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Aliases for BID Gene

Aliases for BID Gene

  • BH3 Interacting Domain Death Agonist 2 3 5
  • P22 BID 3 4
  • BH3 Interacting Domain Death Agonist Si6 Isoform 3
  • BH3-Interacting Domain Death Agonist 3
  • Human BID Coding Sequence 3
  • Apoptic Death Agonist 3
  • BID Isoform ES(1b) 3
  • Desmocollin Type 4 3
  • BID Isoform L(2) 3
  • BID Isoform Si6 3
  • FP497 3

External Ids for BID Gene

Previous GeneCards Identifiers for BID Gene

  • GC22M015157
  • GC22M016591
  • GC22M016592
  • GC22M018216
  • GC22M002030

Summaries for BID Gene

Entrez Gene Summary for BID Gene

  • This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for BID Gene

BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Gastric Adenocarcinoma and Cat Eye Syndrome. Among its related pathways are Gene Expression and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.

UniProtKB/Swiss-Prot for BID Gene

  • The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Wiki entry for BID Gene

Additional gene information for BID Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BID Gene

Genomics for BID Gene

GeneHancer (GH) Regulatory Elements for BID Gene

Promoters and enhancers for BID Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J017769 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 664.9 +0.6 628 10 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 BID MICAL3 HDHD5 BCL2L13 CECR2 LINC00528 PIR62667
GH22J017780 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 25.4 -6.7 -6683 2.3 BATF ZNF48 ZNF614 GLIS2 FOS RUNX3 SMARCA5 CEBPB KAT8 TGIF2 BID BCL2L13 CECR2 USP18 ATP6V1E1 LINC00528 PIR46133
GH22J017705 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 19 +68.2 68162 3 HDGF PKNOX1 SMAD1 SIN3A IRF4 RAD21 RFX5 YY1 ZNF121 ATF7 BID ATP6V1E1 BCL2L13 PIR47030
GH22J017741 Enhancer 0.9 ENCODE dbSUPER 28.7 +32.4 32369 0.8 CTCF TFAP4 USF1 RB1 SIN3A ERF RAD21 RELA CC2D1A CTBP1 BID PIR31207 MIR3198-1
GH22J017794 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -23.2 -23232 7.1 HDGF PKNOX1 FOXA2 SMAD1 RB1 ZFP64 STAT5A BMI1 BATF KLF5 PIR46133 BID MICAL3 ENSG00000093100 LINC00528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BID on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BID gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for BID Gene

Genomic Locations for BID Gene
40,633 bases
Minus strand
40,631 bases
Minus strand

Genomic View for BID Gene

Genes around BID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BID Gene

Proteins for BID Gene

  • Protein details for BID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BH3-interacting domain death agonist
    Protein Accession:
    Secondary Accessions:
    • Q549M7
    • Q71T04
    • Q7Z4M9
    • Q8IY86

    Protein attributes for BID Gene

    195 amino acids
    Molecular mass:
    21995 Da
    Quaternary structure:
    • Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH.
    • Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BID Gene

    Alternative splice isoforms for BID Gene


neXtProt entry for BID Gene

Post-translational modifications for BID Gene

  • TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
  • p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
  • Ubiquitination at posLast=158158
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BID Gene

Domains & Families for BID Gene

Gene Families for BID Gene

Protein Domains for BID Gene

Graphical View of Domain Structure for InterPro Entry



  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
genes like me logo Genes that share domains with BID: view

Function for BID Gene

Molecular function for BID Gene

UniProtKB/Swiss-Prot Function:
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
GENATLAS Biochemistry:
BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation

Phenotypes From GWAS Catalog for BID Gene

Gene Ontology (GO) - Molecular Function for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding TAS 8918887
GO:0005515 protein binding IPI 9463381
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with BID: view
genes like me logo Genes that share phenotypes with BID: view

Animal Models for BID Gene

MGI Knock Outs for BID:
  • Bid Bid<tm1Sjk>
  • Bid Bid<tm1.1Ast>

Animal Model Products

Clone Products

  • Addgene plasmids for BID

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BID Gene

Localization for BID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BID Gene

Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.
BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250}.
Isoform 1: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BID gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 5
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion TAS 9727491
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane TAS 8918887
genes like me logo Genes that share ontologies with BID: view

Pathways & Interactions for BID Gene

genes like me logo Genes that share pathways with BID: view

SIGNOR curated interactions for BID Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IDA 17052454
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS 9727491
genes like me logo Genes that share ontologies with BID: view

Drugs & Compounds for BID Gene

(44) Drugs for BID Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 577
Ribavirin Approved Pharma 1017
Anti-Infective Agents Pharma 23607
Antimetabolites Pharma 12587
Antiviral Agents Pharma 10348

(17) Additional Compounds for BID Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BID: view

Transcripts for BID Gene

Unigene Clusters for BID Gene

BH3 interacting domain death agonist:
Representative Sequences:

Clone Products

  • Addgene plasmids for BID

Alternative Splicing Database (ASD) splice patterns (SP) for BID Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for BID Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BID Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for BID Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BID Gene

Protein tissue co-expression partners for BID Gene

NURSA nuclear receptor signaling pathways regulating expression of BID Gene:


SOURCE GeneReport for Unigene cluster for BID Gene:


mRNA Expression by UniProt/SwissProt for BID Gene:

Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).

Evidence on tissue expression from TISSUES for BID Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Skin(4.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with BID: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BID Gene

Orthologs for BID Gene

This gene was present in the common ancestor of chordates.

Orthologs for BID Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BID 34 33
  • 99.45 (n)
(Mus musculus)
Mammalia Bid 16 34 33
  • 75.79 (n)
(Canis familiaris)
Mammalia BID 34 33
  • 75.77 (n)
(Rattus norvegicus)
Mammalia Bid 33
  • 73.37 (n)
(Bos Taurus)
Mammalia BID 33
  • 71.87 (n)
BID1 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia BID 34
  • 43 (a)
(Monodelphis domestica)
Mammalia BID 34
  • 33 (a)
(Gallus gallus)
Aves BID 34 33
  • 52.02 (n)
(Anolis carolinensis)
Reptilia BID 34
  • 37 (a)
Species where no ortholog for BID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BID Gene

Gene Tree for BID (if available)
Gene Tree for BID (if available)
Evolutionary constrained regions (ECRs) for BID: view image

Paralogs for BID Gene

No data available for Paralogs for BID Gene

Variants for BID Gene

Sequence variations from dbSNP and Humsavar for BID Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000025988 -- 17,765,441(-) T/A intron_variant
rs1000051641 -- 17,755,792(-) T/C intron_variant
rs1000105028 -- 17,771,021(-) T/C intron_variant
rs1000108780 -- 17,749,654(-) AA/A intron_variant
rs1000210491 -- 17,738,882(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BID Gene

Variant ID Type Subtype PubMed ID
esv2662076 CNV deletion 23128226
esv3647235 CNV loss 21293372
esv3893428 CNV loss 25118596
nsv1116010 CNV insertion 24896259
nsv1136651 CNV deletion 24896259
nsv1139043 CNV deletion 24896259
nsv428385 CNV gain+loss 18775914
nsv526826 CNV gain 19592680
nsv834119 CNV loss 17160897
nsv834120 CNV loss 17160897
nsv979630 CNV duplication 23825009

Variation tolerance for BID Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene

Disorders for BID Gene

MalaCards: The human disease database

(2) MalaCards diseases for BID Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
cat eye syndrome
  • ces
- elite association - COSMIC cancer census association via MalaCards
Search BID in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BID

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BID: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BID Gene

Publications for BID Gene

  1. Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PMID: 14583606) Renshaw SA … Whyte MK (The Journal of biological chemistry 2004) 3 4 22 58
  2. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz TK … McDermid HE (Genomics 1998) 2 3 4 58
  3. BID: a novel BH3 domain-only death agonist. (PMID: 8918887) Wang K … Korsmeyer SJ (Genes & development 1996) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for BID Gene

  • Addgene plasmids for BID

Sources for BID Gene

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