Aliases for BCR Gene
Aliases for BCR Gene
External Ids for BCR Gene
- HGNC: 1014
- Entrez Gene: 613
- Ensembl: ENSG00000186716
- OMIM: 151410
- UniProtKB: P11274
Previous HGNC Symbols for BCR Gene
- D22S11
- BCR1
Previous GeneCards Identifiers for BCR Gene
- GC22P020221
- GC22P021847
- GC22P021822
- GC22P023521
- GC22P006461
Summaries for BCR Gene
-
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCR Gene
BCR (BCR, RhoGEF And GTPase Activating Protein) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid and Leukemia, Acute Lymphoblastic 3. Among its related pathways are Endometrial cancer and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein tyrosine kinase activity and enzyme binding. An important paralog of this gene is ABR.
UniProtKB/Swiss-Prot for BCR Gene
-
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Additional gene information for BCR Gene
- Monarch Initiative
- Search for BCR at DataMed
- Search for BCR at HumanCyc
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for BCR Gene
Genomics for BCR Gene
GeneHancer (GH) Regulatory Elements for BCR Gene
Promoters and enhancers for BCR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BCR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BCR gene promoter:
-
- p53
- NF-kappaB1
- HOXA5
- AREB6
- HSF1 (long)
- HSF1short
- POU6F1 (c2)
Regulatory Element Products
Genomic Locations for BCR Gene
Genomic Locations for BCR Gene
- chr22:23,179,704-23,318,037
- (GRCh38/hg38)
- Size:
- 138,334 bases
- Orientation:
- Plus strand
- chr22:23,521,891-23,660,224
- (GRCh37/hg19)
- Size:
- 138,334 bases
- Orientation:
- Plus strand
Genomic View for BCR Gene
Genes around BCR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Entrez Gene
- 22q11.23 by HGNC
- 22q11.23 by Ensembl
BCR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCR Gene
Proteins for BCR Gene
-
Protein details for BCR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11274-BCR_HUMAN
- Recommended name:
- Breakpoint cluster region protein
- Protein Accession:
- P11274
- P78501
- Q12842
- Q4LE80
- Q6NZI3
Protein attributes for BCR Gene
- Size:
- 1271 amino acids
- Molecular mass:
- 142819 Da
- Quaternary structure:
-
- Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. Interacts with SH2D5 (PubMed:25331951).
- SequenceCaution:
-
- Sequence=BAE06073.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for BCR Gene
Protein Expression for BCR Gene
Post-translational modifications for BCR Gene
- Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BCR (BCR)
- Novus Biologicals Antibodies for BCR
- Invitrogen Antibodies for BCR
- antibodies-online: Search results for 189 available BCR Antibodies ranked by validation data
- Compare Top BCR Antibodies
-
Recommended
- 102 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 70 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex BCR Antibody for BCR
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCR
Protein Products
-
OriGene Purified Proteins for BCR
- Search Origene for MassSpec and Protein Over-expression Lysates for BCR
- Origene Custom Protein Services for BCR
- Search GeneTex for Proteins for BCR
Assay Products
No data available for DME Specific Peptides for BCR Gene
Domains & Families for BCR Gene
Gene Families for BCR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for BCR Gene
Suggested Antigen Peptide Sequences for BCR Gene
Graphical View of Domain Structure for InterPro Entry
P11274UniProtKB/Swiss-Prot:
BCR_HUMAN :- The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
- Domain:
-
- The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
- The DH domain is involved in interaction with CCPG1.
Function for BCR Gene
Molecular function for BCR Gene
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- GENATLAS Biochemistry:
- breakpoint cluster region
Enzyme Numbers (IUBMB) for BCR Gene
Phenotypes From GWAS Catalog for BCR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005096 | GTPase activator activity | IEA,TAS | -- |
Phenotypes for BCR Gene
- MGI mutant phenotypes for BCR:
-
inferred from 2 alleles
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for BCR:
-
- Decreased substrate adherent cell growth
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased shRNA abundance (Z-score > 2)
- Increased cell death HMECs cells
- Increased circadian period length
- Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection
- Decreased viability
- Increased cell migration
- Decreased cell migration
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Transferrin accumulation in the perinuclear area
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for BCR Gene
- MGI Knock Outs for BCR:
-
- Bcr Bcr<tm1Hkp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCR
-
CRISPR Products
-
OriGene CRISPR knockouts for BCR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCR
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- Applied Biological Materials CRISPR for BCR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- GenScript: Design CRISPR guide RNA sequences for BCR
miRNA for BCR Gene
- miRTarBase miRNAs that target BCR
-
- hsa-mir-744-5p (MIRT037631)
- hsa-mir-10a-5p (MIRT047744)
- hsa-mir-197-3p (MIRT048049)
- hsa-mir-6781-5p (MIRT489907)
- hsa-mir-6877-5p (MIRT489908)
- hsa-mir-4743-5p (MIRT489909)
- hsa-mir-3202 (MIRT489910)
- hsa-mir-6853-5p (MIRT489911)
- hsa-mir-4768-3p (MIRT489912)
- hsa-mir-6125 (MIRT489913)
- hsa-mir-3141 (MIRT489914)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCR
- Browse OriGene Inhibitory RNA Products For BCR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCR
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
Clone Products
- Sino Biological Human cDNA Clone for BCR
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCR
- Applied Biological Materials Clones for BCR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Transcription Factor Targets and HOMER Transcription for BCR Gene
Localization for BCR Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCR Gene
- Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | ISS | -- |
Pathways & Interactions for BCR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | G-protein signaling M-RAS regulation pathway | ||
| 4 | Endometrial cancer | ||
| 5 | Pathways in cancer | ||
Pathways by source for BCR Gene
2 BioSystems pathways for BCR Gene
9 Reactome pathways for BCR Gene
1 PharmGKB pathway for BCR Gene
2 KEGG pathways for BCR Gene
6 GeneGo (Thomson Reuters) pathways for BCR Gene
1 Cell Signaling Technology pathway for BCR Gene
Interacting Proteins for BCR Gene
Selected Interacting proteins:
P11274-BCR_HUMAN
ENSP00000303507
for BCR Gene via
IID
MINT
UniProtKB
STRING
GPS-Prot Interaction Network for BCR
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002692 | negative regulation of cellular extravasation | IEA | -- |
| GO:0003014 | renal system process | IEA | -- |
| GO:0006468 | protein phosphorylation | TAS | 1657398 |
| GO:0007165 | signal transduction | TAS | 1657398 |
| GO:0007420 | brain development | IEA | -- |
Drugs & Compounds for BCR Gene
(62) Drugs for BCR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dasatinib | Approved, Investigational | Pharma | Inhibition, inhibitor, Target | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 295 | |
| Ponatinib | Approved, Investigational | Pharma | inhibitor, Target | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 36 | |
| imatinib | Approved | Pharma | inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| bosutinib | Approved | Pharma | Target, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| Busulfan | Approved, Investigational | Pharma | 569 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
(17) ApexBio Compounds for BCR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Adaphostin | P210bcr/abl tyrosine kinase inhibitor | 241127-58-2 |
| Bafetinib (INNO-406) | Bcr-Abl/Lyn tyrosine kinase inhibitor | 887650-05-7 |
| Bosutinib (SKI-606) | Potent Abl/Src kinases | 380843-75-4 |
| CHMFL-ABL-053 | BCR-ABL inhibitor | 1808287-83-3 |
| Dasatinib (BMS-354825) | Src and BCR-Abl inhibitor | 302962-49-8 |
| DCC-2036 (Rebastinib) | Bcr-Abl inhibitor | 1020172-07-9 |
| DPH | c-ABL activitor | 484049-04-9 |
| GNF 2 | Bcr-Abl inhibitor | 778270-11-4 |
| GNF 5 | Bcr-Abl inhibitor | 778277-15-9 |
| GNF-7 | 839706-07-9 | |
| GZD824 | Bcr-Abl inhibitor,novel orally bioavailable | 1421783-64-3 |
| Nilotinib monohydrochloride monohydrate | 923288-90-8 | |
| Nilotinib(AMN-107) | Bcr-Abl kinase inhibitor,selective | 641571-10-0 |
| ON 146040 | 1404231-34-0 | |
| PD 180970 | P210bcr/abl tyrosine kinase inhibitor | 287204-45-9 |
| PD173955 | Dual Src/Abl kinase inhibitor, ATP-competitive, | 260415-63-2 |
| Ponatinib (AP24534) | pan-BCR-ABL inhibitor,multi-kinase inhibitor | 943319-70-8 |
Transcripts for BCR Gene
mRNA/cDNA for BCR Gene
- (2) REFSEQ mRNAs :
- (57) Additional mRNA sequences :
- (127) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000305877 7082 bps (uc002zww.4)
- ENST00000359540 4708 bps (uc002zwx.4)
- ENST00000419722 788 bps (uc062cez.1)
- ENST00000427791 771 bps (uc062cew.1)
- ENST00000436990 4188 bps (uc062cfd.1)
Unigene Clusters for BCR Gene
CRISPR Products
-
OriGene CRISPR knockouts for BCR
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCR
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- Applied Biological Materials CRISPR for BCR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- GenScript: Design CRISPR guide RNA sequences for BCR
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCR
- Browse OriGene Inhibitory RNA Products For BCR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCR
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
Clone Products
- Sino Biological Human cDNA Clone for BCR
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCR
- Applied Biological Materials Clones for BCR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for BCR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Cervix (7.7), Placenta (7.2), and Frontal cortex (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BCR Gene:
BCRSOURCE GeneReport for Unigene cluster for BCR Gene:
Hs.517461Evidence on tissue expression from TISSUES for BCR Gene
- Nervous system(4.9)
- Blood(4.5)
- Liver(4.3)
- Bone marrow(3)
- Skin(2.4)
- Lung(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BCR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- bone marrow
- hair
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BCR
- genomics-online: primer clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BCR Gene
Orthologs for BCR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCR 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | BCR 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BCR 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bcr 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcr 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BCR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BCR 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | BCR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcr 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bcr 34 33 |
|
OneToMany | |
| BCR (1 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGAP1A 34 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BEM2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for BCR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for BCR Gene
- ENSEMBL:
- Gene Tree for BCR (if available)
- TreeFam:
- Gene Tree for BCR (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCR: view image
Paralogs for BCR Gene
Paralogs for BCR Gene
(11) SIMAP similar genes for BCR Gene using alignment to 13 proteins:
- BCR_HUMAN
- H0Y554_HUMAN
- Q12843_HUMAN
- Q12844_HUMAN
- Q12845_HUMAN
- Q5XJ20_HUMAN
- Q6QJE3_HUMAN
- Q6QJE4_HUMAN
- Q6QJE5_HUMAN
- Q6QJE6_HUMAN
- Q6QJE7_HUMAN
- Q6QJE8_HUMAN
- Q6QJE9_HUMAN
Pseudogenes.org Pseudogenes for BCR Gene
Variants for BCR Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs527236142 | not-provided, Chronic myeloid leukemia | 23,289,642(+) | G/T | intron_variant | |
| rs527236143 | not-provided, Chronic myeloid leukemia | 23,290,381(+) | T/A/C | coding_sequence_variant, missense_variant | |
| rs752530462 | not-provided, Chronic myeloid leukemia | 23,289,613(+) | A/G/T | coding_sequence_variant, missense_variant | |
| VAR_041883 | A bladder transitional cell carcinoma sample | p.Ser400Pro | |||
| rs879255379 | uncertain-significance, not specified | 23,311,830(+) | G/A | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
3.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.04;
68.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCR Gene
Disorders for BCR Gene
(29) MalaCards diseases for BCR Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukemia, chronic myeloid |
|
|
| leukemia, acute lymphoblastic 3 |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| myeloid leukemia |
|
|
| leukemia |
|
Search BCR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCR_HUMAN- Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. {ECO:0000269 PubMed:2407300, ECO:0000269 PubMed:3107980, ECO:0000269 PubMed:3540951}. Note=The gene represented in this entry is involved in disease pathogenesis.
- Note=A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). {ECO:0000269 PubMed:3107980, ECO:0000269 PubMed:7665185}.
Additional Disease Information for BCR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for BCR Gene
Publications for BCR Gene
- The BCR gene encodes a novel serine/threonine kinase activity within a single exon. (PMID: 1657398) Maru Y … Witte ON (Cell 1991) 2 3 4 22 58
- Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. (PMID: 15494376) Malmberg EK … Riordan JR (Journal of cell science 2004) 3 4 22 58
- BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. (PMID: 1712671) Pendergast AM … Witte ON (Cell 1991) 3 4 22 58
- Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. (PMID: 1900918) Shah NP … Denny CT (Molecular and cellular biology 1991) 3 4 22 58
- Bcr encodes a GTPase-activating protein for p21rac. (PMID: 1903516) Diekmann D … Hall A (Nature 1991) 3 4 22 58
Products for BCR Gene
- R&D Systems Antibodies for BCR (BCR)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for BCR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BCR
- Search Origene for MassSpec and Protein Over-expression Lysates for BCR
- Origene Custom Protein Services for BCR
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCR
- Browse OriGene Inhibitory RNA Products For BCR
- OriGene qPCR primer pairs for BCR
- OriGene CRISPR knockouts for BCR
- OriGene ORF clones in human for BCR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCR
- GenScript: Next-day shipping of latest version cDNA ORF clones for BCR in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BCR
- GenScript Custom Assay Services for BCR
- GenScript Custom overexpressing Cell Line Services for BCR
- GenScript: Design CRISPR guide RNA sequences for BCR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BCR
- Sino Biological Human cDNA Clone for BCR
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for BCR
- Novus Biologicals proteins and lysates for BCR
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for BCR
- ApexBio compounds for BCR
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCR
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- antibodies-online: Search results for 189 available BCR Antibodies ranked by validation data
- Compare Top BCR Antibodies
- Recommended
- 102 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 70 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 16 available BCR Elisa Kits ranked by validation data
- Compare Top BCR Elisa Kits
- antibodies-online: Search results for 7 available BCR Proteins ranked by validation data
- Compare Top BCR Proteins
- GeneTex BCR Antibody for BCR
- Search GeneTex for Proteins for BCR
- Santa Cruz Biotechnology (SCBT) Antibodies for BCR
- Search Santa Cruz Biotechnology (SCBT) for BCR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- Horizon Cell Lines for BCR
- genomics-online: cdna clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- orf clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: primer clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCR
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCR
- GeneCopoeia miRNA 3'UTR Target clone products for BCR
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCR
Sources for BCR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt