Aliases for BCR Gene
Aliases for BCR Gene
External Ids for BCR Gene
- HGNC: 1014
- Entrez Gene: 613
- Ensembl: ENSG00000186716
- OMIM: 151410
- UniProtKB: P11274
Previous HGNC Symbols for BCR Gene
- D22S11
- BCR1
Previous GeneCards Identifiers for BCR Gene
- GC22P020221
- GC22P021847
- GC22P021822
- GC22P023521
- GC22P006461
Summaries for BCR Gene
-
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCR Gene
BCR (BCR, RhoGEF And GTPase Activating Protein) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid and Leukemia, Acute Lymphoblastic 3. Among its related pathways are Chronic myeloid leukemia and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include protein tyrosine kinase activity and enzyme binding. An important paralog of this gene is ABR.
UniProtKB/Swiss-Prot for BCR Gene
-
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Additional gene information for BCR Gene
- Monarch Initiative
- Search for BCR at DataMed
- Search for BCR at HumanCyc
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for BCR Gene
Genomics for BCR Gene
GeneHancer (GH) Regulatory Elements for BCR Gene
Promoters and enhancers for BCR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BCR on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BCR gene promoter:
Regulatory Element Products
Genomic Locations for BCR Gene
Genomic Locations for BCR Gene
- chr22:23,179,704-23,318,037
- (GRCh38/hg38)
- Size:
- 138,334 bases
- Orientation:
- Plus strand
- chr22:23,521,891-23,660,224
- (GRCh37/hg19)
Genomic View for BCR Gene
Genes around BCR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Ensembl
- 22q11.23 by Entrez Gene
- 22q11.23 by HGNC
BCR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCR Gene
Proteins for BCR Gene
-
Protein details for BCR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11274-BCR_HUMAN
- Recommended name:
- Breakpoint cluster region protein
- Protein Accession:
- P11274
- P78501
- Q12842
- Q4LE80
- Q6NZI3
Protein attributes for BCR Gene
- Size:
- 1271 amino acids
- Molecular mass:
- 142819 Da
- Quaternary structure:
-
- Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. Interacts with SH2D5 (PubMed:25331951).
- SequenceCaution:
-
- Sequence=BAE06073.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for BCR Gene
Selected DME Specific Peptides for BCR Gene
- P11274:
-
- IRRLEQE
- GLEMRKWV
- RLEQEVN
Post-translational modifications for BCR Gene
- Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for BCR Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BCR (BCR)
- Novus Biologicals Antibodies for BCR
-
Abcam antibodies for BCR
-
Cloud-Clone Corp. Antibodies for BCR
- Invitrogen Antibodies for BCR
- antibodies-online: Search results for 189 available BCR Antibodies ranked by validation data
- Compare Top BCR Antibodies
-
Recommended
- 1 IHC (p) Antibody (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 70 WB Antibodies (anti-mouse)
- 1 RIA Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 8 IHC Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 102 WB Antibodies (anti-human)
- GeneTex BCR antibody for BCR
-
Santa Cruz Biotechnology (SCBT) Antibodies for BCR
Protein Products
-
OriGene Purified Proteins for BCR
- Search Origene for MassSpec and Protein Over-expression Lysates for BCR
- Origene Custom Protein Services for BCR
-
Cloud-Clone Corp. Proteins for BCR
- Search GeneTex for Proteins for BCR
-
Abcam proteins for BCR
Assay Products
Domains & Families for BCR Gene
Gene Families for BCR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for BCR Gene
Suggested Antigen Peptide Sequences for BCR Gene
Graphical View of Domain Structure for InterPro Entry
P11274UniProtKB/Swiss-Prot:
BCR_HUMAN :- The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
- Domain:
-
- The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
- The DH domain is involved in interaction with CCPG1.
Function for BCR Gene
Molecular function for BCR Gene
- GENATLAS Biochemistry:
- breakpoint cluster region
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
Enzyme Numbers (IUBMB) for BCR Gene
Phenotypes From GWAS Catalog for BCR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | TAS,IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | -- |
| GO:0005096 | GTPase activator activity | TAS | -- |
Phenotypes for BCR Gene
- MGI mutant phenotypes for BCR:
-
inferred from 2 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for BCR:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased cell migration
- Increased cell death HMECs cells
- Increased circadian period length
- Decreased substrate adherent cell growth
- Increased cell migration
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
Animal Models for BCR Gene
- MGI Knock Outs for BCR:
-
- Bcr tm1Hkp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BCR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCR gene
- Search ViGene Biosciences for BCR
CRISPR Products
-
OriGene CRISPR knockouts for BCR
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- Applied Biological Materials CRISPR for BCR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- GenScript: Design CRISPR guide RNA sequences for BCR
miRNA for BCR Gene
- miRTarBase miRNAs that target BCR
-
- hsa-mir-744-5p (MIRT037631)
- hsa-mir-10a-5p (MIRT047744)
- hsa-mir-197-3p (MIRT048049)
- hsa-mir-6781-5p (MIRT489907)
- hsa-mir-6877-5p (MIRT489908)
- hsa-mir-4743-5p (MIRT489909)
- hsa-mir-3202 (MIRT489910)
- hsa-mir-6853-5p (MIRT489911)
- hsa-mir-4768-3p (MIRT489912)
- hsa-mir-6125 (MIRT489913)
- hsa-mir-3141 (MIRT489914)
miRNA Products
- Search ViGene Biosciences for BCR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BCR
- Browse OriGene Inhibitory RNA Products For BCR
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCR gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- Applied Biological Materials Clones for BCR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for BCR
-
ViGene Biosciences adenoviral particle packaged cDNA for BCR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BCR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BCR gene
No data available for Transcription Factor Targets and HOMER Transcription for BCR Gene
Localization for BCR Gene
Subcellular locations from UniProtKB/Swiss-Prot for BCR Gene
- Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | ISS | -- |
Pathways & Interactions for BCR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | G-protein signaling TC21 regulation pathway | ||
| 4 | Chronic myeloid leukemia | ||
| 5 | Pathways in cancer | ||
Pathways by source for BCR Gene
2 BioSystems pathways for BCR Gene
9 Reactome pathways for BCR Gene
1 PharmGKB pathway for BCR Gene
2 KEGG pathways for BCR Gene
6 GeneGo (Thomson Reuters) pathways for BCR Gene
1 Cell Signaling Technology pathway for BCR Gene
Interacting Proteins for BCR Gene
Selected Interacting proteins:
P11274-BCR_HUMAN
ENSP00000303507
for BCR Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002692 | negative regulation of cellular extravasation | IEA | -- |
| GO:0003014 | renal system process | IEA | -- |
| GO:0006468 | protein phosphorylation | TAS | 1657398 |
| GO:0007165 | signal transduction | TAS | 1657398 |
| GO:0007420 | brain development | IEA | -- |
Drugs & Compounds for BCR Gene
(61) Drugs for BCR Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dasatinib | Approved, Investigational | Pharma | Target, Inhibition, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 295 | |
| ponatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 36 | |
| imatinib | Approved | Pharma | inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| bosutinib | Approved | Pharma | Target, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| Busulfan | Approved, Investigational | Pharma | 569 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(17) ApexBio Compounds for BCR Gene
| Compound | Action | Cas Number |
|---|---|---|
| Adaphostin | P210bcr/abl tyrosine kinase inhibitor | 241127-58-2 |
| Bafetinib (INNO-406) | Bcr-Abl/Lyn tyrosine kinase inhibitor | 887650-05-7 |
| Bosutinib (SKI-606) | Potent Abl/Src kinases | 380843-75-4 |
| CHMFL-ABL-053 | BCR-ABL inhibitor | 1808287-83-3 |
| Dasatinib (BMS-354825) | Src and BCR-Abl inhibitor | 302962-49-8 |
| DCC-2036 (Rebastinib) | Bcr-Abl inhibitor | 1020172-07-9 |
| DPH | c-ABL activitor | 484049-04-9 |
| GNF 2 | Bcr-Abl inhibitor | 778270-11-4 |
| GNF 5 | Bcr-Abl inhibitor | 778277-15-9 |
| GNF-7 | 839706-07-9 | |
| GZD824 | Bcr-Abl inhibitor,novel orally bioavailable | 1421783-64-3 |
| Nilotinib monohydrochloride monohydrate | 923288-90-8 | |
| Nilotinib(AMN-107) | Bcr-Abl kinase inhibitor,selective | 641571-10-0 |
| ON 146040 | 1404231-34-0 | |
| PD 180970 | P210bcr/abl tyrosine kinase inhibitor | 287204-45-9 |
| PD173955 | Dual Src/Abl kinase inhibitor, ATP-competitive, | 260415-63-2 |
| Ponatinib (AP24534) | pan-BCR-ABL inhibitor,multi-kinase inhibitor | 943319-70-8 |
Transcripts for BCR Gene
mRNA/cDNA for BCR Gene
- (2) REFSEQ mRNAs :
- (127) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for BCR
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- Applied Biological Materials CRISPR for BCR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- GenScript: Design CRISPR guide RNA sequences for BCR
miRNA Products
- Search ViGene Biosciences for BCR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BCR
- Browse OriGene Inhibitory RNA Products For BCR
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BCR gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- Applied Biological Materials Clones for BCR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for BCR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Cervix (7.7), Placenta (7.2), and Frontal cortex (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of BCR Gene:
BCRSOURCE GeneReport for Unigene cluster for BCR Gene:
Hs.517461Evidence on tissue expression from TISSUES for BCR Gene
- Nervous system(4.9)
- Blood(4.5)
- Liver(4.3)
- Bone marrow(3)
- Skin(2.4)
- Lung(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for BCR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- chin
- ear
- eye
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- outer ear
- skull
Thorax:
- aorta
- heart
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- bone marrow
- hair
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for BCR
- genomics-online: primer clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BCR Gene
Orthologs for BCR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCR 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | BCR 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BCR 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Bcr 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Bcr 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | BCR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | BCR 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | BCR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcr 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bcr 33 34 |
|
||
| BCR (1 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | RhoGAP1A 35 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BEM2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for BCR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for BCR Gene
Paralogs for BCR Gene
(11) SIMAP similar genes for BCR Gene using alignment to 13 proteins:
Pseudogenes.org Pseudogenes for BCR Gene
Variants for BCR Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs527236142 | not-provided, Chronic myeloid leukemia | 23,289,642(+) | G/T | intron_variant | |
| rs527236143 | not-provided, Chronic myeloid leukemia | 23,290,381(+) | T/A/C | coding_sequence_variant, missense_variant | |
| rs752530462 | not-provided, Chronic myeloid leukemia | 23,289,613(+) | A/G/T | coding_sequence_variant, missense_variant | |
| VAR_041883 | A bladder transitional cell carcinoma sample | p.Ser400Pro | |||
| rs879255379 | uncertain-significance, not specified | 23,311,830(+) | G/A | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
3.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.04;
68.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCR Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCR Gene
Disorders for BCR Gene
(31) MalaCards diseases for BCR Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukemia, chronic myeloid |
|
|
| leukemia, acute lymphoblastic 3 |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| philadelphia-negative chronic myeloid leukemia |
|
|
| myeloid leukemia |
|
Search BCR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCR_HUMAN- Leukemia, chronic myeloid (CML) [MIM:608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. {ECO:0000269 PubMed:2407300, ECO:0000269 PubMed:3107980, ECO:0000269 PubMed:3540951}. Note=The gene represented in this entry is involved in disease pathogenesis.
- Note=A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). {ECO:0000269 PubMed:3107980, ECO:0000269 PubMed:7665185}.
Additional Disease Information for BCR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for BCR Gene
Publications for BCR Gene
- The BCR gene encodes a novel serine/threonine kinase activity within a single exon. (PMID: 1657398) Maru Y … Witte ON (Cell 1991) 2 3 4 22 58
- Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. (PMID: 15494376) Malmberg EK … Riordan JR (Journal of cell science 2004) 3 4 22 58
- BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. (PMID: 1712671) Pendergast AM … Witte ON (Cell 1991) 3 4 22 58
- Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. (PMID: 1900918) Shah NP … Denny CT (Molecular and cellular biology 1991) 3 4 22 58
- Bcr encodes a GTPase-activating protein for p21rac. (PMID: 1903516) Diekmann D … Hall A (Nature 1991) 3 4 22 58
Products for BCR Gene
- R&D Systems Antibodies for BCR (BCR)
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- Custom Antibody ServicesOriGene Antibodies for BCR
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BCR
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCR
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BCR
- GenScript: Next-day shipping of latest version cDNA ORF clones for BCR in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BCR
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- GenScript: Design CRISPR guide RNA sequences for BCR
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagent
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- Novus Biologicals Antibodies for BCR
- Novus Biologicals lysates and proteins for BCR
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- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for BCR
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- Cloud-Clone Corp. Antibodies for BCR
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- Browse Assay Kits at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for BCR
- Cyagen custom Knockout/knockin (KOKI) mouse models for BCR
- VectorBuilder custom plasmid, inducible vectors for BCR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BCR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BCR
- antibodies-online: Search results for 189 available BCR Antibodies ranked by validation data
- Compare Top BCR Antibodies
- Recommended
- 102 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 PLA Antibody (anti-human)
- 1 RIA Antibody (anti-human)
- 70 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 16 available BCR Elisa Kits ranked by validation data
- Compare Top BCR Elisa Kits
- antibodies-online: Search results for 7 available BCR Proteins ranked by validation data
- Compare Top BCR Proteins
- GeneTex BCR antibody for BCR
- Search GeneTex for Proteins for BCR
- ViGene Biosciences adenoviral particle packaged cDNA for BCR gene
- ViGene Biosciences lentiviral particle packaged cDNA for BCR gene
- ViGene Biosciences ready-to-package AAV shRNAs for BCR gene
- Search ViGene Biosciences for BCR
- Santa Cruz Biotechnology (SCBT) Antibodies for BCR
- Search Santa Cruz Biotechnology (SCBT) for BCR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BCR
- Horizon Cell Lines for BCR
- genomics-online: cdna clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- orf clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: gRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: primer clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
- genomics-online: shRNA clones - Search results for 61 available BCR gene related products
- Overview of 61 available BCR gene related products
Sources for BCR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
- (123) CDC
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems