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The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting protein... See more...
Aliases for BIK Gene
Aliases for BIK Gene
External Ids for BIK Gene
- HGNC: 1051
- Entrez Gene: 638
- Ensembl: ENSG00000100290
- OMIM: 603392
- UniProtKB: Q13323
Previous GeneCards Identifiers for BIK Gene
- GC22P040109
- GC22P041737
- GC22P041831
- GC22P043506
- GC22P026465
Summaries for BIK Gene
-
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
GeneCards Summary for BIK Gene
BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include B-Cell Lymphoma. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and BH domain binding.
UniProtKB/Swiss-Prot Summary for BIK Gene
-
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Additional gene information for BIK Gene
- HGNC(1051)
- Entrez Gene(638)
- Ensembl(ENSG00000100290)
- OMIM(603392)
- UniProtKB(Q13323)
- Open Targets Platform(ENSG00000100290)
- Monarch Initiative
- Search for BIK at DataMed
- Search for BIK at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BIK Gene
Genomics for BIK Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BIK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BIK on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BIK
- Top Transcription factor binding sites by QIAGEN in the BIK gene promoter:
-
- AML1a
- AP-4
- FOXL1
- GATA-1
- GATA-6
- HSF2
- Pax-4a
- RFX1
- STAT5B
Genomic Locations for BIK Gene
Genomic Locations for BIK Gene
- chr22:43,110,750-43,129,712
- (GRCh38/hg38)
- Size:
- 18,963 bases
- Orientation:
- Plus strand
- chr22:43,506,754-43,525,718
- (GRCh37/hg19)
- Size:
- 18,965 bases
- Orientation:
- Plus strand
Genomic View for BIK Gene
Genes around BIK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.2 by HGNC
- 22q13.2 by Entrez Gene
- 22q13.2 by Ensembl
BIK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BIK Gene
Proteins for BIK Gene
-
Protein details for BIK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13323-BIK_HUMAN
- Recommended name:
- Bcl-2-interacting killer
- Protein Accession:
- Q13323
- Q16582
- Q6FH93
Protein attributes for BIK Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18016 Da
- Quaternary structure:
-
- Interacts with RHBDL4/RHBDD1.
Post-translational modifications for BIK Gene
- Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BIK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BIK Antibody and BIK Monoclonal Antibody
- NSJ Bioreagents BIK Antibody / BCL2-interacting killer
- Creative Diagnostics Anti-BIK monoclonal antibody, clone 5H23
-
Custom Antibody ServicesOriGene Antibodies for BIK
- Novus Biologicals Antibodies for BIK
-
Abcam antibodies for BIK
- Invitrogen Antibodies for BIK (AFLGC-BIK)
-
Biorbyt antibodies for BIK
-
Custom Antibody ServicesProSci Antibodies for BIK
-
Santa Cruz Biotechnology (SCBT) Antibodies for BIK
- Sino Biological Antibodies for BIK
Protein Products
-
OriGene Purified Proteins for BIK
- Search Origene for MassSpec and Protein Over-expression Lysates for BIK
- Origene Custom Protein Services for BIK
- Novus Biologicals proteins for BIK
- antibodies-online: Show 5 available BIK Proteins ranked by validation data
- Compare Top BIK Proteins
-
Abcam proteins for BIK
Assay Products
- antibodies-online: Show 3 available BIK Elisa Kits ranked by validation data
- Compare Top BIK Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for BIK Gene
Domains & Families for BIK Gene
Gene Families for BIK Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for BIK Gene
- InterPro:
- Blocks:
-
- Apoptosis regulator Bcl-2 protein, BH
- ProtoNet:
Suggested Antigen Peptide Sequences for BIK Gene
- GenScript: Design optimal peptide antigens:
-
- BP4 (BIK_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13323UniProtKB/Swiss-Prot:
BIK_HUMAN :- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Domain:
-
- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function for BIK Gene
Molecular function for BIK Gene
- UniProtKB/Swiss-Prot Function:
- Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
- GENATLAS Biochemistry:
- BCL2-interacting killer (apoptosis-inducing)
Phenotypes From GWAS Catalog for BIK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9027312 |
Phenotypes for BIK Gene
- MGI mutant phenotypes for BIK:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BIK:
Animal Models for BIK Gene
- MGI Knock Outs for BIK:
-
- Bik Bik<tm1Ast>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BIK - Select products 50% OFF >
- * BIK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BIK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BIK
-
Santa Cruz Biotechnology (SCBT) CRISPR for BIK
miRNA for BIK Gene
- miRTarBase miRNAs that target BIK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BIK
- Browse OriGene Inhibitory RNA Products For BIK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIK
Clone Products
- Applied Biological Materials (abm): Clones for BIK - Select products 50% OFF >
- * BIK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BIK
- Addgene plasmids for BIK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BIK
Cell Line Products
-
Horizon Cell Lines for BIK
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIK Gene
Localization for BIK Gene
Subcellular locations from UniProtKB/Swiss-Prot for BIK Gene
- Endomembrane system. Single-pass membrane protein. Mitochondrion membrane. Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0012505 | endomembrane system | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0031966 | mitochondrial membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BIK Gene
Pathways & Interactions for BIK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and Autophagy | ||
| 2 | Glioma | ||
| 3 | Busulfan Pathway, Pharmacodynamics | ||
| 4 | Apoptotic Pathways in Synovial Fibroblasts |
DHA Signaling
.74
|
|
| 5 | Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins |
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
-
|
|
Pathways by source for BIK Gene
2 BioSystems pathways for BIK Gene
1 PharmGKB pathway for BIK Gene
1 KEGG pathway for BIK Gene
1 GeneGo (Thomson Reuters) pathway for BIK Gene
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
1 Qiagen pathway for BIK Gene
- DHA Signaling
1 Cell Signaling Technology pathway for BIK Gene
Interacting Proteins for BIK Gene
Selected Interacting proteins:
Q13323-BIK_HUMAN
ENSP00000216115
for BIK Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BIK
SIGNOR curated interactions for BIK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS | 10381623 |
| GO:0008584 | male gonad development | IBA | 21873635 |
| GO:0008637 | apoptotic mitochondrial changes | IBA | 21873635 |
| GO:0031334 | positive regulation of protein complex assembly | IDA | 21041309 |
| GO:0042981 | regulation of apoptotic process | IEA | -- |
Drugs & Compounds for BIK Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bortezomib (PS-341) | Pharma | Proteasome Inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for BIK Gene
| Compound | Action | Cas Number |
|---|---|---|
| Bortezomib (PS-341) | Proteasome Inhibitor | 179324-69-7 |
Transcripts for BIK Gene
mRNA/cDNA for BIK Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216115 951 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BIK - Select products 50% OFF >
- * BIK CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BIK
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BIK
-
Santa Cruz Biotechnology (SCBT) CRISPR for BIK
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BIK
- Browse OriGene Inhibitory RNA Products For BIK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIK
Clone Products
- Applied Biological Materials (abm): Clones for BIK - Select products 50% OFF >
- * BIK as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for BIK
- Addgene plasmids for BIK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BIK
Relevant External Links for BIK Gene
- GeneLoc Exon Structure for
- BIK
Expression for BIK Gene
mRNA differential expression in normal tissues according to GTEx for BIK Gene
This gene is overexpressed in Minor Salivary Gland (x7.7), Colon - Transverse (x5.2), Esophagus - Mucosa (x4.5), and Prostate (x4.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BIK
SOURCE GeneReport for Unigene cluster for BIK Gene:
Hs.475055Evidence on tissue expression from TISSUES for BIK Gene
- Blood(2.3)
- Intestine(2.2)
- Spleen(2.1)
- Kidney(2)
- Skin(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for BIK
-
OriGene qPCR primer pairs and template standards for BIK
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIK Gene
Orthologs for BIK Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BIK 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bik 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Bik 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BIK 31 |
|
OneToOne |
- Species where no ortholog for BIK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BIK Gene
- ENSEMBL:
- Gene Tree for BIK (if available)
- TreeFam:
- Gene Tree for BIK (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BIK: view image
Paralogs for BIK Gene
No data available for Paralogs for BIK Gene
Variants for BIK Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BIK Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11090143 | - | p.Thr26Ile | |||
| rs11574527 | - | p.Leu148Pro | |||
| rs4988415 | - | p.Glu19Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762124 | CNV | gain | 21179565 |
| esv33816 | CNV | gain | 17666407 |
| esv3647853 | CNV | loss | 21293372 |
| esv3647854 | CNV | loss | 21293372 |
| nsv1061240 | CNV | gain | 25217958 |
| nsv459889 | CNV | gain | 19166990 |
| nsv589085 | CNV | gain | 21841781 |
| nsv589086 | CNV | loss | 21841781 |
| nsv834214 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.45;
28.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BIK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BIK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIK Gene
Disorders for BIK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| b-cell lymphoma |
|
Search BIK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BIK
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BIK Gene
Publications for BIK Gene
- Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PMID: 7478623) Boyd JM … Lutz RJ (Oncogene 1995) 2 3 4 23
- A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. (PMID: 18953687) Wang Y … Wang L (Cellular and molecular life sciences : CMLS 2008) 3 4 23
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
- Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PMID: 8816500) Han J … White E (Molecular and cellular biology 1996) 3 4 23
- Genome-wide association study identifies new prostate cancer susceptibility loci. (PMID: 21743057) Schumacher FR … Kraft P (Human molecular genetics 2011) 3 41
ExternalLinks
Products for BIK Gene
- Custom Antibody ServicesOriGene Antibodies for BIK
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BIK
- Search Origene for MassSpec and Protein Over-expression Lysates for BIK
- Origene Custom Protein Services for BIK
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BIK
- Browse OriGene Inhibitory RNA Products For BIK
- OriGene qPCR primer pairs for BIK
- OriGene qPCR primer pairs and template standards for BIK
- OriGene CRISPR knockouts for BIK
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BIK
- Sino Biological Human cDNA Clone for BIK
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for BIK
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BIK
- Novus Biologicals proteins for BIK
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BIK
- Abcam proteins for BIK
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for BIK (AFLGC-BIK)
- ApexBio compounds for BIK
- VectorBuilder Custom and pre-made DNA vectors for BIK (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BIK (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BIK (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BIK CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BIK
- Addgene plasmids for BIK
- antibodies-online: Show 41 available BIK Antibodies ranked by validation data
- Compare Top BIK Antibodies
- antibodies-online: Show 3 available BIK Elisa Kits ranked by validation data
- Compare Top BIK Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available BIK Proteins ranked by validation data
- Compare Top BIK Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BIK
- Search Santa Cruz Biotechnology (SCBT) for BIK siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BIK
- Custom Antibody ServicesProSci Antibodies for BIK
- Search for BIK Proteins at ProSci
- Horizon Cell Lines for BIK
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BIK
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BIK
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BIK
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIK
- Biorbyt antibodies for BIK
Sources for BIK Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB