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Aliases for BEND5 Gene

Aliases for BEND5 Gene

  • BEN Domain Containing 5 2 3 5
  • C1orf165 3 4
  • Chromosome 1 Open Reading Frame 165 2
  • BEN Domain-Containing Protein 5 3

External Ids for BEND5 Gene

Previous HGNC Symbols for BEND5 Gene

  • C1orf165

Previous GeneCards Identifiers for BEND5 Gene

  • GC01M048966
  • GC01M049193
  • GC01M047312

Summaries for BEND5 Gene

GeneCards Summary for BEND5 Gene

BEND5 (BEN Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BEND5 Gene

  • Acts as a transcriptional repressor (PubMed:23468431).

Additional gene information for BEND5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND5 Gene

Genomics for BEND5 Gene

GeneHancer (GH) Regulatory Elements for BEND5 Gene

Promoters and enhancers for BEND5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I048775 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 556.5 +0.2 192 2.4 MXI1 SIN3A ZNF335 ZFHX2 GLIS2 POLR2A ZNF366 PRDM10 CHD2 ZBTB20 BEND5 GC01M048775 GC01P048747
GH01I048710 Enhancer 0.4 ENCODE 10.8 +66.4 66413 1 SP1 USF1 MAX BEND5 GC01M048699 PIR57047 GC01P048747
GH01I048767 Enhancer 0.7 ENCODE dbSUPER 5.8 +8.7 8698 1.4 SCRT2 MAX ZFP36 MYC TCF7L2 BEND5 GC01P048747
GH01I048572 Enhancer 0.9 FANTOM5 ENCODE 3.3 +204.2 204199 0.3 CTCF ZSCAN4 FEZF1 RAD21 ZFHX2 ZNF239 ZNF143 SMC3 RCOR1 RUNX3 BEND5 SPATA6 GC01M048581 GC01P048499
GH01I048931 Enhancer 1 FANTOM5 Ensembl ENCODE 1.3 -154.9 -154885 0.9 ZNF362 ZBTB21 JUN CEBPB FEZF1 SP1 JUND POLR2A RCOR1 FOSL2 SLC5A9 BEND5 GC01M048924 GC01P048862
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BEND5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEND5 gene promoter:

Genomic Locations for BEND5 Gene

Genomic Locations for BEND5 Gene
chr1:48,727,523-48,776,969
(GRCh38/hg38)
Size:
49,447 bases
Orientation:
Minus strand
chr1:49,193,195-49,242,641
(GRCh37/hg19)

Genomic View for BEND5 Gene

Genes around BEND5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND5 Gene

Proteins for BEND5 Gene

  • Protein details for BEND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4P6-BEND5_HUMAN
    Recommended name:
    BEN domain-containing protein 5
    Protein Accession:
    Q7L4P6
    Secondary Accessions:
    • D3DQ27
    • Q96A62
    • Q9HAI3

    Protein attributes for BEND5 Gene

    Size:
    421 amino acids
    Molecular mass:
    48182 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11804.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BEND5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BEND5 Gene

Post-translational modifications for BEND5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BEND5 Gene

Domains & Families for BEND5 Gene

Gene Families for BEND5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEND5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BEND5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L4P6

UniProtKB/Swiss-Prot:

BEND5_HUMAN :
  • The BEN domain mediates DNA-binding.
Domain:
  • The BEN domain mediates DNA-binding.
genes like me logo Genes that share domains with BEND5: view

Function for BEND5 Gene

Molecular function for BEND5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor (PubMed:23468431).

Gene Ontology (GO) - Molecular Function for BEND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BEND5: view
genes like me logo Genes that share phenotypes with BEND5: view

Animal Model Products

miRNA for BEND5 Gene

miRTarBase miRNAs that target BEND5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEND5 Gene

Localization for BEND5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEND5 gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for BEND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with BEND5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for BEND5 Gene

Pathways & Interactions for BEND5 Gene

SuperPathways for BEND5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BEND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 23468431
genes like me logo Genes that share ontologies with BEND5: view

No data available for Pathways by source and SIGNOR curated interactions for BEND5 Gene

Drugs & Compounds for BEND5 Gene

No Compound Related Data Available

Transcripts for BEND5 Gene

Unigene Clusters for BEND5 Gene

BEN domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEND5 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for BEND5 Gene

GeneLoc Exon Structure for
BEND5
ECgene alternative splicing isoforms for
BEND5

Expression for BEND5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEND5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BEND5 Gene

This gene is overexpressed in Plasma (24.7), Spleen (14.4), Testis (11.6), and Uterus (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BEND5 Gene



NURSA nuclear receptor signaling pathways regulating expression of BEND5 Gene:

BEND5

SOURCE GeneReport for Unigene cluster for BEND5 Gene:

Hs.475348

Evidence on tissue expression from TISSUES for BEND5 Gene

  • Muscle(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with BEND5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEND5 Gene

Orthologs for BEND5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BEND5 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia BEND5 33 34
  • 95.72 (n)
mouse
(Mus musculus)
Mammalia Bend5 33 16 34
  • 94.46 (n)
dog
(Canis familiaris)
Mammalia BEND5 33 34
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Bend5 33
  • 93.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BEND5 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves BEND5 33 34
  • 81.29 (n)
lizard
(Anolis carolinensis)
Reptilia BEND5 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bend5 33
  • 71.56 (n)
zebrafish
(Danio rerio)
Actinopterygii bend5 33 34
  • 64.52 (n)
Species where no ortholog for BEND5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND5 Gene

ENSEMBL:
Gene Tree for BEND5 (if available)
TreeFam:
Gene Tree for BEND5 (if available)

Paralogs for BEND5 Gene

No data available for Paralogs for BEND5 Gene

Variants for BEND5 Gene

Sequence variations from dbSNP and Humsavar for BEND5 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193921115 uncertain-significance, Malignant tumor of prostate 48,727,942(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000039843 -- 48,779,211(-) A/G upstream_transcript_variant
rs1000072865 -- 48,737,066(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000148165 -- 48,734,425(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000178764 -- 48,752,889(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BEND5 Gene

Variant ID Type Subtype PubMed ID
esv3585974 CNV loss 21293372
nsv829771 CNV gain 17160897

Variation tolerance for BEND5 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEND5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BEND5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND5 Gene

Disorders for BEND5 Gene

Additional Disease Information for BEND5

No disorders were found for BEND5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND5 Gene

Publications for BEND5 Gene

  1. The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors. (PMID: 23468431) Dai Q … Lai EC (Genes & development 2013) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for BEND5 Gene

Sources for BEND5 Gene

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