Aliases for BICRAL Gene

Aliases for BICRAL Gene

  • BRD4 Interacting Chromatin Remodeling Complex Associated Protein Like 2 3 5
  • KIAA0240 2 3 4
  • BRD4-Interacting Chromatin-Remodeling Complex-Associated Protein-Like 3 4
  • Glioma Tumor Suppressor Candidate Region Gene 1 Protein-Like 3 4
  • GLTSCR1 Like 2 3
  • GLTSCR1L 3 4
  • BRD4 Interacting Chromatin Remodelling Complex Associated Protein Like 3
  • GLTSCR1-Like 2

External Ids for BICRAL Gene

Previous HGNC Symbols for BICRAL Gene

  • KIAA0240

Previous GeneCards Identifiers for BICRAL Gene

  • GC06P043071
  • GC06P043275
  • GC06P042753
  • GC06P043065
  • GC06P043062

Summaries for BICRAL Gene

GeneCards Summary for BICRAL Gene

BICRAL (BRD4 Interacting Chromatin Remodeling Complex Associated Protein Like) is a Protein Coding gene. An important paralog of this gene is BICRA.

UniProtKB/Swiss-Prot Summary for BICRAL Gene

  • Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.

Additional gene information for BICRAL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BICRAL Gene

Genomics for BICRAL Gene

GeneHancer (GH) Regulatory Elements for BICRAL Gene

Promoters and enhancers for BICRAL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BICRAL on UCSC Golden Path with GeneCards custom track

Genomic Locations for BICRAL Gene

Genomic Locations for BICRAL Gene
121,603 bases
Plus strand
86,534 bases
Plus strand

Genomic View for BICRAL Gene

Genes around BICRAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICRAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICRAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICRAL Gene

Proteins for BICRAL Gene

  • Protein details for BICRAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRD4-interacting chromatin-remodeling complex-associated protein-like
    Protein Accession:
    Secondary Accessions:
    • A1L3W2
    • Q5TFZ3
    • Q92514

    Protein attributes for BICRAL Gene

    1079 amino acids
    Molecular mass:
    115084 Da
    Quaternary structure:
    • Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A.
    • Sequence=BAA13246.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for BICRAL Gene

Post-translational modifications for BICRAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICRAL Gene

No data available for DME Specific Peptides for BICRAL Gene

Domains & Families for BICRAL Gene

Gene Families for BICRAL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICRAL Gene

genes like me logo Genes that share domains with BICRAL: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BICRAL Gene

Function for BICRAL Gene

Molecular function for BICRAL Gene

UniProtKB/Swiss-Prot Function:
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.

Phenotypes From GWAS Catalog for BICRAL Gene

genes like me logo Genes that share phenotypes with BICRAL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BICRAL Gene

Localization for BICRAL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICRAL gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 0
cytoskeleton 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BICRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016514 SWI/SNF complex IDA 29374058
genes like me logo Genes that share ontologies with BICRAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BICRAL Gene

Pathways & Interactions for BICRAL Gene

PathCards logo

SuperPathways for BICRAL Gene

No Data Available

Interacting Proteins for BICRAL Gene

Gene Ontology (GO) - Biological Process for BICRAL Gene


No data available for Pathways by source and SIGNOR curated interactions for BICRAL Gene

Drugs & Compounds for BICRAL Gene

No Compound Related Data Available

Transcripts for BICRAL Gene


(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICRAL Gene

No ASD Table

Relevant External Links for BICRAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BICRAL Gene

NURSA nuclear receptor signaling pathways regulating expression of BICRAL Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICRAL Gene

Orthologs for BICRAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for BICRAL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLTSCR1L 33 32
  • 99.54 (n)
(Canis familiaris)
Mammalia GLTSCR1L 33 32
  • 92.77 (n)
(Bos Taurus)
Mammalia GLTSCR1L 33 32
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Gltscr1l 32
  • 86.91 (n)
(Mus musculus)
Mammalia Gltscr1l 33 32
  • 85.53 (n)
Bicral 17
(Monodelphis domestica)
Mammalia GLTSCR1L 33
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia GLTSCR1L 33
  • 77 (a)
(Gallus gallus)
Aves KIAA0240 32
  • 76.39 (n)
  • 72 (a)
(Anolis carolinensis)
Reptilia GLTSCR1L 33
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1l 32
  • 61.43 (n)
(Danio rerio)
Actinopterygii gltscr1l 33 32
  • 55.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 26 (a)
Species where no ortholog for BICRAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICRAL Gene

Gene Tree for BICRAL (if available)
Gene Tree for BICRAL (if available)
Evolutionary constrained regions (ECRs) for BICRAL: view image

Paralogs for BICRAL Gene

Paralogs for BICRAL Gene

genes like me logo Genes that share paralogs with BICRAL: view

Variants for BICRAL Gene

Sequence variations from dbSNP and Humsavar for BICRAL Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs193921035 uncertain-significance, Malignant tumor of prostate 42,830,111(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000032114 -- 42,761,050(+) A/G/T genic_upstream_transcript_variant, intron_variant
rs1000038181 -- 42,855,127(+) C/T intron_variant
rs1000050543 -- 42,769,688(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000087928 -- 42,820,826(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BICRAL Gene

Variant ID Type Subtype PubMed ID
esv2668024 CNV deletion 23128226
esv3576145 CNV gain 25503493
esv3608805 CNV loss 21293372
nsv1017398 CNV gain 25217958
nsv433480 CNV loss 18776910
nsv830650 CNV loss 17160897
nsv830651 CNV loss 17160897
nsv958388 CNV deletion 24416366

Variation tolerance for BICRAL Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BICRAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICRAL Gene

Disorders for BICRAL Gene

Additional Disease Information for BICRAL

No disorders were found for BICRAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICRAL Gene

Publications for BICRAL Gene

  1. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. (PMID: 29374058) Alpsoy A … Dykhuizen EC (The Journal of biological chemistry 2018) 3 4 56
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for BICRAL Gene

Sources for BICRAL Gene