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This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene. Diseases associated with BIRC5 include Adenocarcinoma and Malignant Peritoneal Mesothelioma. Among its related pathways are Signaling by GPCR and Interleukin-4 and 13 signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BIRC2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004869 | cysteine-type endopeptidase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 11024045 |
GO:0008017 | microtubule binding | TAS | 21536684 |
GO:0019899 | enzyme binding | IPI | 16322459 |
GO:0030414 | peptidase inhibitor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000228 | nuclear chromosome | IDA | 16322459 |
GO:0000775 | chromosome, centromeric region | IEA,IDA | 11084331 |
GO:0000776 | kinetochore | IEA | -- |
GO:0000777 | condensed chromosome kinetochore | IEA,IDA | 15665297 |
GO:0005634 | nucleus | IBA,IDA | 15665297 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis Modulation and Signaling |
.41
|
.31
|
2 | Immune response IL-23 signaling pathway |
Development Angiopoietin - Tie2 signaling
.38
Angiopoietin-TIE2 Signaling
.36
|
|
3 | Cell Cycle, Mitotic |
.83
|
.60
|
4 | Mitotic Metaphase and Anaphase |
.94
|
|
5 | Mitotic Prometaphase |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000226 | microtubule cytoskeleton organization | IEA | -- |
GO:0006468 | protein phosphorylation | IDA | 21252625 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007059 | chromosome segregation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Docetaxel | Approved, Investigational | Pharma | Inhibition, inhibitor, Biomarker | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes | 2403 | |
Paclitaxel | Approved, Vet_approved | Pharma | inhibitor, Biomarker, binder | Tubulin and Bcl2 inhibitor, Taxanes | 3927 | |
Berberine | Approved, Investigational | Pharma | Target | 0 | ||
Reserpine | Approved, Investigational | Pharma | Target | Inhibitor of vesicular monoamine transport | 9 | |
LY2181308 | Investigational | Pharma | Target, antisense, Inhibitor | Survivin inhibitors | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
YM155 | Survivin suppressant,apoptosis inhibitor | 781661-94-7 |
YM-155 hydrochloride | Potent survivin inhibitor | 355406-09-6 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||
SP4: | |||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BIRC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BIRC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BIRC5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Birc5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Birc5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | BIRC5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BIRC5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BIRC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BIRC5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | birc5.2 30 |
|
||
Str.8111 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | birc5a 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1470 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Det 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2071214 | - |
p.Lys129Glu |
Disorder | Aliases | PubMed IDs |
---|---|---|
adenocarcinoma |
|
|
malignant peritoneal mesothelioma |
|
|
vulvar intraepithelial neoplasia |
|
|
cervical intraepithelial neoplasia |
|
|
cervical carcinosarcoma |
|
|