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Aliases for BEND4 Gene

Aliases for BEND4 Gene

  • BEN Domain Containing 4 2 3 5
  • Coiled-Coil Domain-Containing Protein 4 3 4
  • Coiled-Coil Domain Containing 4 2 3
  • CCDC4 3 4
  • BEN Domain-Containing Protein 4 3

External Ids for BEND4 Gene

Previous HGNC Symbols for BEND4 Gene

  • CCDC4

Previous GeneCards Identifiers for BEND4 Gene

  • GC04M041808
  • GC04M041434

Summaries for BEND4 Gene

GeneCards Summary for BEND4 Gene

BEND4 (BEN Domain Containing 4) is a Protein Coding gene.

Additional gene information for BEND4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND4 Gene

Genomics for BEND4 Gene

GeneHancer (GH) Regulatory Elements for BEND4 Gene

Promoters and enhancers for BEND4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J042151 Promoter/Enhancer 1.2 Ensembl ENCODE 650.7 +0.5 463 1.2 CTCF MXI1 PKNOX1 SUZ12 BACH1 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 BEND4 ENSG00000285454
GH04J042179 Enhancer 0.2 FANTOM5 11.3 -27.1 -27123 0.1 BEND4 GC04M042155 ENSG00000285454 PIR59452
GH04J042148 Enhancer 1.2 VISTA UCNEbase 0.7 +4.3 4317 1 PKNOX1 ZNF10 FEZF1 ZEB2 ZNF843 BCL11B OSR2 PRDM6 BCL11A SCRT2 GC04P042148 BEND4 ENSG00000285454
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BEND4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEND4 gene promoter:
  • Nkx2-5
  • GR-beta
  • GR-alpha
  • GR
  • POU2F1a
  • POU2F1
  • SRF
  • Pax-2a
  • Pax-2
  • Evi-1

Genomic Locations for BEND4 Gene

Genomic Locations for BEND4 Gene
42,026 bases
Minus strand
42,026 bases
Minus strand

Genomic View for BEND4 Gene

Genes around BEND4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND4 Gene

Proteins for BEND4 Gene

  • Protein details for BEND4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A1A5D6
    • A1A5D7
    • C9JQZ5
    • Q58A26
    • Q58A27

    Protein attributes for BEND4 Gene

    534 amino acids
    Molecular mass:
    58375 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI28593.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI28594.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD93191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD93192.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BEND4 Gene


neXtProt entry for BEND4 Gene

Post-translational modifications for BEND4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND4 Gene

No data available for DME Specific Peptides for BEND4 Gene

Domains & Families for BEND4 Gene

Gene Families for BEND4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEND4 Gene


Suggested Antigen Peptide Sequences for BEND4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BEND4: view

No data available for UniProtKB/Swiss-Prot for BEND4 Gene

Function for BEND4 Gene

Phenotypes From GWAS Catalog for BEND4 Gene

genes like me logo Genes that share phenotypes with BEND4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEND4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BEND4 Gene

Localization for BEND4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEND4 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BEND4 Gene

Pathways & Interactions for BEND4 Gene

SuperPathways for BEND4 Gene

No Data Available

Interacting Proteins for BEND4 Gene

Selected Interacting proteins: Q6ZU67-BEND4_HUMAN for BEND4 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BEND4 Gene


No data available for Pathways by source and SIGNOR curated interactions for BEND4 Gene

Drugs & Compounds for BEND4 Gene

No Compound Related Data Available

Transcripts for BEND4 Gene

mRNA/cDNA for BEND4 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEND4 Gene

BEN domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BEND4

Alternative Splicing Database (ASD) splice patterns (SP) for BEND4 Gene

No ASD Table

Relevant External Links for BEND4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEND4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BEND4 Gene

This gene is overexpressed in Testis (x10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BEND4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BEND4 Gene:


SOURCE GeneReport for Unigene cluster for BEND4 Gene:

genes like me logo Genes that share expression patterns with BEND4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEND4 Gene

Orthologs for BEND4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BEND4 34 33
  • 98.56 (n)
(Canis familiaris)
Mammalia BEND4 34 33
  • 92.34 (n)
(Bos Taurus)
Mammalia BEND4 34 33
  • 90.58 (n)
(Rattus norvegicus)
Mammalia Bend4 33
  • 88.47 (n)
(Mus musculus)
Mammalia Bend4 16 34 33
  • 87.23 (n)
(Monodelphis domestica)
Mammalia BEND4 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia BEND4 34
  • 74 (a)
(Gallus gallus)
Aves BEND4 34 33
  • 84.49 (n)
(Anolis carolinensis)
Reptilia BEND4 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bend4 33
  • 74.83 (n)
(Danio rerio)
Actinopterygii LOC566937 33
  • 65.38 (n)
BEND4 34
  • 58 (a)
Species where no ortholog for BEND4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND4 Gene

Gene Tree for BEND4 (if available)
Gene Tree for BEND4 (if available)
Evolutionary constrained regions (ECRs) for BEND4: view image

Paralogs for BEND4 Gene

No data available for Paralogs for BEND4 Gene

Variants for BEND4 Gene

Sequence variations from dbSNP and Humsavar for BEND4 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000091765 -- 42,129,654(-) T/A intron_variant
rs1000234016 -- 42,118,162(-) T/C intron_variant
rs1000290012 -- 42,149,863(-) G/A/T intron_variant
rs1000382220 -- 42,120,991(-) C/A/T intron_variant
rs1000384129 -- 42,134,824(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BEND4 Gene

Variant ID Type Subtype PubMed ID
dgv870n67 CNV gain 20364138
nsv523585 CNV gain 19592680
nsv527340 CNV loss 19592680
nsv822545 CNV gain 20364138

Variation tolerance for BEND4 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEND4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND4 Gene

Disorders for BEND4 Gene

Additional Disease Information for BEND4

No disorders were found for BEND4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND4 Gene

Publications for BEND4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Asbestos-associated genome-wide DNA methylation changes in lung cancer. (PMID: 28722770) Kettunen E … Husgafvel-Pursiainen K (International journal of cancer 2017) 3 58
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for BEND4 Gene

Sources for BEND4 Gene

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