Aliases for BGLAP Gene
External Ids for BGLAP Gene
Previous GeneCards Identifiers for BGLAP Gene
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
GeneCards Summary for BGLAP Gene
BGLAP (Bone Gamma-Carboxyglutamate Protein) is a Protein Coding gene. Diseases associated with BGLAP include Osteitis Fibrosa and Glucocorticoid-Induced Osteoporosis. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Parathyroid hormone synthesis, secretion and action. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydroxyapatite binding.
UniProtKB/Swiss-Prot Summary for BGLAP Gene
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.