Aliases for BICRA Gene

Aliases for BICRA Gene

  • BRD4 Interacting Chromatin Remodeling Complex Associated Protein 2 3 5
  • BRD4-Interacting Chromatin-Remodeling Complex-Associated Protein 3 4
  • Glioma Tumor Suppressor Candidate Region Gene 1 Protein 3 4
  • GLTSCR1 3 4
  • BRD4 Interacting Chromatin Remodelling Complex Associated Protein 3
  • Glioma Tumor Suppressor Candidate Region Gene 1 2

External Ids for BICRA Gene

Previous HGNC Symbols for BICRA Gene

  • GLTSCR1

Summaries for BICRA Gene

GeneCards Summary for BICRA Gene

BICRA (BRD4 Interacting Chromatin Remodeling Complex Associated Protein) is a Protein Coding gene. Diseases associated with BICRA include Acoustic Neuroma and Neuroma. An important paralog of this gene is BICRAL.

UniProtKB/Swiss-Prot Summary for BICRA Gene

  • Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).

Additional gene information for BICRA Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BICRA Gene

Genomics for BICRA Gene

GeneHancer (GH) Regulatory Elements for BICRA Gene

Promoters and enhancers for BICRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BICRA on UCSC Golden Path with GeneCards custom track

Genomic Locations for BICRA Gene

Genomic Locations for BICRA Gene
chr19:47,608,196-47,703,277
(GRCh38/hg38)
Size:
95,082 bases
Orientation:
Plus strand
chr19:48,111,453-48,206,534
(GRCh37/hg19)
Size:
95,082 bases
Orientation:
Plus strand

Genomic View for BICRA Gene

Genes around BICRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICRA Gene

Proteins for BICRA Gene

  • Protein details for BICRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZM4-BICRA_HUMAN
    Recommended name:
    BRD4-interacting chromatin-remodeling complex-associated protein
    Protein Accession:
    Q9NZM4
    Secondary Accessions:
    • A8MW01

    Protein attributes for BICRA Gene

    Size:
    1560 amino acids
    Molecular mass:
    158490 Da
    Quaternary structure:
    • Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:29374058, PubMed:21555454).
    SequenceCaution:
    • Sequence=AAF62874.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BICRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BICRA Gene

Post-translational modifications for BICRA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICRA Gene

No data available for DME Specific Peptides for BICRA Gene

Domains & Families for BICRA Gene

Gene Families for BICRA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICRA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BICRA Gene

GenScript: Design optimal peptide antigens:
  • Glioma tumor suppressor candidate region gene 1 protein (GSCR1_HUMAN)
genes like me logo Genes that share domains with BICRA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BICRA Gene

Function for BICRA Gene

Molecular function for BICRA Gene

UniProtKB/Swiss-Prot Function:
Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454).

Phenotypes From GWAS Catalog for BICRA Gene

Gene Ontology (GO) - Molecular Function for BICRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP 21555454
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with BICRA: view
genes like me logo Genes that share phenotypes with BICRA: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for BICRA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BICRA Gene

Localization for BICRA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICRA gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BICRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 21555454
GO:0016514 SWI/SNF complex IEA,IDA 29374058
genes like me logo Genes that share ontologies with BICRA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BICRA Gene

Pathways & Interactions for BICRA Gene

PathCards logo

SuperPathways for BICRA Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated IMP 21555454
genes like me logo Genes that share ontologies with BICRA: view

No data available for Pathways by source and SIGNOR curated interactions for BICRA Gene

Drugs & Compounds for BICRA Gene

No Compound Related Data Available

Transcripts for BICRA Gene

mRNA/cDNA for BICRA Gene

CRISPR Products

Clone Products

  • Addgene plasmids for BICRA

Alternative Splicing Database (ASD) splice patterns (SP) for BICRA Gene

No ASD Table

Relevant External Links for BICRA Gene

GeneLoc Exon Structure for
BICRA
ECgene alternative splicing isoforms for
BICRA

Expression for BICRA Gene

NURSA nuclear receptor signaling pathways regulating expression of BICRA Gene:

BICRA

mRNA Expression by UniProt/SwissProt for BICRA Gene:

Q9NZM4-BICRA_HUMAN
Tissue specificity: Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney.

Evidence on tissue expression from TISSUES for BICRA Gene

  • Nervous system(2.4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICRA Gene

Orthologs for BICRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BICRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLTSCR1 33 32
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GLTSCR1 33 32
  • 88.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gltscr1 32
  • 82.43 (n)
mouse
(Mus musculus)
Mammalia Gltscr1 33 32
  • 82.37 (n)
OneToOne
Bicra 17
cow
(Bos Taurus)
Mammalia GLTSCR1 33
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 73 (a)
OneToMany
-- 33
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101749950 32
  • 72.69 (n)
GLTSCR1 33
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLTSCR1 33
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr1 32
  • 63.16 (n)
zebrafish
(Danio rerio)
Actinopterygii gltscr1 33
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
OneToMany
Species where no ortholog for BICRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICRA Gene

ENSEMBL:
Gene Tree for BICRA (if available)
TreeFam:
Gene Tree for BICRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BICRA: view image

Paralogs for BICRA Gene

Paralogs for BICRA Gene

Pseudogenes.org Pseudogenes for BICRA Gene

genes like me logo Genes that share paralogs with BICRA: view

Variants for BICRA Gene

Sequence variations from dbSNP and Humsavar for BICRA Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs745483989 benign, not specified 47,695,363(+) AGG/ coding_sequence_variant, intron_variant, splice_acceptor_variant
rs1000016718 -- 47,628,619(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000028890 -- 47,637,272(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000034120 -- 47,665,887(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000052849 -- 47,669,817(+) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BICRA Gene

Variant ID Type Subtype PubMed ID
dgv1790n106 CNV deletion 24896259
dgv6506n54 CNV loss 21841781
dgv6507n54 CNV loss 21841781
esv23734 CNV loss 19812545
esv3556494 CNV deletion 23714750
esv3644556 CNV loss 21293372
esv3644557 CNV loss 21293372
nsv1059189 CNV gain 25217958
nsv1114018 CNV deletion 24896259
nsv1143922 CNV deletion 24896259
nsv521727 CNV loss 19592680
nsv579888 CNV gain 21841781
nsv579889 CNV loss 21841781
nsv953592 CNV deletion 24416366
nsv953593 CNV deletion 24416366

Variation tolerance for BICRA Gene

Gene Damage Index Score: 10.72; 91.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BICRA Gene

Human Gene Mutation Database (HGMD)
BICRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BICRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICRA Gene

Disorders for BICRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for BICRA Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acoustic neuroma
  • vestibular neurilemmoma
neuroma
- elite association - COSMIC cancer census association via MalaCards
Search BICRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BICRA

genes like me logo Genes that share disorders with BICRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BICRA Gene

Publications for BICRA Gene

  1. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S … Howley PM (Molecular and cellular biology 2011) 2 3 4 56
  2. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. (PMID: 10708517) Smith JS … Jenkins RB (Genomics 2000) 2 3 4 56
  3. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. (PMID: 29374058) Alpsoy A … Dykhuizen EC (The Journal of biological chemistry 2018) 3 4 56
  4. Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA. (PMID: 30291333) Walker CJ … Bloomfield CD (Leukemia 2019) 3 56
  5. GLTSCR1, ATM, PPP1R13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population. (PMID: 30128886) Yin JY … Sun ZX (Current medical science 2018) 3 56

Products for BICRA Gene

Sources for BICRA Gene