BDKRB2 Gene - Bradykinin Receptor B2

Protein Coding (Updated: Nov 9, 2022)
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate... See more...

Aliases for BDKRB2 Gene

Aliases for BDKRB2 Gene

  • GeneCards Symbol: BDKRB2 2
  • Bradykinin Receptor B2 2 3 5
  • BK-2 2 3 5
  • B2 Bradykinin Receptor 3 4
  • BK-2 Receptor 3 4
  • BKR2 3 4
  • B2R 3 4
  • BRB2 3
  • BK2 3

External Ids for BDKRB2 Gene

Previous GeneCards Identifiers for BDKRB2 Gene

  • GC14P094182
  • GC14P090487
  • GC14P094661
  • GC14P095740
  • GC14P096671
  • GC14P076856

Summaries for BDKRB2 Gene

Entrez Gene Summary for BDKRB2 Gene

  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]

GeneCards Summary for BDKRB2 Gene

BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include Brain Edema and Brucella Abortus Brucellosis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and protease binding. An important paralog of this gene is BDKRB1.

UniProtKB/Swiss-Prot Summary for BDKRB2 Gene

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. ( BKRB2_HUMAN,P30411 )

Tocris Summary for BDKRB2 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB2 Gene

Additional gene information for BDKRB2 Gene

No data available for CIViC Summary , PharmGKB Summary , Rfam classification and piRNA Summary for BDKRB2 Gene

Genomics for BDKRB2 Gene

Subsections:

  1. Promoters/Enhancers
  2. Location

GeneHancer (GH) Regulatory Elements (see citations)

Download GeneHancer 2017 data
Promoters and enhancers for BDKRB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J096203 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.70 476.24 +0.7 1 3.7 ATF2 KLF17 JUND ZNF600 ZIC2 HIC1 CEBPB ZNF217 MAX ZNF341 ENSG00000258691 BDKRB2 BDKRB1 ENSG00000258412
GH14J096238 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 255.20 239.66 +34.9 6 2.4 ATF2 CEBPB EP300 RFX5 STAT3 TBP TCF7L2 ZKSCAN1 ZFP36 KLF1 BDKRB2 ENSG00000258793 lnc-ATG2B-2 ENSG00000259036 BDKRB1 ENSG00000258691
GH14J096243 Promoter 0.4 EPDnew 250.30 107.22 +38.8 6 0.1 ZBTB12 E2F8 lnc-ATG2B-2 BDKRB2 ENSG00000259036 BDKRB1 ENSG00000258691
GH14J096237 Promoter 0.2 EPDnew 250.30 62.58 +32.5 6 0.1 BDKRB2 ENSG00000259036 lnc-ATG2B-2 BDKRB1 ENSG00000258691
GH14J096241 Promoter 0.2 EPDnew 250.30 62.57 +36.7 6 0.1 BDKRB2 lnc-ATG2B-2 ENSG00000259036 BDKRB1 ENSG00000258691

GeneHancers around BDKRB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BDKRB2

Top Transcription factor binding sites by QIAGEN in the BDKRB2 gene promoter:
  • CREB
  • deltaCREB
  • Nkx2-5
  • STAT1alpha

Genomic Locations for BDKRB2 Gene

Latest Assembly
chr14:96,204,679-96,244,166
(GRCh38/hg38)
Size:
39,488 bases
Orientation:
Plus strand

Previous Assembly
chr14:96,671,176-96,710,501
(GRCh37/hg19 by Entrez Gene)
Size:
39,326 bases
Orientation:
Plus strand

chr14:96,671,016-96,710,666
(GRCh37/hg19 by Ensembl)
Size:
39,651 bases
Orientation:
Plus strand

Genomic View for BDKRB2 Gene

Genes around BDKRB2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19) IMPROVED

Cytogenetic band:
BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB2 Gene
Genomic Neighborhood
•
Exon Structure
•
Gene Densities
IMPROVED

RefSeq DNA sequence for BDKRB2 Gene

Proteins for BDKRB2 Gene

Subsections:

  1. 3D Structures
  2. Alternative Splicing
  3. Protein References
  4. Post-Translational Modifications

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for BDKRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30411-BKRB2_HUMAN
    Recommended name:
    B2 bradykinin receptor
    Protein Accession:
    P30411

    Protein attributes for BDKRB2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44461 Da
    Quaternary structure:

    • Forms a complex with PECAM1 and GNAQ.
      Interacts with PECAM1.

    Three dimensional structure from AlphaFold (predicted) for BDKRB2 Gene

    NEW
    Model Confidence:
    Very high (pLDDT > 90)
    Confident (90 > pLDDT > 70)
    Low (70 > pLDDT > 50)
    Very low (pLDDT < 50)
    PDB ID PDBe RCSB-PDB OCA Proteopedia
    7F2O (3D) (3D) (3D)

    Alternative splice isoforms for BDKRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BDKRB2 Gene

Protein Expression for BDKRB2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BDKRB2 Gene

  • Glycosylation at Asn30, Asn39, and Asn207
    NX_P30411 (NX_P30411-1)
  • Modification sites at PhosphoSitePlus
    P30411
  • Glycosylation from GlyGen (P30411) 3 sites NEW

Other Protein References for BDKRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB2 Gene

Domains & Families for BDKRB2 Gene

Gene Families for BDKRB2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for BDKRB2 Gene

InterPro:
Blocks:
  • Bradykinin receptor signature
  • B2 bradykinin receptor signature

Suggested Antigen Peptide Sequences for BDKRB2 Gene

GenScript: Design optimal peptide antigens:
  • B2 bradykinin receptor (BKRB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30411

UniProtKB/Swiss-Prot:

BKRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
Genes that share domains with BDKRB2: view

Function for BDKRB2 Gene

Subsections:

  1. GWAS Phenotypes
  2. GO Terms
  3. MGI/GenomeRNAi Phenotypes

Products:

  1. Animal Models for research
  2. CRISPR products for research
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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for BDKRB2 Gene according to UniProtKB/Swiss-Prot

Function:
  • Receptor for bradykinin.
    It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. BKRB2_HUMAN,P30411

Molecular function for BDKRB2 Gene according to GENATLAS

Biochemistry:
  • bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD) BDKRB2

Gene Ontology (GO) - Molecular Function for BDKRB2 Gene

IMPROVED
GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 3 5 enables protease binding IPI 17077303
GO:0004435 3 5 enables phosphatidylinositol phospholipase C activity TAS 8302267
GO:0004930 3 5 enables G protein-coupled receptor activity IBA 21873635
GO:0004947 3 5 enables bradykinin receptor activity IDA, IBA, TAS 1314587
GO:0005515 3 5 enables protein binding IPI 18672896
Genes that share ontologies with BDKRB2: view
Genes that share phenotypes with BDKRB2: view

Animal Models for BDKRB2 Gene

MGI Knock Outs for BDKRB2:

miRNA products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for BDKRB2 Gene

Localization for BDKRB2 Gene

Subsections:

  1. Cellular Components

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BDKRB2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
endosome 4
cytosol 2
endoplasmic reticulum 2
nucleus 2
mitochondrion 2
cytoskeleton 2
extracellular 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BDKRB2 Gene

IMPROVED
GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 3 5 located_in endosome IDA 17077303
GO:0005794 3 5 located_in Golgi apparatus IDA
GO:0005886 3 5 located_in plasma membrane IDA, IBA, TAS
GO:0005887 5 plasma membrane TAS
GO:0016020 5 membrane IEA
Genes that share ontologies with BDKRB2: view

Pathways & Interactions for BDKRB2 Gene

Subsections:

  1. SuperPathways
  2. String Interactions
  3. Interacting Proteins
  4. Curated Interactions
  5. GO Terms
Genes that share pathways with BDKRB2: view

Additional Pathway Information for BDKRB2 Gene

Interacting Proteins for BDKRB2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network for BDKRB2
Selected Interacting proteins: P30411-BKRB2_HUMAN ENSP00000450482 for BDKRB2 Gene via UniProtKB STRING IID

Symbol External ID(s) Details
ACE
AGTR1
BAG3
BDKRB1
EPB41L3
GNA11
GNA14
GNA15
GNAQ
GRK2
GRK3
GRK5
GRK6
GRSF1
HAX1
KNG1
LMNA
NOS1
NOS3
OPRD1
PPL
PRKCD
PTPN11
SHARPIN
STUB1
GPS-Prot Interaction Network for BDKRB2

SIGNOR curated interactions for BDKRB2 Gene

IMPROVED
Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BDKRB2 Gene

IMPROVED
GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 3 5 involved_in smooth muscle contraction IC 17077303
GO:0006954 3 5 involved_in inflammatory response IC 17077303
GO:0007165 5 signal transduction IEA
GO:0007166 3 5 involved_in cell surface receptor signaling pathway TAS 7916737
GO:0007169 3 5 involved_in transmembrane receptor protein tyrosine kinase signaling pathway TAS 10653985
Genes that share ontologies with BDKRB2: view

Drugs & Compounds for BDKRB2 Gene

Subsections:

  1. Drugs
  2. Inferred drugs
  3. Compounds
  4. Inferred compounds
  5. Commercial compounds

Products:

  1. Drug products for research

(24) Drugs for BDKRB2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant 21 23 24 75 81 93 Approved, Investigational 23 Pharma Antagonist, Target Anti-Inflammatory Agents, Non-Steroidal, Small Molecule
Lisinopril 21 22 93 Approved, Investigational 23 Pharma ACE inhibitor, Antihypertensive Agents, Small Molecule
Atorvastatin 22 93 Approved 23 Pharma Anticholesteremic Agents, Small Molecule
Enalapril 22 93 Approved, Vet_approved 23 Pharma Antihypertensive Agents, Small Molecule
Anatibant 21 23 75 93 Investigational 23 Pharma Antagonist, Target Small Molecule

(35) Inferred Drugs for BDKRB2 Gene

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin 21 Approved, Investigational, Withdrawn 23 Pharma Inhibitor of bovine pancreatic trypsin
Captopril 21 Approved 23 Pharma ACE inhibitor, Antihypertensive Agents, Small Molecule, ACE inhibitor; also inhibits LTA4 hydrolase
Carboplatin 21 Approved 23 Pharma Antitumor agent that forms platinum-DNA adducts.
Dexamethasone 21 Approved, Investigational, Vet_approved 23 Pharma Glucocorticoids, Anti-Inflammatory Agents, Small Molecule, Anti-inflammatory glucocorticoid
Diphenhydramine 21 Approved, Investigational 23 Pharma Anti-Allergic Agents, Antitussives, Hypnotics And Sedatives, Antipruritics, Antiemetics, Small Molecule

(24) Additional Compounds for BDKRB2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FR173657
  • FK-3657|FR 173657|FR-173657
FR190997
  • FR 190997|FR-190997
[<sup>125</sup>I][Tyr<sup>8</sup>]bradykinin
  • [<sup>125</sup>I]-[Tyr<sup>8</sup>]-bradykinin|[<sup>125</sup>I]-[Tyr<sup>8</sup>]BK|[<sup>125</sup>I][Tyr<sup>8</sup>]BK
[<sup>125</sup>I]HPP-HOE140
  • [<sup>125</sup>I]-3-4-hydroxyphenyl-propionyl-d-Arg<sup>0</sup>-[Hyp<sup>3</sup>,Thi<sup>5</sup>,d-Tic<sup>7</sup>,Oic<sup>8</sup>]bradykinin
[<sup>125</sup>I]-HPP-icatibant
  • [(125)I]-HPP-Hoe 140|[<sup>125</sup>I]3-4 hydroxyphenyl-propionyl-D-Arg[Hyp<sup>3</sup>, Thi<sup>5</sup>, D-Tic<sup>7</sup>, Oic<sup>8</sup>]-BK|[<sup>125</sup>I]3-4 hydroxyphenyl-propionyl-D-Arg[Hyp<sup>3</sup>, Thi<sup>5</sup>, D-Tic<sup>7</sup>, Oic<sup>8</sup>]-bradykinin|[<sup>125</sup>I]3-4 hydroxyphenyl-propionyl-icatibant

(22) Additional Inferred Compounds for BDKRB2 Gene

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
Cereport
cgmp
Des-arg(10)-kallidin
DMSO

(5) Tocris Compounds for BDKRB2 Gene

Compound Action Cas Number
[Des-Arg9]-Bradykinin Bradykinin receptor agonist (B1 > B2) 15958-92-6
Bombinakinin M Potent bradykinin receptor agonist 509151-65-9
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) 342-10-9

(11) ApexBio Compounds for BDKRB2 Gene

Compound Action Cas Number
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin 118122-39-7
Bombinakinin M 509151-65-9
Bombinakinin-GAP 573671-91-7
HOE 140 130308-48-4
Lys-[Des-Arg9]Bradykinin 71800-36-7
Lys-Bradykinin 342-10-9
MEN 11270 235082-52-7
R 715 185052-09-9
R 892 229030-05-1
Sar-[D-Phe8]-des-Arg9-Bradykinin 126959-88-4
WIN 64338 hydrochloride bradykinin B2 receptor antagonist, competitive 163727-74-0
Genes that share compounds with BDKRB2: view

Transcripts for BDKRB2 Gene

Subsections:

  1. Alternative Splicing
  2. External Links

Products:

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  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for BDKRB2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

miRNA products for research

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB2 Gene

No ASD Table

Relevant External Links for BDKRB2 Gene

GeneLoc Exon Structure for
BDKRB2

Expression for BDKRB2 Gene

Subsections:

  1. Expression in stem cells
  2. Protein expression
  3. Co-Expression partners

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BDKRB2 Gene

mRNA expression in normal human tissues for BDKRB2 Gene
mRNA expression by GTEx for BDKRB2 GenemRNA expression by BioGPS for BDKRB2 Gene

Protein differential expression in normal tissues from HIPED for BDKRB2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BDKRB2 Gene



Protein tissue co-expression partners for BDKRB2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BDKRB2

SOURCE GeneReport for Unigene cluster for BDKRB2 Gene:

Hs.654542

mRNA Expression by UniProt/SwissProt for BDKRB2 Gene:

P30411-BKRB2_HUMAN
Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.

Evidence on tissue expression from TISSUES for BDKRB2 Gene

  • Lung(4.5)
  • Nervous system(2.8)
  • Kidney(2.5)
  • Blood(2.3)
  • Heart(2.3)
  • Muscle(2.2)

Bgee gene expression patterns for BDKRB2 gene:

  • Expressed in stromal cell of endometrium, mucosa of urinary bladder, pancreatic ductal cell and 142 other tissues.
Genes that share expression patterns with BDKRB2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BDKRB2 Gene

Orthologs for BDKRB2 Gene

Subsections:

  1. CladeOScope co-evolved genes

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia BDKRB2 28 29
  • 99.32 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia BDKRB2 28 29
  • 87.09 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia BDKRB2 28 29
  • 85.68 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Bdkrb2 28 16 29
  • 83.25 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Bdkrb2 28
  • 81.97 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia BDKRB2 29
  • 66 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia BDKRB2 29
  • 59 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves BDKRB2 28 29
  • 62.55 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia BDKRB2 29
  • 51 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia bdkrb2 28
  • 59.88 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC100330960 28
  • 55.42 (n)
CABZ01058422.1 29
  • 44 (a)
 OneToMany
BDKRB2 (1 of 2) 29
  • 38 (a)
 OneToMany
Species where no ortholog for BDKRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BDKRB2 Gene

ENSEMBL:
Gene Tree for BDKRB2 (if available)
TreeFam:
Gene Tree for BDKRB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BDKRB2: view image
Alliance of Genome Resources:
Additional Orthologs for BDKRB2

CladeOScope co-evolved genes for BDKRB2 gene NEW

Clade Top 10 Co-Evolved Genes Normalized Phylogenetic Profile HeatMap (PPH)
Top Genes From All Clades
Eukaryota
Chordata
Mammalia
Fungi
Viridiplantae
Archelosauria
Ecdysozoa
Nematoda
Arthropoda
Platyhelminthes
Alveolata
Stramenopiles
Fungi_Incertae_Sedis
Ascomycota
Basidiomycota
Liliopsida
Eudicotyledons

Paralogs for BDKRB2 Gene

Paralogs for BDKRB2 Gene

(20) SIMAP paralogs for BDKRB2 Gene using alignment to 2 proteins:

  • BKRB2_HUMAN
  • L8EC45_HUMAN
Genes that share paralogs with BDKRB2: view

Variants for BDKRB2 Gene

Subsections:

  1. Variation Tolerance
  2. External Links

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BDKRB2 Gene

IMPROVED
SNP ID Clinical significance and condition Chr 14 pos Variation AA Info # Cit Type
rs143778180 5 109

Likely Benign: not provided

96,241,390(+) G/ANM_001379692.1(BDKRB2):c.1062G>A (p.Gly354=)
SYNONYMOUS
rs2227279 5 109 4

Benign: not provided

96,241,389(+) G/ANM_001379692.1(BDKRB2):c.1061G>A (p.Gly354Glu)
p.Gly354Glu
MISSENSE 4
rs2229415 5 109

Benign: not provided

96,241,261(+) T/CNM_001379692.1(BDKRB2):c.933T>C (p.Asp311=)
SYNONYMOUS 2
rs1595266840 5 109

not provided: Hereditary Angioedema With Normal C1inh; Angioedema, Hereditary, 3

96,241,525(+) T/ANM_001379692.1(BDKRB2):c.*21T>A
THREE_PRIME_UTR
rs1046248 5 4 p.Arg14Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BDKRB2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BDKRB2 Gene

Variant ID Type Subtype PubMed ID
nsv4227653 CNV duplication 32461652
esv3635417 CNV gain 21293372
esv3635418 CNV gain 21293372
nsv4335021 OTHER sequence alteration 32461652
nsv1051786 CNV gain 25217958
nsv3352178 CNV insertion 30661756
nsv1416 CNV insertion 18451855
nsv4221094 CNV deletion 32461652
esv3635419 CNV loss 21293372
nsv515629 CNV loss 19592680
dgv262n27 CNV loss 19166990
nsv565647 CNV loss 21841781
nsv983853 CNV duplication 23825009
esv3635420 CNV gain 21293372
nsv4217774 CNV duplication 32461652
esv1004672 CNV insertion 20482838
nsv4232094 CNV duplication 32461652
nsv4223768 CNV deletion 32461652
SVs/CNVs around BDKRB2 on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for BDKRB2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BDKRB2 Gene

Mastermind
See all genomic literature for BDKRB2 gene in Mastermind NEW
Human Gene Mutation Database (HGMD)
BDKRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BDKRB2
Leiden Open Variation Database (LOVD)
BDKRB2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB2 Gene

Disorders for BDKRB2 Gene

Subsections:

  1. External links

Products:

  1. Animal Models for research

(12) MalaCards diseases for BDKRB2 Gene - From: DISEASES, Novoseek, and GeneCards IMPROVED

Disorder Aliases PubMed IDs
Brain Edema 1 21 64
  • Cerebral Edema
  • Intracranial Swelling
  • Wet Brain
 14534854 14753436
Brucella Abortus Brucellosis 64
  • Brucellosis, Bovine
Angioedema 1 21 64
  • Angioneurotic Oedema
  • Quincke'S Edema
  • Angioneurotic Edema
  • Giant Urticaria
 20461661
Hereditary Angioedema 21 64
  • Hereditary Angioneurotic Edema
  • Hereditary Angioedema Type 1
  • Hane
  • Angioedema, Hereditary
  • Hae
  • Angioedemas, Hereditary
  • Deficiency Of C1 Esterase Inhibitor
  • C1 Esterase Inhibitor Deficiency
  • C1 Inhibitor Deficiency
  • Familial Angioneurotic Edema
  • Hereditary Bradykinine-Induced Angioedema
  • Hereditary Non Histamine-Induced Angioedema
  • Hae 1
  • Hae-I
  • Hereditary Angioneurotic Edema Type 1
  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
  • Hereditary Angioedema Types I And Ii
  • Hereditary Angioneurotic Oedema
  • Familial Angioedema
  • Hae - [Hereditary Angioneurotic Oedema]
  • Bannister Disease, Hereditary
  • Quincke Disease Or Oedema
  • Hereditary Quincke Oedema
 19758369 17073887
End Stage Renal Disease 1 64
  • End Stage Renal Failure
  • End-Stage Kidney Disease
  • Kidney Failure, Chronic
  • Chronic Kidney Disease Stage 5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BDKRB2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
Cancer Target Discovery and Development
(CTD² Dashboard)
The FABRIC Cancer Portal
(FABRIC)
Genes that share disorders with BDKRB2: view

No data available for UniProtKB/Swiss-Prot and GENATLAS for BDKRB2 Gene

Publications for BDKRB2 Gene

  1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PMID: 7916737) Powell SJ … Graham A (Genomics 1993) 2 3 4 21
  2. Genetic influence on baroreflex sensitivity in normotensive young men. (PMID: 20300066) Xing-Sheng Y … Shu-Zheng L (American journal of hypertension 2010) 3 21 39
  3. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. (PMID: 19744011) Woo SW … Lee SH (Journal of clinical pharmacy and therapeutics 2009) 3 21 39
  4. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PMID: 16461337) Saunders CJ … Collins M (Human molecular genetics 2006) 3 21 39
  5. Dipsogenic genes associated with weight changes during Ironman Triathlons. (PMID: 16950802) Saunders CJ … Collins M (Human molecular genetics 2006) 3 21 39

ExternalLinks

See all genomic literature for BDKRB2 gene in Mastermind NEW

Products for BDKRB2 Gene

Sources for BDKRB2 Gene