BCL7A Gene (Protein Coding)

BAF Chromatin Remodeling Complex Subunit BCL7A

GC12P122019
GIFtS:
37
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes ... See more...

Aliases for BCL7A Gene

Aliases for BCL7A Gene

  • BAF Chromatin Remodeling Complex Subunit BCL7A 2 3 5
  • B-Cell CLL/Lymphoma 7 Protein Family Member A 3 4
  • BCL7A, BAF Complex Component 2 3
  • BCL Tumor Suppressor 7A 2 3
  • B-Cell CLL/Lymphoma 7A 2 3
  • B-Cell CLL/Lymphoma-7 3
  • BCL7A 5
  • BCL7 3

External Ids for BCL7A Gene

Previous HGNC Symbols for BCL7A Gene

  • BCL7

Previous GeneCards Identifiers for BCL7A Gene

  • GC12M120913
  • GC12P121880
  • GC12P122228
  • GC12P120857
  • GC12P120921
  • GC12P122459
  • GC12P119470

Summaries for BCL7A Gene

Entrez Gene Summary for BCL7A Gene

  • This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL7A Gene

BCL7A (BAF Chromatin Remodeling Complex Subunit BCL7A) is a Protein Coding gene. Diseases associated with BCL7A include Lymphoma and B-Cell Non-Hodgkin Lymphoma. An important paralog of this gene is BCL7C.

Additional gene information for BCL7A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL7A Gene

Genomics for BCL7A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for BCL7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL7A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL7A

Top Transcription factor binding sites by QIAGEN in the BCL7A gene promoter:
  • c-Myb
  • E47
  • FOXO1
  • FOXO1a
  • GATA-2
  • MIF-1
  • Pax-3
  • Pax-5
  • PPAR-alpha

Genomic Locations for BCL7A Gene

Latest Assembly
chr12:122,019,422-122,062,044
(GRCh38/hg38)
Size:
42,623 bases
Orientation:
Plus strand

Previous Assembly
chr12:122,459,790-122,499,950
(GRCh37/hg19 by Entrez Gene)
Size:
40,161 bases
Orientation:
Plus strand

chr12:122,457,328-122,499,948
(GRCh37/hg19 by Ensembl)
Size:
42,621 bases
Orientation:
Plus strand

Genomic View for BCL7A Gene

Genes around BCL7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL7A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BCL7A Gene

Proteins for BCL7A Gene

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  3. Assay products for research

  • Protein details for BCL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC05-BCL7A_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 7 protein family member A
    Protein Accession:
    Q4VC05
    Secondary Accessions:
    • B4DJN6
    • B7ZB21
    • Q13843
    • Q14CT7

    Protein attributes for BCL7A Gene

    Size:
    210 amino acids
    Molecular mass:
    22810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BCL7A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCL7A Gene

Protein Expression for BCL7A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BCL7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL7A Gene

Domains & Families for BCL7A Gene

Gene Families for BCL7A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BCL7A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BCL7A Gene

GenScript: Design optimal peptide antigens:
  • B-cell CLL/lymphoma 7 protein family member A (BCL7A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4VC05

UniProtKB/Swiss-Prot:

BCL7A_HUMAN :
  • Belongs to the BCL7 family.
Family:
  • Belongs to the BCL7 family.
genes like me logo Genes that share domains with BCL7A: view

Function for BCL7A Gene

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  6. Cell Lines for research

Molecular function for BCL7A Gene

GENATLAS Biochemistry:
putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cell line with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)

Phenotypes From GWAS Catalog for BCL7A Gene

Gene Ontology (GO) - Molecular Function for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BCL7A: view
genes like me logo Genes that share phenotypes with BCL7A: view

Animal Models for BCL7A Gene

MGI Knock Outs for BCL7A:
  • Bcl7a Bcl7a<tm1b(EUCOMM)Wtsi>
  • Bcl7a Bcl7a<tm1.1Ban>

Animal Models for research

miRNA for BCL7A Gene

miRTarBase miRNAs that target BCL7A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL7A Gene

Localization for BCL7A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL7A gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BCL7A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL7A Gene

Pathways & Interactions for BCL7A Gene

PathCards logo

SuperPathways for BCL7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated NAS 15897551
genes like me logo Genes that share ontologies with BCL7A: view

No data available for Pathways by source and SIGNOR curated interactions for BCL7A Gene

Drugs & Compounds for BCL7A Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for BCL7A Gene

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mRNA/cDNA for BCL7A Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A

Alternative Splicing Database (ASD) splice patterns (SP) for BCL7A Gene

No ASD Table

Relevant External Links for BCL7A Gene

GeneLoc Exon Structure for
BCL7A

Expression for BCL7A Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL7A Gene

mRNA expression in normal human tissues for BCL7A Gene
mRNA expression by GTEx for BCL7A GenemRNA expression by BioGPS for BCL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCL7A Gene

This gene is overexpressed in Blymphocyte (45.8), Fetal gut (7.9), and Islet of Langerhans (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL7A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL7A

SOURCE GeneReport for Unigene cluster for BCL7A Gene:

Hs.530970

Evidence on tissue expression from TISSUES for BCL7A Gene

  • Nervous system(4.6)
  • Kidney(4.3)
  • Liver(4.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with BCL7A: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL7A Gene

Orthologs for BCL7A Gene

This gene was present in the common ancestor of animals.

Orthologs for BCL7A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia BCL7A 30 31
  • 99.57 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia BCL7A 30 31
  • 90.48 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Bcl7a 30 17 31
  • 89.37 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC690085 30
  • 89.35 (n)
Cow
(Bos Taurus)
 Mammalia BCL7A 30 31
  • 83.93 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia BCL7A 31
  • 79 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia BCL7A 31
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves gga-mir-762 31
  • 79 (a)
 OneToOne
BCL7A 30
  • 78.89 (n)
Lizard
(Anolis carolinensis)
 Reptilia BCL7A 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia bcl7a 30
  • 66.83 (n)
Zebrafish
(Danio rerio)
 Actinopterygii bcl7a 30 31
  • 69.4 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta BCL7-like 31
  • 34 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea C28H8.1 31
  • 32 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 36 (a)
 OneToMany
Species where no ortholog for BCL7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for BCL7A Gene

ENSEMBL:
Gene Tree for BCL7A (if available)
TreeFam:
Gene Tree for BCL7A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL7A: view image

Paralogs for BCL7A Gene

Paralogs for BCL7A Gene

(2) SIMAP similar genes for BCL7A Gene using alignment to 1 proteins:

  • BCL7A_HUMAN
genes like me logo Genes that share paralogs with BCL7A: view

Variants for BCL7A Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL7A Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs34821485 - p.Asn120Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BCL7A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BCL7A Gene

Variant ID Type Subtype PubMed ID
esv2676551 CNV deletion 23128226
esv3630966 CNV loss 21293372
nsv1070557 CNV deletion 25765185
nsv1112622 CNV deletion 24896259
nsv472490 CNV novel sequence insertion 20440878
nsv473807 CNV novel sequence insertion 20440878
nsv473912 CNV novel sequence insertion 20440878
nsv473975 CNV novel sequence insertion 20440878
nsv475357 CNV novel sequence insertion 20440878
nsv475750 CNV novel sequence insertion 20440878
nsv478278 CNV novel sequence insertion 20440878
nsv479148 CNV novel sequence insertion 20440878
nsv479488 CNV novel sequence insertion 20440878
nsv479754 CNV novel sequence insertion 20440878
nsv479770 CNV novel sequence insertion 20440878
nsv479804 CNV novel sequence insertion 20440878
nsv480041 CNV novel sequence insertion 20440878
nsv480071 CNV novel sequence insertion 20440878
nsv480129 CNV novel sequence insertion 20440878
nsv480167 CNV novel sequence insertion 20440878
nsv480235 CNV novel sequence insertion 20440878
nsv480649 CNV novel sequence insertion 20440878
nsv480742 CNV novel sequence insertion 20440878
nsv481123 CNV novel sequence insertion 20440878
nsv481247 CNV novel sequence insertion 20440878

Variation tolerance for BCL7A Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL7A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL7A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7A Gene

Disorders for BCL7A Gene

MalaCards: The human disease database

(3) MalaCards diseases for BCL7A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
b-cell non-hodgkin lymphoma
  • b-cell nhl
burkitt lymphoma
  • bl
- elite association - COSMIC cancer census association via MalaCards
Search BCL7A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BCL7A_HUMAN
  • Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. {ECO:0000269 PubMed:8605326}.

Additional Disease Information for BCL7A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BCL7A: view

No data available for Genatlas for BCL7A Gene

Publications for BCL7A Gene

  1. Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani VJ … Dyer MJ (Blood 1996) 2 3 4 23
  2. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
  3. The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel DM … Dyer MJ (Gene 1998) 2 3 23
  4. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (PMID: 23644491) Kadoch C … Crabtree GR (Nature genetics 2013) 2 3
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41

ExternalLinks

View latest publications for BCL7A gene in Mastermind

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