Aliases for BICDL1 Gene

Aliases for BICDL1 Gene

  • BICD Family Like Cargo Adaptor 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 64A 3 4
  • BICD Family-Like Cargo Adapter 1 3 4
  • Coiled-Coil Domain Containing 64 2 3
  • Bicaudal D-Related Protein 1 3 4
  • BICD-Related Protein 1 3 4
  • BICDR-1 3 4
  • CCDC64A 3 4
  • CCDC64 3 4
  • BICDR1 3 4
  • Bicaudal D Related 1 2
  • H_267D11.1 3

External Ids for BICDL1 Gene

Previous HGNC Symbols for BICDL1 Gene

  • CCDC64

Summaries for BICDL1 Gene

GeneCards Summary for BICDL1 Gene

BICDL1 (BICD Family Like Cargo Adaptor 1) is a Protein Coding gene. Diseases associated with BICDL1 include Neuronitis and Spastic Ataxia 3. An important paralog of this gene is BICDL2.

UniProtKB/Swiss-Prot Summary for BICDL1 Gene

  • Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

Additional gene information for BICDL1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BICDL1 Gene

Genomics for BICDL1 Gene

GeneHancer (GH) Regulatory Elements for BICDL1 Gene

Promoters and enhancers for BICDL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J119988 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 507.7 -0.1 -60 3.3 ZNF217 EP300 CTCF SIN3A NRF1 ZNF10 ZIC2 REST POLR2A ZBTB10 BICDL1 GCN1 piR-39336
GH12J120011 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 31.5 +24.1 24128 4.4 ZBTB40 EP300 NCOR1 TCF7 RFX1 RELA SKI TRIM22 TEAD1 ATF2 BICDL1 RAB35 MLEC ENSG00000278250 lnc-SIRT4-31
GH12J120085 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.9 +97.0 97036 2.3 RXRA EP300 ZNF217 CTCF SIN3A TCF12 POLR2G USF1 SP1 JUND piR-57138-023 GCN1 RPL31P52 BICDL1 RAB35 MLEC piR-50443-096 RF00017-1304
GH12J120054 Enhancer 1 Ensembl ENCODE 18.3 +65.7 65728 1.8 EP300 TCF12 NCOR1 ZBTB25 FOXA2 NR2F2 CEBPB KAT7 CEBPG FOS ENSG00000255575 BICDL1 RAB35 RF01210-091
GH12J120078 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 +89.9 89933 2.7 ZNF217 ZFX CLOCK KLF4 CUX1 CHD1 EP300 SIN3A MYC ZNF592 RAB35 BICDL1 piR-57138-023 piR-57461-055 RF00017-1304
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BICDL1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BICDL1

Genomic Locations for BICDL1 Gene

Genomic Locations for BICDL1 Gene
chr12:119,989,799-120,094,495
(GRCh38/hg38)
Size:
104,697 bases
Orientation:
Plus strand
chr12:120,427,648-120,532,299
(GRCh37/hg19)
Size:
104,652 bases
Orientation:
Plus strand

Genomic View for BICDL1 Gene

Genes around BICDL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICDL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICDL1 Gene

Proteins for BICDL1 Gene

  • Protein details for BICDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP65-BICL1_HUMAN
    Recommended name:
    BICD family-like cargo adapter 1
    Protein Accession:
    Q6ZP65
    Secondary Accessions:
    • A8MUC8
    • B4DWL0
    • B5MDJ0
    • O95000

    Protein attributes for BICDL1 Gene

    Size:
    573 amino acids
    Molecular mass:
    64841 Da
    Quaternary structure:
    • Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6 (By similarity).
    SequenceCaution:
    • Sequence=AAC83181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85259.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for BICDL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BICDL1 Gene

Post-translational modifications for BICDL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BICDL1 Gene

Domains & Families for BICDL1 Gene

Gene Families for BICDL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICDL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BICDL1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55282 (B4DNE7_HUMAN)
  • cDNA FLJ50263 (B4DWL0_HUMAN)
  • Coiled-coil domain-containing protein 64A (BICR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZP65

UniProtKB/Swiss-Prot:

BICL1_HUMAN :
  • Belongs to the BICDR family.
Family:
  • Belongs to the BICDR family.
genes like me logo Genes that share domains with BICDL1: view

Function for BICDL1 Gene

Molecular function for BICDL1 Gene

UniProtKB/Swiss-Prot Function:
Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

Phenotypes From GWAS Catalog for BICDL1 Gene

Gene Ontology (GO) - Molecular Function for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding ISS,IEA --
GO:0034452 dynactin binding IEA,ISS --
genes like me logo Genes that share ontologies with BICDL1: view
genes like me logo Genes that share phenotypes with BICDL1: view

Animal Models for BICDL1 Gene

MGI Knock Outs for BICDL1:
  • Bicdl1 Bicdl1<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for BICDL1 Gene

miRTarBase miRNAs that target BICDL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BICDL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BICDL1 Gene

Localization for BICDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BICDL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes around the centrosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICDL1 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS,IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with BICDL1: view

Pathways & Interactions for BICDL1 Gene

PathCards logo

SuperPathways for BICDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0031175 neuron projection development ISS,IEA --
GO:0047496 vesicle transport along microtubule IBA 21873635
GO:0055107 Golgi to secretory granule transport ISS,IEA --
genes like me logo Genes that share ontologies with BICDL1: view

No data available for Pathways by source and SIGNOR curated interactions for BICDL1 Gene

Drugs & Compounds for BICDL1 Gene

No Compound Related Data Available

Transcripts for BICDL1 Gene

mRNA/cDNA for BICDL1 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BICDL1

Alternative Splicing Database (ASD) splice patterns (SP) for BICDL1 Gene

No ASD Table

Relevant External Links for BICDL1 Gene

GeneLoc Exon Structure for
BICDL1

Expression for BICDL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BICDL1

Evidence on tissue expression from TISSUES for BICDL1 Gene

  • Kidney(4.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICDL1 Gene

Orthologs for BICDL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BICDL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC64 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC64 31 30
  • 91.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC64 31 30
  • 90.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc64 30
  • 90.15 (n)
mouse
(Mus musculus)
Mammalia Ccdc64 31 30
  • 90.05 (n)
OneToOne
Bicdl1 17
oppossum
(Monodelphis domestica)
Mammalia CCDC64 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC64 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC64 31 30
  • 81.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC64 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc64 30
  • 72.05 (n)
Str.19901 30
zebrafish
(Danio rerio)
Actinopterygii LOC100537719 30
  • 64.27 (n)
si:ch211-235m3.5 31
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32137 31 30
  • 50.71 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001308 30
  • 49.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
ManyToMany
CSA.2341 31
  • 26 (a)
ManyToMany
Species where no ortholog for BICDL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICDL1 Gene

ENSEMBL:
Gene Tree for BICDL1 (if available)
TreeFam:
Gene Tree for BICDL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BICDL1: view image

Paralogs for BICDL1 Gene

Paralogs for BICDL1 Gene

genes like me logo Genes that share paralogs with BICDL1: view

Variants for BICDL1 Gene

Additional dbSNP identifiers (rs#s) for BICDL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for BICDL1 Gene

Variant ID Type Subtype PubMed ID
dgv2906n54 CNV gain 21841781
dgv2907n54 CNV gain 21841781
dgv2908n54 CNV gain 21841781
dgv2910n54 CNV gain 21841781
dgv2911n54 CNV loss 21841781
dgv2912n54 CNV gain 21841781
dgv2913n54 CNV gain+loss 21841781
dgv2914n54 CNV gain 21841781
esv26018 CNV loss 19812545
esv3630918 CNV loss 21293372
nsv1069700 CNV deletion 25765185
nsv1121854 CNV deletion 24896259
nsv1143575 CNV deletion 24896259
nsv1151919 CNV insertion 26484159
nsv510323 OTHER sequence alteration 20534489
nsv510575 CNV deletion 20534489
nsv560408 CNV gain 21841781
nsv560424 CNV loss 21841781
nsv7237 OTHER inversion 18451855
nsv903 CNV insertion 18451855
nsv952492 CNV deletion 24416366

Variation tolerance for BICDL1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BICDL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BICDL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BICDL1 Gene

Disorders for BICDL1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BICDL1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BICDL1

genes like me logo Genes that share disorders with BICDL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BICDL1 Gene

Publications for BICDL1 Gene

  1. Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding. (PMID: 26822037) Hoogenraad CC … Akhmanova A (Trends in cell biology 2016) 2 3 54
  2. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PMID: 20360680) Schlager MA … Hoogenraad CC (The EMBO journal 2010) 2 3 54
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz HJ … Yaspo ML (The Journal of biological chemistry 2011) 3 54

Products for BICDL1 Gene

Sources for BICDL1 Gene