Aliases for BEND3 Gene
External Ids for BEND3 Gene
Previous HGNC Symbols for BEND3 Gene
Previous GeneCards Identifiers for BEND3 Gene
GeneCards Summary for BEND3 Gene
BEND3 (BEN Domain Containing 3) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for BEND3 Gene
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671).