Aliases for BICD1 Gene
External Ids for BICD1 Gene
Previous GeneCards Identifiers for BICD1 Gene
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
GeneCards Summary for BICD1 Gene
BICD1 (BICD Cargo Adaptor 1) is a Protein Coding gene. Diseases associated with BICD1 include Lissencephaly 1 and Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and structural constituent of cytoskeleton. An important paralog of this gene is BICD2.
UniProtKB/Swiss-Prot Summary for BICD1 Gene
Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.