This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [pro... See more...

Aliases for BCL7C Gene

Aliases for BCL7C Gene

  • BAF Chromatin Remodeling Complex Subunit BCL7C 2 3 5
  • B-Cell CLL/Lymphoma 7 Protein Family Member C 3 4
  • BCL7C, BAF Complex Component 2 3
  • BCL Tumor Suppressor 7C 2 3
  • B-Cell CLL/Lymphoma 7C 2 3

External Ids for BCL7C Gene

Previous GeneCards Identifiers for BCL7C Gene

  • GC16P9B0085
  • GC16M031396
  • GC16M030896
  • GC16M030935
  • GC16M030806
  • GC16M030847

Summaries for BCL7C Gene

Entrez Gene Summary for BCL7C Gene

  • This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for BCL7C Gene

BCL7C (BAF Chromatin Remodeling Complex Subunit BCL7C) is a Protein Coding gene. Diseases associated with BCL7C include Lymphoma and Burkitt Lymphoma. An important paralog of this gene is BCL7B.

UniProtKB/Swiss-Prot Summary for BCL7C Gene

Additional gene information for BCL7C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL7C Gene

Genomics for BCL7C Gene

GeneHancer (GH) Regulatory Elements for BCL7C Gene

Promoters and enhancers for BCL7C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL7C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL7C

Top Transcription factor binding sites by QIAGEN in the BCL7C gene promoter:
  • ARP-1
  • CUTL1
  • NF-kappaB
  • NF-kappaB1
  • p53
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for BCL7C Gene

Genomic Locations for BCL7C Gene
chr16:30,833,626-30,894,960
(GRCh38/hg38)
Size:
61,335 bases
Orientation:
Minus strand
chr16:30,844,947-30,906,281
(GRCh37/hg19)
Size:
61,335 bases
Orientation:
Minus strand

Genomic View for BCL7C Gene

Genes around BCL7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL7C Gene

Proteins for BCL7C Gene

  • Protein details for BCL7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUZ0-BCL7C_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member C
    Protein Accession:
    Q8WUZ0
    Secondary Accessions:
    • O43770
    • Q6PD89

    Protein attributes for BCL7C Gene

    Size:
    217 amino acids
    Molecular mass:
    23468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL7C Gene

Post-translational modifications for BCL7C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BCL7C Gene

Domains & Families for BCL7C Gene

Gene Families for BCL7C Gene

Protein Domains for BCL7C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL7C Gene

GenScript: Design optimal peptide antigens:
  • B-cell CLL/lymphoma 7 protein family member C (BCL7C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WUZ0

UniProtKB/Swiss-Prot:

BCL7C_HUMAN :
  • Belongs to the BCL7 family.
Family:
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7C: view

Function for BCL7C Gene

Molecular function for BCL7C Gene

UniProtKB/Swiss-Prot Function:
May play an anti-apoptotic role.
GENATLAS Biochemistry:
putative F-actin cross-linking protein 12,homolog,BCL7A family

Phenotypes From GWAS Catalog for BCL7C Gene

genes like me logo Genes that share phenotypes with BCL7C: view

Animal Model Products

CRISPR Products

miRNA for BCL7C Gene

miRTarBase miRNAs that target BCL7C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL7C Gene

Localization for BCL7C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL7C gene
Compartment Confidence
nucleus 4
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BCL7C Gene

Pathways & Interactions for BCL7C Gene

PathCards logo

SuperPathways for BCL7C Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with BCL7C: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7C Gene

Drugs & Compounds for BCL7C Gene

No Compound Related Data Available

Transcripts for BCL7C Gene

mRNA/cDNA for BCL7C Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7C Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for BCL7C Gene

GeneLoc Exon Structure for
BCL7C

Expression for BCL7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL7C Gene

Protein differential expression in normal tissues from HIPED for BCL7C Gene

This gene is overexpressed in Nasal epithelium (33.9), Blymphocyte (10.2), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL7C Gene



Protein tissue co-expression partners for BCL7C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL7C

SOURCE GeneReport for Unigene cluster for BCL7C Gene:

Hs.658547

mRNA Expression by UniProt/SwissProt for BCL7C Gene:

Q8WUZ0-BCL7C_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for BCL7C Gene

  • Muscle(4.2)
  • Liver(4.1)
  • Pancreas(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with BCL7C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL7C Gene

Orthologs for BCL7C Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BCL7C 31 30
  • 94.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BCL7C 31 30
  • 92.17 (n)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCL7C 31 30
  • 92.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl7c 17 31 30
  • 90.32 (n)
rat
(Rattus norvegicus)
Mammalia Bcl7c 30
  • 90.17 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL7C 31
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL7C 31
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL7C 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158618 30
  • 58.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 31
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.1 31
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for BCL7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BCL7C Gene

ENSEMBL:
Gene Tree for BCL7C (if available)
TreeFam:
Gene Tree for BCL7C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL7C: view image

Paralogs for BCL7C Gene

Paralogs for BCL7C Gene

(3) SIMAP similar genes for BCL7C Gene using alignment to 3 proteins:

  • BCL7C_HUMAN
  • I3L1Q2_HUMAN
  • I3L4D5_HUMAN
genes like me logo Genes that share paralogs with BCL7C: view

Variants for BCL7C Gene

Additional dbSNP identifiers (rs#s) for BCL7C Gene

Structural Variations from Database of Genomic Variants (DGV) for BCL7C Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
esv28742 CNV loss 19812545
nsv1060384 CNV gain 25217958
nsv1113781 CNV deletion 24896259
nsv457483 CNV loss 19166990
nsv507813 OTHER sequence alteration 20534489
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for BCL7C Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL7C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL7C Gene

Disorders for BCL7C Gene

MalaCards: The human disease database

(3) MalaCards diseases for BCL7C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
burkitt lymphoma
  • bl
capgras syndrome
  • capgras delusion theory
- elite association - COSMIC cancer census association via MalaCards
Search BCL7C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BCL7C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BCL7C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL7C Gene

Publications for BCL7C Gene

  1. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel DM … Dyer MJ (Gene 1998) 2 3 4 23 54
  2. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (PMID: 23644491) Kadoch C … Crabtree GR (Nature genetics 2013) 2 3 54
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41 54
  4. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 41 54
  5. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang XS … Goldin LR (British journal of haematology 2009) 3 41 54

Products for BCL7C Gene

Sources for BCL7C Gene