Aliases for BIN2 Gene
Aliases for BIN2 Gene
External Ids for BIN2 Gene
- HGNC: 1053
- Entrez Gene: 51411
- Ensembl: ENSG00000110934
- OMIM: 605936
- UniProtKB: Q9UBW5
Previous GeneCards Identifiers for BIN2 Gene
- GC12M051831
- GC12M051697
- GC12M051391
- GC12M049961
- GC12M048707
- GC12M051674
Summaries for BIN2 Gene
GeneCards Summary for BIN2 Gene
BIN2 (Bridging Integrator 2) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include phospholipid binding. An important paralog of this gene is BIN1.
UniProtKB/Swiss-Prot for BIN2 Gene
-
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIN2 Gene
Genomics for BIN2 Gene
GeneHancer (GH) Regulatory Elements for BIN2 Gene
Promoters and enhancers for BIN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around BIN2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BIN2 gene promoter:
-
- Tal-1
- E47
- AML1a
- HNF-4alpha2
- HNF-4alpha1
- AP-1
- c-Fos
- c-Jun
Regulatory Element Products
Genomic Locations for BIN2 Gene
Genomic Locations for BIN2 Gene
- chr12:51,281,038-51,324,680
- (GRCh38/hg38)
- Size:
- 43,643 bases
- Orientation:
- Minus strand
- chr12:51,674,822-51,718,452
- (GRCh37/hg19)
- Size:
- 43,631 bases
- Orientation:
- Minus strand
Genomic View for BIN2 Gene
Genes around BIN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
- 12q13.13 by Ensembl
BIN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BIN2 Gene
Proteins for BIN2 Gene
-
Protein details for BIN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBW5-BIN2_HUMAN
- Recommended name:
- Bridging integrator 2
- Protein Accession:
- Q9UBW5
- Q86VV0
- Q9NWK4
- Q9UKN4
Protein attributes for BIN2 Gene
- Size:
- 565 amino acids
- Molecular mass:
- 61874 Da
- Quaternary structure:
-
- Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2.
- SequenceCaution:
-
- Sequence=BAA91376.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91376.1; Type=Frameshift; Positions=156; Evidence={ECO:0000305};
Protein Expression for BIN2 Gene
Post-translational modifications for BIN2 Gene
Other Protein References for BIN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for BIN2
- Novus Biologicals Antibodies for BIN2
- Invitrogen Antibodies for BIN2 (AFLGC-BIN2)
- antibodies-online: Search results for available BIN2 related products ranked by validation data
- GeneTex BIN2 Antibody for BIN2
-
Boster Bio Antibodies for BIN2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BIN2
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Protein Products
-
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- ProSpec Recombinant Proteins for BIN2
- antibodies-online: Search results for available BIN2 related products ranked by validation data
- Search GeneTex for Proteins for BIN2
-
ProSci Proteins for BIN2
Assay Products
- antibodies-online: Search results for available BIN2 related products ranked by validation data
No data available for DME Specific Peptides for BIN2 Gene
Domains & Families for BIN2 Gene
Gene Families for BIN2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BIN2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BIN2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBW5UniProtKB/Swiss-Prot:
BIN2_HUMAN :- The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
- Domain:
-
- The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.
Function for BIN2 Gene
Molecular function for BIN2 Gene
- UniProtKB/Swiss-Prot Function:
- Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated during monocytic differentiation.
Phenotypes From GWAS Catalog for BIN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10903846 |
| GO:0005543 | phospholipid binding | IDA | 23285027 |
Phenotypes for BIN2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
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- Overview of 88 available BIN2 gene related products
- Applied Biological Materials CRISPR for BIN2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BIN2
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miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 88 available BIN2 gene related products
- Overview of 88 available BIN2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BIN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BIN2
- Applied Biological Materials Clones for BIN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BIN2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BIN2 Gene
Localization for BIN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BIN2 Gene
- Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269 PubMed:23285027}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| nucleus | 3 |
| cytosol | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001891 | colocalizes_with phagocytic cup | IDA | 23285027 |
| GO:0002102 | podosome | IDA | 23285027 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005938 | cell cortex | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BIN2 Gene
Pathways & Interactions for BIN2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for BIN2 Gene
3 Reactome pathways for BIN2 Gene
Interacting Proteins for BIN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006911 | phagocytosis, engulfment | IMP | 23285027 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
| GO:0060326 | cell chemotaxis | IMP | 23285027 |
| GO:0071800 | podosome assembly | IMP | 23285027 |
| GO:0097320 | plasma membrane tubulation | IDA | 23285027 |
No data available for SIGNOR curated interactions for BIN2 Gene
Transcripts for BIN2 Gene
mRNA/cDNA for BIN2 Gene
- (7) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000604560 2003 bps (uc058oco.1)
- ENST00000605039 2781 bps (uc001ryh.4)
- ENST00000452142 2115 bps (uc009zlz.4)
- ENST00000615107 2255 bps (uc001ryg.4)
- ENST00000544402 1990 bps (uc010sng.3)
CRISPR Products
-
OriGene CRISPR knockouts for BIN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BIN2
- genomics-online: gRNA clones - Search results for 88 available BIN2 gene related products
- Overview of 88 available BIN2 gene related products
- Applied Biological Materials CRISPR for BIN2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BIN2
- GenScript: Design CRISPR guide RNA sequences for BIN2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BIN2
- Browse OriGene Inhibitory RNA Products For BIN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIN2
- genomics-online: shRNA clones - Search results for 88 available BIN2 gene related products
- Overview of 88 available BIN2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for BIN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BIN2
- Applied Biological Materials Clones for BIN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for BIN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for BIN2 Gene
This gene is overexpressed in Whole Blood (x36.3).
This gene is overexpressed in Peripheral blood mononuclear cells (19.4), Platelet (19.2), and Lavage (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BIN2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BIN2 Gene:
BIN2SOURCE GeneReport for Unigene cluster for BIN2 Gene:
Hs.14770mRNA Expression by UniProt/SwissProt for BIN2 Gene:
Q9UBW5-BIN2_HUMAN
Tissue specificity:
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Evidence on tissue expression from TISSUES for BIN2 Gene
- Blood(4.4)
- Intestine(4.3)
- Liver(4.3)
- Bone marrow(2.4)
- Lymph node(2.4)
- Spleen(2.4)
Primer Products
-
OriGene qPCR primer pairs for BIN2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BIN2 Gene
Orthologs for BIN2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BIN2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BIN2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BIN2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BIN2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bin2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bin2 33 |
|
||
| chicken (Gallus gallus) |
Aves | BIN2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BIN2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | bin2b 34 |
|
OneToMany | |
| bin2a 34 |
|
OneToMany | |||
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Amph 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | F58G6.1 35 |
|
|
|
| amph-1 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3172 34 |
|
OneToMany |
- Species where no ortholog for BIN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for BIN2 Gene
- ENSEMBL:
- Gene Tree for BIN2 (if available)
- TreeFam:
- Gene Tree for BIN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BIN2: view image
Paralogs for BIN2 Gene
(2) SIMAP similar genes for BIN2 Gene using alignment to 4 proteins:
- BIN2_HUMAN
- F5H0W4_HUMAN
- S4R3J0_HUMAN
- S4R418_HUMAN
Pseudogenes.org Pseudogenes for BIN2 Gene
Variants for BIN2 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000101899 | -- | 51,281,727(-) | A/G | intron_variant | |
| rs1000130252 | -- | 51,323,684(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000134515 | -- | 51,281,237(-) | T/A | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000143285 | -- | 51,292,421(-) | G/A | intron_variant | |
| rs1000159138 | -- | 51,322,837(-) | T/C/G | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.76;
73.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BIN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BIN2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIN2 Gene
Disorders for BIN2 Gene
Additional Disease Information for BIN2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for BIN2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BIN2 Gene
Publications for BIN2 Gene
- Bin2, a functionally nonredundant member of the BAR adaptor gene family. (PMID: 10903846) Ge K … Prendergast GC (Genomics 2000) 2 3 4 58
- Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis. (PMID: 23285027) Sánchez-Barrena MJ … McMahon HT (PloS one 2012) 3 4 58
- A genome-wide association study of aging. (PMID: 21782286) Walter S … Franceschini N (Neurobiology of aging 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
Products for BIN2 Gene
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- GeneTex BIN2 Antibody for BIN2
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- genomics-online: cdna clones - Search results for 88 available BIN2 gene related products
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Sources for BIN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
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