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Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Diseases associated with BDKRB1 include C1 Inhibitor Deficiency and End Stage Renal Disease. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bradykinin receptor activity. An important paralog of this gene is BDKRB2.
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004947 | bradykinin receptor activity | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 23597562 |
GO:0042277 | peptide binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | TAS | 9930991 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 8063797 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
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2 | Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics | ||
3 | Signaling by GPCR | ||
4 | Complement and coagulation cascades | ||
5 | Regulation of actin cytoskeleton |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
GO:0002687 | positive regulation of leukocyte migration | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Icatibant | Approved, Investigational | Pharma | Antagonist, antagonist | 21 | ||
Captopril | Approved | Pharma | Inhibitor, Inhibition, Target | ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase | 50 | |
Enalaprilat | Approved | Pharma | Target | 143 | ||
Ramipril | Approved | Pharma | Target | 169 | ||
Zinc | Approved, Investigational | Pharma | Target | 1594 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[Des-Arg9]-Bradykinin |
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15958-92-6 |
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Compound | Action | Cas Number |
---|---|---|
[Des-Arg9]-Bradykinin | Bradykinin receptor agonist (B1 > B2) | 15958-92-6 |
Bombinakinin M | Potent bradykinin receptor agonist | 509151-65-9 |
Bradykinin | Endogenous agonist at bradykinin receptors (B2 > B1) | 58-82-2 |
Lys-[Des-Arg9]Bradykinin | Selective B1 agonist | 71800-36-7 |
Lys-Bradykinin | Potent bradykinin receptor agonist (B2 > B1) | 342-10-9 |
Compound | Action | Cas Number |
---|---|---|
[Phe8Ψ(CH-NH)-Arg9]-Bradykinin | 118122-39-7 | |
Bombinakinin M | 509151-65-9 | |
Bombinakinin-GAP | 573671-91-7 | |
ELN441958 | Potent and selective bradykinin B1 receptor antagonist | 913064-47-8 |
HOE 140 | 130308-48-4 | |
Lys-[Des-Arg9]Bradykinin | 71800-36-7 | |
Lys-Bradykinin | 342-10-9 | |
MEN 11270 | 235082-52-7 | |
R 715 | 185052-09-9 | |
R 892 | 229030-05-1 | |
Sar-[D-Phe8]-des-Arg9-Bradykinin | 126959-88-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | BDKRB1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | BDKRB1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | BDKRB1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Bdkrb1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Bdkrb1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | BDKRB1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | BDKRB1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | BDKRB1 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | bdkrb1 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3635420 | CNV | gain | 21293372 |
nsv565648 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
c1 inhibitor deficiency |
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end stage renal disease |
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chronic pain |
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angioedema |
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obstructive nephropathy |
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