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BIN2 (Bridging Integrator 2) is a Protein Coding gene. Diseases associated with BIN2 include Kummell's Disease and Acute Tympanitis. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include phospholipid binding. An important paralog of this gene is BIN1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 10903846 |
GO:0005543 | phospholipid binding | IBA,IDA | 23285027 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001891 | colocalizes_with phagocytic cup | IBA,IDA | 23285027 |
GO:0002102 | podosome | IBA,IDA | 23285027 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006911 | phagocytosis, engulfment | IMP | 23285027 |
GO:0043312 | neutrophil degranulation | TAS | -- |
GO:0060326 | cell chemotaxis | IMP | 23285027 |
GO:0071800 | podosome assembly | IBA,IMP | 23285027 |
GO:0097320 | plasma membrane tubulation | IBA,IDA | 23285027 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BIN2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BIN2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BIN2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BIN2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bin2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bin2 30 |
|
||
Chicken (Gallus gallus) |
Aves | BIN2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BIN2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | bin2b 31 |
|
OneToMany | |
bin2a 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Amph 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F58G6.1 32 |
|
|
|
amph-1 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3172 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
kummell's disease |
|
|
acute tympanitis |
|
|
myringitis bullosa hemorrhagica |
|
|
arteriovenous malformations of the brain |
|
|