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Aliases for BCL7B Gene

Aliases for BCL7B Gene

  • BCL Tumor Suppressor 7B 2 3 5
  • B-Cell CLL/Lymphoma 7B 2
  • Allergen Hom S 3 4

External Ids for BCL7B Gene

Previous GeneCards Identifiers for BCL7B Gene

  • GC07M071591
  • GC07M072348
  • GC07M072362
  • GC07M072395
  • GC07M072588
  • GC07M072950
  • GC07M068832

Summaries for BCL7B Gene

Entrez Gene Summary for BCL7B Gene

  • This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for BCL7B Gene

BCL7B (BCL Tumor Suppressor 7B) is a Protein Coding gene. Diseases associated with BCL7B include Lymphoma and Dermatitis. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is BCL7C.

UniProtKB/Swiss-Prot for BCL7B Gene

  • Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).

Additional gene information for BCL7B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL7B Gene

Genomics for BCL7B Gene

GeneHancer (GH) Regulatory Elements for BCL7B Gene

Promoters and enhancers for BCL7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I073555 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.9 +1.0 1013 3.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B YY1 BCL7B MLXIPL POM121 POM121B MIR590 TBL2 NSUN5P2 STAG3L3 ELN-AS1 BAZ1B
GH07I073575 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15 -19.8 -19832 4 HDGF SMAD1 ATF1 SIN3A ZNF48 YY1 ZNF280A ZNF121 POLR2B ZNF766 TBL2 MLXIPL BCL7B POM121B RFC2 NSUN5P2 POM121 ABHD11-AS1 GC07M073571 PIR55446
GH07I073518 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.1 +37.0 36982 4.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 BAZ1B TBL2 POM121B STAG3L3 POM121 FKBP6 MIR590 BUD23 MLXIPL NSUN5P2
GH07I073622 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.9 -65.8 -65837 2.6 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B MLXIPL BCL7B ENSG00000274080 GC07P073590
GH07I073433 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.9 +124.2 124221 1.2 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B GLIS2 ZNF143 KLF7 FZD9 STAG3L3 NSUN5P2 POM121B PMS2P7 POM121 TBL2 BCL7B MIR590 METTL27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BCL7B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL7B gene promoter:

Genomic Locations for BCL7B Gene

Genomic Locations for BCL7B Gene
chr7:73,536,353-73,558,002
(GRCh38/hg38)
Size:
21,650 bases
Orientation:
Minus strand
chr7:72,950,683-72,972,332
(GRCh37/hg19)

Genomic View for BCL7B Gene

Genes around BCL7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL7B Gene

Proteins for BCL7B Gene

  • Protein details for BCL7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE9-BCL7B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member B
    Protein Accession:
    Q9BQE9
    Secondary Accessions:
    • A8K226
    • C9JWD3
    • D3DXF0
    • O43769
    • Q13845
    • Q6ZW75

    Protein attributes for BCL7B Gene

    Size:
    202 amino acids
    Molecular mass:
    22195 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL7B Gene

Post-translational modifications for BCL7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL7B Gene

No data available for DME Specific Peptides for BCL7B Gene

Domains & Families for BCL7B Gene

Gene Families for BCL7B Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BCL7B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQE9

UniProtKB/Swiss-Prot:

BCL7B_HUMAN :
  • Belongs to the BCL7 family.
Family:
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7B: view

Function for BCL7B Gene

Molecular function for BCL7B Gene

GENATLAS Biochemistry:
putative F-actin cross linking protein 12 homolog,BCL7A family,involved in cellular and developmental functions,highly expressed in heart,skeletal muscle and fetal liver,located in the commonly Williams region,atopy-related IgE autoantigen,detected in the serum of patients with severe atopic dermatitis,not rearranged in lymphoid malignancies
UniProtKB/Swiss-Prot Function:
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).

Phenotypes From GWAS Catalog for BCL7B Gene

Gene Ontology (GO) - Molecular Function for BCL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 8605326
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with BCL7B: view
genes like me logo Genes that share phenotypes with BCL7B: view

Animal Model Products

CRISPR Products

miRNA for BCL7B Gene

miRTarBase miRNAs that target BCL7B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BCL7B Gene

Localization for BCL7B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL7B gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BCL7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL7B Gene

Pathways & Interactions for BCL7B Gene

SuperPathways for BCL7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008150 biological_process ND --
GO:0016055 Wnt signaling pathway IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with BCL7B: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7B Gene

Drugs & Compounds for BCL7B Gene

No Compound Related Data Available

Transcripts for BCL7B Gene

Unigene Clusters for BCL7B Gene

B-cell CLL/lymphoma 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h · 8i
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - - -
SP10: -

Relevant External Links for BCL7B Gene

GeneLoc Exon Structure for
BCL7B
ECgene alternative splicing isoforms for
BCL7B

Expression for BCL7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL7B Gene

This gene is overexpressed in Blymphocyte (21.4), Monocytes (15.6), Retina (10.2), CD8 Tcells (8.9), and CD4 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BCL7B Gene



Protein tissue co-expression partners for BCL7B Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL7B Gene:

BCL7B

SOURCE GeneReport for Unigene cluster for BCL7B Gene:

Hs.647051

mRNA Expression by UniProt/SwissProt for BCL7B Gene:

Q9BQE9-BCL7B_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for BCL7B Gene

  • Nervous system(4.6)
  • Muscle(4.5)
  • Liver(4.3)
  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with BCL7B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL7B Gene

Orthologs for BCL7B Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL7B 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia BCL7B 33 34
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia BCL7B 33 34
  • 93.07 (n)
mouse
(Mus musculus)
Mammalia Bcl7b 33 16 34
  • 88.45 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL7B 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL7B 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCL7B 33 34
  • 78.88 (n)
lizard
(Anolis carolinensis)
Reptilia BCL7B 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl7b 33
  • 69.1 (n)
zebrafish
(Danio rerio)
Actinopterygii bcl7ba 33 34
  • 65.64 (n)
bcl7bb 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BCL7-like 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for BCL7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCL7B Gene

ENSEMBL:
Gene Tree for BCL7B (if available)
TreeFam:
Gene Tree for BCL7B (if available)

Paralogs for BCL7B Gene

Paralogs for BCL7B Gene

(2) SIMAP similar genes for BCL7B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BCL7B: view

Variants for BCL7B Gene

Sequence variations from dbSNP and Humsavar for BCL7B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000041237 -- 73,538,535(-) C/A/T intron_variant
rs1000043837 -- 73,549,623(-) G/C intron_variant
rs1000115740 -- 73,537,091(-) C/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1001055730 -- 73,556,576(-) T/C intron_variant
rs1001087004 -- 73,556,778(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL7B Gene

Variant ID Type Subtype PubMed ID
dgv6467n100 CNV gain 25217958
nsv1023520 CNV gain 25217958
nsv831028 CNV loss 17160897

Variation tolerance for BCL7B Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL7B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7B Gene

Disorders for BCL7B Gene

MalaCards: The human disease database

(4) MalaCards diseases for BCL7B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
dermatitis
  • eczema
burkitt lymphoma
  • bl
williams-beuren syndrome
  • wbs
- elite association - COSMIC cancer census association via MalaCards
Search BCL7B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BCL7B_HUMAN
  • Note=BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. {ECO:0000269 PubMed:9860302, ECO:0000269 PubMed:9931421}.

Additional Disease Information for BCL7B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BCL7B: view

No data available for Genatlas for BCL7B Gene

Publications for BCL7B Gene

  1. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. (PMID: 9806765) Natter S … Valenta R (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998) 2 3 4 58
  2. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel DM … Dyer MJ (Gene 1998) 3 4 22 58
  3. Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani VJ … Dyer MJ (Blood 1996) 2 3 4 58
  4. The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway. (PMID: 25569233) Uehara T … Mitani S (PLoS genetics 2015) 3 4 58
  5. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. (PMID: 21300955) Dehghan A … Chasman DI (Circulation 2011) 3 44 58

Products for BCL7B Gene

Sources for BCL7B Gene

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