BIRC5 Gene (Protein Coding)

Baculoviral IAP Repeat Containing 5

GC17P078214
GIFtS:
48
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high ... See more...

Aliases for BIRC5 Gene

Aliases for BIRC5 Gene

  • Baculoviral IAP Repeat Containing 5 2 3 5
  • Apoptosis Inhibitor 4 2 3 4
  • Baculoviral IAP Repeat-Containing Protein 5 3 4
  • Apoptosis Inhibitor Survivin 3 4
  • Survivin Variant 3 Alpha 2 3
  • API4 3 4
  • Baculoviral IAP Repeat-Containing 5 2
  • EPR-1 3
  • IAP4 4

External Ids for BIRC5 Gene

Previous HGNC Symbols for BIRC5 Gene

  • API4

Previous GeneCards Identifiers for BIRC5 Gene

  • GC17M076124
  • GC17P079197
  • GC17P076671
  • GC17P076808
  • GC17P076809
  • GC17P073722
  • GC17P076210
  • GC17P071634

Summaries for BIRC5 Gene

Entrez Gene Summary for BIRC5 Gene

  • This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

CIViC Summary for BIRC5 Gene

GeneCards Summary for BIRC5 Gene

BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene. Diseases associated with BIRC5 include Childhood Malignant Schwannoma and Vulvar Intraepithelial Neoplasia. Among its related pathways are Immune response IL-23 signaling pathway and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot Summary for BIRC5 Gene

  • Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).

Gene Wiki entry for BIRC5 Gene

Additional gene information for BIRC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BIRC5 Gene

Genomics for BIRC5 Gene

GeneHancer (GH) Regulatory Elements for BIRC5 Gene

Promoters and enhancers for BIRC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BIRC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BIRC5 gene promoter:
  • Sp1
  • STAT3

Genomic Locations for BIRC5 Gene

Genomic Locations for BIRC5 Gene
chr17:78,214,186-78,225,636
(GRCh38/hg38)
Size:
11,451 bases
Orientation:
Plus strand
chr17:76,210,267-76,221,717
(GRCh37/hg19)
Size:
11,451 bases
Orientation:
Plus strand

Genomic View for BIRC5 Gene

Genes around BIRC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BIRC5 Gene

Proteins for BIRC5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for BIRC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15392-BIRC5_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 5
    Protein Accession:
    O15392
    Secondary Accessions:
    • A2SUH6
    • B2R4R1
    • Q2I3N8
    • Q4VGX0
    • Q53F61
    • Q5MGC6
    • Q6FHL2
    • Q75SP2
    • Q9P2W8

    Protein attributes for BIRC5 Gene

    Size:
    142 amino acids
    Molecular mass:
    16389 Da
    Quaternary structure:
    • Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8 (PubMed:17956729). Interacts with JTB. Interacts (via BIR domain) with histone H3 phosphorylated at 'Thr-3' (H3pT3). Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for BIRC5 Gene

    Alternative splice isoforms for BIRC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC5 Gene

Protein Expression for BIRC5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BIRC5 Gene

  • Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
  • In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes (PubMed:14610074). Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities (PubMed:21252625). Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity (PubMed:24866247). Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis.
  • Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
  • Ubiquitination at Lys23
  • Modification sites at PhosphoSitePlus

Other Protein References for BIRC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BIRC5 Gene

Domains & Families for BIRC5 Gene

Gene Families for BIRC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for BIRC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BIRC5 Gene

GenScript: Design optimal peptide antigens:
  • Survivin isoform Ex2+4/2B/3B (A3E0Z4_HUMAN)
  • Survivin isoform 2B/3B (A3E0Z5_HUMAN)
  • Survivin isoform deltaEx3/3B (A3E0Z6_HUMAN)
  • Survivin isoform 2B+32/3B (A3E0Z7_HUMAN)
  • Survivin isoform B+int2B/3B (A3E0Z8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15392

UniProtKB/Swiss-Prot:

BIRC5_HUMAN :
  • The BIR repeat is necessary and sufficient for LAMTOR5 binding.
  • Belongs to the IAP family.
Domain:
  • The BIR repeat is necessary and sufficient for LAMTOR5 binding.
Family:
  • Belongs to the IAP family.
genes like me logo Genes that share domains with BIRC5: view

Function for BIRC5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for BIRC5 Gene

UniProtKB/Swiss-Prot Function:
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
UniProtKB/Swiss-Prot Induction:
Up-regulated by COMP.

Phenotypes From GWAS Catalog for BIRC5 Gene

Gene Ontology (GO) - Molecular Function for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 11024045
GO:0008017 microtubule binding TAS 21536684
GO:0008536 Ran GTPase binding IPI 18591255
GO:0019899 enzyme binding IPI 16322459
genes like me logo Genes that share ontologies with BIRC5: view
genes like me logo Genes that share phenotypes with BIRC5: view

Animal Models for BIRC5 Gene

MGI Knock Outs for BIRC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for BIRC5

CRISPR Products

miRNA for BIRC5 Gene

miRTarBase miRNAs that target BIRC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC5 Gene

Localization for BIRC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC5 Gene

Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331). Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074). Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784). {ECO:0000250 UniProtKB:E3SCZ8, ECO:0000269 PubMed:11084331, ECO:0000269 PubMed:14610074, ECO:0000269 PubMed:20826784}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIRC5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 16322459
GO:0000775 chromosome, centromeric region IEA,IDA 11084331
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA,IDA 15665297
GO:0005634 nucleus IDA,IBA 15665297
genes like me logo Genes that share ontologies with BIRC5: view

Pathways & Interactions for BIRC5 Gene

genes like me logo Genes that share pathways with BIRC5: view

Pathways by source for BIRC5 Gene

2 Sino Biological pathways for BIRC5 Gene
1 R&D Systems pathway for BIRC5 Gene
4 Qiagen pathways for BIRC5 Gene
  • Angiopoietin-TIE2 Signaling
  • Colorectal Cancer Metastasis
  • Pancreatic Adenocarcinoma
  • WNT Signaling
1 Cell Signaling Technology pathway for BIRC5 Gene
1 GeneTex pathway for BIRC5 Gene

SIGNOR curated interactions for BIRC5 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 21252625
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
GO:0007346 regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with BIRC5: view

Drugs & Compounds for BIRC5 Gene

Products:

  1. Drug

(95) Drugs for BIRC5 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2231
Paclitaxel Approved, Vet_approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 3454
Berberine Approved, Investigational Pharma Target 0
Reserpine Approved, Investigational Pharma Inhibition, Inhibitor, Target Inhibitor of vesicular monoamine transport 8
LY2181308 Investigational Pharma Target, antisense, Inhibitor Survivin inhibitors 0

(72) Additional Compounds for BIRC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for BIRC5 Gene

Compound Action Cas Number
YM155 Survivin suppressant,apoptosis inhibitor 781661-94-7
YM-155 hydrochloride Potent survivin inhibitor 355406-09-6
genes like me logo Genes that share compounds with BIRC5: view

Transcripts for BIRC5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for BIRC5 Gene

(3) REFSEQ mRNAs :
(36) Additional mRNA sequences :
(516) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for BIRC5 Gene

GeneLoc Exon Structure for
BIRC5
ECgene alternative splicing isoforms for
BIRC5

Expression for BIRC5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIRC5 Gene

mRNA expression in normal human tissues for BIRC5 Gene
mRNA expression by GTEx for BIRC5 GenemRNA expression by BioGPS for BIRC5 Gene

mRNA differential expression in normal tissues according to GTEx for BIRC5 Gene

This gene is overexpressed in Testis (x14.6).

Protein differential expression in normal tissues from HIPED for BIRC5 Gene

This gene is overexpressed in Stomach (53.4) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BIRC5 Gene



Protein tissue co-expression partners for BIRC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of BIRC5 Gene:

BIRC5

SOURCE GeneReport for Unigene cluster for BIRC5 Gene:

Hs.744872

mRNA Expression by UniProt/SwissProt for BIRC5 Gene:

O15392-BIRC5_HUMAN
Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126).

Evidence on tissue expression from TISSUES for BIRC5 Gene

  • Lung(4.4)
  • Muscle(4.2)
  • Nervous system(4.2)
  • Skin(2.5)
  • Intestine(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with BIRC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIRC5 Gene

Orthologs for BIRC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia BIRC5 33 32
  • 98.84 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia BIRC5 33 32
  • 90.14 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia BIRC5 33 32
  • 90.14 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Birc5 17 33 32
  • 82.62 (n)
rat
(Rattus norvegicus)
 Mammalia Birc5 32
  • 81.32 (n)
oppossum
(Monodelphis domestica)
 Mammalia BIRC5 33
  • 71 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia BIRC5 33
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BIRC5 33 32
  • 65.69 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia BIRC5 33
  • 57 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia birc5.2 32
  • 64.2 (n)
Str.8111 32
zebrafish
(Danio rerio)
 Actinopterygii birc5a 33 32 32
  • 58.01 (n)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.1470 32
fruit fly
(Drosophila melanogaster)
 Insecta Det 33
  • 31 (a)
 OneToOne
Species where no ortholog for BIRC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)