The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced tr... See more...

Aliases for BIRC2 Gene

Aliases for BIRC2 Gene

  • Baculoviral IAP Repeat Containing 2 2 3 5
  • C-IAP1 2 3 4
  • RNF48 2 3 4
  • MIHB 2 3 4
  • Baculoviral IAP Repeat-Containing Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase BIRC2 3 4
  • TNFR2-TRAF-Signaling Complex Protein 2 3 4
  • NFR2-TRAF Signalling Complex Protein 2 3
  • Cellular Inhibitor Of Apoptosis 1 3 4
  • Inhibitor Of Apoptosis Protein 2 3 4
  • RING Finger Protein 48 3 4
  • Apoptosis Inhibitor 1 2 3
  • IAP Homolog B 3 4
  • Hiap-2 2 3
  • HIAP2 3 4
  • CIAP1 2 3
  • API1 3 4
  • Baculoviral IAP Repeat-Containing 2 2
  • EC 2.3.2.27 4
  • HIAP-2 4
  • IAP-2 3
  • BIRC2 5

External Ids for BIRC2 Gene

Previous HGNC Symbols for BIRC2 Gene

  • API1

Previous GeneCards Identifiers for BIRC2 Gene

  • GC11P104413
  • GC11P103575
  • GC11P102252
  • GC11P101757
  • GC11P101755
  • GC11P101723
  • GC11P098144

Summaries for BIRC2 Gene

Entrez Gene Summary for BIRC2 Gene

  • The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for BIRC2 Gene

BIRC2 (Baculoviral IAP Repeat Containing 2) is a Protein Coding gene. Diseases associated with BIRC2 include Lung Cancer and Burkitt Lymphoma. Among its related pathways are Apoptosis Modulation and Signaling and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. Gene Ontology (GO) annotations related to this gene include ligase activity and transcription coactivator activity. An important paralog of this gene is BIRC3.

UniProtKB/Swiss-Prot Summary for BIRC2 Gene

  • Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Gene Wiki entry for BIRC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BIRC2 Gene

Genomics for BIRC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BIRC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BIRC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BIRC2

Top Transcription factor binding sites by QIAGEN in the BIRC2 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • HOXA5
  • Nkx2-5
  • p53
  • SRF (504 AA)
  • TBP
  • TFIID

Genomic Locations for BIRC2 Gene

Genomic Locations for BIRC2 Gene
chr11:102,347,182-102,378,670
(GRCh38/hg38)
Size:
31,489 bases
Orientation:
Plus strand
chr11:102,217,942-102,249,401
(GRCh37/hg19)
Size:
31,460 bases
Orientation:
Plus strand

Genomic View for BIRC2 Gene

Genes around BIRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC2 Gene

Proteins for BIRC2 Gene

  • Protein details for BIRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13490-BIRC2_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 2
    Protein Accession:
    Q13490
    Secondary Accessions:
    • B4E026
    • Q16516
    • Q4TTG0

    Protein attributes for BIRC2 Gene

    Size:
    618 amino acids
    Molecular mass:
    69900 Da
    Quaternary structure:
    • Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE ubiquitination. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19. HSP90AB1 (PubMed:25486457). Interacts with UBXN1 (PubMed:25681446). Interacts with GSK3B (PubMed:18846110). Interacts with several death receptors, inclusing FAS, TNFRSF10A and TNFRSF10B (PubMed:18846110). Recruited to TNFRSF10B in the absence of receptor stimulation. When TNFRSF10B is stimulated, further recruited to the receptor and cleaved by caspases. Proteolytic fragments remain associated with TNFRSF10B (PubMed:18846110).

    Three dimensional structures from OCA and Proteopedia for BIRC2 Gene

    Alternative splice isoforms for BIRC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BIRC2 Gene

Post-translational modifications for BIRC2 Gene

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
  • Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein.
  • Ubiquitination at Lys19, Lys36, Lys40, Lys94, Lys126, Lys233, Lys328, Lys416, Lys425, Lys441, and Lys537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BIRC2 Gene

Domains & Families for BIRC2 Gene

Gene Families for BIRC2 Gene

Protein Domains for BIRC2 Gene

InterPro:
Blocks:
  • Zn-finger, RING
  • CARD interaction domain
  • Baculovirus inhibitor of apoptosis protein repeat (BIR)
ProtoNet:

Suggested Antigen Peptide Sequences for BIRC2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57692 (B4E026_HUMAN)
  • TNFR2-TRAF-signaling complex protein 2 (BIRC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13490

UniProtKB/Swiss-Prot:

BIRC2_HUMAN :
  • The BIR domains mediate nuclear localization.
  • Belongs to the IAP family.
Domain:
  • The BIR domains mediate nuclear localization.
  • The CARD domain is necessary to stabilize the protein and inhibit the activation of E3 ubiquitin-protein ligase activity of BIRC2/c-IAP1 by preventing RING domain dimerization and E2 ubiquitin donor binding and activation.
Family:
  • Belongs to the IAP family.
genes like me logo Genes that share domains with BIRC2: view

Function for BIRC2 Gene

Molecular function for BIRC2 Gene

UniProtKB/Swiss-Prot Function:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969};.
UniProtKB/Swiss-Prot EnzymeRegulation:
The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination.

Enzyme Numbers (IUBMB) for BIRC2 Gene

Phenotypes From GWAS Catalog for BIRC2 Gene

Gene Ontology (GO) - Molecular Function for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP 21653699
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 11084335
GO:0008270 zinc ion binding IDA 19153467
GO:0016740 transferase activity EXP 19008929
genes like me logo Genes that share ontologies with BIRC2: view
genes like me logo Genes that share phenotypes with BIRC2: view

Animal Models for BIRC2 Gene

MGI Knock Outs for BIRC2:

Animal Model Products

CRISPR Products

miRNA for BIRC2 Gene

miRTarBase miRNAs that target BIRC2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIRC2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIRC2 Gene

Localization for BIRC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC2 Gene

Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIRC2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001741 XY body IEA --
GO:0005634 nucleus IBA,IDA 15665297
GO:0005737 cytoplasm IBA,IDA 16510124
GO:0005829 cytosol TAS --
GO:0009898 cytoplasmic side of plasma membrane IEA,ISS --
genes like me logo Genes that share ontologies with BIRC2: view

Pathways & Interactions for BIRC2 Gene

genes like me logo Genes that share pathways with BIRC2: view

Pathways by source for BIRC2 Gene

5 GeneGo (Thomson Reuters) pathways for BIRC2 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival TNFR1 signaling pathway
15 Qiagen pathways for BIRC2 Gene
  • Apoptosis through Death Receptors
  • Apoptotic Pathways Triggered By HIV1
  • Caspase Cascade
  • Cellular Apoptosis Pathway
  • DR3 Signaling
1 Cell Signaling Technology pathway for BIRC2 Gene
1 GeneTex pathway for BIRC2 Gene

SIGNOR curated interactions for BIRC2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BIRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 11907583
GO:0001666 response to hypoxia IEA --
GO:0001890 placenta development IEA --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BIRC2: view

Drugs & Compounds for BIRC2 Gene

(34) Drugs for BIRC2 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
GDC-0152 Investigational Pharma IAP antagonist,potent amd samll-molecule 0
Birinapant Investigational Pharma antagonist inhibitor of apoptosis (IAP) antagonist 0
LCL161 Pharma Antagonist Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist 0
AT-406 (SM-406) Pharma 0

(11) Additional Compounds for BIRC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(7) ApexBio Compounds for BIRC2 Gene

Compound Action Cas Number
AT-406 (SM-406) 1071992-99-8
Birinapant (TL32711) Potent XIAP/cIAP1 antagonist 1260251-31-7
BV6 1001600-56-1
GDC-0152 IAP antagonist,potent amd samll-molecule 873652-48-3
LCL161 Antagonist of IAPs inhibitor 1005342-46-0
Mitomycin C Inhibits DNA synthesis,antibiotic and antitumor agent 1950-07-7
SM-164 Anticancer agent 957135-43-2
genes like me logo Genes that share compounds with BIRC2: view

Transcripts for BIRC2 Gene

mRNA/cDNA for BIRC2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIRC2

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: -

Relevant External Links for BIRC2 Gene

GeneLoc Exon Structure for
BIRC2

Expression for BIRC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BIRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BIRC2 Gene

This gene is overexpressed in Fetal Brain (25.6), Peripheral blood mononuclear cells (16.5), Testis (13.9), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BIRC2 Gene



Protein tissue co-expression partners for BIRC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BIRC2

SOURCE GeneReport for Unigene cluster for BIRC2 Gene:

Hs.696238

mRNA Expression by UniProt/SwissProt for BIRC2 Gene:

Q13490-BIRC2_HUMAN
Tissue specificity: Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for BIRC2 Gene

  • Liver(4.6)
  • Blood(3.1)
  • Intestine(3.1)
  • Spleen(3)
  • Kidney(3)
  • Heart(3)
  • Nervous system(3)
  • Lung(2.9)
  • Lymph node(2.9)
  • Muscle(2.8)
  • Bone marrow(2.8)
  • Skin(2.7)
  • Pancreas(2.5)
  • Stomach(2.4)
  • Adrenal gland(2.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with BIRC2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIRC2 Gene

Orthologs for BIRC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BIRC2 30 31
  • 99.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC539314 30
  • 90.99 (n)
BIRC2 31
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia BIRC2 30 31
  • 85.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Birc2 30 17 31
  • 84.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Birc2 30
  • 82.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
ManyToMany
-- 31
  • 73 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
OneToMany
Chicken
(Gallus gallus)
Aves BIRC2 30
  • 73.3 (n)
ITA 31
  • 71 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia birc2 30
  • 64.03 (n)
Str.8459 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14508 30
Zebrafish
(Danio rerio)
Actinopterygii birc2 30 31
  • 61.93 (n)
OneToMany
birc3 30
Fruit Fly
(Drosophila melanogaster)
Insecta Iap2 30 31 32
  • 45.47 (n)
ManyToMany
th 31
  • 23 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for BIRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BIRC2 Gene

ENSEMBL:
Gene Tree for BIRC2 (if available)
TreeFam:
Gene Tree for BIRC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BIRC2: view image

Paralogs for BIRC2 Gene

Paralogs for BIRC2 Gene

(4) SIMAP similar genes for BIRC2 Gene using alignment to 7 proteins:

  • BIRC2_HUMAN
  • E9PI77_HUMAN
  • E9PIW1_HUMAN
  • E9PMH5_HUMAN
  • E9PNM6_HUMAN
  • E9PQZ9_HUMAN
  • H0YDY3_HUMAN
genes like me logo Genes that share paralogs with BIRC2: view

Variants for BIRC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BIRC2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs34510872 - p.Ala506Val
rs34749508 - p.Met453Ile
rs35494784 - p.Pro549Ser
rs370745983 - p.Met453Val

Additional dbSNP identifiers (rs#s) for BIRC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for BIRC2 Gene

Variant ID Type Subtype PubMed ID
dgv1269n100 CNV gain 25217958
nsv1134170 CNV deletion 24896259

Variation tolerance for BIRC2 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIRC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIRC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC2 Gene

Disorders for BIRC2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for BIRC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
burkitt lymphoma
  • bl
lymphoma, mucosa-associated lymphoid type
  • malt lymphoma
lymphoproliferative syndrome, x-linked, 2
  • xlp2
b-cell lymphoma
  • b-cell lymphocytic neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search BIRC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BIRC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BIRC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIRC2 Gene

Publications for BIRC2 Gene

  1. The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9. (PMID: 19153467) Kulathila R … Price A (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 23
  2. Identification of an antiapoptotic protein complex at death receptors. (PMID: 18846110) Sun M … Jope RS (Cell death and differentiation 2008) 3 4 23
  3. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PMID: 15665297) Samuel T … Reed JC (Cancer research 2005) 3 4 23
  4. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P … Korneluk RG (Nature 1996) 2 3 4
  5. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PMID: 8548810) Rothe M … Goeddel DV (Cell 1995) 2 3 4

Products for BIRC2 Gene

Sources for BIRC2 Gene