Aliases for BCR Gene
External Ids for BCR Gene
Previous HGNC Symbols for BCR Gene
Previous GeneCards Identifiers for BCR Gene
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCR Gene
BCR (BCR, RhoGEF And GTPase Activating Protein) is a Protein Coding gene. Diseases associated with BCR include Leukemia, Chronic Myeloid and Leukemia, Acute Lymphoblastic 3. Among its related pathways are Chronic myeloid leukemia and G-protein signaling_Regulation of RAC1 activity. Gene Ontology (GO) annotations related to this gene include protein tyrosine kinase activity and enzyme binding. An important paralog of this gene is ABR.
UniProtKB/Swiss-Prot for BCR Gene
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.