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This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020]
BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Bladder Transitional Cell Papilloma and Colon Adenocarcinoma. Among its related pathways are Granzyme Pathway and Apoptosis and survival Caspase cascade. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005123 | death receptor binding | TAS | 8918887 |
GO:0005515 | protein binding | IPI | 9463381 |
GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | TAS,IBA | 21873635 |
GO:0005741 | mitochondrial outer membrane | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | TAS | 8918887 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
DR3 Signaling
.87
TWEAK Pathway
.87
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
Apoptotic Pathways Triggered By HIV1
.42
|
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
Fas Signaling
.35
.34
|
2 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
3 | Activation of BH3-only proteins | ||
4 | Nanomaterial induced apoptosis | ||
5 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
|
p53 Mediated Apoptosis
.84
DHA Signaling
.74
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001836 | release of cytochrome c from mitochondria | IDA | 17052454 |
GO:0006626 | protein targeting to mitochondrion | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IBA | 21873635 |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | TAS | 9727491 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BID 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bid 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BID 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bid 30 |
|
||
Cow (Bos Taurus) |
Mammalia | BID 30 |
|
||
BID1 31 |
|
OneToOne | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | BID 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BID 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BID 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BID 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17853595 | - |
p.His162Gln |
|||
rs59225839 | - |
p.Met194Thr |
|||
rs8190315 | - |
p.Ser10Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2662076 | CNV | deletion | 23128226 |
esv3647235 | CNV | loss | 21293372 |
esv3893428 | CNV | loss | 25118596 |
nsv1116010 | CNV | insertion | 24896259 |
nsv1136651 | CNV | deletion | 24896259 |
nsv1139043 | CNV | deletion | 24896259 |
nsv428385 | CNV | gain+loss | 18775914 |
nsv526826 | CNV | gain | 19592680 |
nsv834119 | CNV | loss | 17160897 |
nsv834120 | CNV | loss | 17160897 |
nsv979630 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bladder transitional cell papilloma |
|
|
colon adenocarcinoma |
|
|
breast disease |
|
|
colorectal cancer |
|
|
pancreatic cancer |
|
|