BIK Gene (Protein Coding)

BCL2 Interacting Killer

GC22P043110
GIFtS:
41
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting protein... See more...

Aliases for BIK Gene

Aliases for BIK Gene

  • BCL2 Interacting Killer 2 3 5
  • NBK 2 3 4
  • BCL2-Interacting Killer (Apoptosis-Inducing) 2 3
  • Bcl-2-Interacting Killer 3 4
  • Apoptosis Inducer NBK 3 4
  • Natural Born Killer 2 3
  • BIP1 3 4
  • BP4 3 4
  • Apoptosis-Inducing NBK 3
  • BIK 5

External Ids for BIK Gene

Previous GeneCards Identifiers for BIK Gene

  • GC22P040109
  • GC22P041737
  • GC22P041831
  • GC22P043506
  • GC22P026465

Summaries for BIK Gene

Entrez Gene Summary for BIK Gene

  • The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for BIK Gene

BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include Wolfram Syndrome 2. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot Summary for BIK Gene

  • Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.

Gene Wiki entry for BIK Gene

Additional gene information for BIK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BIK Gene

Genomics for BIK Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for BIK Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22J043110 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 264.1 +0.3 323 2.1 SP1 ZMYM3 POLR2A ZIC2 ZBTB10 BHLHE40 MNT CTCF SIN3A KLF9 BIK MCAT HSALNG0135767
GH22J043109 Enhancer 0.2 Ensembl 250.7 -1.6 -1649 0.2 BIK MCAT TSPO ARFGAP3 lnc-TTLL1-2 TTLL1
GH22J043142 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.1 +32.9 32862 3.2 BCLAF1 SP1 ZNF207 MYC ZNF580 POLR2A ZBTB10 YY1 MXD4 CTCF MCAT lnc-TSPO-5 RRP7BP POLDIP3 RN7SKP80 BIK TSPO TTLL12 HSALNG0135770
GH22J043103 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.9 -6.5 -6529 2 NCOR1 IKZF1 SSRP1 ZNF592 CEBPA MXD4 REST SMAD5 HES1 BHLHE40 ARFGAP3 MCAT TSPO CYB5R3 BIK CYP2D7 lnc-TTLL1-2 TTLL1
GH22J043066 Enhancer 1 Ensembl ENCODE 11.5 -43.4 -43447 1.8 ZNF580 ATF2 ZNF10 NFIC ZIC2 BHLHE40 ZNF639 ZNF341 ZEB1 MNT RPS25P10 TTLL1 BIK A4GALT MCAT ENSG00000227370 RF00017-3488 piR-35674-339 PACSIN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BIK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BIK

Top Transcription factor binding sites by QIAGEN in the BIK gene promoter:
  • AML1a
  • AP-4
  • FOXL1
  • GATA-1
  • GATA-6
  • HSF2
  • Pax-4a
  • RFX1
  • STAT5B

Genomic Locations for BIK Gene

Latest Assembly
chr22:43,110,750-43,129,712
(GRCh38/hg38)
Size:
18,963 bases
Orientation:
Plus strand

Previous Assembly
chr22:43,506,756-43,525,718
(GRCh37/hg19 by Entrez Gene)
Size:
18,963 bases
Orientation:
Plus strand

chr22:43,506,754-43,525,718
(GRCh37/hg19 by Ensembl)
Size:
18,965 bases
Orientation:
Plus strand

Genomic View for BIK Gene

Genes around BIK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BIK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BIK Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BIK Gene

Proteins for BIK Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for BIK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13323-BIK_HUMAN
    Recommended name:
    Bcl-2-interacting killer
    Protein Accession:
    Q13323
    Secondary Accessions:
    • Q16582
    • Q6FH93

    Protein attributes for BIK Gene

    Size:
    160 amino acids
    Molecular mass:
    18016 Da
    Quaternary structure:
    • Interacts with RHBDL4/RHBDD1.

    Three dimensional structures from OCA and Proteopedia for BIK Gene

neXtProt entry for BIK Gene

Post-translational modifications for BIK Gene

  • Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BIK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BIK Gene

Domains & Families for BIK Gene

Gene Families for BIK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for BIK Gene

InterPro:
Blocks:
  • Apoptosis regulator Bcl-2 protein, BH

Suggested Antigen Peptide Sequences for BIK Gene

GenScript: Design optimal peptide antigens:
  • BP4 (BIK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13323

UniProtKB/Swiss-Prot:

BIK_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
genes like me logo Genes that share domains with BIK: view

Function for BIK Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for BIK Gene

UniProtKB/Swiss-Prot Function:
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
GENATLAS Biochemistry:
BCL2-interacting killer (apoptosis-inducing)

Phenotypes From GWAS Catalog for BIK Gene

Gene Ontology (GO) - Molecular Function for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9027312
genes like me logo Genes that share ontologies with BIK: view
genes like me logo Genes that share phenotypes with BIK: view

Animal Models for BIK Gene

MGI Knock Outs for BIK:
  • Bik Bik<tm1Ast>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BIK Gene

Localization for BIK Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIK Gene

Endomembrane system. Single-pass membrane protein. Mitochondrion membrane. Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BIK gene
Compartment Confidence
mitochondrion 4
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with BIK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BIK Gene

Pathways & Interactions for BIK Gene

PathCards logo

SuperPathways for BIK Gene

genes like me logo Genes that share pathways with BIK: view

Pathways by source for BIK Gene

1 PharmGKB pathway for BIK Gene
1 KEGG pathway for BIK Gene
1 GeneGo (Thomson Reuters) pathway for BIK Gene
  • Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
1 Qiagen pathway for BIK Gene
  • DHA Signaling
1 Cell Signaling Technology pathway for BIK Gene

SIGNOR curated interactions for BIK Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BIK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10381623
GO:0008584 male gonad development IBA 21873635
GO:0008637 apoptotic mitochondrial changes IBA 21873635
GO:0031334 positive regulation of protein complex assembly IDA 21041309
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with BIK: view

Drugs & Compounds for BIK Gene

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  1. Drug products for research

(5) Drugs for BIK Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0

(1) Additional Compounds for BIK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for BIK Gene

Compound Action Cas Number
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
genes like me logo Genes that share compounds with BIK: view

Drug products for research

Transcripts for BIK Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for BIK Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BIK

Alternative Splicing Database (ASD) splice patterns (SP) for BIK Gene

No ASD Table

Relevant External Links for BIK Gene

GeneLoc Exon Structure for
BIK

Expression for BIK Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BIK Gene

mRNA expression in normal human tissues for BIK Gene
mRNA expression by BioGPS for BIK GenemRNA expression by GTEx for BIK Gene

mRNA differential expression in normal tissues according to GTEx for BIK Gene

This gene is overexpressed in Minor Salivary Gland (x7.7), Colon - Transverse (x5.2), Esophagus - Mucosa (x4.5), and Prostate (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BIK

SOURCE GeneReport for Unigene cluster for BIK Gene:

Hs.475055

Evidence on tissue expression from TISSUES for BIK Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with BIK: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BIK Gene

Orthologs for BIK Gene

This gene was present in the common ancestor of mammals.

Orthologs for BIK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia BIK 29 30
  • 98.75 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Bik 29
  • 65.61 (n)
Mouse
(Mus musculus)
 Mammalia Bik 29 16 30
  • 62.4 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia BIK 30
  • 45 (a)
 OneToOne
Species where no ortholog for BIK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BIK Gene

ENSEMBL:
Gene Tree for BIK (if available)
TreeFam:
Gene Tree for BIK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BIK: view image
Alliance of Genome Resources:
Additional Orthologs for BIK

Paralogs for BIK Gene

No data available for Paralogs for BIK Gene

Variants for BIK Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BIK Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs11090143 -- p.Thr26Ile
rs11574527 -- p.Leu148Pro
rs4988415 -- p.Glu19Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BIK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BIK Gene

Variant ID Type Subtype PubMed ID
esv2762124 CNV gain 21179565
esv33816 CNV gain 17666407
esv3647853 CNV loss 21293372
esv3647854 CNV loss 21293372
nsv1061240 CNV gain 25217958
nsv459889 CNV gain 19166990
nsv589085 CNV gain 21841781
nsv589086 CNV loss 21841781
nsv834214 CNV gain 17160897

Variation tolerance for BIK Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BIK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BIK
Leiden Open Variation Database (LOVD)
BIK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIK Gene

Disorders for BIK Gene

MalaCards: The human disease database

(1) MalaCards diseases for BIK Gene - From: COP

Disorder Aliases PubMed IDs
wolfram syndrome 2
  • wfs2
- elite association - COSMIC cancer census association via MalaCards
Search BIK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BIK

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BIK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BIK Gene

Publications for BIK Gene

  1. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. (PMID: 7478623) Boyd JM … Lutz RJ (Oncogene 1995) 2 3 4 22
  2. A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. (PMID: 18953687) Wang Y … Wang L (Cellular and molecular life sciences : CMLS 2008) 3 4 22
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 4
  4. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. (PMID: 8816500) Han J … White E (Molecular and cellular biology 1996) 3 4 22
  5. Genome-wide association study identifies new prostate cancer susceptibility loci. (PMID: 21743057) Schumacher FR … Kraft P (Human molecular genetics 2011) 3 40

ExternalLinks

View latest publications for BIK gene in Mastermind

Products for BIK Gene

  • Addgene plasmids for BIK

Sources for BIK Gene