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The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
BIK (BCL2 Interacting Killer) is a Protein Coding gene. Diseases associated with BIK include B-Cell Lymphoma. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and BH domain binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9027312 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0012505 | endomembrane system | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0031966 | mitochondrial membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptosis and Autophagy | ||
2 | Glioma | ||
3 | Busulfan Pathway, Pharmacodynamics | ||
4 | Apoptotic Pathways in Synovial Fibroblasts |
DHA Signaling
.74
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|
5 | Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins |
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | TAS | 10381623 |
GO:0008584 | male gonad development | IBA | 21873635 |
GO:0008637 | apoptotic mitochondrial changes | IBA | 21873635 |
GO:0031334 | positive regulation of protein complex assembly | IDA | 21041309 |
GO:0042981 | regulation of apoptotic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bortezomib (PS-341) | Pharma | Proteasome Inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Bortezomib (PS-341) | Proteasome Inhibitor | 179324-69-7 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BIK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bik 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Bik 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BIK 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11090143 | - | p.Thr26Ile | |||
rs11574527 | - | p.Leu148Pro | |||
rs4988415 | - | p.Glu19Lys |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762124 | CNV | gain | 21179565 |
esv33816 | CNV | gain | 17666407 |
esv3647853 | CNV | loss | 21293372 |
esv3647854 | CNV | loss | 21293372 |
nsv1061240 | CNV | gain | 25217958 |
nsv459889 | CNV | gain | 19166990 |
nsv589085 | CNV | gain | 21841781 |
nsv589086 | CNV | loss | 21841781 |
nsv834214 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
b-cell lymphoma |
|