External Ids for BCL7B Gene
Previous GeneCards Identifiers for BCL7B Gene
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for BCL7B Gene
BCL7B (BCL Tumor Suppressor 7B) is a Protein Coding gene. Diseases associated with BCL7B include Lymphoma and Dermatitis. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is BCL7C.
UniProtKB/Swiss-Prot for BCL7B Gene
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity).