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Aliases for BEX5 Gene

Aliases for BEX5 Gene

  • Brain Expressed X-Linked 5 2 3 5
  • Nerve Growth Factor Receptor-Associated Protein 2 3 4
  • Brain-Expressed X-Linked Protein 5 3 4
  • NGFRAP1-Like Protein 1 3 4
  • BEX Family Member 5 2 3
  • NGFRAP1-Like 1 2 3
  • NGFRAP1L1 3 4
  • Protein BEX5 3
  • NADE2 4

External Ids for BEX5 Gene

Previous HGNC Symbols for BEX5 Gene


Previous GeneCards Identifiers for BEX5 Gene

  • GC0XM101296
  • GC0XM101408
  • GC0XM091216

Summaries for BEX5 Gene

GeneCards Summary for BEX5 Gene

BEX5 (Brain Expressed X-Linked 5) is a Protein Coding gene. An important paralog of this gene is BEX3.

Additional gene information for BEX5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX5 Gene

Genomics for BEX5 Gene

GeneHancer (GH) Regulatory Elements for BEX5 Gene

Promoters and enhancers for BEX5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ102154 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +0.4 378 1.8 HDGF CTCF ATF1 SP2 POLR2A MTA1 CREB1 CREM BEX5 NXF2 NXF2B TCEAL6
GH0XJ101930 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 14.9 +224.4 224381 2.1 ATF1 ZNF48 YY1 ATF7 SP3 RXRA NFYC REST ZNF592 ATF4 ZMAT1 BEX5 TCEAL6 RNU6-345P
GH0XJ101622 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 9.9 +532.7 532706 2.6 ATF1 ZNF133 SIN3A STAT5A YY1 ZNF335 ZNF213 ZNF366 ATF7 IKZF2 ARMCX3-AS1 ARMCX3 BEX5 ARMCX6
GH0XJ101658 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 8.4 +496.8 496757 2.3 MEIS2 PKNOX1 KLF1 USF1 ZBTB21 MAX SIN3A YY1 ZNF366 POLR2A ARMCX2 ARMCX3 RNU6-30P RNU6-587P BEX5 GC0XP101635
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BEX5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEX5 gene promoter:
  • GCNF-2
  • GCNF-1
  • GCNF
  • FOXL1
  • NF-E2 p45
  • NF-E2
  • Tal-1beta
  • ITF-2
  • TBP
  • HOXA3

Genomic Locations for BEX5 Gene

Genomic Locations for BEX5 Gene
2,351 bases
Minus strand
2,351 bases
Minus strand

Genomic View for BEX5 Gene

Genes around BEX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX5 Gene

Proteins for BEX5 Gene

  • Protein details for BEX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BEX5
    Protein Accession:
    Secondary Accessions:
    • Q569J0
    • Q56A74

    Protein attributes for BEX5 Gene

    111 amino acids
    Molecular mass:
    12602 Da
    Quaternary structure:
    No Data Available
    • The mouse orthologous protein seems not to exist. Koo et al (PubMed:15861462) have described a sequence that they named Bex5, but it probably represents a pseudogene.

neXtProt entry for BEX5 Gene

Post-translational modifications for BEX5 Gene

Other Protein References for BEX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX5 Gene

Domains & Families for BEX5 Gene

Gene Families for BEX5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEX5 Gene


Suggested Antigen Peptide Sequences for BEX5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BEX family.
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX5: view

Function for BEX5 Gene

Gene Ontology (GO) - Molecular Function for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX5: view
genes like me logo Genes that share phenotypes with BEX5: view

Animal Model Products

CRISPR Products

miRNA for BEX5 Gene

miRTarBase miRNAs that target BEX5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEX5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX5 Gene

Localization for BEX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEX5 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for BEX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with BEX5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BEX5 Gene

Pathways & Interactions for BEX5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEX5 Gene


No data available for Pathways by source and SIGNOR curated interactions for BEX5 Gene

Drugs & Compounds for BEX5 Gene

No Compound Related Data Available

Transcripts for BEX5 Gene

mRNA/cDNA for BEX5 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEX5 Gene

Brain expressed, X-linked 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEX5

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX5 Gene

No ASD Table

Relevant External Links for BEX5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEX5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Cortex (x4.8), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for BEX5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BEX5 Gene

Protein tissue co-expression partners for BEX5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BEX5 Gene:


SOURCE GeneReport for Unigene cluster for BEX5 Gene:


Evidence on tissue expression from TISSUES for BEX5 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with BEX5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEX5 Gene

Orthologs for BEX5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BEX5 34 33
  • 99.1 (n)
(Canis familiaris)
Mammalia BEX5 34 33
  • 88.59 (n)
(Bos Taurus)
Mammalia BEX5 34 33
  • 85.59 (n)
Species where no ortholog for BEX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX5 Gene

Gene Tree for BEX5 (if available)
Gene Tree for BEX5 (if available)
Evolutionary constrained regions (ECRs) for BEX5: view image

Paralogs for BEX5 Gene

Paralogs for BEX5 Gene

(4) SIMAP similar genes for BEX5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX5: view

Variants for BEX5 Gene

Sequence variations from dbSNP and Humsavar for BEX5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000140685 -- 102,155,949(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1004767818 -- 102,155,252(-) A/G intron_variant
rs1009695047 -- 102,153,404(-) G/T downstream_transcript_variant
rs1012669917 -- 102,157,594(-) C/T upstream_transcript_variant
rs1014314160 -- 102,155,850(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BEX5 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV loss 16826518

Variation tolerance for BEX5 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEX5 Gene

Disorders for BEX5 Gene

Additional Disease Information for BEX5

No disorders were found for BEX5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX5 Gene

Publications for BEX5 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E … Freed CR (Gene 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for BEX5 Gene

Sources for BEX5 Gene

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