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Aliases for BEX4 Gene

Aliases for BEX4 Gene

  • Brain Expressed X-Linked 4 2 3 5
  • Nerve Growth Factor Receptor-Associated Protein 3 3 4
  • Brain Expressed X-Linked-Like 1 2 3
  • BEX Family Member 4 2 3
  • BEX1-Like Protein 1 3 4
  • BEXL1 3 4
  • Brain-Expressed X-Linked Protein 4 4
  • Protein BEX4 3
  • NADE3 4

External Ids for BEX4 Gene

Previous HGNC Symbols for BEX4 Gene

  • BEXL1

Previous GeneCards Identifiers for BEX4 Gene

  • GC0XP102357
  • GC0XP102470
  • GC0XP092133

Summaries for BEX4 Gene

Entrez Gene Summary for BEX4 Gene

  • This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEX4 Gene

BEX4 (Brain Expressed X-Linked 4) is a Protein Coding gene. An important paralog of this gene is BEX3.

UniProtKB/Swiss-Prot for BEX4 Gene

  • May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progression and genomic stability.

Additional gene information for BEX4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX4 Gene

Genomics for BEX4 Gene

GeneHancer (GH) Regulatory Elements for BEX4 Gene

Promoters and enhancers for BEX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103214 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 590.6 +0.7 670 2.6 HDGF ATF1 YY1 POLR2B GLIS2 ATF7 SP3 YY2 REST ATF4 BEX4 TCEAL8 LOC100420653 BEX1 BEX2 GC0XM103234
GH0XI103063 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 32.4 -151.3 -151276 1.6 TFAP4 USF1 ZBTB21 SIN3A ZIC2 HIC1 GLIS2 POLR2A PATZ1 PRDM10 BEX1 BEX4 GC0XP103022
GH0XI103310 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 26.5 +95.8 95819 1.4 HDAC1 ATF1 SIN3A POLR2B GLIS2 EGR1 ZNF366 ATF7 CREM EGR2 BEX2 BEX4 BEX1 GPRASP2 TCEAL5
GH0XI103403 Promoter/Enhancer 1.4 Ensembl ENCODE 23.2 +189.7 189705 1.6 HDAC1 ATF1 SIN3A BMI1 ZBTB40 YY1 ZNF335 ATF7 CREM SMAD5 ENSG00000281091 LL0XNC01-250H12.3 BEX4 TCEAL5 BEX3 PIR37216
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BEX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEX4 gene promoter:

Genomic Locations for BEX4 Gene

Genomic Locations for BEX4 Gene
2,155 bases
Plus strand

Genomic View for BEX4 Gene

Genes around BEX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX4 Gene

Proteins for BEX4 Gene

  • Protein details for BEX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BEX4
    Protein Accession:

    Protein attributes for BEX4 Gene

    120 amino acids
    Molecular mass:
    14067 Da
    Quaternary structure:
    • Interacts with alpha-tubulin (PubMed:27512957). Interacts with SIRT2 (PubMed:27512957).

neXtProt entry for BEX4 Gene

Post-translational modifications for BEX4 Gene

Other Protein References for BEX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX4 Gene

Domains & Families for BEX4 Gene

Gene Families for BEX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEX4 Gene


Suggested Antigen Peptide Sequences for BEX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BEX family.
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX4: view

Function for BEX4 Gene

Molecular function for BEX4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progression and genomic stability.

Gene Ontology (GO) - Molecular Function for BEX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IPI 27512957
GO:0043014 alpha-tubulin binding IDA 27512957
genes like me logo Genes that share ontologies with BEX4: view
genes like me logo Genes that share phenotypes with BEX4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEX4 Gene

Localization for BEX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX4 Gene

Cytoplasm, cytoskeleton, spindle pole. Nucleus. Cytoplasm. Note=Also localizes to microtubules. {ECO:0000269 PubMed:27512957}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEX4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BEX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 27512957
GO:0005634 nucleus IDA,IBA 27512957
GO:0005737 cytoplasm IDA,IBA 27512957
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IDA 27512957
genes like me logo Genes that share ontologies with BEX4: view

Pathways & Interactions for BEX4 Gene

No Data Available

Interacting Proteins for BEX4 Gene

Gene Ontology (GO) - Biological Process for BEX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 27512957
GO:0030334 regulation of cell migration IMP 27512957
GO:0042127 regulation of cell proliferation IMP 27512957
GO:1904428 negative regulation of tubulin deacetylation IMP 27512957
genes like me logo Genes that share ontologies with BEX4: view

No data available for Pathways by source and SIGNOR curated interactions for BEX4 Gene

Drugs & Compounds for BEX4 Gene

No Compound Related Data Available

Transcripts for BEX4 Gene

mRNA/cDNA for BEX4 Gene

Unigene Clusters for BEX4 Gene

Brain expressed, X-linked 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEX4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: -
SP2: -
SP3: - -

Relevant External Links for BEX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of BEX4 Gene:


SOURCE GeneReport for Unigene cluster for BEX4 Gene:


mRNA Expression by UniProt/SwissProt for BEX4 Gene:

Tissue specificity: Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain.

Evidence on tissue expression from TISSUES for BEX4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with BEX4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEX4 Gene

Orthologs for BEX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BEX4 33 34
  • 100 (n)
(Canis familiaris)
Mammalia LOC100688441 33
  • 83.9 (n)
BEX4 34 34
  • 75 (a)
(Bos Taurus)
Mammalia LOC100337331 33
  • 80.56 (n)
MGC140151 34 34
  • 66 (a)
(Rattus norvegicus)
Mammalia Bex4 33
  • 77.68 (n)
(Mus musculus)
Mammalia Bex4 33 16 34
  • 75.99 (n)
Bex6 34
  • 49 (a)
Species where no ortholog for BEX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX4 Gene

Gene Tree for BEX4 (if available)
Gene Tree for BEX4 (if available)

Paralogs for BEX4 Gene

Paralogs for BEX4 Gene

(4) SIMAP similar genes for BEX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEX4: view

Variants for BEX4 Gene

Sequence variations from dbSNP and Humsavar for BEX4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000558680 -- 103,217,020(+) C/G 3_prime_UTR_variant
rs1002500324 -- 103,216,379(+) G/A coding_sequence_variant, missense_variant
rs1004220666 -- 103,214,367(+) G/A upstream_transcript_variant
rs1004553294 -- 103,214,813(+) A/T upstream_transcript_variant
rs1005427643 -- 103,215,836(+) G/T intron_variant

Variation tolerance for BEX4 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX4 Gene

Disorders for BEX4 Gene

Additional Disease Information for BEX4

No disorders were found for BEX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX4 Gene

Publications for BEX4 Gene

  1. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E … Freed CR (Gene 2005) 2 3 4 58
  2. Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition. (PMID: 27512957) Lee JK … Lee CW (Cell death & disease 2016) 3 4 58
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for BEX4 Gene

Sources for BEX4 Gene

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