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This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
BECN1 (Beclin 1) is a Protein Coding gene. Diseases associated with BECN1 include Sphingolipidosis and Cervix Carcinoma. Among its related pathways are Macroautophagy and Spinocerebellar ataxia. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and phosphatidylinositol 3-kinase binding. An important paralog of this gene is BECN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16417406 |
GO:0019901 | protein kinase binding | IPI | 27853422 |
GO:0031625 | ubiquitin protein ligase binding | IPI | 25127057 |
GO:0043548 | phosphatidylinositol 3-kinase binding | IPI | 23878393 |
GO:0051020 | GTPase binding | IPI | 25891078 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000407 | phagophore assembly site | IBA | 21873635 |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | colocalizes_with mitochondrion | IMP | 23878393 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Parkinson disease | ||
2 | Macroautophagy |
.34
|
|
3 | Deubiquitination |
.74
|
|
4 | Metabolism of proteins | ||
5 | Apoptosis and Autophagy |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000045 | autophagosome assembly | IBA,ISS | -- |
GO:0000422 | autophagy of mitochondrion | IMP | 25215947 |
GO:0000423 | mitophagy | IMP | 23878393 |
GO:0006897 | endocytosis | IEA | -- |
GO:0006914 | autophagy | IEA,IMP | 23184933 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Estradiol | Approved, Investigational, Vet_approved | Pharma | Target, binder | Sex hormone | 1113 | |
Estradiol acetate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
estradiol benzoate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
Estradiol cypionate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
Estradiol dienanthate | Approved, Investigational, Vet_approved | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | |||||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BECN1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | BECN1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BECN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BECN1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Becn1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Becn1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BECN1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BECN1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | BECN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | becn1 30 |
|
||
Str.10355 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | becn1 30 31 |
|
OneToOne | |
-- 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003858 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Atg6 30 31 |
|
OneToOne | |
CG5429 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | bec-1 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR154W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS30 30 31 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F01166g 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ATG6 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0681400 30 |
|
||
Os.24872 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.2772 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.12996 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2825 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03122 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | atg6 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783784 | Benign: not provided | 42,814,515(-) | A/G | INTRON_VARIANT | |
VAR_005236 | - | p.Ile403Thr | |||
VAR_010384 | - | p.Ala103Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
sphingolipidosis |
|
|
cervix carcinoma |
|
|
machado-joseph disease |
|
|
cystinosis |
|
|
huntington disease |
|
|