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Aliases for BCORL1 Gene

Aliases for BCORL1 Gene

  • BCL6 Corepressor Like 1 2 3 5
  • BCoR-Like Protein 1 3 4
  • BCoR-L1 3 4
  • Chromosome X Open Reading Frame 10 2
  • BCL-6 Corepressor-Like Protein 1 3
  • BCL6 Co-Repressor-Like 1 2
  • CXorf10 3

External Ids for BCORL1 Gene

Previous HGNC Symbols for BCORL1 Gene

  • CXorf10

Previous GeneCards Identifiers for BCORL1 Gene

  • GC0XP128842
  • GC0XP128944
  • GC0XP129115
  • GC0XP118537

Summaries for BCORL1 Gene

Entrez Gene Summary for BCORL1 Gene

  • The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for BCORL1 Gene

BCORL1 (BCL6 Corepressor Like 1) is a Protein Coding gene. Diseases associated with BCORL1 include Leukemia, Acute Myeloid. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma and Mesodermal Commitment Pathway. An important paralog of this gene is BCOR.

UniProtKB/Swiss-Prot for BCORL1 Gene

  • Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.

Additional gene information for BCORL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCORL1 Gene

Genomics for BCORL1 Gene

GeneHancer (GH) Regulatory Elements for BCORL1 Gene

Promoters and enhancers for BCORL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ129980 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 674.7 +2.2 2217 5.4 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF143 ZNF263 BCORL1 ZNF280C RBMX2 ELF4 FAM45BP PIR40748
GH0XJ129979 Enhancer 0.3 ENCODE 650.7 -0.9 -855 0.5 EZH2 BCORL1 GC0XM129961
GH0XJ130267 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 35.3 +288.0 287975 2.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF280C BCORL1 RBMX2 GC0XP130243
GH0XJ130164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.9 +185.5 185508 3.2 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 AIFM1 RAB33A BCORL1 UTP14A OCRL RBMX2 ELF4 ZNF280C
GH0XJ129770 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.4 -200.5 -200525 17.9 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 IRF4 TCF12 ZNF766 GATA2 ZNF207 SASH3 BCORL1 ZNF280C XPNPEP2 UTP14A SLC25A14 OCRL ELF4 ENSG00000240143 ZDHHC9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCORL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCORL1 gene promoter:
  • GATA-1
  • POU2F1
  • POU2F1a

Genomic Locations for BCORL1 Gene

Genomic Locations for BCORL1 Gene
77,801 bases
Plus strand
76,976 bases
Plus strand

Genomic View for BCORL1 Gene

Genes around BCORL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCORL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCORL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCORL1 Gene

Proteins for BCORL1 Gene

  • Protein details for BCORL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BCL-6 corepressor-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B5MDQ8
    • Q5H9F2
    • Q5H9F4
    • Q6ZVE0
    • Q8TEN3
    • Q9Y528

    Protein attributes for BCORL1 Gene

    1711 amino acids
    Molecular mass:
    182526 Da
    Quaternary structure:
    • Interacts with CTBP1. Interacts with HDAC4, HDAC5 and HDAC7. Interacts with PCGF1; the interaction is direct.
    • Sequence=BAC85922.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCORL1 Gene

    Alternative splice isoforms for BCORL1 Gene


neXtProt entry for BCORL1 Gene

Post-translational modifications for BCORL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCORL1 Gene

Domains & Families for BCORL1 Gene

Gene Families for BCORL1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for BCORL1 Gene

Suggested Antigen Peptide Sequences for BCORL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BCOR family.
  • Belongs to the BCOR family.
genes like me logo Genes that share domains with BCORL1: view

Function for BCORL1 Gene

Molecular function for BCORL1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.

Phenotypes From GWAS Catalog for BCORL1 Gene

genes like me logo Genes that share phenotypes with BCORL1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCORL1 Gene

Localization for BCORL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCORL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCORL1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BCORL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with BCORL1: view

Pathways & Interactions for BCORL1 Gene

genes like me logo Genes that share pathways with BCORL1: view

Pathways by source for BCORL1 Gene

Gene Ontology (GO) - Biological Process for BCORL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BCORL1: view

No data available for SIGNOR curated interactions for BCORL1 Gene

Drugs & Compounds for BCORL1 Gene

No Compound Related Data Available

Transcripts for BCORL1 Gene

Unigene Clusters for BCORL1 Gene

BCL6 corepressor-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCORL1 Gene

No ASD Table

Relevant External Links for BCORL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BCORL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCORL1 Gene

Protein differential expression in normal tissues from HIPED for BCORL1 Gene

This gene is overexpressed in Bone (41.5), Platelet (12.2), Fetal heart (9.0), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCORL1 Gene

Protein tissue co-expression partners for BCORL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BCORL1 Gene:


SOURCE GeneReport for Unigene cluster for BCORL1 Gene:


mRNA Expression by UniProt/SwissProt for BCORL1 Gene:

Tissue specificity: Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen.

Evidence on tissue expression from TISSUES for BCORL1 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with BCORL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCORL1 Gene

Orthologs for BCORL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BCORL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BCORL1 33
  • 91.09 (n)
(Canis familiaris)
Mammalia BCORL1 34 33
  • 90.61 (n)
(Bos Taurus)
Mammalia BCORL1 34 33
  • 88.65 (n)
(Rattus norvegicus)
Mammalia Bcorl1 33
  • 86.82 (n)
(Mus musculus)
Mammalia Bcorl1 16 34 33
  • 86.79 (n)
(Monodelphis domestica)
Mammalia BCORL1 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia BCORL1 34
  • 58 (a)
(Gallus gallus)
Aves BCORL1 34 33
  • 66.82 (n)
(Anolis carolinensis)
Reptilia BCORL1 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bcorl1 33
  • 55.83 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12934 33
(Danio rerio)
Actinopterygii CU459160.2 34
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14073 34
  • 12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOS4 34
  • 11 (a)
Species where no ortholog for BCORL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCORL1 Gene

Gene Tree for BCORL1 (if available)
Gene Tree for BCORL1 (if available)
Evolutionary constrained regions (ECRs) for BCORL1: view image

Paralogs for BCORL1 Gene

Paralogs for BCORL1 Gene

(5) SIMAP similar genes for BCORL1 Gene using alignment to 5 proteins:

  • H7C4B2_HUMAN
  • L8EB38_HUMAN
  • Q86YA6_HUMAN
genes like me logo Genes that share paralogs with BCORL1: view

Variants for BCORL1 Gene

Sequence variations from dbSNP and Humsavar for BCORL1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs398123004 uncertain-significance, Intellectual functioning disability 130,015,231(+) A/G coding_sequence_variant, missense_variant
VAR_037468 A breast cancer sample p.Gly832Asp
rs778386483 likely-benign, not specified 130,028,685(+) C/T coding_sequence_variant, missense_variant
rs1057521222 uncertain-significance, not specified 130,055,925(+) G/A coding_sequence_variant, missense_variant
rs1057521638 uncertain-significance, not specified 130,014,259(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for BCORL1 Gene

Variant ID Type Subtype PubMed ID
esv3574556 CNV loss 25503493
nsv528290 CNV gain 19592680
nsv7090 CNV deletion 18451855

Variation tolerance for BCORL1 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCORL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCORL1 Gene

Disorders for BCORL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCORL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • aml
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for BCORL1

genes like me logo Genes that share disorders with BCORL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCORL1 Gene

Publications for BCORL1 Gene

  1. Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. (PMID: 23523425) Junco SE … Kim CA (Structure (London, England : 1993) 2013) 3 4 58
  2. A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. (PMID: 17379597) Pagan JK … Khanna KK (The Journal of biological chemistry 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for BCORL1 Gene

Sources for BCORL1 Gene

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