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Aliases for BIN3 Gene

Aliases for BIN3 Gene

  • Bridging Integrator 3 2 3 3 5

External Ids for BIN3 Gene

Previous GeneCards Identifiers for BIN3 Gene

  • GC08P022082
  • GC08M022831
  • GC08M022298
  • GC08M022499
  • GC08M022533
  • GC08M021021
  • GC08M022477

Summaries for BIN3 Gene

Entrez Gene Summary for BIN3 Gene

  • The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for BIN3 Gene

BIN3 (Bridging Integrator 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytoskeletal adaptor activity.

UniProtKB/Swiss-Prot for BIN3 Gene

  • Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Gene Wiki entry for BIN3 Gene

Additional gene information for BIN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN3 Gene

Genomics for BIN3 Gene

GeneHancer (GH) Regulatory Elements for BIN3 Gene

Promoters and enhancers for BIN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022666 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 793 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 SLC30A9 POLR2B E2F8 BIN3 C8orf58 POLR3D LOC105369180 GC08P022638
GH08J021917 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 24.9 +749.0 749033 4.3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 ZNF207 XPO7 ENSG00000253200 BIN3 C8orf58 FGF17 CCAR2 FAM160B2 NPM2 ENSG00000251034 POLR3D
GH08J022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.5 -25.4 -25435 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 E2F8 EGR3 LOC105379322 LOC105379321 ENSG00000253200 FAM160B2 ENSG00000245025 BMP1 C8orf58 LOXL2 CCAR2
GH08J022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.1 +64.1 64140 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CCAR2 GC08P022605 PIR42411 PIR62346 PIR54985 C8orf58 ENSG00000253200 FAM160B2 ENTPD4 BIN3
GH08J023223 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.5 -556.0 -555996 3.5 HDGF ATF1 ARNT ARID4B SIN3A YY1 ZNF280A GTF3C2 ZNF207 ZNF143 TNFRSF10A LOC389641 CHMP7 ENSG00000253200 BIN3 CCAR2 C8orf58 POLR3D ENSG00000250714
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BIN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BIN3 gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • LCR-F1
  • AP-1
  • E47
  • Tal-1beta
  • GATA-6

Genomic Locations for BIN3 Gene

Genomic Locations for BIN3 Gene
48,731 bases
Minus strand
48,731 bases
Minus strand

Genomic View for BIN3 Gene

Genes around BIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIN3 Gene

Proteins for BIN3 Gene

  • Protein details for BIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bridging integrator 3
    Protein Accession:
    Secondary Accessions:
    • Q9BVG2
    • Q9NVY9

    Protein attributes for BIN3 Gene

    253 amino acids
    Molecular mass:
    29665 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01223.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BIN3 Gene


neXtProt entry for BIN3 Gene

Post-translational modifications for BIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BIN3 Gene

Domains & Families for BIN3 Gene

Gene Families for BIN3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BIN3 Gene


Suggested Antigen Peptide Sequences for BIN3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BIN3: view

No data available for UniProtKB/Swiss-Prot for BIN3 Gene

Function for BIN3 Gene

Molecular function for BIN3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Phenotypes From GWAS Catalog for BIN3 Gene

Gene Ontology (GO) - Molecular Function for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18654987
GO:0008093 cytoskeletal adaptor activity NAS 11274158
genes like me logo Genes that share ontologies with BIN3: view
genes like me logo Genes that share phenotypes with BIN3: view

Animal Models for BIN3 Gene

MGI Knock Outs for BIN3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIN3 Gene

Localization for BIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIN3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIN3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with BIN3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BIN3 Gene

Pathways & Interactions for BIN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000917 division septum assembly IEA --
GO:0007015 actin filament organization NAS 11274158
GO:0007049 cell cycle IEA --
GO:0008104 protein localization IMP 11274158
GO:0009826 unidimensional cell growth IMP 11274158
genes like me logo Genes that share ontologies with BIN3: view

No data available for Pathways by source and SIGNOR curated interactions for BIN3 Gene

Drugs & Compounds for BIN3 Gene

No Compound Related Data Available

Transcripts for BIN3 Gene

Unigene Clusters for BIN3 Gene

Bridging integrator 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIN3

Alternative Splicing Database (ASD) splice patterns (SP) for BIN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -

Relevant External Links for BIN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BIN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIN3 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for BIN3 Gene

This gene is overexpressed in Breast (36.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BIN3 Gene

Protein tissue co-expression partners for BIN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BIN3 Gene:


SOURCE GeneReport for Unigene cluster for BIN3 Gene:


mRNA Expression by UniProt/SwissProt for BIN3 Gene:

Tissue specificity: Ubiquitously expressed except in brain.

Evidence on tissue expression from TISSUES for BIN3 Gene

  • Skin(4.4)
  • Lung(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with BIN3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BIN3 Gene

Orthologs for BIN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BIN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BIN3 34 33
  • 99.34 (n)
(Monodelphis domestica)
Mammalia BIN3 34
  • 91 (a)
(Canis familiaris)
Mammalia BIN3 34 33
  • 90.65 (n)
(Ornithorhynchus anatinus)
Mammalia BIN3 34
  • 90 (a)
(Bos Taurus)
Mammalia BIN3 34 33
  • 89.86 (n)
(Mus musculus)
Mammalia Bin3 16 34 33
  • 87.88 (n)
(Rattus norvegicus)
Mammalia Bin3 33
  • 87.62 (n)
(Anolis carolinensis)
Reptilia BIN3 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bin3 33
  • 71.43 (n)
Str.9914 33
(Danio rerio)
Actinopterygii BIN3 (2 of 2) 34
  • 84 (a)
bin3 34 33
  • 76.55 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER193W 33
  • 49.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11903g 33
  • 42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RVS161 36 34 33
  • 40.86 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01069 33
  • 44.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hob3 33
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for BIN3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIN3 Gene

Gene Tree for BIN3 (if available)
Gene Tree for BIN3 (if available)
Evolutionary constrained regions (ECRs) for BIN3: view image

Paralogs for BIN3 Gene

(1) SIMAP similar genes for BIN3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BIN3: view

No data available for Paralogs for BIN3 Gene

Variants for BIN3 Gene

Sequence variations from dbSNP and Humsavar for BIN3 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000022196 -- 22,620,118(-) C/T downstream_transcript_variant
rs1000039434 -- 22,650,938(-) A/T intron_variant
rs1000053184 -- 22,619,963(-) C/T downstream_transcript_variant
rs1000072755 -- 22,669,348(-) C/G upstream_transcript_variant
rs1000164878 -- 22,670,410(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BIN3 Gene

Variant ID Type Subtype PubMed ID
esv1623916 CNV insertion 17803354
esv1939469 CNV deletion 18987734
esv2759604 CNV loss 17122850
esv3386084 CNV duplication 20981092
esv3572633 CNV loss 25503493
nsv1140898 CNV deletion 24896259

Variation tolerance for BIN3 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIN3 Gene

Disorders for BIN3 Gene

Additional Disease Information for BIN3

No disorders were found for BIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIN3 Gene

Publications for BIN3 Gene

  1. Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p. (PMID: 11274158) Routhier EL … Prendergast GC (The Journal of biological chemistry 2001) 3 4 22 58
  2. The BAR domain proteins: molding membranes in fission, fusion, and phagy. (PMID: 16524918) Ren G … Munn AL (Microbiology and molecular biology reviews : MMBR 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BIN3 Gene

Sources for BIN3 Gene

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