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This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the sh... See more...
Aliases for BHLHE41 Gene
Aliases for BHLHE41 Gene
External Ids for BHLHE41 Gene
- HGNC: 16617
- Entrez Gene: 79365
- Ensembl: ENSG00000123095
- OMIM: 606200
- UniProtKB: Q9C0J9
Previous HGNC Symbols for BHLHE41 Gene
- BHLHB3
Previous GeneCards Identifiers for BHLHE41 Gene
- GC12M026165
- GC12M026272
- GC12M026043
Summaries for BHLHE41 Gene
-
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]
GeneCards Summary for BHLHE41 Gene
BHLHE41 (Basic Helix-Loop-Helix Family Member E41) is a Protein Coding gene. Diseases associated with BHLHE41 include Short Sleep, Familial Natural, 1 and Advanced Sleep Phase Syndrome, Familial, 1. Among its related pathways are Circadian rhythm and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is BHLHE40.
UniProtKB/Swiss-Prot Summary for BHLHE41 Gene
-
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity).
Additional gene information for BHLHE41 Gene
- HGNC(16617)
- Entrez Gene(79365)
- Ensembl(ENSG00000123095)
- OMIM(606200)
- UniProtKB(Q9C0J9)
- Open Targets Platform(ENSG00000123095)
- Monarch Initiative
- Search for BHLHE41 at DataMed
- Search for BHLHE41 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BHLHE41 Gene
Genomics for BHLHE41 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BHLHE41 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BHLHE41 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BHLHE41
- Top Transcription factor binding sites by QIAGEN in the BHLHE41 gene promoter:
-
- C/EBPalpha
- CHOP-10
- GCNF
- GCNF-1
- GCNF-2
- Lmo2
- MyoD
- PPAR-alpha
- TBP
Genomic Locations for BHLHE41 Gene
Genomic Locations for BHLHE41 Gene
- chr12:26,120,030-26,125,037
- (GRCh38/hg38)
- Size:
- 5,008 bases
- Orientation:
- Minus strand
- chr12:26,272,959-26,278,060
- (GRCh37/hg19)
- Size:
- 5,102 bases
- Orientation:
- Minus strand
Genomic View for BHLHE41 Gene
Genes around BHLHE41 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.1 by HGNC
- 12p12.1 by Entrez Gene
- 12p12.1 by Ensembl
BHLHE41 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BHLHE41 Gene
Proteins for BHLHE41 Gene
-
Protein details for BHLHE41 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0J9-BHE41_HUMAN
- Recommended name:
- Class E basic helix-loop-helix protein 41
- Protein Accession:
- Q9C0J9
- A2I2N8
Protein attributes for BHLHE41 Gene
- Size:
- 482 amino acids
- Molecular mass:
- 50498 Da
- Quaternary structure:
-
- Homodimer (By similarity). Heterodimer with BHLHE40/DEC1 (PubMed:15193144). Interacts with CIART and ARNTL/BMAL1 (By similarity). Interacts with RXRA (PubMed:19786558). Interacts with NR0B2 and HNF1A (By similarity).
Protein Expression for BHLHE41 Gene
Post-translational modifications for BHLHE41 Gene
Other Protein References for BHLHE41 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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- TA333644
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- TA806354S
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- TA806391S
- TA806394
- TA806394S
- TA806407
- TA806407S
- TA806408
- TA806408S
- TA806438
- TA806438S
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- TA806439S
- TA806440
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-
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Assay Products
- antibodies-online: Show 13 available BHLHE41 Elisa Kits ranked by validation data
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Quality Products:
No data available for DME Specific Peptides for BHLHE41 Gene
Domains & Families for BHLHE41 Gene
Gene Families for BHLHE41 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for BHLHE41 Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- Orange
- ProtoNet:
Suggested Antigen Peptide Sequences for BHLHE41 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ61743, highly similar to Class B basic helix-loop-helix protein 3 (B7Z8M6_HUMAN)
- Enhancer-of-split and hairy-related protein 1 (BHE41_HUMAN)
- Basic helix-loop-helix protein 3 isoform 2 (Q5SCI4_HUMAN)
- Basic helix-loop-helix protein 3 isoform 1 (Q8TAT1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BHLHE41 Gene
Function for BHLHE41 Gene
Molecular function for BHLHE41 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:11278948, PubMed:14672706, PubMed:15193144, PubMed:15560782, PubMed:18411297, PubMed:19786558, PubMed:25083013). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:25083013). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11 (By similarity).
Phenotypes From GWAS Catalog for BHLHE41 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISS | -- |
| GO:0001102 | RNA polymerase II activating transcription factor binding | ISS | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | ISS | -- |
Phenotypes for BHLHE41 Gene
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miRNA for BHLHE41 Gene
- miRTarBase miRNAs that target BHLHE41
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Clone Products
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Horizon Cell Lines for BHLHE41
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BHLHE41 Gene
Localization for BHLHE41 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BHLHE41 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
Pathways & Interactions for BHLHE41 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Circadian rhythm |
.30
|
Circadian Clock in Mammals
.30
|
| 2 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 3 | Th2 Differentiation | ||
| 4 | Circadian rythm related genes | ||
| 5 | HIF-1-alpha transcription factor network | ||
Pathways by source for BHLHE41 Gene
2 BioSystems pathways for BHLHE41 Gene
2 Reactome pathways for BHLHE41 Gene
1 KEGG pathway for BHLHE41 Gene
1 R&D Systems pathway for BHLHE41 Gene
1 Qiagen pathway for BHLHE41 Gene
- Circadian Clock in Mammals
Interacting Proteins for BHLHE41 Gene
Selected Interacting proteins:
Q9C0J9-BHE41_HUMAN
ENSP00000242728
for BHLHE41 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BHLHE41
SIGNOR curated interactions for BHLHE41 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 14672706 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007623 | circadian rhythm | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IBA | 21873635 |
| GO:0010832 | negative regulation of myotube differentiation | IEA,ISS | -- |
Transcripts for BHLHE41 Gene
mRNA/cDNA for BHLHE41 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000242728 3743 nts (view in UCSC)
- ENST00000394326 350 nts (view in UCSC)
- ENST00000541271 438 nts (view in UCSC)
CRISPR Products
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Relevant External Links for BHLHE41 Gene
- GeneLoc Exon Structure for
- BHLHE41
Expression for BHLHE41 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Umbilical Cord (Extraembryonic Tissues)
- Mesenchymal Stem Cells (Uncategorized)
- Eye (Sensory Organs)
-
Thyroid (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for BHLHE41 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BHLHE41 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BHLHE41
SOURCE GeneReport for Unigene cluster for BHLHE41 Gene:
Hs.177841mRNA Expression by UniProt/SwissProt for BHLHE41 Gene:
Q9C0J9-BHE41_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle and brain, moderately expressed in pancreas and heart, weakly expressed in placenta, lung, liver and kidney.
Evidence on tissue expression from TISSUES for BHLHE41 Gene
- Nervous system(3.8)
- Muscle(3.2)
- Intestine(2.8)
- Heart(2.7)
- Eye(2.7)
- Stomach(2.6)
- Skin(2.5)
- Liver(2.3)
- Kidney(2.2)
- Spleen(2.2)
- Thyroid gland(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for BHLHE41
-
OriGene qPCR primer pairs and template standards for BHLHE41
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BHLHE41 Gene
Orthologs for BHLHE41 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BHLHE41 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bhlhe41 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BHLHE41 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BHLHE41 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BHLHE41 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BHLHE41 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | bhlhe41 31 |
|
OneToOne |
- Species where no ortholog for BHLHE41 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BHLHE41 Gene
- ENSEMBL:
- Gene Tree for BHLHE41 (if available)
- TreeFam:
- Gene Tree for BHLHE41 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BHLHE41: view image
Paralogs for BHLHE41 Gene
Variants for BHLHE41 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for BHLHE41 Gene
- BHE41_HUMAN-Q9C0J9
- Genetic variations in BHLHE41 are associated with the familial natural short sleep 1 (FNSS1) phenotype, an autosomal dominant trait [MIM:612975]. Individuals with this trait require less sleep in any 24-hour period than is typical for their age group.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BHLHE41 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 691289 | Affects: Short sleep, familial natural, 1 | 26,122,431(-) | A/G | MISSENSE_VARIANT | |
| 712110 | Likely Benign: not provided | 26,122,435(-) | G/C | SYNONYMOUS_VARIANT | |
| rs121912617 | Affects: Short sleep, familial natural, 1. - | 26,122,364(-) | G/Cp.Pro384Arg | MISSENSE_VARIANT | |
| VAR_082585 | - | p.Tyr362His | |||
| VAR_082586 | - | p.Pro384Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3581126 | CNV | gain | 25503493 |
Gene Damage Index Score:
10.12;
90.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BHLHE41 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for BHLHE41 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| short sleep, familial natural, 1 |
|
|
| advanced sleep phase syndrome, familial, 1 |
|
|
| advanced sleep phase syndrome |
|
|
| febrile seizures, familial, 5 |
|
|
Search BHLHE41 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BHLHE41
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BHLHE41 Gene
Publications for BHLHE41 Gene
- Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. (PMID: 11162494) Fujimoto K … Kato Y (Biochemical and biophysical research communications 2001) 2 3 4 23
- Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. (PMID: 15560782) Sato F … Kato Y (European journal of biochemistry 2004) 3 4 23
- A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. (PMID: 25083013) Pellegrino R … Pack AI (Sleep 2014) 3 4
- The transcriptional repressor DEC2 regulates sleep length in mammals. (PMID: 19679812) He Y … Fu YH (Science (New York, N.Y.) 2009) 3 4
- The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. (PMID: 19786558) Cho Y … Makishima M (Molecular pharmacology 2009) 3 4
ExternalLinks
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- VectorBuilder Viral vectors for BHLHE41 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BHLHE41 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BHLHE41 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BHLHE41
- antibodies-online: Show 36 available BHLHE41 Antibodies ranked by validation data
- Compare Top BHLHE41 Antibodies
- antibodies-online: Show 13 available BHLHE41 Elisa Kits ranked by validation data
- Compare Top BHLHE41 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available BHLHE41 Proteins ranked by validation data
- Compare Top BHLHE41 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BHLHE41
- Search Santa Cruz Biotechnology (SCBT) for BHLHE41 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BHLHE41
- Horizon Cell Lines for BHLHE41
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BHLHE41
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BHLHE41
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BHLHE41
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BHLHE41
Sources for BHLHE41 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB