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Aliases for BICDL1 Gene

Aliases for BICDL1 Gene

  • BICD Family Like Cargo Adaptor 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 64A 3 4
  • Coiled-Coil Domain Containing 64 2 3
  • Bicaudal D-Related Protein 1 3 4
  • BICD-Related Protein 1 3 4
  • Bicaudal D Related 1 2 3
  • BICDR-1 3 4
  • CCDC64A 3 4
  • CCDC64 3 4
  • BICDR1 3 4
  • BICD Family-Like Cargo Adapter 1 3
  • WUGSC:H_267D11.1 3
  • H_267D11.1 3

External Ids for BICDL1 Gene

Previous HGNC Symbols for BICDL1 Gene

  • CCDC64

Summaries for BICDL1 Gene

GeneCards Summary for BICDL1 Gene

BICDL1 (BICD Family Like Cargo Adaptor 1) is a Protein Coding gene. An important paralog of this gene is BICDL2.

UniProtKB/Swiss-Prot for BICDL1 Gene

  • Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

Additional gene information for BICDL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BICDL1 Gene

Genomics for BICDL1 Gene

GeneHancer (GH) Regulatory Elements for BICDL1 Gene

Promoters and enhancers for BICDL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I119988 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 557.8 -0.6 -618 2.2 HDGF ARID4B SIN3A FEZF1 DMAP1 ZBTB7B ZNF766 CBX5 ZNF207 ZNF143 BICDL1 GCN1 PIR62381
GH12I120011 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 31.4 +24.1 24128 4.4 HDGF PKNOX1 ATF1 FOXA2 SMAD1 BRCA1 ZNF207 ATF7 FOS RUNX3 BICDL1 RAB35 MLEC ENSG00000278250
GH12I120054 Enhancer 0.8 ENCODE 18.3 +65.7 65728 1.8 FOXA2 RAD21 YY1 RCOR1 THAP11 RXRA CEBPB REST NFIL3 SMARCA4 ENSG00000255575 BICDL1 RAB35 ENSG00000278250
GH12I120085 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +97.0 97035 2.3 HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B IRF4 BICDL1 RAB35 MLEC GC12M120095 ENSG00000255575
GH12I120078 Enhancer 1 ENCODE dbSUPER 11.4 +90.0 89959 2.6 NCOA3 PKNOX1 KLF1 JUN KLF17 SIN3A ZBTB40 GATA3 FOSL2 ZNF444 RAB35 BICDL1 GC12M120095 ENSG00000255575
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BICDL1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BICDL1 Gene

Genomic Locations for BICDL1 Gene
104,697 bases
Plus strand

Genomic View for BICDL1 Gene

Genes around BICDL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BICDL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BICDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BICDL1 Gene

Proteins for BICDL1 Gene

  • Protein details for BICDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BICD family-like cargo adapter 1
    Protein Accession:
    Secondary Accessions:
    • A8MUC8
    • B4DWL0
    • B5MDJ0
    • O95000

    Protein attributes for BICDL1 Gene

    573 amino acids
    Molecular mass:
    64841 Da
    Quaternary structure:
    • Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6 (By similarity).
    • Sequence=AAC83181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85259.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for BICDL1 Gene


neXtProt entry for BICDL1 Gene

Post-translational modifications for BICDL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BICDL1 Gene

Domains & Families for BICDL1 Gene

Gene Families for BICDL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BICDL1 Gene


Suggested Antigen Peptide Sequences for BICDL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BICDR family.
  • Belongs to the BICDR family.
genes like me logo Genes that share domains with BICDL1: view

Function for BICDL1 Gene

Molecular function for BICDL1 Gene

UniProtKB/Swiss-Prot Function:
Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

Phenotypes From GWAS Catalog for BICDL1 Gene

Gene Ontology (GO) - Molecular Function for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IEA,ISS --
GO:0034452 dynactin binding ISS,IEA --
genes like me logo Genes that share ontologies with BICDL1: view
genes like me logo Genes that share phenotypes with BICDL1: view

Animal Models for BICDL1 Gene

MGI Knock Outs for BICDL1:

Animal Model Products

miRNA for BICDL1 Gene

miRTarBase miRNAs that target BICDL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BICDL1 Gene

Localization for BICDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BICDL1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes around the centrosome. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BICDL1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
extracellular 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA,ISS --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with BICDL1: view

Pathways & Interactions for BICDL1 Gene

SuperPathways for BICDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BICDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007399 nervous system development IEA --
GO:0031175 neuron projection development ISS,IEA --
GO:0055107 Golgi to secretory granule transport ISS,IEA --
genes like me logo Genes that share ontologies with BICDL1: view

No data available for Pathways by source and SIGNOR curated interactions for BICDL1 Gene

Drugs & Compounds for BICDL1 Gene

No Compound Related Data Available

Transcripts for BICDL1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BICDL1 Gene

No ASD Table

Relevant External Links for BICDL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BICDL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BICDL1 Gene:


Evidence on tissue expression from TISSUES for BICDL1 Gene

  • Kidney(4.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BICDL1 Gene

Orthologs for BICDL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BICDL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC64 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia CCDC64 33 34
  • 91.26 (n)
(Bos Taurus)
Mammalia CCDC64 33 34
  • 90.24 (n)
(Rattus norvegicus)
Mammalia Ccdc64 33
  • 90.15 (n)
(Mus musculus)
Mammalia Ccdc64 33 34
  • 90.05 (n)
Bicdl1 16
(Monodelphis domestica)
Mammalia CCDC64 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC64 34
  • 68 (a)
(Gallus gallus)
Aves CCDC64 33 34
  • 81.39 (n)
(Anolis carolinensis)
Reptilia CCDC64 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc64 33
  • 72.05 (n)
Str.19901 33
(Danio rerio)
Actinopterygii LOC100537719 33
  • 64.27 (n)
si:ch211-235m3.5 34
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32137 33 34
  • 50.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001308 33
  • 49.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
CSA.2341 34
  • 26 (a)
Species where no ortholog for BICDL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BICDL1 Gene

Gene Tree for BICDL1 (if available)
Gene Tree for BICDL1 (if available)

Paralogs for BICDL1 Gene

Paralogs for BICDL1 Gene

genes like me logo Genes that share paralogs with BICDL1: view

Variants for BICDL1 Gene

Sequence variations from dbSNP and Humsavar for BICDL1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000000512 -- 120,044,908(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000033170 -- 120,044,648(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000041220 -- 120,003,139(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000077130 -- 120,062,822(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000083142 -- 120,016,877(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BICDL1 Gene

Variant ID Type Subtype PubMed ID
dgv2906n54 CNV gain 21841781
dgv2907n54 CNV gain 21841781
dgv2908n54 CNV gain 21841781
dgv2910n54 CNV gain 21841781
dgv2911n54 CNV loss 21841781
dgv2912n54 CNV gain 21841781
dgv2913n54 CNV gain+loss 21841781
dgv2914n54 CNV gain 21841781
esv26018 CNV loss 19812545
esv3630918 CNV loss 21293372
nsv1069700 CNV deletion 25765185
nsv1121854 CNV deletion 24896259
nsv1143575 CNV deletion 24896259
nsv1151919 CNV insertion 26484159
nsv510323 OTHER sequence alteration 20534489
nsv510575 CNV deletion 20534489
nsv560408 CNV gain 21841781
nsv560424 CNV loss 21841781
nsv7237 OTHER inversion 18451855
nsv903 CNV insertion 18451855
nsv952492 CNV deletion 24416366

Variation tolerance for BICDL1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BICDL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BICDL1 Gene

Disorders for BICDL1 Gene

No disorders were found for BICDL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BICDL1 Gene

Publications for BICDL1 Gene

  1. Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding. (PMID: 26822037) Hoogenraad CC … Akhmanova A (Trends in cell biology 2016) 2 3 58
  2. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. (PMID: 20360680) Schlager MA … Hoogenraad CC (The EMBO journal 2010) 2 3 58
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  4. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz HJ … Yaspo ML (The Journal of biological chemistry 2011) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for BICDL1 Gene

Sources for BICDL1 Gene

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