This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it tr... See more...

Aliases for BID Gene

Aliases for BID Gene

  • BH3 Interacting Domain Death Agonist 2 3 5
  • BH3-Interacting Domain Death Agonist 3 4
  • P22 BID 3 4
  • BH3 Interacting Domain Death Agonist Si6 Isoform 3
  • Human BID Coding Sequence 3
  • Apoptic Death Agonist 3
  • BID Isoform ES(1b) 3
  • Desmocollin Type 4 3
  • BID Isoform L(2) 3
  • BID Isoform Si6 3
  • FP497 3
  • BID 5

External Ids for BID Gene

Previous GeneCards Identifiers for BID Gene

  • GC22M015157
  • GC22M016591
  • GC22M016592
  • GC22M018216
  • GC22M002030

Summaries for BID Gene

Entrez Gene Summary for BID Gene

  • This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jan 2020]

GeneCards Summary for BID Gene

BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Bladder Transitional Cell Papilloma and Colon Adenocarcinoma. Among its related pathways are Apoptosis Modulation and Signaling and ATM Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.

UniProtKB/Swiss-Prot Summary for BID Gene

  • The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Wiki entry for BID Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BID Gene

Genomics for BID Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BID Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J017769 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 614.8 +0.6 628 10 SP1 HNRNPL GATAD2A PRDM10 IKZF1 NFKBIZ POLR2A BACH1 ETV6 LARP7 BID LINC00528 MICAL3 HDHD5 BCL2L13 CECR2 piR-39622-002
GH22J017780 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 25.4 -6.7 -6683 2.3 HNRNPL GATAD2A ZBTB33 LEF1 BACH1 LARP7 RELA ZIC2 PATZ1 TRIM22 BID BCL2L13 CECR2 USP18 ATP6V1E1 piR-52134 MICAL3
GH22J017741 Enhancer 1 Ensembl ENCODE dbSUPER 28.8 +32.3 32272 1 CTCF JUND REST RAD21 TRIM22 RELA CTBP1 RUNX3 HDGF BCLAF1 HE856131 BID hsa-miR-5095-329 BCL2L13
GH22J017637 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +135.8 135799 3.5 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 ZNF512 LEF1 BCL2L13 NONHSAG033213.2 ATP6V1E1 SLC25A18 BID HDHD5-AS1 SNODB1282
GH22J017705 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 19 +68.1 68125 3.1 PRDM10 BACH1 PRDM1 IKZF2 POLR2A TRIM22 ZNF600 PKNOX1 EED SP1 BID ATP6V1E1 BCL2L13 piR-53031 piR-43105-415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BID on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BID

Top Transcription factor binding sites by QIAGEN in the BID gene promoter:
  • ATF-2
  • c-Jun

Genomic Locations for BID Gene

Genomic Locations for BID Gene
chr22:17,734,138-17,774,770
(GRCh38/hg38)
Size:
40,633 bases
Orientation:
Minus strand
chr22:18,216,906-18,257,536
(GRCh37/hg19)
Size:
40,631 bases
Orientation:
Minus strand

Genomic View for BID Gene

Genes around BID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BID Gene

Proteins for BID Gene

  • Protein details for BID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55957-BID_HUMAN
    Recommended name:
    BH3-interacting domain death agonist
    Protein Accession:
    P55957
    Secondary Accessions:
    • Q549M7
    • Q71T04
    • Q7Z4M9
    • Q8IY86

    Protein attributes for BID Gene

    Size:
    195 amino acids
    Molecular mass:
    21995 Da
    Quaternary structure:
    • Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH (PubMed:20392206). Interacts with PLEKHN1 (PubMed:29531808).
    SequenceCaution:
    • Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BID Gene

    Alternative splice isoforms for BID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BID Gene

Post-translational modifications for BID Gene

  • TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
  • p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
  • Ubiquitination at Lys158
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BID Gene

Domains & Families for BID Gene

Gene Families for BID Gene

Protein Domains for BID Gene

Suggested Antigen Peptide Sequences for BID Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94329, Homo sapiens BH3 interacting domain death agonist (BID), mRNA (A8ASI8_HUMAN)
  • BID isoform Si6 (B2ZP78_HUMAN)
  • BID isoform ES(1b) (B2ZP79_HUMAN)
  • p22 BID (BID_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55957

UniProtKB/Swiss-Prot:

BID_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
genes like me logo Genes that share domains with BID: view

Function for BID Gene

Molecular function for BID Gene

UniProtKB/Swiss-Prot Function:
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
GENATLAS Biochemistry:
BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation

Phenotypes From GWAS Catalog for BID Gene

Gene Ontology (GO) - Molecular Function for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005123 death receptor binding TAS 8918887
GO:0005515 protein binding IPI 9463381
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with BID: view
genes like me logo Genes that share phenotypes with BID: view

Animal Models for BID Gene

MGI Knock Outs for BID:
  • Bid Bid<tm1Sjk>
  • Bid Bid<tm1.1Ast>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BID

Clone Products

  • Addgene plasmids for BID

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BID Gene

Localization for BID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BID Gene

Cytoplasm. Mitochondrion membrane. Mitochondrion outer membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
[BH3-interacting domain death agonist p15]: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250 UniProtKB:P70444}.
[BH3-interacting domain death agonist p13]: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250 UniProtKB:P70444}.
[Isoform 1]: Cytoplasm.
[Isoform 3]: Cytoplasm.
[Isoform 2]: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. {ECO:0000269 PubMed:14583606}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BID gene
Compartment Confidence
mitochondrion 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion TAS,IBA 21873635
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane TAS 8918887
genes like me logo Genes that share ontologies with BID: view

Pathways & Interactions for BID Gene

PathCards logo

SuperPathways for BID Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
.87
.87
.56
.55
.52
.42
.42
.40
.35
2 Apoptosis Modulation and Signaling
.41
.35
.31
3 Activation of BH3-only proteins
4 Nanomaterial induced apoptosis
5 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.74
genes like me logo Genes that share pathways with BID: view

Pathways by source for BID Gene

2 Sino Biological pathways for BID Gene
5 GeneGo (Thomson Reuters) pathways for BID Gene
  • Apoptosis and survival Apoptotic TNF-family pathways
  • Apoptosis and survival Caspase cascade
  • Apoptosis and survival FAS signaling cascades
  • Apoptosis and survival TNFR1 signaling pathway
  • Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins
1 R&D Systems pathway for BID Gene
22 Qiagen pathways for BID Gene
  • 14-3-3 Induced Apoptosis
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Apoptosis through Death Receptors
  • Apoptotic Pathways Triggered By HIV1
  • ATM Pathway
1 Cell Signaling Technology pathway for BID Gene
1 GeneTex pathway for BID Gene

SIGNOR curated interactions for BID Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001836 release of cytochrome c from mitochondria IDA 17052454
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA 21873635
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS 9727491
genes like me logo Genes that share ontologies with BID: view

Drugs & Compounds for BID Gene

(45) Drugs for BID Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 591
Ribavirin Approved Pharma 1068
Anti-Infective Agents Pharma 22229
Antimetabolites Pharma 12215
Antiviral Agents Pharma 10667

(18) Additional Compounds for BID Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BID: view

Transcripts for BID Gene

mRNA/cDNA for BID Gene

7 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BID

Clone Products

  • Addgene plasmids for BID

Alternative Splicing Database (ASD) splice patterns (SP) for BID Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for BID Gene

GeneLoc Exon Structure for
BID

Expression for BID Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BID Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for BID Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BID Gene



Protein tissue co-expression partners for BID Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BID

SOURCE GeneReport for Unigene cluster for BID Gene:

Hs.591054

mRNA Expression by UniProt/SwissProt for BID Gene:

P55957-BID_HUMAN
Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).

Evidence on tissue expression from TISSUES for BID Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Skin(4.4)
  • Blood(2.7)
  • Intestine(2.6)
  • Spleen(2.5)
  • Bone marrow(2.5)
  • Lymph node(2.4)
  • Heart(2.3)
  • Muscle(2.2)
  • Lung(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with BID: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BID Gene

Orthologs for BID Gene

This gene was present in the common ancestor of chordates.

Orthologs for BID Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BID 30 31
  • 99.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Bid 30 17 31
  • 75.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BID 30 31
  • 75.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bid 30
  • 73.37 (n)
Cow
(Bos Taurus)
Mammalia BID 30
  • 71.87 (n)
BID1 31
  • 57 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BID 31
  • 43 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BID 31
  • 33 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BID 30 31
  • 52.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BID 31
  • 37 (a)
OneToOne
Species where no ortholog for BID was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BID Gene

ENSEMBL:
Gene Tree for BID (if available)
TreeFam:
Gene Tree for BID (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BID: view image

Paralogs for BID Gene

No data available for Paralogs for BID Gene

Variants for BID Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BID Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs17853595 - p.His162Gln
rs59225839 - p.Met194Thr
rs8190315 - p.Ser10Gly

Additional dbSNP identifiers (rs#s) for BID Gene

Structural Variations from Database of Genomic Variants (DGV) for BID Gene

Variant ID Type Subtype PubMed ID
esv2662076 CNV deletion 23128226
esv3647235 CNV loss 21293372
esv3893428 CNV loss 25118596
nsv1116010 CNV insertion 24896259
nsv1136651 CNV deletion 24896259
nsv1139043 CNV deletion 24896259
nsv428385 CNV gain+loss 18775914
nsv526826 CNV gain 19592680
nsv834119 CNV loss 17160897
nsv834120 CNV loss 17160897
nsv979630 CNV duplication 23825009

Variation tolerance for BID Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BID Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BID

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene

Disorders for BID Gene

MalaCards: The human disease database

(9) MalaCards diseases for BID Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder transitional cell papilloma
  • bladder papilloma
colon adenocarcinoma
  • adenocarcinoma of colon
gastric adenocarcinoma
  • adenocarcinoma of stomach
cat eye syndrome
  • ces
cervical cancer
  • cervical cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search BID in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BID

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with BID: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BID Gene

Publications for BID Gene

  1. Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot). (PMID: 17534194) Ester AR … Hecht JT (Clinical orthopaedics and related research 2007) 3 23 41
  2. Three novel Bid proteins generated by alternative splicing of the human Bid gene. (PMID: 14583606) Renshaw SA … Whyte MK (The Journal of biological chemistry 2004) 3 4 23
  3. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz TK … McDermid HE (Genomics 1998) 2 3 4
  4. BID: a novel BH3 domain-only death agonist. (PMID: 8918887) Wang K … Korsmeyer SJ (Genes & development 1996) 2 3 4
  5. PLEKHN1 promotes apoptosis by enhancing Bax-Bak hetro-oligomerization through interaction with Bid in human colon cancer. (PMID: 29531808) Kuriyama S … Tanaka M (Cell death discovery 2018) 3 4

Products for BID Gene

  • Addgene plasmids for BID

Sources for BID Gene