BECN1 Gene (Protein Coding)

Beclin 1

GC17M042810
GIFtS:
47
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Altern... See more...

Aliases for BECN1 Gene

Aliases for BECN1 Gene

  • Beclin 1 2 3 5
  • Coiled-Coil Myosin-Like BCL2-Interacting Protein 3 4
  • Beclin 1, Autophagy Related 2 3
  • Beclin-1 3 4
  • VPS30 2 3
  • ATG6 2 3
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2 Interacting Protein) 2
  • Beclin 1 (Coiled-Coil, Moesin-Like BCL2-Interacting Protein) 3
  • ATG6 Autophagy Related 6 Homolog (S. Cerevisiae) 2
  • Testis Secretory Sperm-Binding Protein Li 215e 3
  • ATG6 Autophagy Related 6 Homolog 3
  • Protein GT197 4
  • Beclin1 3
  • BECN1 5
  • GT197 4

External Ids for BECN1 Gene

Previous GeneCards Identifiers for BECN1 Gene

  • GC17P040655
  • GC17M043124
  • GC17M040870
  • GC17M041335
  • GC17M038215
  • GC17M040963
  • GC17M036726

Summaries for BECN1 Gene

Entrez Gene Summary for BECN1 Gene

  • This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for BECN1 Gene

BECN1 (Beclin 1) is a Protein Coding gene. Diseases associated with BECN1 include Sphingolipidosis and Huntington Disease. Among its related pathways are Apelin signaling pathway and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and phosphatidylinositol 3-kinase binding. An important paralog of this gene is BECN2.

UniProtKB/Swiss-Prot Summary for BECN1 Gene

  • Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
  • Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

Gene Wiki entry for BECN1 Gene

Additional gene information for BECN1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BECN1 Gene

Genomics for BECN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for BECN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BECN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BECN1

Top Transcription factor binding sites by QIAGEN in the BECN1 gene promoter:
  • AP-1
  • GR
  • GR-alpha
  • GR-beta
  • p53

Genomic Locations for BECN1 Gene

Latest Assembly
chr17:42,810,132-42,833,350
(GRCh38/hg38)
Size:
23,219 bases
Orientation:
Minus strand

Previous Assembly
chr17:40,962,150-40,976,300
(GRCh37/hg19 by Entrez Gene)
Size:
14,151 bases
Orientation:
Minus strand

chr17:40,962,152-40,985,367
(GRCh37/hg19 by Ensembl)
Size:
23,216 bases
Orientation:
Minus strand

Genomic View for BECN1 Gene

Genes around BECN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BECN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BECN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BECN1 Gene

Proteins for BECN1 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for BECN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14457-BECN1_HUMAN
    Recommended name:
    Beclin-1
    Protein Accession:
    Q14457
    Secondary Accessions:
    • B2R6N7
    • O75595
    • Q9UNA8

    Protein attributes for BECN1 Gene

    Size:
    450 amino acids
    Molecular mass:
    51896 Da
    Quaternary structure:
    • A homodimeric form is proposed to exist; this metastable form readily transits to ATG14- or UVRAG-containing complexes with BECN1:UVRAG being more stable than BECN1:ATG14 (By similarity). Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxilliary subunits to form alternative complex forms. Alternative complex forms containing a forth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex (PubMed:18843052, PubMed:19050071, PubMed:19270696, PubMed:23878393, PubMed:25490155). Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1 and AMBRA1 (PubMed:20643123, PubMed:19270696). PI3KC3-C1 probably associates with PIK3CB (By similarity). Interacts with AMBRA1, GOPC, GRID2 (By similarity). Interacts with BCL2 and BCL2L1 isoform Bcl-X(L); the interaction inhibits BECN1 function in promoting autophagy by interfering with the formation of the PI3K complex (PubMed:9765397, PubMed:16179260, PubMed:17446862, PubMed:17337444, PubMed:17659302). Interacts with cytosolic HMGB1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy (PubMed:20819940). Interacts with USP10, USP13, VMP1, DAPK1, RAB39A (PubMed:19180116, PubMed:17724469, PubMed:17337444, PubMed:21962518, PubMed:24349490). Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-402 and stabilizes BECN1 (PubMed:28445460). Interacts with SLAMF1 (PubMed:22493499). Interacts with TRIM5; the interaction causes activation of BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Interacts with active ULK1 (phosphorylated on 'Ser-317') and MEFV simultaneously (PubMed:26347139). Interacts with WDR81 and WDR91; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes (PubMed:26783301). Interacts with LAPTM4B; competes with EGFR for LAPTM4B binding; regulates EGFR activity (PubMed:28479384). Interacts with TRIM50 (PubMed:29604308). Interacts with TRIM16. Interacts with ATG14; this interaction is increased in the absence of TMEM39A (PubMed:31806350).
    • (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein TRS1.
    • (Microbial infection) Interacts with murine gammaherpesvirus 68 M11.
    • (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) protein ICP34.5; this interaction antagonizes the host autophagy response.
    Miscellaneous:
    • Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (PubMed:28445460).

    Three dimensional structures from OCA and Proteopedia for BECN1 Gene

neXtProt entry for BECN1 Gene

Protein Expression for BECN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BECN1 Gene

  • Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (PubMed:19180116). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy (PubMed:23878393).
  • Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (PubMed:21936852). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (PubMed:21936852). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (PubMed:21962518). Polyubiquitinated at Lys-402 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked polyubiquitination of Lys-402 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460).
  • Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.
  • Ubiquitination at Lys32 and Lys402
  • Modification sites at PhosphoSitePlus

Other Protein References for BECN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for BECN1 Gene

Domains & Families for BECN1 Gene

Gene Families for BECN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BECN1 Gene

InterPro:
Blocks:
  • Autophagy protein Apg6

Suggested Antigen Peptide Sequences for BECN1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53178, highly similar to Beclin-1 (B4DS82_HUMAN)
  • Protein GT197 (BECN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14457

UniProtKB/Swiss-Prot:

BECN1_HUMAN :
  • The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes.
  • Belongs to the beclin family.
Domain:
  • The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes.
  • The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD (PubMed:28445460). As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3 (PubMed:28445460).
Family:
  • Belongs to the beclin family.
genes like me logo Genes that share domains with BECN1: view

Function for BECN1 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for BECN1 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
UniProtKB/Swiss-Prot Function:
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
GENATLAS Biochemistry:
beclin 1,myosin-like BCL2-interacting protein,potentially involved in antiviral host defense,deleted in breast cancer cell lines

Phenotypes From GWAS Catalog for BECN1 Gene

Gene Ontology (GO) - Molecular Function for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16417406
GO:0019901 protein kinase binding IPI 27853422
GO:0031625 ubiquitin protein ligase binding IPI 25127057
GO:0042802 identical protein binding IEA --
GO:0043548 phosphatidylinositol 3-kinase binding IPI 23878393
genes like me logo Genes that share ontologies with BECN1: view
genes like me logo Genes that share phenotypes with BECN1: view

Animal Models for BECN1 Gene

MGI Knock Outs for BECN1:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BECN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BECN1 Gene

Localization for BECN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BECN1 Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane. Peripheral membrane protein. Endosome membrane. Peripheral membrane protein. Endoplasmic reticulum membrane. Peripheral membrane protein. Mitochondrion membrane. Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). {ECO:0000250 UniProtKB:O88597, ECO:0000269 PubMed:19050071}.
[Beclin-1-C 35 kDa]: Mitochondrion. Nucleus. Cytoplasm.
[Beclin-1-C 37 kDa]: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BECN1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
cytosol 5
mitochondrion 4
nucleus 4
lysosome 4
plasma membrane 3
extracellular 3
cytoskeleton 3
golgi apparatus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 colocalizes_with mitochondrion IMP 23878393
GO:0005768 endosome IDA 23878393
genes like me logo Genes that share ontologies with BECN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BECN1 Gene

Pathways & Interactions for BECN1 Gene

genes like me logo Genes that share pathways with BECN1: view

Pathways by source for BECN1 Gene

1 Sino Biological pathway for BECN1 Gene
3 GeneGo (Thomson Reuters) pathways for BECN1 Gene
  • Apoptosis and survival BAD phosphorylation
  • Immune response TLR signaling pathways
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
1 R&D Systems pathway for BECN1 Gene
1 Cell Signaling Technology pathway for BECN1 Gene
1 GeneTex pathway for BECN1 Gene

SIGNOR curated interactions for BECN1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BECN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA,ISS --
GO:0000422 autophagy of mitochondrion IMP 25215947
GO:0000423 mitophagy IMP 23878393
GO:0001666 response to hypoxia IEA --
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with BECN1: view

Drugs & Compounds for BECN1 Gene

Products:

  1. Drug products for research

(14) Drugs for BECN1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational, Vet_approved Pharma Target, binder Sex hormone 1160
Estradiol acetate Approved, Investigational, Vet_approved Pharma Target 0
estradiol benzoate Approved, Investigational, Vet_approved Pharma Target 0
Estradiol cypionate Approved, Investigational, Vet_approved Pharma Target 0
Estradiol dienanthate Approved, Investigational, Vet_approved Pharma Target 0

(5) Additional Compounds for BECN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BECN1: view

Transcripts for BECN1 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for BECN1 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BECN1

Alternative Splicing Database (ASD) splice patterns (SP) for BECN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - -
SP11: -
SP12:
SP13:

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BECN1 Gene

GeneLoc Exon Structure for
BECN1

Expression for BECN1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BECN1 Gene

mRNA expression in normal human tissues for BECN1 Gene
mRNA expression by BioGPS for BECN1 GenemRNA expression by GTEx for BECN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BECN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5) and Neutrophil (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BECN1 Gene



Protein tissue co-expression partners for BECN1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BECN1

SOURCE GeneReport for Unigene cluster for BECN1 Gene:

Hs.716464

mRNA Expression by UniProt/SwissProt for BECN1 Gene:

Q14457-BECN1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for BECN1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(3.5)
  • Muscle(3.3)
  • Heart(3.3)
  • Intestine(3.2)
  • Kidney(3.1)
  • Skin(3.1)
  • Blood(3)
  • Lymph node(3)
  • Spleen(2.9)
  • Stomach(2.8)
  • Bone marrow(2.8)
  • Adrenal gland(2.8)
  • Pancreas(2.7)
  • Thyroid gland(2.5)
  • Eye(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with BECN1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BECN1 Gene

Orthologs for BECN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BECN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia BECN1 29 30
  • 99.78 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia BECN1 30
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia BECN1 29 30
  • 94.94 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia BECN1 29 30
  • 94.79 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Becn1 29
  • 92.49 (n)
Mouse
(Mus musculus)
 Mammalia Becn1 29 16 30
  • 92.11 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia BECN1 30
  • 86 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves BECN1 29 30
  • 79.12 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia BECN1 30
  • 91 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia becn1 29
  • 77.4 (n)
Str.10355 29
Zebrafish
(Danio rerio)
 Actinopterygii becn1 29 30
  • 71.89 (n)
 OneToOne
-- 29
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003858 29
  • 59.02 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Atg6 29 30
  • 58.13 (n)
 OneToOne
CG5429 31
  • 50 (a)
Worm
(Caenorhabditis elegans)
 Secernentea bec-1 29 30
  • 44.08 (n)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ACR154W 29
  • 47.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes VPS30 29 30 32
  • 47.02 (n)
 OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F01166g 29
  • 44.51 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons ATG6 29
  • 44.84 (n)
Rice
(Oryza sativa)
 Liliopsida Os01g0681400 29
  • 51.68 (n)
Os.24872 29
Wheat
(Triticum aestivum)
 Liliopsida Ta.2772 29
Corn
(Zea mays)
 Liliopsida Zm.12996 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2825 30
  • 55 (a)
 OneToOne
Bread mold
(Neurospora crassa)
 Ascomycetes NCU03122 29
  • 49.25 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes atg6 29
  • 44.87 (n)
Species where no ortholog for BECN1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for BECN1 Gene

ENSEMBL:
Gene Tree for BECN1 (if available)
TreeFam:
Gene Tree for BECN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BECN1: view image
Alliance of Genome Resources:
Additional Orthologs for BECN1

Paralogs for BECN1 Gene

Paralogs for BECN1 Gene

(51) SIMAP similar genes for BECN1 Gene using alignment to 13 proteins:

  • BECN1_HUMAN
  • E7EV84_HUMAN
  • K7EKK2_HUMAN
  • K7EL88_HUMAN
  • K7ELY9_HUMAN
  • K7EMA2_HUMAN
  • K7EN35_HUMAN
  • K7EPZ0_HUMAN
  • K7EQQ7_HUMAN
  • K7ER46_HUMAN
  • K7ERY0_HUMAN
  • K7ES83_HUMAN
  • K7ESG3_HUMAN

Pseudogenes.org Pseudogenes for BECN1 Gene

genes like me logo Genes that share paralogs with BECN1: view

Variants for BECN1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BECN1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs57695719 Benign: not provided 42,814,515(-) A/G
NM_001313998.2(BECN1):c.980+9T>C 		INTRON
VAR_005236 -- p.Ile403Thr
VAR_010384 -- p.Ala103Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BECN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BECN1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897

Variation tolerance for BECN1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BECN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BECN1
Leiden Open Variation Database (LOVD)
BECN1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BECN1 Gene

Disorders for BECN1 Gene

MalaCards: The human disease database

(23) MalaCards diseases for BECN1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sphingolipidosis
  • sphingolipidoses
huntington disease
  • hd
cervix carcinoma
  • cancer of cervix
machado-joseph disease
  • mjd
cystinosis
  • cystine storage disease
- elite association - COSMIC cancer census association via MalaCards
Search BECN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BECN1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BECN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BECN1 Gene

Publications for BECN1 Gene

  1. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. (PMID: 19713971) Luo S … Rubinsztein DC (Cell death and differentiation 2010) 3 4 22
  2. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. (PMID: 19180116) Zalckvar E … Kimchi A (EMBO reports 2009) 3 4 22
  3. Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. (PMID: 18797192) Sinha S … Levine B (Autophagy 2008) 3 4 22
  4. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PMID: 19050071) Sun Q … Zhong Q (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 22
  5. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E … Mizushima N (Molecular biology of the cell 2008) 3 4 22

ExternalLinks

View latest publications for BECN1 gene in Mastermind

Products for BECN1 Gene

  • Addgene plasmids for BECN1