Aliases for BICDL2 Gene

Aliases for BICDL2 Gene

  • BICD Family Like Cargo Adaptor 2 2 3 5
  • Coiled-Coil Domain-Containing Protein 64B 3 4
  • Coiled-Coil Domain Containing 64B 2 3
  • BICD Family-Like Cargo Adapter 2 3 4
  • Bicaudal D-Related Protein 2 3 4
  • BICD-Related Protein 2 3 4
  • BICDR-2 3 4
  • CCDC64B 3 4
  • BICDR2 3 4
  • BICDL2 5

External Ids for BICDL2 Gene

Previous HGNC Symbols for BICDL2 Gene

  • CCDC64B

Summaries for BICDL2 Gene

GeneCards Summary for BICDL2 Gene

BICDL2 (BICD Family Like Cargo Adaptor 2) is a Protein Coding gene. An important paralog of this gene is BICDL1.

Additional gene information for BICDL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BICDL2 Gene

Genomics for BICDL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BICDL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BICDL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BICDL2

Genomic Locations for BICDL2 Gene

Genomic Locations for BICDL2 Gene
chr16:3,027,682-3,036,985
(GRCh38/hg38)
Size:
9,304 bases
Orientation:
Minus strand
chr16:3,077,683-3,086,927
(GRCh37/hg19)
Size:
9,245 bases
Orientation:
Minus strand

Genomic View for BICDL2 Gene

Genes around BICDL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICDL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICDL2 Gene

Proteins for BICDL2 Gene

  • Protein details for BICDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A5D9-BICL2_HUMAN
    Recommended name:
    BICD family-like cargo adapter 2
    Protein Accession:
    A1A5D9
    Secondary Accessions:
    • Q658L9

    Protein attributes for BICDL2 Gene

    Size:
    508 amino acids
    Molecular mass:
    56834 Da
    Quaternary structure:
    • Interacts with RAB13.

    Alternative splice isoforms for BICDL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BICDL2 Gene

Post-translational modifications for BICDL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BICDL2 Gene

No data available for DME Specific Peptides for BICDL2 Gene

Domains & Families for BICDL2 Gene

Gene Families for BICDL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICDL2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BICDL2 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 64B (BICR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A1A5D9

UniProtKB/Swiss-Prot:

BICL2_HUMAN :
  • Belongs to the BICDR family.
Family:
  • Belongs to the BICDR family.
genes like me logo Genes that share domains with BICDL2: view

Function for BICDL2 Gene

Phenotypes From GWAS Catalog for BICDL2 Gene

Gene Ontology (GO) - Molecular Function for BICDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017137 Rab GTPase binding IBA 21873635
genes like me logo Genes that share ontologies with BICDL2: view

Phenotypes for BICDL2 Gene

GenomeRNAi human phenotypes for BICDL2:
genes like me logo Genes that share phenotypes with BICDL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BICDL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BICDL2 Gene

Localization for BICDL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICDL2 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BICDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BICDL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BICDL2 Gene

Pathways & Interactions for BICDL2 Gene

PathCards logo

SuperPathways for BICDL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047496 vesicle transport along microtubule IBA 21873635
GO:0055107 Golgi to secretory granule transport IBA 21873635
genes like me logo Genes that share ontologies with BICDL2: view

No data available for Pathways by source and SIGNOR curated interactions for BICDL2 Gene

Drugs & Compounds for BICDL2 Gene

No Compound Related Data Available

Transcripts for BICDL2 Gene

mRNA/cDNA for BICDL2 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BICDL2

Alternative Splicing Database (ASD) splice patterns (SP) for BICDL2 Gene

No ASD Table

Relevant External Links for BICDL2 Gene

GeneLoc Exon Structure for
BICDL2

Expression for BICDL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BICDL2

Evidence on tissue expression from TISSUES for BICDL2 Gene

  • Stomach(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICDL2 Gene

Orthologs for BICDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BICDL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC64B 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC64B 30 31
  • 86.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC64B 30 31
  • 85.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc64b 30
  • 82.21 (n)
Mouse
(Mus musculus)
Mammalia Ccdc64b 30 31
  • 80.96 (n)
OneToOne
Bicdl2 17
Oppossum
(Monodelphis domestica)
Mammalia CCDC64B 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC64B 31
  • 56 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC64B 31
  • 42 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccdc64b 30
  • 50.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii CCDC64B 31
  • 15 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG32137 31
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
ManyToMany
CSA.2341 31
  • 18 (a)
ManyToMany
Species where no ortholog for BICDL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BICDL2 Gene

ENSEMBL:
Gene Tree for BICDL2 (if available)
TreeFam:
Gene Tree for BICDL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BICDL2: view image

Paralogs for BICDL2 Gene

Paralogs for BICDL2 Gene

genes like me logo Genes that share paralogs with BICDL2: view

Variants for BICDL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BICDL2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2244494 - p.Gln273Arg
rs7204908 - p.Gln55Glu

Additional dbSNP identifiers (rs#s) for BICDL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for BICDL2 Gene

Variant ID Type Subtype PubMed ID
esv2763127 CNV loss 21179565
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for BICDL2 Gene

Gene Damage Index Score: 15.77; 97.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BICDL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BICDL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICDL2 Gene

Disorders for BICDL2 Gene

No disorders were found for BICDL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICDL2 Gene

Publications for BICDL2 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for BICDL2 Gene

Sources for BICDL2 Gene