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Aliases for BEX1 Gene

Aliases for BEX1 Gene

  • Brain Expressed X-Linked 1 2 3 5
  • Brain-Expressed X-Linked Protein 1 3 4
  • Ovarian Granulosa Cell 13.0 KDa Protein HGR74 3
  • Protein BEX1 3
  • HGR74-H 3
  • HBEX2 3
  • BEX2 3

External Ids for BEX1 Gene

Previous GeneCards Identifiers for BEX1 Gene

  • GC0XM097619
  • GC0XM099226
  • GC0XM100350
  • GC0XM101089
  • GC0XM102123
  • GC0XM102204
  • GC0XM102317
  • GC0XM091981

Summaries for BEX1 Gene

GeneCards Summary for BEX1 Gene

BEX1 (Brain Expressed X-Linked 1) is a Protein Coding gene. Among its related pathways are p75(NTR)-mediated signaling. Gene Ontology (GO) annotations related to this gene include RNA polymerase II activating transcription factor binding. An important paralog of this gene is BEX2.

UniProtKB/Swiss-Prot for BEX1 Gene

  • Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

Gene Wiki entry for BEX1 Gene

Additional gene information for BEX1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEX1 Gene

Genomics for BEX1 Gene

GeneHancer (GH) Regulatory Elements for BEX1 Gene

Promoters and enhancers for BEX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ103063 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 666.3 +0.4 424 1.6 TFAP4 USF1 ZBTB21 SIN3A ZIC2 HIC1 GLIS2 POLR2A PATZ1 PRDM10 BEX1 BEX4 GC0XP103022
GH0XJ103214 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 9.3 -151.5 -151522 2.6 HDGF ATF1 YY1 POLR2B GLIS2 ATF7 SP3 YY2 REST ATF4 BEX4 TCEAL8 LOC100420653 BEX1 BEX2 GC0XM103234
GH0XJ103253 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 8 -190.5 -190469 2.8 PKNOX1 ATF1 SIN3A FEZF1 ZNF48 YY1 ETS1 TCF12 ZNF143 ZFP91 TCEAL8 BEX1 GC0XM103234
GH0XJ103310 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 7.9 -246.7 -246671 1.4 HDAC1 ATF1 SIN3A POLR2B GLIS2 EGR1 ZNF366 ATF7 CREM EGR2 BEX2 TCEAL7 BEX4 BEX1 GPRASP2 TCEAL5
GH0XJ103151 Enhancer 1.1 Ensembl ENCODE 9.6 -88.1 -88069 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BEX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEX1 gene promoter:

Genomic Locations for BEX1 Gene

Genomic Locations for BEX1 Gene
chrX:103,062,651-103,064,240
(GRCh38/hg38)
Size:
1,590 bases
Orientation:
Minus strand
chrX:102,317,579-102,319,168
(GRCh37/hg19)

Genomic View for BEX1 Gene

Genes around BEX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEX1 Gene

Proteins for BEX1 Gene

  • Protein details for BEX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH7-BEX1_HUMAN
    Recommended name:
    Protein BEX1
    Protein Accession:
    Q9HBH7
    Secondary Accessions:
    • A0AVN1
    • A8K4J3
    • Q9NZ33

    Protein attributes for BEX1 Gene

    Size:
    125 amino acids
    Molecular mass:
    14860 Da
    Quaternary structure:
    • Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).

neXtProt entry for BEX1 Gene

Post-translational modifications for BEX1 Gene

  • Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).
  • Ubiquitinated. Degraded by the proteasome (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BEX1 Gene

Domains & Families for BEX1 Gene

Gene Families for BEX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBH7

UniProtKB/Swiss-Prot:

BEX1_HUMAN :
  • Belongs to the BEX family.
Family:
  • Belongs to the BEX family.
genes like me logo Genes that share domains with BEX1: view

Function for BEX1 Gene

Molecular function for BEX1 Gene

UniProtKB/Swiss-Prot Function:
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

Gene Ontology (GO) - Molecular Function for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16314316
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEX1: view
genes like me logo Genes that share phenotypes with BEX1: view

Animal Models for BEX1 Gene

MGI Knock Outs for BEX1:
  • Bex2 Bex2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for BEX1 Gene

miRTarBase miRNAs that target BEX1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEX1

Clone Products

  • Addgene plasmids for BEX1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BEX1 Gene

Localization for BEX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BEX1 Gene

Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEX1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IDA 16314316
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BEX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BEX1 Gene

Pathways & Interactions for BEX1 Gene

SuperPathway Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with BEX1: view

Pathways by source for BEX1 Gene

1 BioSystems pathway for BEX1 Gene

Gene Ontology (GO) - Biological Process for BEX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 16314316
GO:0051091 positive regulation of DNA binding transcription factor activity IDA 16314316
genes like me logo Genes that share ontologies with BEX1: view

No data available for SIGNOR curated interactions for BEX1 Gene

Drugs & Compounds for BEX1 Gene

No Compound Related Data Available

Transcripts for BEX1 Gene

mRNA/cDNA for BEX1 Gene

(181) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEX1 Gene

Brain expressed, X-linked 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEX1

Clone Products

  • Addgene plasmids for BEX1

Alternative Splicing Database (ASD) splice patterns (SP) for BEX1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for BEX1 Gene

GeneLoc Exon Structure for
BEX1
ECgene alternative splicing isoforms for
BEX1

Expression for BEX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEX1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Frontal Cortex (BA9) (x4.7), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Amygdala (x4.6), and Brain - Cortex (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of BEX1 Gene:

BEX1

SOURCE GeneReport for Unigene cluster for BEX1 Gene:

Hs.334370

mRNA Expression by UniProt/SwissProt for BEX1 Gene:

Q9HBH7-BEX1_HUMAN
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.

Evidence on tissue expression from TISSUES for BEX1 Gene

  • Nervous system(4.9)
  • Adrenal gland(4.3)
  • Pancreas(3.5)
genes like me logo Genes that share expression patterns with BEX1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEX1 Gene

Orthologs for BEX1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BEX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEX1 34 33
  • 99.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bex2 33
  • 84.27 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Bex2 16 34 33
  • 81.6 (n)
Bex1 34
  • 69 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia BEX2 34 34
  • 79 (a)
ManyToMany
Species where no ortholog for BEX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BEX1 Gene

ENSEMBL:
Gene Tree for BEX1 (if available)
TreeFam:
Gene Tree for BEX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BEX1: view image

Paralogs for BEX1 Gene

Paralogs for BEX1 Gene

(4) SIMAP similar genes for BEX1 Gene using alignment to 1 proteins:

  • BEX1_HUMAN
genes like me logo Genes that share paralogs with BEX1: view

Variants for BEX1 Gene

Sequence variations from dbSNP and Humsavar for BEX1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002587678 -- 103,065,226(-) A/G upstream_transcript_variant
rs1003066320 -- 103,064,931(-) A/G upstream_transcript_variant
rs1003210186 -- 103,065,487(-) C/G upstream_transcript_variant
rs1005166888 -- 103,063,762(-) C/T intron_variant
rs1005556596 -- 103,066,210(-) C/A upstream_transcript_variant

Variation tolerance for BEX1 Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BEX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BEX1 Gene

Disorders for BEX1 Gene

Additional Disease Information for BEX1

No disorders were found for BEX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEX1 Gene

Publications for BEX1 Gene

  1. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. (PMID: 11989783) Yang QS … Mao YM (Biochemical genetics 2002) 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PMID: 16314316) Han C … Peng X (Nucleic acids research 2005) 3 22 58
  4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  5. Characterization of the Bex gene family in humans, mice, and rats. (PMID: 15958283) Alvarez E … Freed CR (Gene 2005) 3 4 58

Products for BEX1 Gene

  • Addgene plasmids for BEX1

Sources for BEX1 Gene

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