Aliases for BDKRB1 Gene
External Ids for BDKRB1 Gene
Previous GeneCards Identifiers for BDKRB1 Gene
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for BDKRB1 Gene
BDKRB1 (Bradykinin Receptor B1) is a Protein Coding gene. Diseases associated with BDKRB1 include C1 Inhibitor Deficiency and End Stage Renal Disease. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and bradykinin receptor activity. An important paralog of this gene is BDKRB2.
UniProtKB/Swiss-Prot Summary for BDKRB1 Gene
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Bradykinin and related kinins are a family of small peptides which act as mediators of pain and inflammation. They exert a variety of biological effects on the endothelium and peripheral circulation through their action on two bradykinin receptor subtypes: B1 and B2.