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Aliases for BEND2 Gene

Aliases for BEND2 Gene

  • BEN Domain Containing 2 2 3 5
  • CXorf20 3 4
  • Chromosome X Open Reading Frame 20 2
  • BEN Domain-Containing Protein 2 3

External Ids for BEND2 Gene

Previous HGNC Symbols for BEND2 Gene

  • CXorf20

Previous GeneCards Identifiers for BEND2 Gene

  • GC0XM015938

Summaries for BEND2 Gene

Entrez Gene Summary for BEND2 Gene

  • This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for BEND2 Gene

BEND2 (BEN Domain Containing 2) is a Protein Coding gene.

Additional gene information for BEND2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BEND2 Gene

Genomics for BEND2 Gene

GeneHancer (GH) Regulatory Elements for BEND2 Gene

Promoters and enhancers for BEND2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ018220 Promoter 0.5 EPDnew 650.7 -0.1 -53 0.1 BEND2 TMSB10P2
GH0XJ018219 Enhancer 0.3 Ensembl 650.7 +1.6 1603 0.6 RNF2 BEND2 GC0XM017968
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BEND2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BEND2 gene promoter:
  • Evi-1
  • HFH-3
  • FOXI1
  • Cdc5
  • ISGF-3
  • FOXJ2
  • FOXJ2 (long isoform)
  • C/EBPalpha

Genomic Locations for BEND2 Gene

Genomic Locations for BEND2 Gene
57,974 bases
Minus strand
57,974 bases
Minus strand

Genomic View for BEND2 Gene

Genes around BEND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BEND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BEND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BEND2 Gene

Proteins for BEND2 Gene

  • Protein details for BEND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BEN domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • E9PFY2
    • Q4V9S2
    • Q5JXE5

    Protein attributes for BEND2 Gene

    799 amino acids
    Molecular mass:
    87919 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BEND2 Gene


neXtProt entry for BEND2 Gene

Post-translational modifications for BEND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BEND2 Gene

No data available for DME Specific Peptides for BEND2 Gene

Domains & Families for BEND2 Gene

Gene Families for BEND2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BEND2 Gene


Suggested Antigen Peptide Sequences for BEND2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BEND2: view

No data available for UniProtKB/Swiss-Prot for BEND2 Gene

Function for BEND2 Gene

Phenotypes From GWAS Catalog for BEND2 Gene

genes like me logo Genes that share phenotypes with BEND2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BEND2 Gene

Localization for BEND2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BEND2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for BEND2 Gene

Pathways & Interactions for BEND2 Gene

SuperPathways for BEND2 Gene

No Data Available

Interacting Proteins for BEND2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8NDZ0-BEND2_HUMAN ENSP00000369372 for BEND2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for BEND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048741 NOT skeletal muscle fiber development IBA --
genes like me logo Genes that share ontologies with BEND2: view

No data available for Pathways by source and SIGNOR curated interactions for BEND2 Gene

Drugs & Compounds for BEND2 Gene

No Compound Related Data Available

Transcripts for BEND2 Gene

mRNA/cDNA for BEND2 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BEND2 Gene

BEN domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BEND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5

Relevant External Links for BEND2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BEND2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BEND2 Gene

mRNA differential expression in normal tissues according to GTEx for BEND2 Gene

This gene is overexpressed in Testis (x35.8) and Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for BEND2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BEND2 Gene

Protein tissue co-expression partners for BEND2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BEND2 Gene:


SOURCE GeneReport for Unigene cluster for BEND2 Gene:

genes like me logo Genes that share expression patterns with BEND2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BEND2 Gene

Orthologs for BEND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BEND2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BEND2 34 33
  • 95.05 (n)
(Bos Taurus)
Mammalia BEND2 34
  • 44 (a)
(Canis familiaris)
Mammalia BEND2 34
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia BEND2 34
  • 30 (a)
(Gallus gallus)
Aves BEND2 34
  • 32 (a)
(Anolis carolinensis)
Reptilia BEND2 34
  • 42 (a)
(Danio rerio)
Actinopterygii BEND2 (1 of 2) 34
  • 22 (a)
BEND2 (2 of 2) 34
  • 16 (a)
Species where no ortholog for BEND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BEND2 Gene

Gene Tree for BEND2 (if available)
Gene Tree for BEND2 (if available)
Evolutionary constrained regions (ECRs) for BEND2: view image

Paralogs for BEND2 Gene

(6) SIMAP similar genes for BEND2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BEND2: view

No data available for Paralogs for BEND2 Gene

Variants for BEND2 Gene

Sequence variations from dbSNP and Humsavar for BEND2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1064794338 uncertain-significance, not specified 18,174,115(-) CC/C coding_sequence_variant, frameshift
rs1000120610 -- 18,211,893(-) T/G intron_variant
rs1000181111 -- 18,202,044(-) C/A intron_variant
rs1000184859 -- 18,186,949(-) A/G intron_variant
rs1000189734 -- 18,164,695(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BEND2 Gene

Variant ID Type Subtype PubMed ID
dgv2230e212 CNV loss 25503493
dgv2231e212 CNV gain 25503493
esv3573621 CNV loss 25503493
esv3573622 CNV loss 25503493
esv3573624 CNV loss 25503493
nsv510818 CNV deletion 20534489

Variation tolerance for BEND2 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BEND2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BEND2 Gene

Disorders for BEND2 Gene

Additional Disease Information for BEND2

No disorders were found for BEND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BEND2 Gene

Publications for BEND2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Epileptic encephalopathy in a girl with an interstitial deletion of Xp22 comprising promoter and exon 1 of the CDKL5 gene. (PMID: 19455595) Bahi-Buisson N … Bienvenu T (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 58

Products for BEND2 Gene

Sources for BEND2 Gene

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