Aliases for BECN2 Gene

Aliases for BECN2 Gene

  • Beclin 2 2 3 5
  • Beclin-1 Autophagy-Related Pseudogene 1 3 4
  • Beclin-1-Like Protein 1 3 4
  • Beclin-2 3 4
  • BECN1L1 3 4
  • BECN1P1 3 4
  • Beclin 1, Autophagy Related, Pseudogene 1 2
  • BECN2 5

External Ids for BECN2 Gene

Previous HGNC Symbols for BECN2 Gene

  • BECN1P1

Summaries for BECN2 Gene

GeneCards Summary for BECN2 Gene

BECN2 (Beclin 2) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and Pathways of neurodegeneration - multiple diseases. An important paralog of this gene is BECN1.

UniProtKB/Swiss-Prot Summary for BECN2 Gene

  • Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BECN2 Gene

Genomics for BECN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BECN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J241998 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +41.1 41081 1.3 ZNF600 IKZF1 NONO REST DEK MNT KLF7 CTCF ZNF217 SIN3A MAP1LC3C RF00017-480 HSALNG0011980 BECN2
GH01J241944 Enhancer 0.9 FANTOM5 ENCODE 0.4 -12.9 -12879 1.3 MYC CEBPA CEBPB TBP ZFP64 IRF2 PRDM1 STAT3 NUFIP1 EP400 HSALNG0011972 BECN2 HSALNG0011973 EXO1
GH01J241933 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 0.4 -23.2 -23217 1.7 ATF2 TEAD3 JUND INSM2 ZNF274 ATF4 RFX1 JUN ATF3 ZNF692 HSALNG0011972 HSALNG0011973 BECN2 EXO1
GH01J241988 Enhancer 1 Ensembl ENCODE 0.3 +31.3 31334 1.8 ZNF600 ZNF580 NFIC ZIC2 BCL11A REST FEZF1 ZNF639 MNT ZNF610 CFL1P4 HSALNG0011980 MAP1LC3C BECN2
GH01J241846 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.1 -109.0 -108987 3.6 BCLAF1 SP1 ZNF207 MYC ZNF600 SIX5 ZNF580 ZNF592 ATF2 POLR2A EXO1 HSALNG0011967 HSALNG0011968 BECN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BECN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BECN2

Genomic Locations for BECN2 Gene

Latest Assembly
chr1:241,957,767-241,959,062
(GRCh38/hg38)
Size:
1,296 bases
Orientation:
Plus strand

Previous Assembly
chr1:242,121,069-242,122,364
(GRCh37/hg19 by Entrez Gene)
Size:
1,296 bases
Orientation:
Plus strand

chr1:242,121,039-242,122,364
(GRCh37/hg19 by Ensembl)
Size:
1,326 bases
Orientation:
Plus strand

Genomic View for BECN2 Gene

Genes around BECN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BECN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BECN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BECN2 Gene

Proteins for BECN2 Gene

  • Protein details for BECN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MW95-BECN2_HUMAN
    Recommended name:
    Beclin-2
    Protein Accession:
    A8MW95
    Secondary Accessions:
    • E9KNW0

    Protein attributes for BECN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    48153 Da
    Quaternary structure:
    • Homodimer (via coiled-coil domain) (PubMed:28218432). Interacts (via coiled-coil domain) with ATG14 (via coiled-coil domain); this interaction is tighter than BECN2 self-association (PubMed:23954414, PubMed:28218432). Interacts with AMBRA1, UVRAG and PIK3C3/VPS34; these interactions are not disrupted by starvation (PubMed:23954414). Does not interact with RUBCN (PubMed:23954414). Interacts (via N-terminus) with GPRASP1/GASP1; the interaction is direct (PubMed:23954414).

    Three dimensional structures from OCA and Proteopedia for BECN2 Gene

neXtProt entry for BECN2 Gene

Post-translational modifications for BECN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BECN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BECN2 Gene

Domains & Families for BECN2 Gene

Gene Families for BECN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BECN2 Gene

Suggested Antigen Peptide Sequences for BECN2 Gene

GenScript: Design optimal peptide antigens:
  • Beclin-1-like protein 1 (BCN1L_HUMAN)
  • Beclin 2 (E9KNW0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MW95

UniProtKB/Swiss-Prot:

BECN2_HUMAN :
  • Belongs to the beclin family.
Family:
  • Belongs to the beclin family.
genes like me logo Genes that share domains with BECN2: view

Function for BECN2 Gene

Molecular function for BECN2 Gene

UniProtKB/Swiss-Prot Function:
Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1.

Phenotypes From GWAS Catalog for BECN2 Gene

Gene Ontology (GO) - Molecular Function for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23954414
GO:0044877 protein-containing complex binding IEA --
genes like me logo Genes that share ontologies with BECN2: view

Phenotypes for BECN2 Gene

genes like me logo Genes that share phenotypes with BECN2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BECN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BECN2 Gene

Localization for BECN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN2 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA 21873635
GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA 21873635
genes like me logo Genes that share ontologies with BECN2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for BECN2 Gene

Pathways & Interactions for BECN2 Gene

genes like me logo Genes that share pathways with BECN2: view

Pathways by source for BECN2 Gene

Interacting Proteins for BECN2 Gene

Gene Ontology (GO) - Biological Process for BECN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA 21873635
GO:0006914 autophagy IMP 23954414
GO:0006995 cellular response to nitrogen starvation IBA 21873635
GO:0008333 endosome to lysosome transport IEA,IMP 23954414
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with BECN2: view

No data available for SIGNOR curated interactions for BECN2 Gene

Drugs & Compounds for BECN2 Gene

No Compound Related Data Available

Transcripts for BECN2 Gene

mRNA/cDNA for BECN2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BECN2

Alternative Splicing Database (ASD) splice patterns (SP) for BECN2 Gene

No ASD Table

Relevant External Links for BECN2 Gene

GeneLoc Exon Structure for
BECN2

Expression for BECN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BECN2 Gene

Protein differential expression in normal tissues from HIPED for BECN2 Gene

This gene is overexpressed in Serum (55.7) and Platelet (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BECN2 Gene



Protein tissue co-expression partners for BECN2 Gene

mRNA Expression by UniProt/SwissProt for BECN2 Gene:

A8MW95-BECN2_HUMAN
Tissue specificity: Present in fetal and adult brain (at protein level).
genes like me logo Genes that share expression patterns with BECN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BECN2 Gene

Orthologs for BECN2 Gene

Evolution for BECN2 Gene

ENSEMBL:
Gene Tree for BECN2 (if available)
TreeFam:
Gene Tree for BECN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BECN2: view image
Alliance of Genome Resources:
Additional Orthologs for BECN2

No data available for Orthologs for BECN2 Gene

Paralogs for BECN2 Gene

Paralogs for BECN2 Gene

genes like me logo Genes that share paralogs with BECN2: view

Variants for BECN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BECN2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs3851304 Benign: not provided 241,958,494(+) G/T
NM_001290693.1(BECN2):c.728G>T (p.Arg243Met)
MISSENSE
rs56335758 Benign: not provided 241,958,238(+) G/A
NM_001290693.1(BECN2):c.472G>A (p.Glu158Lys)
MISSENSE
rs61736147 Benign: not provided 241,958,075(+) T/G
NM_001290693.1(BECN2):c.309T>G (p.Ile103Met)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BECN2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BECN2 Gene

Variant ID Type Subtype PubMed ID
dgv16e55 CNV gain 17911159
nsv1002309 CNV gain 25217958
nsv1008886 CNV gain 25217958
nsv947475 CNV duplication 23825009

Additional Variant Information for BECN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BECN2
Leiden Open Variation Database (LOVD)
BECN2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BECN2 Gene

Disorders for BECN2 Gene

Additional Disease Information for BECN2

No disorders were found for BECN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BECN2 Gene

Publications for BECN2 Gene

  1. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. (PMID: 23954414) He C … Levine B (Cell 2013) 2 3 4
  2. BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. (PMID: 28218432) Su M … Sinha SC (Protein science : a publication of the Protein Society 2017) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Beclin 2 negatively regulates innate immune signaling and tumor development. (PMID: 32865519) Zhu M … Wang RF (The Journal of clinical investigation 2020) 3
  5. Reactive Oxygen Species-Mediated c-Jun NH2-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction. (PMID: 28515304) Zhong L … Xiong S (Journal of virology 2017) 3

Products for BECN2 Gene

Sources for BECN2 Gene