Aliases for BIK Gene
External Ids for BIK Gene
Previous GeneCards Identifiers for BIK Gene
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
GeneCards Summary for BIK Gene
BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include B-Cell Lymphoma. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and BH domain binding.
UniProtKB/Swiss-Prot Summary for BIK Gene
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.