Aliases for BGLAP Gene
External Ids for BGLAP Gene
Previous GeneCards Identifiers for BGLAP Gene
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
GeneCards Summary for BGLAP Gene
BGLAP (Bone Gamma-Carboxyglutamate Protein) is a Protein Coding gene. Diseases associated with BGLAP include Osteitis Fibrosa and Renal Osteodystrophy. Among its related pathways are Notch-mediated HES/HEY network and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and hydroxyapatite binding.
UniProtKB/Swiss-Prot Summary for BGLAP Gene
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.