Free for academic non-profit institutions. Other users need a Commercial license

BDKRB1 Gene(Protein Coding)

Bradykinin Receptor B1

GCID:
GC14P096255
GIFtS:
47
Genes Participants
UDN Logo

Aliases for BDKRB1 Gene

Aliases for BDKRB1 Gene

  • Bradykinin Receptor B1 2 3 5
  • BK-1 Receptor 3 4
  • BRADYB1 3 4
  • B1R 3 4
  • B1 Bradykinin Receptor 3
  • Bradykinin B1 Receptor 3
  • Bradykinin Receptor B2 3
  • Bradykinin Receptor 1 3
  • BDKRB2 3
  • B1BKR 3
  • BKB1R 3
  • BKR1 3

External Ids for BDKRB1 Gene

Previous GeneCards Identifiers for BDKRB1 Gene

  • GC14P094233
  • GC14P090539
  • GC14P094712
  • GC14P095792
  • GC14P096722
  • GC14P076907

Summaries for BDKRB1 Gene

Entrez Gene Summary for BDKRB1 Gene

  • Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for BDKRB1 Gene

BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bradykinin receptor activity. An important paralog of this gene is BDKRB2.

UniProtKB/Swiss-Prot for BDKRB1 Gene

  • This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Tocris Summary for BDKRB1 Gene

  • Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.

Gene Wiki entry for BDKRB1 Gene

Additional gene information for BDKRB1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BDKRB1 Gene

Genomics for BDKRB1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for BDKRB1 Gene

Promoters and enhancers for BDKRB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J096203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.2 -50.4 -50406 3.7 PKNOX1 SIN3A FEZF1 GLIS2 FOS ATF7 REST NFIL3 GLIS1 WT1 ENSG00000258691 BDKRB2 BDKRB1 PAPOLA SCARNA13 SNHG10 ENSG00000258412
GH14J096251 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655.7 -1.1 -1053 6.2 MEIS2 FOXA2 JUN MAX ZIC2 RAD21 ZNF366 POLR2A SMC3 FOSL2 BDKRB1 PIR41586 ENSG00000258793 CKS1BP1 BDKRB2 ENSG00000259036 ENSG00000258691
GH14J096260 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 650.4 +6.3 6255 3.7 NFIB SIN3A ZBTB7B ZBTB40 POLR3A RCOR1 HCFC1 CEBPB GATAD2B ZNF217 BDKRB1 BDKRB2 ATG2B PAPOLA ENSG00000258793 GC14M096266 ENSG00000258691
GH14J095290 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 -964.2 -964160 2.4 PKNOX1 SMAD1 ZFP64 NCOA2 ZNF121 ATF7 RXRA ZNF662 ZNF491 GLIS1 SNHG10 SCARNA13 DICER1 CLMN BDKRB1 ENSG00000258615
GH14J095494 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -759.7 -759688 4 HDGF PKNOX1 NFIB STAT5A BMI1 BATF KLF5 IRF4 ZBTB40 ZNF143 ATG2B SNHG10 BDKRB1 SYNE3 CLMN LOC101929107 LOC105370641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BDKRB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BDKRB1 gene promoter:
  • Nkx2-5
  • p300
  • HOXA5
  • SEF-1 (1)
  • Bach2
  • XBP-1
  • E47

Genomic Locations for BDKRB1 Gene

Genomic Locations for BDKRB1 Gene
chr14:96,255,824-96,268,967
(GRCh38/hg38)
Size:
13,144 bases
Orientation:
Plus strand
chr14:96,722,161-96,735,304
(GRCh37/hg19)
Size:
13,144 bases
Orientation:
Plus strand

Genomic View for BDKRB1 Gene

Genes around BDKRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BDKRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BDKRB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BDKRB1 Gene

Proteins for BDKRB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for BDKRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46663-BKRB1_HUMAN
    Recommended name:
    B1 bradykinin receptor
    Protein Accession:
    P46663
    Secondary Accessions:
    • A8K7F5
    • Q546S7
    • Q8N0Y8

    Protein attributes for BDKRB1 Gene

    Size:
    353 amino acids
    Molecular mass:
    40495 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BDKRB1 Gene

Post-translational modifications for BDKRB1 Gene

  • Glycosylation at Asn185, Asn22, and Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for BDKRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BDKRB1 Gene

Domains & Families for BDKRB1 Gene

Gene Families for BDKRB1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for BDKRB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BDKRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46663

UniProtKB/Swiss-Prot:

BKRB1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
genes like me logo Genes that share domains with BDKRB1: view

Function for BDKRB1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for BDKRB1 Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
GENATLAS Biochemistry:
bradykinin B1 receptor,selectively sensible to fragments of kinins,lacking the Cter Arg,G protein coupled receptor superfamily,putatively exercying protective role in the end stage renal disease (ESRD)

Gene Ontology (GO) - Molecular Function for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004947 bradykinin receptor activity TAS,IEA --
GO:0005515 protein binding IPI 23597562
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with BDKRB1: view
genes like me logo Genes that share phenotypes with BDKRB1: view

Animal Models for BDKRB1 Gene

MGI Knock Outs for BDKRB1:

Animal Model Products

miRNA for BDKRB1 Gene

miRTarBase miRNAs that target BDKRB1

Clone Products

  • R&D Systems cDNA Clones for BDKRB1 (Bradykinin RB1/BDKRB1)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BDKRB1 Gene

Localization for BDKRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BDKRB1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BDKRB1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1

Gene Ontology (GO) - Cellular Components for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9930991
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8063797
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BDKRB1 Gene

Pathways & Interactions for BDKRB1 Gene

genes like me logo Genes that share pathways with BDKRB1: view

Gene Ontology (GO) - Biological Process for BDKRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006950 response to stress IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with BDKRB1: view

No data available for SIGNOR curated interactions for BDKRB1 Gene

Drugs & Compounds for BDKRB1 Gene

Products:

  1. Drug

(60) Drugs for BDKRB1 Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Icatibant Approved, Investigational Pharma Antagonist, antagonist 18
Captopril Approved Pharma Inhibition, Inhibitor, Target ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 37
Enalaprilat Approved Pharma Target 129
Ramipril Approved Pharma Target 155
Zinc Approved, Investigational Pharma Target 2430

(7) Additional Compounds for BDKRB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Des-Arg9]-Bradykinin
15958-92-6

(5) Tocris Compounds for BDKRB1 Gene

Compound Action Cas Number
[Des-Arg9]-Bradykinin Bradykinin receptor agonist (B1 > B2) 15958-92-6
Bombinakinin M Potent bradykinin receptor agonist 509151-65-9
Bradykinin Endogenous agonist at bradykinin receptors (B2 > B1) 58-82-2
Lys-[Des-Arg9]Bradykinin Selective B1 agonist 71800-36-7
Lys-Bradykinin Potent bradykinin receptor agonist (B2 > B1) 342-10-9
genes like me logo Genes that share compounds with BDKRB1: view

Transcripts for BDKRB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for BDKRB1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BDKRB1 Gene

Bradykinin receptor B1:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for BDKRB1 (Bradykinin RB1/BDKRB1)

Alternative Splicing Database (ASD) splice patterns (SP) for BDKRB1 Gene

No ASD Table

Relevant External Links for BDKRB1 Gene

GeneLoc Exon Structure for
BDKRB1
ECgene alternative splicing isoforms for
BDKRB1

Expression for BDKRB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BDKRB1 Gene

mRNA expression in normal human tissues for BDKRB1 Gene
mRNA expression by BioGPS for BDKRB1 GenemRNA expression by GTEx for BDKRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BDKRB1 Gene

This gene is overexpressed in Pancreas (x9.8), Esophagus - Mucosa (x5.5), and Testis (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of BDKRB1 Gene:

BDKRB1

SOURCE GeneReport for Unigene cluster for BDKRB1 Gene:

Hs.525572

Evidence on tissue expression from TISSUES for BDKRB1 Gene

  • Lung(4.4)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with BDKRB1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BDKRB1 Gene

Orthologs for BDKRB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BDKRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia BDKRB1 34 33
  • 99.43 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia BDKRB1 34 33
  • 81.58 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia BDKRB1 34 33
  • 80.65 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Bdkrb1 16 34 33
  • 79.34 (n)
rat
(Rattus norvegicus)
 Mammalia Bdkrb1 33
  • 78.38 (n)
oppossum
(Monodelphis domestica)
 Mammalia BDKRB1 34
  • 62 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia BDKRB1 34
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BDKRB1 34 33
  • 55.1 (n)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii bdkrb1 34
  • 33 (a)
 OneToOne
Species where no ortholog for BDKRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BDKRB1 Gene

ENSEMBL:
Gene Tree for BDKRB1 (if available)
TreeFam:
Gene Tree for BDKRB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BDKRB1: view image

Paralogs for BDKRB1 Gene

Paralogs for BDKRB1 Gene

(31) SIMAP similar genes for BDKRB1 Gene using alignment to 2 proteins:

  • BKRB1_HUMAN
  • G3V4Y2_HUMAN
genes like me logo Genes that share paralogs with BDKRB1: view

Variants for BDKRB1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for BDKRB1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000091722 -- 96,263,797(+) G/A coding_sequence_variant, missense_variant
rs1000345993 -- 96,259,870(+) C/T intron_variant
rs1000652713 -- 96,259,309(+) A/G intron_variant
rs1001439191 -- 96,258,650(+) A/T intron_variant
rs1001752758 -- 96,258,478(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BDKRB1 Gene

Variant ID Type Subtype PubMed ID
esv3635420 CNV gain 21293372
nsv565648 CNV loss 21841781

Variation tolerance for BDKRB1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BDKRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BDKRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BDKRB1 Gene

Disorders for BDKRB1 Gene

Additional Disease Information for BDKRB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BDKRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BDKRB1 Gene

Publications for BDKRB1 Gene

  1. A synergistic association of ACE I/D and eNOS G894T gene variants with the progression of immunoglobulin A nephropathy - a pilot study. (PMID: 19546528) Rodríguez-Pérez JC … Torres A (American journal of nephrology 2009) 3 22 44 58
  2. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. (PMID: 15643125) Cui J … Gavras H (Journal of hypertension 2005) 3 22 44 58
  3. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. (PMID: 10422787) Jones C … McIntyre P (European journal of pharmacology 1999) 3 4 22 58
  4. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). (PMID: 8660997) Bachvarov DR … Marceau F (Genomics 1996) 3 4 22 58
  5. Expression cloning of a human B1 bradykinin receptor. (PMID: 8063797) Menke JG … Hess JF (The Journal of biological chemistry 1994) 3 4 22 58

Products for BDKRB1 Gene

Sources for BDKRB1 Gene

Content
Loading form....