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This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it tr... See more...
Aliases for BID Gene
Aliases for BID Gene
External Ids for BID Gene
- HGNC: 1050
- Entrez Gene: 637
- Ensembl: ENSG00000015475
- OMIM: 601997
- UniProtKB: P55957
Previous GeneCards Identifiers for BID Gene
- GC22M015157
- GC22M016591
- GC22M016592
- GC22M018216
- GC22M002030
Summaries for BID Gene
-
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jan 2020]
GeneCards Summary for BID Gene
BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Bladder Transitional Cell Papilloma and Colon Adenocarcinoma. Among its related pathways are Apoptosis Modulation and Signaling and ATM Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.
UniProtKB/Swiss-Prot Summary for BID Gene
-
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Additional gene information for BID Gene
- HGNC(1050)
- Entrez Gene(637)
- Ensembl(ENSG00000015475)
- OMIM(601997)
- UniProtKB(P55957)
- Open Targets Platform(ENSG00000015475)
- Search for BID at DataMed
- Search for BID at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BID Gene
Genomics for BID Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BID Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BID on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BID
- Top Transcription factor binding sites by QIAGEN in the BID gene promoter:
-
- ATF-2
- c-Jun
Genomic Locations for BID Gene
Genomic Locations for BID Gene
- chr22:17,734,138-17,774,770
- (GRCh38/hg38)
- Size:
- 40,633 bases
- Orientation:
- Minus strand
- chr22:18,216,906-18,257,536
- (GRCh37/hg19)
- Size:
- 40,631 bases
- Orientation:
- Minus strand
Genomic View for BID Gene
Genes around BID on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by HGNC
- 22q11.21 by Entrez Gene
- 22q11.21 by Ensembl
BID Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BID Gene
Proteins for BID Gene
-
Protein details for BID Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55957-BID_HUMAN
- Recommended name:
- BH3-interacting domain death agonist
- Protein Accession:
- P55957
- Q549M7
- Q71T04
- Q7Z4M9
- Q8IY86
Protein attributes for BID Gene
- Size:
- 195 amino acids
- Molecular mass:
- 21995 Da
- Quaternary structure:
-
- Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH (PubMed:20392206). Interacts with PLEKHN1 (PubMed:29531808).
- SequenceCaution:
-
- Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BID Gene
Protein Expression for BID Gene
Post-translational modifications for BID Gene
- TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
- p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
-
Ubiquitination at Lys158
- NX_P55957 (NX_P55957-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BID Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences BID Antibody (LS-B2715) and BID Antibody (LS-B11168)
- G Biosciences Immunotag™ BID Antibody
- SouthernBiotech Mouse Anti-Human Bid-UNLB
- RayBiotech Rabbit Anti-Human BID
- GeneTex Anti-Bid antibody [N1C3-2] and Anti-Bid antibody [N1C3]
- BioLegend BID Antibody (645001) and BID Antibody (650502)
-
Custom Antibody ServicesOriGene Antibodies for BID
- AM06611SU-N
- AM08190PU-N
- AM09052PU-N
- AM09052PU-S
- AP00056PU-N
- AP00085PU-N
- AP06621PU-N
- AP08938PU-N
- AP08939PU-N
- AP11299PU-N
- AP11300PU-N
- AP12572PU-N
- CF506755
- CF506756
- CF506759
- CF506762
- CF506763
- CF506764
- CF506765
- CF506766
- CF506767
- CF506768
- TA302648
- TA306177
- TA306178
- TA323206
- TA323207
- TA326772
- TA328058
- TA506755
- TA506755S
- TA506756
- TA506756S
- TA506759
- TA506759S
- TA506762
- TA506762S
- TA506763
- TA506763S
- TA506764
- TA506764S
- TA506765
- TA506765S
- TA506766
- TA506766S
- TA506767
- TA506767S
- TA506768
- TA506768S
- UM500101
- UM500101CF
- UM570101
- Novus Biologicals Antibodies for BID
-
Abcam antibodies for BID
- Invitrogen Antibodies for BID (AFLGC-BID)
- antibodies-online: Show 126 available BID Antibodies ranked by validation data
- Compare Top BID Antibodies
-
Recommended
- 279 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 137 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Boster Bio Antibodies for BID
- Sino Biological Antibodies for BID
Protein Products
- G Biosciences Human BID/BH3-interacting domain death agonist, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for BID
- Origene Custom Protein Services for BID
- Sino Biological Recombinant Proteins for BID
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BID
- antibodies-online: Show 42 available BID Proteins ranked by validation data
- Compare Top BID Proteins
-
ProSci Proteins for BID
-
Abcam proteins for BID
Assay Products
- RayBiotech Human BID ELISA
- Novus Biologicals ELISA Kits for BID
- antibodies-online: Show 73 available BID Elisa Kits ranked by validation data
- Compare Top BID Elisa Kits
-
Quality Products:
- ABIN1113756
- ABIN2691093
- ABIN365900
- ABIN414503
- ABIN1028244
- ABIN3199199
- ABIN5519947
- ABIN5706231
- ABIN5668353
- ABIN5591696
- ABIN1113758
- ABIN415449
- ABIN1568619
- ABIN5519948
- ABIN4885440
- ABIN5669701
- ABIN627578
- ABIN1380953
- ABIN6384274
- ABIN5652219
- ABIN431428
- ABIN1568620
- ABIN1113757
- ABIN5519949
- ABIN5670361
- ABIN626748
- ABIN5591697
- ABIN5652220
- ABIN2542063
- ABIN4967504
-
Boster Bio ELISA Kits for BID
- Sino Biological Assays for BID
No data available for DME Specific Peptides for BID Gene
Domains & Families for BID Gene
Gene Families for BID Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BID Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BID Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ94329, Homo sapiens BH3 interacting domain death agonist (BID), mRNA (A8ASI8_HUMAN)
- BID isoform Si6 (B2ZP78_HUMAN)
- BID isoform ES(1b) (B2ZP79_HUMAN)
- p22 BID (BID_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P55957UniProtKB/Swiss-Prot:
BID_HUMAN :- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Domain:
-
- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function for BID Gene
Molecular function for BID Gene
- UniProtKB/Swiss-Prot Function:
- The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
- GENATLAS Biochemistry:
- BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation
Phenotypes From GWAS Catalog for BID Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005123 | death receptor binding | TAS | 8918887 |
| GO:0005515 | protein binding | IPI | 9463381 |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
Phenotypes for BID Gene
- MGI mutant phenotypes for BID:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for BID:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased shRNA abundance
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BID - Select products 50% OFF >
- * BID CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BID
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BID
-
Santa Cruz Biotechnology (SCBT) CRISPR for BID
miRNA for BID Gene
- miRTarBase miRNAs that target BID
-
- hsa-miR-492 (MIRT006072)
- hsa-miR-149-5p (MIRT045661)
- hsa-miR-92a-3p (MIRT049655)
- hsa-miR-129-5p (MIRT626395)
- hsa-miR-3680-3p (MIRT626396)
- hsa-miR-557 (MIRT626397)
- hsa-miR-507 (MIRT626398)
- hsa-miR-450b-5p (MIRT626399)
- hsa-miR-5006-3p (MIRT626400)
- hsa-miR-4755-5p (MIRT626401)
- hsa-miR-211-5p (MIRT626402)
- hsa-miR-204-5p (MIRT626403)
- hsa-miR-623 (MIRT626404)
- hsa-miR-6832-3p (MIRT626405)
- hsa-miR-141-5p (MIRT626406)
- hsa-miR-195-3p (MIRT647840)
- hsa-miR-16-2-3p (MIRT647841)
- hsa-miR-26b-5p (MIRT728202)
- hsa-miR-26a-5p (MIRT728203)
- hsa-miR-20a-3p (MIRT733808)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BID
- Browse OriGene Inhibitory RNA Products For BID
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BID
Clone Products
- Applied Biological Materials (abm): Clones for BID - Select products 50% OFF >
- * BID as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201913
- MR201913
- MR201913L3
- MR201913L4
- RC207261
- RC207261L3
- RC207261L4
- RC213884
- RC213884L3
- RC213884L4
- RC221674
- RC221674L1
- RC221674L2
- RC221674L3
- RC221674L4
- RC233255
- RC233256
- RC233257
- RC233408
- RG207261
- RG213884
- RG221674
- RG233255
- RG233256
- RG233257
- RG233408
- RR212362
- RR212362L3
- RR212362L4
- MR201913L3V
- MR201913L4V
- RC207261L3V
- RC207261L4V
- RC213884L3V
- RC213884L4V
- RC221674L1V
- RC221674L2V
- RC221674L3V
- RC221674L4V
- RR212362L3V
- RR212362L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BID
- Addgene plasmids for BID
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BID
Cell Line Products
-
Horizon Cell Lines for BID
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BID Gene
Localization for BID Gene
Subcellular locations from UniProtKB/Swiss-Prot for BID Gene
- Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
- [BH3-interacting domain death agonist p15]: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250 UniProtKB:P70444}.
- [BH3-interacting domain death agonist p13]: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250 UniProtKB:P70444}.
- [Isoform 1]: Cytoplasm.
- [Isoform 3]: Cytoplasm.
- [Isoform 2]: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269 PubMed:14583606}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | TAS,IBA | 21873635 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | TAS | 8918887 |
Pathways & Interactions for BID Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
DR3 Signaling
.87
TWEAK Pathway
.87
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
|
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
Fas Signaling
.35
.34
|
| 2 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
| 3 | Activation of BH3-only proteins | ||
| 4 | Nanomaterial induced apoptosis | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
p53 Mediated Apoptosis
.84
DHA Signaling
.74
|
Pathways by source for BID Gene
2 Sino Biological pathways for BID Gene
20 BioSystems pathways for BID Gene
14 Reactome pathways for BID Gene
22 KEGG pathways for BID Gene
5 GeneGo (Thomson Reuters) pathways for BID Gene
- Apoptosis and survival Apoptotic TNF-family pathways
- Apoptosis and survival Caspase cascade
- Apoptosis and survival FAS signaling cascades
- Apoptosis and survival TNFR1 signaling pathway
- Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
1 R&D Systems pathway for BID Gene
22 Qiagen pathways for BID Gene
- 14-3-3 Induced Apoptosis
- all-trans-Retinoic Acid Mediated Apoptosis
- Apoptosis through Death Receptors
- Apoptotic Pathways Triggered By HIV1
- ATM Pathway
1 Cell Signaling Technology pathway for BID Gene
1 GeneTex pathway for BID Gene
Interacting Proteins for BID Gene
Selected Interacting proteins:
P55957-BID_HUMAN
ENSP00000318822
for BID Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for BID
SIGNOR curated interactions for BID Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IDA | 17052454 |
| GO:0006626 | protein targeting to mitochondrion | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IBA | 21873635 |
| GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | TAS | 9727491 |
Drugs & Compounds for BID Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human BID/BH3-interacting domain death agonist, Liquid
Transcripts for BID Gene
mRNA/cDNA for BID Gene
- 7 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000317361 2495 nts (view in UCSC)
- ENST00000399774 2167 nts (view in UCSC)
- ENST00000399765 1879 nts (view in UCSC)
- ENST00000494097 2429 nts (view in UCSC)
- ENST00000342111 854 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BID - Select products 50% OFF >
- * BID CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BID
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BID
-
Santa Cruz Biotechnology (SCBT) CRISPR for BID
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BID
- Browse OriGene Inhibitory RNA Products For BID
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BID
Clone Products
- Applied Biological Materials (abm): Clones for BID - Select products 50% OFF >
- * BID as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201913
- MR201913
- MR201913L3
- MR201913L4
- RC207261
- RC207261L3
- RC207261L4
- RC213884
- RC213884L3
- RC213884L4
- RC221674
- RC221674L1
- RC221674L2
- RC221674L3
- RC221674L4
- RC233255
- RC233256
- RC233257
- RC233408
- RG207261
- RG213884
- RG221674
- RG233255
- RG233256
- RG233257
- RG233408
- RR212362
- RR212362L3
- RR212362L4
- MR201913L3V
- MR201913L4V
- RC207261L3V
- RC207261L4V
- RC213884L3V
- RC213884L4V
- RC221674L1V
- RC221674L2V
- RC221674L3V
- RC221674L4V
- RR212362L3V
- RR212362L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BID
- Addgene plasmids for BID
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BID
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - |
Relevant External Links for BID Gene
- GeneLoc Exon Structure for
- BID
Expression for BID Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for BID Gene
This gene is overexpressed in Whole Blood (x6.9).
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BID Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BID
SOURCE GeneReport for Unigene cluster for BID Gene:
Hs.591054mRNA Expression by UniProt/SwissProt for BID Gene:
P55957-BID_HUMAN
Tissue specificity:
Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
Evidence on tissue expression from TISSUES for BID Gene
- Nervous system(4.8)
- Liver(4.5)
- Skin(4.4)
- Blood(2.7)
- Intestine(2.6)
- Spleen(2.5)
- Bone marrow(2.5)
- Lymph node(2.4)
- Heart(2.3)
- Muscle(2.2)
- Lung(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for BID
-
OriGene qPCR primer pairs and template standards for BID
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BID Gene
Orthologs for BID Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BID 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bid 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BID 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Bid 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | BID 30 |
|
||
| BID1 31 |
|
OneToOne | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BID 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BID 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | BID 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BID 31 |
|
OneToOne |
- Species where no ortholog for BID was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BID Gene
- ENSEMBL:
- Gene Tree for BID (if available)
- TreeFam:
- Gene Tree for BID (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BID: view image
Paralogs for BID Gene
No data available for Paralogs for BID Gene
Variants for BID Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BID Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs17853595 | - | p.His162Gln | |||
| rs59225839 | - | p.Met194Thr | |||
| rs8190315 | - | p.Ser10Gly |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2662076 | CNV | deletion | 23128226 |
| esv3647235 | CNV | loss | 21293372 |
| esv3893428 | CNV | loss | 25118596 |
| nsv1116010 | CNV | insertion | 24896259 |
| nsv1136651 | CNV | deletion | 24896259 |
| nsv1139043 | CNV | deletion | 24896259 |
| nsv428385 | CNV | gain+loss | 18775914 |
| nsv526826 | CNV | gain | 19592680 |
| nsv834119 | CNV | loss | 17160897 |
| nsv834120 | CNV | loss | 17160897 |
| nsv979630 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BID Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BID
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene
Disorders for BID Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bladder transitional cell papilloma |
|
|
| colon adenocarcinoma |
|
|
| gastric adenocarcinoma |
|
|
| cat eye syndrome |
|
|
| cervical cancer |
|
Search BID in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BID
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BID Gene
Publications for BID Gene
- Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PMID: 17534194) Ester AR … Hecht JT (Clinical orthopaedics and related research 2007) 3 23 41
- Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PMID: 14583606) Renshaw SA … Whyte MK (The Journal of biological chemistry 2004) 3 4 23
- The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz TK … McDermid HE (Genomics 1998) 2 3 4
- BID: a novel BH3 domain-only death agonist. (PMID: 8918887) Wang K … Korsmeyer SJ (Genes & development 1996) 2 3 4
- PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. (PMID: 29531808) Kuriyama S … Tanaka M (Cell death discovery 2018) 3 4
ExternalLinks
Products for BID Gene
- Custom Antibody ServicesOriGene Antibodies for BID
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- UM500101
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- Browse OriGene ELISA Kits
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- RR212362L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BID
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- Sino Biological Assays for BID
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BID
- Novus Biologicals proteins and lysates for BID
- Novus Biologicals ELISA Kits for BID
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BID
- Abcam proteins for BID
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for BID (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BID (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for BID
- Addgene plasmids for BID
- antibodies-online: Show 126 available BID Antibodies ranked by validation data
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- 1 IF/ICC Antibody (anti-human)
- 137 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 49 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 73 available BID Elisa Kits ranked by validation data
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- Quality Products:
- ABIN1113756
- ABIN2691093
- ABIN365900
- ABIN414503
- ABIN1028244
- ABIN3199199
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- ABIN5652220
- ABIN2542063
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- antibodies-online: Show 42 available BID Proteins ranked by validation data
- Compare Top BID Proteins
- Search Santa Cruz Biotechnology (SCBT) for BID siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BID
- Custom Antibody ServicesProSci Antibodies for BID
- ProSci Proteins for BID
- Horizon Cell Lines for BID
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BID
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BID
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BID
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BID
- Boster Bio Antibodies for BID
- Boster Bio ELISA Kits for BID
Sources for BID Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB