47.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002651 33
  • 46.13 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-17 35 34
  • 52 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9070 33
Species where no ortholog for BIRC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BIRC6 Gene

ENSEMBL:
Gene Tree for BIRC6 (if available)
TreeFam:
Gene Tree for BIRC6 (if available)

Paralogs for BIRC6 Gene

Paralogs for BIRC6 Gene

(5) SIMAP similar genes for BIRC6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BIRC6: view

Variants for BIRC6 Gene

Sequence variations from dbSNP and Humsavar for BIRC6 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000012621 -- 32,368,547(+) AAATAAATAAATAAATAAATAAA/AAATAAATAAATAAA/AAATAAATAAATAAATAAA intron_variant
rs1000016902 -- 32,616,415(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000018059 -- 32,542,320(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000047407 -- 32,472,688(+) C/T intron_variant
rs1000051893 -- 32,446,056(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BIRC6 Gene

Variant ID Type Subtype PubMed ID
nsv833703 CNV loss 17160897
nsv833692 CNV loss 17160897
nsv833681 CNV gain+loss 17160897
nsv581281 CNV gain 21841781
nsv581274 CNV gain 21841781
nsv516173 CNV gain+loss 19592680
nsv478791 CNV novel sequence insertion 20440878
nsv470448 CNV gain 18288195
nsv470447 CNV loss 18288195
nsv456108 CNV gain 19166990
nsv1138763 CNV deletion 24896259
nsv1109243 CNV deletion 24896259
nsv1005939 CNV gain 25217958
esv3891703 CNV gain 25118596
esv3590256 CNV gain 21293372
esv3590254 CNV gain 21293372
esv3590252 CNV gain 21293372
esv3590251 CNV gain 21293372
esv3590250 CNV gain 21293372
esv3590249 CNV gain 21293372
esv3590248 CNV gain 21293372
esv3590247 CNV loss 21293372
esv2763243 CNV gain 21179565
esv2751888 CNV gain 17911159
esv2719881 CNV deletion 23290073
esv2664912 CNV deletion 23128226
esv2464710 CNV deletion 19546169
esv2422472 CNV duplication 17116639
esv2422335 CNV duplication 17116639
dgv6750n54 CNV gain 21841781
dgv443n27 CNV gain 19166990
dgv3750n100 CNV gain 25217958
dgv3749n100 CNV gain 25217958
dgv1109e212 CNV gain 25503493

Variation tolerance for BIRC6 Gene

Residual Variation Intolerance Score: 0.0602% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIRC6 Gene

Human Gene Mutation Database (HGMD)
BIRC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIRC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC6 Gene

Disorders for BIRC6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BIRC6 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search BIRC6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BIRC6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BIRC6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC6 Gene

Publications for BIRC6 Gene

  1. A human IAP-family gene, apollon, expressed in human brain cancer cells. (PMID: 10544019) Chen Z … Tsuruo T (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. (PMID: 15200957) Bartke T … Jentsch S (Molecular cell 2004) 3 4 22 58
  3. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PMID: 14765125) Qiu XB … Goldberg AL (The EMBO journal 2004) 3 4 22 58
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58

Products for BIRC6 Gene

Sources for BIRC6 Gene

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