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This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes ... See more...
Aliases for BCL7A Gene
Aliases for BCL7A Gene
External Ids for BCL7A Gene
- HGNC: 1004
- Entrez Gene: 605
- Ensembl: ENSG00000110987
- OMIM: 601406
- UniProtKB: Q4VC05
Previous HGNC Symbols for BCL7A Gene
- BCL7
Previous GeneCards Identifiers for BCL7A Gene
- GC12M120913
- GC12P121880
- GC12P122228
- GC12P120857
- GC12P120921
- GC12P122459
- GC12P119470
Summaries for BCL7A Gene
-
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL7A Gene
BCL7A (BAF Chromatin Remodeling Complex Subunit BCL7A) is a Protein Coding gene. Diseases associated with BCL7A include Lymphoma and B-Cell Non-Hodgkin Lymphoma. An important paralog of this gene is BCL7C.
Additional gene information for BCL7A Gene
- Monarch Initiative
- Search for BCL7A at DataMed
- Search for BCL7A at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL7A Gene
Genomics for BCL7A Gene
GeneHancer (GH) Regulatory Elements for BCL7A Gene
Promoters and enhancers for BCL7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL7A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BCL7A gene promoter:
-
- c-Myb
- E47
- FOXO1
- FOXO1a
- GATA-2
- MIF-1
- Pax-3
- Pax-5
- PPAR-alpha
Genomic Locations for BCL7A Gene
Genomic Locations for BCL7A Gene
- chr12:122,019,422-122,062,044
- (GRCh38/hg38)
- Size:
- 42,623 bases
- Orientation:
- Plus strand
- chr12:122,457,328-122,499,950
- (GRCh37/hg19)
- Size:
- 42,623 bases
- Orientation:
- Plus strand
Genomic View for BCL7A Gene
Genes around BCL7A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
BCL7A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL7A Gene
Proteins for BCL7A Gene
-
Protein details for BCL7A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4VC05-BCL7A_HUMAN
- Recommended name:
- B-cell CLL/lymphoma 7 protein family member A
- Protein Accession:
- Q4VC05
- B4DJN6
- B7ZB21
- Q13843
- Q14CT7
Protein attributes for BCL7A Gene
- Size:
- 210 amino acids
- Molecular mass:
- 22810 Da
- Quaternary structure:
- No Data Available
Protein Expression for BCL7A Gene
Post-translational modifications for BCL7A Gene
Other Protein References for BCL7A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ BCL7A Antibody
- Atlas Antibodies Anti-BCL7A Antibody
- Creative Diagnostics Anti-BCL7A monoclonal antibody and Rabbit anti-Human Bcl 7A polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for BCL7A
- Novus Biologicals Antibodies for BCL7A
-
Abcam antibodies for BCL7A
- Invitrogen Antibodies for BCL7A (AFLGC-BCL7A)
-
Biorbyt antibodies for BCL7A
Protein Products
- Atlas Antibodies PrEST Antigen BCL7A
-
OriGene Purified Proteins for BCL7A
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL7A
- Origene Custom Protein Services for BCL7A
- ProSpec Recombinant Proteins for BCL7A
- antibodies-online: Show 11 available BCL7A Proteins ranked by validation data
- Compare Top BCL7A Proteins
-
Quality Products:
-
Abcam proteins for BCL7A
No data available for DME Specific Peptides for BCL7A Gene
Domains & Families for BCL7A Gene
Gene Families for BCL7A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for BCL7A Gene
- GenScript: Design optimal peptide antigens:
-
- B-cell CLL/lymphoma 7 protein family member A (BCL7A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4VC05- Family:
-
- Belongs to the BCL7 family.
Function for BCL7A Gene
Molecular function for BCL7A Gene
- GENATLAS Biochemistry:
- putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cell line with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)
Phenotypes From GWAS Catalog for BCL7A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for BCL7A Gene
- MGI mutant phenotypes for BCL7A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for BCL7A:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability after Maraba virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Models for BCL7A Gene
- MGI Knock Outs for BCL7A:
-
- Bcl7a Bcl7a<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for BCL7A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL7A
- genomics-online: gRNA clones - Search results for available BCL7A gene related products
- Applied Biological Materials (abm): CRISPR Clones for BCL7A - Select products 50% OFF >
- * BCL7A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * BCL7A CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL7A
miRNA for BCL7A Gene
- miRTarBase miRNAs that target BCL7A
-
- hsa-let-7b-5p (MIRT002399)
- hsa-mir-29a-3p (MIRT006552)
- hsa-mir-335-5p (MIRT017268)
- hsa-mir-24-3p (MIRT050374)
- hsa-mir-203a-3p (MIRT053446)
- hsa-mir-507 (MIRT062777)
- hsa-mir-557 (MIRT062779)
- hsa-mir-21-5p (MIRT062806)
- hsa-mir-4447 (MIRT062813)
- hsa-mir-4472 (MIRT062814)
- hsa-mir-3976 (MIRT062815)
- hsa-mir-6795-5p (MIRT062822)
- hsa-mir-6887-5p (MIRT062823)
- hsa-mir-7109-5p (MIRT062824)
- hsa-mir-129-5p (MIRT062826)
- hsa-mir-1290 (MIRT062830)
- hsa-mir-1252-5p (MIRT062831)
- hsa-mir-4533 (MIRT062833)
- hsa-mir-4747-5p (MIRT062834)
- hsa-mir-5196-5p (MIRT062836)
- hsa-mir-6828-5p (MIRT062837)
- hsa-mir-6516-5p (MIRT062838)
- hsa-mir-9500 (MIRT062839)
- hsa-mir-15a-5p (MIRT133334)
- hsa-mir-16-5p (MIRT133335)
- hsa-mir-15b-5p (MIRT133337)
- hsa-mir-195-5p (MIRT133339)
- hsa-mir-19a-3p (MIRT133376)
- hsa-mir-19b-3p (MIRT133377)
- hsa-mir-3125 (MIRT241705)
- hsa-mir-3916 (MIRT241706)
- hsa-mir-6758-5p (MIRT241708)
- hsa-mir-6856-5p (MIRT241709)
- hsa-mir-6859-5p (MIRT241710)
- hsa-mir-6748-5p (MIRT270621)
- hsa-mir-6803-5p (MIRT494517)
- hsa-mir-6769b-5p (MIRT494518)
- hsa-mir-6769a-5p (MIRT494519)
- hsa-mir-92a-2-5p (MIRT494520)
- hsa-mir-4483 (MIRT494521)
- hsa-mir-1293 (MIRT494522)
- hsa-mir-6756-5p (MIRT494523)
- hsa-mir-6766-5p (MIRT494524)
- hsa-mir-6745 (MIRT494525)
- hsa-mir-363-5p (MIRT494526)
- hsa-mir-6885-5p (MIRT494527)
- hsa-mir-328-5p (MIRT494528)
- hsa-mir-486-3p (MIRT494529)
- hsa-mir-885-3p (MIRT494530)
- hsa-mir-151b (MIRT494531)
- hsa-mir-151a-5p (MIRT494532)
- hsa-mir-611 (MIRT494533)
- hsa-mir-3131 (MIRT494534)
- hsa-mir-6848-5p (MIRT538969)
- hsa-mir-6846-5p (MIRT538970)
- hsa-mir-4697-5p (MIRT538971)
- hsa-mir-4488 (MIRT538972)
- hsa-mir-1237-5p (MIRT538973)
- hsa-mir-1251-3p (MIRT538974)
- hsa-mir-3158-3p (MIRT538975)
- hsa-mir-3680-3p (MIRT562616)
- hsa-mir-450b-5p (MIRT562617)
- hsa-mir-7113-5p (MIRT562618)
- hsa-mir-455-3p (MIRT562619)
- hsa-mir-4446-5p (MIRT615106)
- hsa-mir-5006-3p (MIRT615107)
- hsa-mir-4755-5p (MIRT615108)
- hsa-mir-623 (MIRT615109)
- hsa-mir-1273g-5p (MIRT615110)
- hsa-mir-203a-5p (MIRT615111)
- hsa-mir-205-3p (MIRT615112)
- hsa-mir-211-5p (MIRT615113)
- hsa-mir-204-5p (MIRT615114)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for BCL7A
- Browse OriGene Inhibitory RNA Products For BCL7A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A
- genomics-online: shRNA clones - Search results for available BCL7A gene related products
Clone Products
-
- MG200442
- MG202275
- MR200442
- MR200442L3
- MR200442L3V
- MR200442L4
- MR200442L4V
- MR202275
- MR202275L3
- MR202275L3V
- MR202275L4
- MR202275L4V
- RC210489
- RC210489L1
- RC210489L1V
- RC210489L2
- RC210489L2V
- RC210489L3
- RC210489L3V
- RC210489L4
- RC210489L4V
- RC223737
- RC223737L3
- RC223737L3V
- RC223737L4
- RC223737L4V
- RG210489
- RG223737
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL7A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL7A
- genomics-online: cdna clones - Search results for available BCL7A gene related products
- orf clones - Search results for available BCL7A gene related products
- Applied Biological Materials (abm): Clones for BCL7A - Select products 50% OFF >
- * BCL7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * BCL7A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for BCL7A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL7A Gene
Localization for BCL7A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| mitochondrion | 1 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL7A Gene
Pathways & Interactions for BCL7A Gene
Interacting Proteins for BCL7A Gene
Selected Interacting proteins:
Q4VC05-BCL7A_HUMAN
ENSP00000445868
for BCL7A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BCL7A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-templated | NAS | 15897551 |
No data available for Pathways by source and SIGNOR curated interactions for BCL7A Gene
Drugs & Compounds for BCL7A Gene
No Compound Related Data Available
Transcripts for BCL7A Gene
mRNA/cDNA for BCL7A Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (140) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000538010 6247 bps (ENST00000538010.5)
- ENST00000261822 2581 bps (ENST00000261822.4)
- ENST00000432926 871 bps (ENST00000432926.2)
CRISPR Products
-
OriGene CRISPR knockouts for BCL7A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL7A
- genomics-online: gRNA clones - Search results for available BCL7A gene related products
- Applied Biological Materials (abm): CRISPR Clones for BCL7A - Select products 50% OFF >
- * BCL7A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * BCL7A CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL7A
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for BCL7A
- Browse OriGene Inhibitory RNA Products For BCL7A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A
- genomics-online: shRNA clones - Search results for available BCL7A gene related products
Clone Products
-
- MG200442
- MG202275
- MR200442
- MR200442L3
- MR200442L3V
- MR200442L4
- MR200442L4V
- MR202275
- MR202275L3
- MR202275L3V
- MR202275L4
- MR202275L4V
- RC210489
- RC210489L1
- RC210489L1V
- RC210489L2
- RC210489L2V
- RC210489L3
- RC210489L3V
- RC210489L4
- RC210489L4V
- RC223737
- RC223737L3
- RC223737L3V
- RC223737L4
- RC223737L4V
- RG210489
- RG223737
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL7A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL7A
- genomics-online: cdna clones - Search results for available BCL7A gene related products
- orf clones - Search results for available BCL7A gene related products
- Applied Biological Materials (abm): Clones for BCL7A - Select products 50% OFF >
- * BCL7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * BCL7A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for BCL7A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
This gene is overexpressed in Blymphocyte (45.8), Fetal gut (7.9), and Islet of Langerhans (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL7A Gene
NURSA nuclear receptor signaling pathways regulating expression of BCL7A Gene:
BCL7ASOURCE GeneReport for Unigene cluster for BCL7A Gene:
Hs.530970Evidence on tissue expression from TISSUES for BCL7A Gene
- Nervous system(4.5)
- Kidney(4.2)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for BCL7A
-
OriGene qPCR primer pairs and template standards for BCL7A
- genomics-online: primer clones - Search results for available BCL7A gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL7A Gene
Orthologs for BCL7A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BCL7A 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | BCL7A 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Bcl7a 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC690085 32 |
|
||
| cow (Bos Taurus) |
Mammalia | BCL7A 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | BCL7A 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | BCL7A 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | gga-mir-762 33 |
|
OneToOne | |
| BCL7A 32 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | BCL7A 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | bcl7a 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | bcl7a 33 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | BCL7-like 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C28H8.1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for BCL7A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for BCL7A Gene
- ENSEMBL:
- Gene Tree for BCL7A (if available)
- TreeFam:
- Gene Tree for BCL7A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL7A: view image
Paralogs for BCL7A Gene
Variants for BCL7A Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006509 | -- | 122,052,488(+) | A/C | intron_variant | |
| rs1000062603 | -- | 122,058,385(+) | A/T | intron_variant | |
| rs1000331779 | -- | 122,043,255(+) | T/A | intron_variant | |
| rs1000378812 | -- | 122,043,493(+) | C/T | intron_variant | |
| rs1000463367 | -- | 122,037,643(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676551 | CNV | deletion | 23128226 |
| esv3630966 | CNV | loss | 21293372 |
| nsv1070557 | CNV | deletion | 25765185 |
| nsv1112622 | CNV | deletion | 24896259 |
| nsv472490 | CNV | novel sequence insertion | 20440878 |
| nsv473807 | CNV | novel sequence insertion | 20440878 |
| nsv473912 | CNV | novel sequence insertion | 20440878 |
| nsv473975 | CNV | novel sequence insertion | 20440878 |
| nsv475357 | CNV | novel sequence insertion | 20440878 |
| nsv475750 | CNV | novel sequence insertion | 20440878 |
| nsv478278 | CNV | novel sequence insertion | 20440878 |
| nsv479148 | CNV | novel sequence insertion | 20440878 |
| nsv479488 | CNV | novel sequence insertion | 20440878 |
| nsv479754 | CNV | novel sequence insertion | 20440878 |
| nsv479770 | CNV | novel sequence insertion | 20440878 |
| nsv479804 | CNV | novel sequence insertion | 20440878 |
| nsv480041 | CNV | novel sequence insertion | 20440878 |
| nsv480071 | CNV | novel sequence insertion | 20440878 |
| nsv480129 | CNV | novel sequence insertion | 20440878 |
| nsv480167 | CNV | novel sequence insertion | 20440878 |
| nsv480235 | CNV | novel sequence insertion | 20440878 |
| nsv480649 | CNV | novel sequence insertion | 20440878 |
| nsv480742 | CNV | novel sequence insertion | 20440878 |
| nsv481123 | CNV | novel sequence insertion | 20440878 |
| nsv481247 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL7A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCL7A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7A Gene
Disorders for BCL7A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma |
|
|
| b-cell non-hodgkin lymphoma |
|
|
| burkitt lymphoma |
|
|
Search BCL7A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCL7A_HUMAN- Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. {ECO:0000269 PubMed:8605326}.
Additional Disease Information for BCL7A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for BCL7A Gene
Publications for BCL7A Gene
- Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani VJ … Dyer MJ (Blood 1996) 2 3 4 23 56
- Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 43 56
- The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel DM … Dyer MJ (Gene 1998) 2 3 23 56
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (PMID: 23644491) Kadoch C … Crabtree GR (Nature genetics 2013) 2 3 56
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 43 56
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Sources for BCL7A Gene
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