Aliases for BID Gene
Aliases for BID Gene
External Ids for BID Gene
- HGNC: 1050
- Entrez Gene: 637
- Ensembl: ENSG00000015475
- OMIM: 601997
- UniProtKB: P55957
Previous GeneCards Identifiers for BID Gene
- GC22M015157
- GC22M016591
- GC22M016592
- GC22M018216
- GC22M002030
Summaries for BID Gene
-
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for BID Gene
BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Cat Eye Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.
UniProtKB/Swiss-Prot for BID Gene
-
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BID Gene
Genomics for BID Gene
GeneHancer (GH) Regulatory Elements for BID Gene
Promoters and enhancers for BID Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I017769 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 564.9 | +0.6 | 628 | 10 | HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 | BID MICAL3 HDHD5 BCL2L13 CECR2 LINC00528 PIR62667 | |
| GH22I017762 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.4 | +12.7 | 12660 | 0.1 | BID MIR3198-1 PIR31207 | ||
| GH22I017780 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 25.4 | -6.7 | -6683 | 2.3 | BATF ZNF48 GLIS2 FOS RUNX3 SMARCA5 CEBPB KAT8 TGIF2 SSRP1 | BID BCL2L13 CECR2 USP18 ATP6V1E1 LINC00528 PIR46133 | |
| GH22I017705 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 19 | +68.2 | 68162 | 3 | HDGF PKNOX1 SMAD1 IRF4 RAD21 RFX5 YY1 ZNF121 ATF7 FOS | BID ATP6V1E1 BCL2L13 PIR47030 | |
| GH22I017741 | Enhancer | 0.9 | ENCODE dbSUPER | 28.8 | +32.4 | 32369 | 0.8 | CTCF TFAP4 USF1 RB1 SIN3A RAD21 RELA CC2D1A CTBP1 ZBTB48 | BID PIR31207 MIR3198-1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BID on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BID gene promoter:
Regulatory Element Products
Genomic Locations for BID Gene
Genomic Locations for BID Gene
- chr22:17,734,138-17,774,770
- (GRCh38/hg38)
- Size:
- 40,633 bases
- Orientation:
- Minus strand
- chr22:18,216,906-18,257,536
- (GRCh37/hg19)
Genomic View for BID Gene
Genes around BID on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
BID Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BID Gene
Proteins for BID Gene
-
Protein details for BID Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55957-BID_HUMAN
- Recommended name:
- BH3-interacting domain death agonist
- Protein Accession:
- P55957
- Q549M7
- Q71T04
- Q7Z4M9
- Q8IY86
Protein attributes for BID Gene
- Size:
- 195 amino acids
- Molecular mass:
- 21995 Da
- Quaternary structure:
-
- Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH.
- SequenceCaution:
-
- Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BID Gene
Protein Expression for BID Gene
Post-translational modifications for BID Gene
- p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
- TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
- Ubiquitination at Lys158
- Modification sites at PhosphoSitePlus
Other Protein References for BID Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BID (BID)
-
Custom Antibody ServicesOriGene Antibodies for BID
- TA506756
- CF506756
- TA506759
- CF506759
- TA506762
- CF506762
- TA506763
- CF506763
- TA506764
- CF506764
- TA506765
- CF506765
- TA506766
- CF506766
- TA506767
- CF506767
- TA506768
- CF506768
- UM500101
- UM570101
- CF506755
- TA506755
- TA328058
- TA326772
- TA323207
- TA323206
- TA306178
- TA306177
- TA302648
- SP2115P
- AP12572PU-N
- AP11299PU-N
- AP08939PU-N
- AP08938PU-N
- AP06621PU-N
- AP00056PU-N
- AM09052PU-S
- AM09052PU-N
- AM08190PU-N
- AM06611SU-N
- Novus Biologicals Antibodies for BID
-
Abcam antibodies for BID
-
Cloud-Clone Corp. Antibodies for BID
- Invitrogen Antibodies for BID
- antibodies-online: Search results for 421 available BID Antibodies ranked by validation data
- Compare Top BID Antibodies
-
Recommended
- 3 IHC (p) Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 45 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 136 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 4 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 278 WB Antibodies (anti-human)
- GeneTex BID antibody for BID
- Sino Biological Antibodies for BID
Protein Products
- R&D Systems Proteins and Enzymes for BID
- Search Origene for MassSpec and Protein Over-expression Lysates for BID
- Origene Custom Protein Services for BID
- Sino Biological Recombinant Proteins for BID
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for BID
-
Cloud-Clone Corp. Proteins for BID
- GeneTex Proteins for BID
-
ProSci Proteins for BID
-
Abcam proteins for BID
No data available for DME Specific Peptides for BID Gene
Domains & Families for BID Gene
Gene Families for BID Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for BID Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BID Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55957UniProtKB/Swiss-Prot:
BID_HUMAN :- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
- Domain:
-
- Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function for BID Gene
Molecular function for BID Gene
- GENATLAS Biochemistry:
- BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation
- UniProtKB/Swiss-Prot Function:
- The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Phenotypes From GWAS Catalog for BID Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005123 | death receptor binding | TAS | 8918887 |
| GO:0005515 | protein binding | IPI | 9463381 |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for BID Gene
- MGI mutant phenotypes for BID:
-
inferred from 4 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for BID:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BID
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BID gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BID gene
- Search ViGene Biosciences for BID
CRISPR Products
-
OriGene CRISPR knockouts for BID
- genomics-online: gRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- Applied Biological Materials CRISPR for BID
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BID
- GenScript: Design CRISPR guide RNA sequences for BID
miRNA for BID Gene
- miRTarBase miRNAs that target BID
-
- hsa-mir-492 (MIRT006072)
- hsa-mir-149-5p (MIRT045661)
- hsa-mir-92a-3p (MIRT049655)
- hsa-mir-129-5p (MIRT626395)
- hsa-mir-3680-3p (MIRT626396)
- hsa-mir-557 (MIRT626397)
- hsa-mir-507 (MIRT626398)
- hsa-mir-450b-5p (MIRT626399)
- hsa-mir-5006-3p (MIRT626400)
- hsa-mir-4755-5p (MIRT626401)
- hsa-mir-211-5p (MIRT626402)
- hsa-mir-204-5p (MIRT626403)
- hsa-mir-623 (MIRT626404)
- hsa-mir-6832-3p (MIRT626405)
- hsa-mir-141-5p (MIRT626406)
- hsa-mir-195-3p (MIRT647840)
- hsa-mir-16-2-3p (MIRT647841)
- hsa-mir-26b-5p (MIRT728202)
- hsa-mir-26a-5p (MIRT728203)
- hsa-mir-20a-3p (MIRT733808)
miRNA Products
- Search ViGene Biosciences for BID
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BID
- Browse OriGene Inhibitory RNA Products For BID
- genomics-online: shRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BID gene
Clone Products
- Sino Biological Human cDNA Clone for BID
- VectorBuilder custom plasmid, inducible vectors for BID
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BID
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BID
- Applied Biological Materials Clones for BID
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BID
-
ViGene Biosciences adenoviral particle packaged cDNA for BID gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BID gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BID gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BID Gene
Localization for BID Gene
Subcellular locations from UniProtKB/Swiss-Prot for BID Gene
- Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
- BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.
- BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250}.
- Isoform 1: Cytoplasm.
- Isoform 3: Cytoplasm.
- Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| cytosol | 5 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | TAS | 9727491 |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | TAS | 8918887 |
Pathways & Interactions for BID Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
.87
.87
.56
.55
|
.40
.35
|
| 2 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 3 | Activation of BH3-only proteins | ||
| 4 | Nanomaterial induced apoptosis | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
|
Pathways by source for BID Gene
2 Sino Biological pathways for BID Gene
1 GeneTex pathway for BID Gene
20 BioSystems pathways for BID Gene
14 Reactome pathways for BID Gene
5 GeneGo (Thomson Reuters) pathways for BID Gene
1 R&D Systems pathway for BID Gene
22 Qiagen pathways for BID Gene
1 Cell Signaling Technology pathway for BID Gene
Interacting Proteins for BID Gene
Selected Interacting proteins:
P55957-BID_HUMAN
ENSP00000318822
for BID Gene via
UniProtKB
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001836 | release of cytochrome c from mitochondria | IDA | 17052454 |
| GO:0006626 | protein targeting to mitochondrion | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | -- |
| GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | TAS | 9727491 |
Drugs & Compounds for BID Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for BID Gene
mRNA/cDNA for BID Gene
- (8) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (273) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BID Gene
CRISPR Products
-
OriGene CRISPR knockouts for BID
- genomics-online: gRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- Applied Biological Materials CRISPR for BID
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BID
- GenScript: Design CRISPR guide RNA sequences for BID
miRNA Products
- Search ViGene Biosciences for BID
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BID
- Browse OriGene Inhibitory RNA Products For BID
- genomics-online: shRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BID gene
Clone Products
- Sino Biological Human cDNA Clone for BID
- VectorBuilder custom plasmid, inducible vectors for BID
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BID
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BID
- Applied Biological Materials Clones for BID
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - |
Expression for BID Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for BID Gene
This gene is overexpressed in Whole Blood (x6.9).
This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BID Gene
NURSA nuclear receptor signaling pathways regulating expression of BID Gene:
BIDSOURCE GeneReport for Unigene cluster for BID Gene:
Hs.591054mRNA Expression by UniProt/SwissProt for BID Gene:
P55957-BID_HUMAN
Tissue specificity:
Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
Evidence on tissue expression from TISSUES for BID Gene
- Nervous system(4.7)
- Liver(4.4)
- Skin(4.1)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for BID
-
OriGene qPCR primer pairs for BID
- genomics-online: primer clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BID Gene
Orthologs for BID Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BID 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bid 33 16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | BID 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bid 33 |
|
||
| cow (Bos Taurus) |
Mammalia | BID 33 |
|
||
| BID1 34 |
|
OneToOne | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BID 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BID 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BID 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BID 34 |
|
OneToOne |
- Species where no ortholog for BID was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for BID Gene
No data available for Paralogs for BID Gene
Variants for BID Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025988 | -- | 17,765,441(-) | T/A | intron_variant | |
| rs1000051641 | -- | 17,755,792(-) | T/C | intron_variant | |
| rs1000105028 | -- | 17,771,021(-) | T/C | intron_variant | |
| rs1000108780 | -- | 17,749,654(-) | AA/A | intron_variant | |
| rs1000210491 | -- | 17,738,882(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2662076 | CNV | deletion | 23128226 |
| esv3647235 | CNV | loss | 21293372 |
| esv3893428 | CNV | loss | 25118596 |
| nsv1116010 | CNV | insertion | 24896259 |
| nsv1136651 | CNV | deletion | 24896259 |
| nsv1139043 | CNV | deletion | 24896259 |
| nsv428385 | CNV | gain+loss | 18775914 |
| nsv526826 | CNV | gain | 19592680 |
| nsv834119 | CNV | loss | 17160897 |
| nsv834120 | CNV | loss | 17160897 |
| nsv979630 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BID Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BID
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene
Disorders for BID Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cat eye syndrome |
|
|
Search BID in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BID
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BID Gene
Publications for BID Gene
- Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PMID: 14583606) Renshaw SA … Whyte MK (The Journal of biological chemistry 2004) 3 4 22 58
- The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz TK … McDermid HE (Genomics 1998) 2 3 4 58
- BID: a novel BH3 domain-only death agonist. (PMID: 8918887) Wang K … Korsmeyer SJ (Genes & development 1996) 2 3 4 58
- TNF superfamily gene polymorphism as prognostic factor in early breast cancer. (PMID: 19890662) Jung JH … Park HY (Journal of cancer research and clinical oncology 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for BID Gene
- R&D Systems Antibodies for BID (BID)
- R&D Systems Proteins and Enzymes for BID
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for BID
- AM06611SU-N
- AM08190PU-N
- AM09052PU-N
- AM09052PU-S
- AP00056PU-N
- AP06621PU-N
- AP08938PU-N
- AP08939PU-N
- AP11299PU-N
- AP12572PU-N
- SP2115P
- TA302648
- TA306177
- TA306178
- TA323206
- TA323207
- TA326772
- TA328058
- TA506755
- CF506755
- TA506756
- CF506756
- TA506759
- CF506759
- TA506762
- CF506762
- TA506763
- CF506763
- TA506764
- CF506764
- TA506765
- CF506765
- TA506766
- CF506766
- TA506767
- CF506767
- TA506768
- CF506768
- UM500101
- UM570101
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for BID
- Origene Custom Protein Services for BID
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BID
- Browse OriGene Inhibitory RNA Products For BID
- OriGene qPCR primer pairs and template standards for BID
- OriGene qPCR primer pairs for BID
- OriGene CRISPR knockouts for BID
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BID
- GenScript: Next-day shipping of latest version cDNA ORF clones for BID in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BID
- GenScript Custom Assay Services for BID
- GenScript Custom overexpressing Cell Line Services for BID
- GenScript: Design CRISPR guide RNA sequences for BID
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BID
- Sino Biological Human cDNA Clone for BID
- Sino Biological Recombinant Proteins for BID
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for BID
- Sino Biological Assays for BID
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for BID
- Novus Biologicals lysates and proteins for BID
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for BID
- Abcam proteins for BID
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for BID
- Cloud-Clone Corp. Antibodies for BID
- Cloud-Clone Corp. Proteins for BID
- Cloud-Clone Corp. Assay Kits for BID
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for BID
- VectorBuilder custom plasmid, inducible vectors for BID
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BID
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BID
- antibodies-online: Search results for 421 available BID Antibodies ranked by validation data
- Compare Top BID Antibodies
- Recommended
- 278 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 136 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 60 available BID Elisa Kits ranked by validation data
- Compare Top BID Elisa Kits
- antibodies-online: Search results for 47 available BID Proteins ranked by validation data
- Compare Top BID Proteins
- GeneTex BID antibody for BID
- GeneTex Proteins for BID
- ViGene Biosciences adenoviral particle packaged cDNA for BID gene
- ViGene Biosciences lentiviral particle packaged cDNA for BID gene
- ViGene Biosciences ready-to-package AAV shRNAs for BID gene
- Search ViGene Biosciences for BID
- Search Santa Cruz Biotechnology (SCBT) for BID siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BID
- Custom Antibody ServicesProSci Antibodies for BID
- ProSci Proteins for BID
- Horizon Cell Lines for BID
- genomics-online: cdna clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- orf clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- genomics-online: gRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- genomics-online: primer clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
- genomics-online: shRNA clones - Search results for 160 available BID gene related products
- Overview of 160 available BID gene related products
Sources for BID Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
