Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BDKRB2 Gene

Aliases for BDKRB2 Gene

  • Bradykinin Receptor B2 2 3 5
  • BK-2 Receptor 3 4
  • BKR2 3 4
  • B2R 3 4
  • B2 Bradykinin Receptor 3
  • BK-2 3
  • BRB2 3
  • BK2 3

External Ids for BDKRB2 Gene

Previous GeneCards Identifiers for BDKRB2 Gene

  • GC14P094182
  • GC14P090487
  • GC14P094661
  • GC14P095740
  • GC14P096671
  • GC14P076856

Summaries for BDKRB2 Gene

Entrez Gene Summary for BDKRB2 Gene

  • This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for BDKRB2 Gene

BDKRB2 (Bradykinin Receptor B2) is a Protein Coding gene. Diseases associated with BDKRB2 include Brain Edema and Hereditary Angioedema. Among its related pathways are Peptide ligand-binding receptors and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and protease binding. An important paralog of this gene is BDKRB1.

UniProtKB/Swiss-Prot for BDKRB2 Gene

  • Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for BDKRB2 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB2 Gene

Additional gene information for BDKRB2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB2 Gene

Genomics for BDKRB2 Gene

GeneHancer (GH) Regulatory Elements for BDKRB2 Gene

Promoters and enhancers for BDKRB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J096203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 739 3.7 PKNOX1 SIN3A FEZF1 GLIS2 FOS ATF7 REST NFIL3 GLIS1 WT1 BDKRB2 ENSG00000258691 BDKRB1 PAPOLA SCARNA13 SNHG10 ENSG00000258412
GH14J096238 Promoter/Enhancer 1.1 EPDnew ENCODE 655.2 +34.9 34917 2.4 KLF1 CEBPB EP300 ATF2 RFX5 ZKSCAN1 ZFP36 STAT3 ATF7 TCF7L2 BDKRB2 ENSG00000258793 ENSG00000259036 PIR41586 ENSG00000258691
GH14J096243 Promoter 0.7 EPDnew 650.3 +38.8 38803 0.1 E2F8 ZBTB12 BDKRB2 ENSG00000259036 PIR41586 ENSG00000258691
GH14J096237 Promoter 0.5 EPDnew 650.3 +32.5 32485 0.1 BDKRB2 ENSG00000259036 PIR41586 ENSG00000258691
GH14J096241 Promoter 0.5 EPDnew 650.3 +36.7 36693 0.1 BDKRB2 ENSG00000259036 PIR41586 ENSG00000258691
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BDKRB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BDKRB2 gene promoter:
  • deltaCREB
  • CREB
  • Nkx2-5
  • STAT1alpha

Genomic Locations for BDKRB2 Gene

Genomic Locations for BDKRB2 Gene
39,651 bases
Plus strand
39,651 bases
Plus strand

Genomic View for BDKRB2 Gene

Genes around BDKRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BDKRB2 Gene

Proteins for BDKRB2 Gene

  • Protein details for BDKRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B2 bradykinin receptor
    Protein Accession:

    Protein attributes for BDKRB2 Gene

    391 amino acids
    Molecular mass:
    44461 Da
    Quaternary structure:
    • Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.

    Alternative splice isoforms for BDKRB2 Gene


neXtProt entry for BDKRB2 Gene

Post-translational modifications for BDKRB2 Gene

  • Glycosylation at Asn207, Asn39, and Asn30
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB2 Gene

Domains & Families for BDKRB2 Gene

Gene Families for BDKRB2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for BDKRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
genes like me logo Genes that share domains with BDKRB2: view

Function for BDKRB2 Gene

Molecular function for BDKRB2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GENATLAS Biochemistry:
bradykinin B2 receptor,sensitive to the full sequence of kinin of Lys-BK type,G protein coupled receptor superfamily,widely expressed,putatively exercying protective role in the end stage renal disease (ESRD)

Phenotypes From GWAS Catalog for BDKRB2 Gene

Gene Ontology (GO) - Molecular Function for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 17077303
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8302267
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004947 bradykinin receptor activity TAS,IDA 17077303
genes like me logo Genes that share ontologies with BDKRB2: view
genes like me logo Genes that share phenotypes with BDKRB2: view

Animal Models for BDKRB2 Gene

MGI Knock Outs for BDKRB2:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for BDKRB2 (Bradykinin RB2/BDKRB2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB2 Gene

Localization for BDKRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BDKRB2 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 17077303
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane TAS 7916737
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BDKRB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BDKRB2 Gene

Pathways & Interactions for BDKRB2 Gene

genes like me logo Genes that share pathways with BDKRB2: view

SIGNOR curated interactions for BDKRB2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BDKRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IC 17077303
GO:0006950 response to stress IEA --
GO:0006954 inflammatory response IC 17077303
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 7916737
genes like me logo Genes that share ontologies with BDKRB2: view

Drugs & Compounds for BDKRB2 Gene

(77) Drugs for BDKRB2 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved, Investigational Pharma Antagonist, antagonist, Target 18
Lisinopril Approved, Investigational Pharma ACE inhibitor 123
calcium Approved Nutra 0
atorvastatin Approved Pharma Competitive, Inhibitor 0
Enalapril Approved, Vet_approved Pharma 129

(24) Additional Compounds for BDKRB2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist

(5) Tocris Compounds for BDKRB2 Gene

Compound Action Cas Number
[Des-Arg9]-Bradykinin Bradykinin receptor agonist (B1 > B2) 15958-92-6
Bombinakinin M Potent bradykinin receptor agonist 509151-65-9
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) 342-10-9
genes like me logo Genes that share compounds with BDKRB2: view

Transcripts for BDKRB2 Gene

mRNA/cDNA for BDKRB2 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BDKRB2 Gene

Bradykinin receptor B2:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for BDKRB2 (Bradykinin RB2/BDKRB2)

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB2 Gene

No ASD Table

Relevant External Links for BDKRB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BDKRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BDKRB2 Gene

Protein differential expression in normal tissues from HIPED for BDKRB2 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BDKRB2 Gene

Protein tissue co-expression partners for BDKRB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BDKRB2 Gene:


SOURCE GeneReport for Unigene cluster for BDKRB2 Gene:


mRNA Expression by UniProt/SwissProt for BDKRB2 Gene:

Tissue specificity: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.

Evidence on tissue expression from TISSUES for BDKRB2 Gene

  • Lung(4.4)
  • Kidney(2.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with BDKRB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BDKRB2 Gene

Orthologs for BDKRB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BDKRB2 34 33
  • 99.32 (n)
(Canis familiaris)
Mammalia BDKRB2 34 33
  • 87.09 (n)
(Bos Taurus)
Mammalia BDKRB2 34 33
  • 85.68 (n)
(Mus musculus)
Mammalia Bdkrb2 16 34 33
  • 83.25 (n)
(Rattus norvegicus)
Mammalia Bdkrb2 33
  • 81.97 (n)
(Ornithorhynchus anatinus)
Mammalia BDKRB2 34
  • 66 (a)
(Monodelphis domestica)
Mammalia BDKRB2 34
  • 59 (a)
(Gallus gallus)
Aves BDKRB2 34 33
  • 62.55 (n)
(Anolis carolinensis)
Reptilia BDKRB2 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bdkrb2 33
  • 59.88 (n)
(Danio rerio)
Actinopterygii LOC100330960 33
  • 55.42 (n)
CABZ01058422.1 34
  • 44 (a)
BDKRB2 (1 of 2) 34
  • 38 (a)
Species where no ortholog for BDKRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB2 Gene

Gene Tree for BDKRB2 (if available)
Gene Tree for BDKRB2 (if available)
Evolutionary constrained regions (ECRs) for BDKRB2: view image

Paralogs for BDKRB2 Gene

Paralogs for BDKRB2 Gene

(20) SIMAP similar genes for BDKRB2 Gene using alignment to 2 proteins:

  • L8EC45_HUMAN
genes like me logo Genes that share paralogs with BDKRB2: view

Variants for BDKRB2 Gene

Sequence variations from dbSNP and Humsavar for BDKRB2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000022034 -- 96,232,997(+) T/C intron_variant
rs1000062201 -- 96,227,589(+) G/A intron_variant
rs1000124055 -- 96,208,683(+) T/A intron_variant
rs1000159767 -- 96,227,894(+) C/T intron_variant
rs1000174964 -- 96,216,119(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB2 Gene

Variant ID Type Subtype PubMed ID
dgv262n27 CNV loss 19166990
esv1004672 CNV insertion 20482838
esv3635417 CNV gain 21293372
esv3635418 CNV gain 21293372
esv3635419 CNV loss 21293372
esv3635420 CNV gain 21293372
nsv1051786 CNV gain 25217958
nsv1416 CNV insertion 18451855
nsv515629 CNV loss 19592680
nsv565647 CNV loss 21841781
nsv983853 CNV duplication 23825009

Variation tolerance for BDKRB2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BDKRB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB2 Gene

Disorders for BDKRB2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for BDKRB2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain edema
  • intracranial swelling
hereditary angioedema
  • hane
retinitis pigmentosa 68
  • rp68
  • angioneurotic edema
c1 inhibitor deficiency
  • quincke edema
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BDKRB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BDKRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BDKRB2 Gene

Publications for BDKRB2 Gene

  1. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. (PMID: 7916737) Powell SJ … Graham A (Genomics 1993) 2 3 4 22 58
  2. The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS3) genes and endurance performance during Ironman Triathlons. (PMID: 16461337) Saunders CJ … Collins M (Human molecular genetics 2006) 3 22 44 58
  3. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J … Gavras H (Journal of hypertension 2005) 3 22 44 58
  4. Association of the human bradykinin B2 receptor gene with chronic renal failure. (PMID: 15771553) Jozwiak L … Buraczynska M (Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 2004) 3 22 44 58
  5. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. (PMID: 15894833) Fu Y … Ogihara T (Hypertension research : official journal of the Japanese Society of Hypertension 2004) 3 22 44 58

Products for BDKRB2 Gene

Sources for BDKRB2 Gene

Loading form....