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This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes ... See more...
Aliases for BCL7A Gene
Aliases for BCL7A Gene
External Ids for BCL7A Gene
- HGNC: 1004
- Entrez Gene: 605
- Ensembl: ENSG00000110987
- OMIM: 601406
- UniProtKB: Q4VC05
Previous HGNC Symbols for BCL7A Gene
- BCL7
Previous GeneCards Identifiers for BCL7A Gene
- GC12M120913
- GC12P121880
- GC12P122228
- GC12P120857
- GC12P120921
- GC12P122459
- GC12P119470
Summaries for BCL7A Gene
-
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL7A Gene
BCL7A (BAF Chromatin Remodeling Complex Subunit BCL7A) is a Protein Coding gene. Diseases associated with BCL7A include Lymphoma and B-Cell Non-Hodgkin Lymphoma. An important paralog of this gene is BCL7C.
Additional gene information for BCL7A Gene
- HGNC(1004)
- Entrez Gene(605)
- Ensembl(ENSG00000110987)
- OMIM(601406)
- UniProtKB(Q4VC05)
- Open Targets Platform(ENSG00000110987)
- Monarch Initiative
- Search for BCL7A at DataMed
- Search for BCL7A at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL7A Gene
Genomics for BCL7A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BCL7A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BCL7A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL7A
- Top Transcription factor binding sites by QIAGEN in the BCL7A gene promoter:
-
- c-Myb
- E47
- FOXO1
- FOXO1a
- GATA-2
- MIF-1
- Pax-3
- Pax-5
- PPAR-alpha
Genomic Locations for BCL7A Gene
Genomic Locations for BCL7A Gene
- chr12:122,019,422-122,062,044
- (GRCh38/hg38)
- Size:
- 42,623 bases
- Orientation:
- Plus strand
- chr12:122,457,328-122,499,950
- (GRCh37/hg19)
- Size:
- 42,623 bases
- Orientation:
- Plus strand
Genomic View for BCL7A Gene
Genes around BCL7A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
BCL7A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BCL7A Gene
Proteins for BCL7A Gene
-
Protein details for BCL7A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4VC05-BCL7A_HUMAN
- Recommended name:
- B-cell CLL/lymphoma 7 protein family member A
- Protein Accession:
- Q4VC05
- B4DJN6
- B7ZB21
- Q13843
- Q14CT7
Protein attributes for BCL7A Gene
- Size:
- 210 amino acids
- Molecular mass:
- 22810 Da
- Quaternary structure:
- No Data Available
Protein Expression for BCL7A Gene
Post-translational modifications for BCL7A Gene
Other Protein References for BCL7A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ BCL7A Antibody
- Creative Diagnostics Anti-BCL7A monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for BCL7A
- Novus Biologicals Antibodies for BCL7A
-
Abcam antibodies for BCL7A
- Invitrogen Antibodies for BCL7A (AFLGC-BCL7A)
-
Biorbyt antibodies for BCL7A
-
Boster Bio Antibodies for BCL7A
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BCL7A
- Origene Custom Protein Services for BCL7A
- ProSpec Recombinant Proteins for BCL7A
- antibodies-online: Show 11 available BCL7A Proteins ranked by validation data
- Compare Top BCL7A Proteins
-
Quality Products:
-
Signalway Proteins for BCL7A
-
Abcam proteins for BCL7A
No data available for DME Specific Peptides for BCL7A Gene
Domains & Families for BCL7A Gene
Gene Families for BCL7A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for BCL7A Gene
- GenScript: Design optimal peptide antigens:
-
- B-cell CLL/lymphoma 7 protein family member A (BCL7A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4VC05- Family:
-
- Belongs to the BCL7 family.
Function for BCL7A Gene
Molecular function for BCL7A Gene
- GENATLAS Biochemistry:
- putative F-actin cross-linking protein 12,homolog to caldesmon,involved with MYC and IGH in a Burkitt lymphoma cell line with complex translocation t(9;14;12)(q24.1;q32.3;q24.1)
Phenotypes From GWAS Catalog for BCL7A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for BCL7A Gene
- MGI mutant phenotypes for BCL7A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for BCL7A:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased IL-8 secretion
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased viability after Maraba virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
Animal Models for BCL7A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL7A - Select products 50% OFF >
- * BCL7A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL7A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL7A
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL7A
miRNA for BCL7A Gene
- miRTarBase miRNAs that target BCL7A
-
- hsa-let-7b-5p (MIRT002399)
- hsa-miR-29a-3p (MIRT006552)
- mmu-miR-541-5p (MIRT008313)
- mmu-miR-34b-5p (MIRT012898)
- hsa-miR-335-5p (MIRT017268)
- hsa-miR-24-3p (MIRT050374)
- hsa-miR-203a-3p (MIRT053446)
- hsa-miR-507 (MIRT062777)
- hsa-miR-557 (MIRT062779)
- hsa-miR-21-5p (MIRT062806)
- hsa-miR-4447 (MIRT062813)
- hsa-miR-4472 (MIRT062814)
- hsa-miR-3976 (MIRT062815)
- hsa-miR-6795-5p (MIRT062822)
- hsa-miR-6887-5p (MIRT062823)
- hsa-miR-7109-5p (MIRT062824)
- hsa-miR-129-5p (MIRT062826)
- hsa-miR-1290 (MIRT062830)
- hsa-miR-1252-5p (MIRT062831)
- hsa-miR-4533 (MIRT062833)
- hsa-miR-4747-5p (MIRT062834)
- hsa-miR-5196-5p (MIRT062836)
- hsa-miR-6828-5p (MIRT062837)
- hsa-miR-6516-5p (MIRT062838)
- hsa-miR-9500 (MIRT062839)
- hsa-miR-15a-5p (MIRT133334)
- hsa-miR-16-5p (MIRT133335)
- hsa-miR-15b-5p (MIRT133337)
- hsa-miR-195-5p (MIRT133339)
- hsa-miR-19a-3p (MIRT133376)
- hsa-miR-19b-3p (MIRT133377)
- hsa-miR-3125 (MIRT241705)
- hsa-miR-3916 (MIRT241706)
- hsa-miR-6758-5p (MIRT241708)
- hsa-miR-6856-5p (MIRT241709)
- hsa-miR-6859-5p (MIRT241710)
- hsa-miR-6748-5p (MIRT270621)
- hsa-miR-6803-5p (MIRT494517)
- hsa-miR-6769b-5p (MIRT494518)
- hsa-miR-6769a-5p (MIRT494519)
- hsa-miR-92a-2-5p (MIRT494520)
- hsa-miR-4483 (MIRT494521)
- hsa-miR-1293 (MIRT494522)
- hsa-miR-6756-5p (MIRT494523)
- hsa-miR-6766-5p (MIRT494524)
- hsa-miR-6745 (MIRT494525)
- hsa-miR-363-5p (MIRT494526)
- hsa-miR-6885-5p (MIRT494527)
- hsa-miR-328-5p (MIRT494528)
- hsa-miR-486-3p (MIRT494529)
- hsa-miR-885-3p (MIRT494530)
- hsa-miR-151b (MIRT494531)
- hsa-miR-151a-5p (MIRT494532)
- hsa-miR-611 (MIRT494533)
- hsa-miR-3131 (MIRT494534)
- hsa-miR-6848-5p (MIRT538969)
- hsa-miR-6846-5p (MIRT538970)
- hsa-miR-4697-5p (MIRT538971)
- hsa-miR-4488 (MIRT538972)
- hsa-miR-1237-5p (MIRT538973)
- hsa-miR-1251-3p (MIRT538974)
- hsa-miR-3158-3p (MIRT538975)
- hsa-miR-3680-3p (MIRT562616)
- hsa-miR-450b-5p (MIRT562617)
- hsa-miR-7113-5p (MIRT562618)
- hsa-miR-455-3p (MIRT562619)
- hsa-miR-4446-5p (MIRT615106)
- hsa-miR-5006-3p (MIRT615107)
- hsa-miR-4755-5p (MIRT615108)
- hsa-miR-623 (MIRT615109)
- hsa-miR-1273g-5p (MIRT615110)
- hsa-miR-203a-5p (MIRT615111)
- hsa-miR-205-3p (MIRT615112)
- hsa-miR-211-5p (MIRT615113)
- hsa-miR-204-5p (MIRT615114)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL7A
- Browse OriGene Inhibitory RNA Products For BCL7A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A
Clone Products
- Applied Biological Materials (abm): Clones for BCL7A - Select products 50% OFF >
- * BCL7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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-
- MG200442
- MG202275
- MR200442
- MR200442L3
- MR200442L4
- MR202275
- MR202275L3
- MR202275L4
- RC210489
- RC210489L1
- RC210489L2
- RC210489L3
- RC210489L4
- RC223737
- RC223737L3
- RC223737L4
- RG210489
- RG223737
- MR200442L3V
- MR200442L4V
- MR202275L3V
- MR202275L4V
- RC210489L1V
- RC210489L2V
- RC210489L3V
- RC210489L4V
- RC223737L3V
- RC223737L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL7A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL7A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL7A Gene
Localization for BCL7A Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for BCL7A Gene
Pathways & Interactions for BCL7A Gene
Interacting Proteins for BCL7A Gene
Selected Interacting proteins:
Q4VC05-BCL7A_HUMAN
ENSP00000445868
for BCL7A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BCL7A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-templated | NAS | 15897551 |
No data available for Pathways by source and SIGNOR curated interactions for BCL7A Gene
Transcripts for BCL7A Gene
mRNA/cDNA for BCL7A Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000538010 6247 nts (view in UCSC)
- ENST00000261822 3722 nts (view in UCSC)
- ENST00000432926 871 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BCL7A - Select products 50% OFF >
- * BCL7A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BCL7A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BCL7A
-
Santa Cruz Biotechnology (SCBT) CRISPR for BCL7A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BCL7A
- Browse OriGene Inhibitory RNA Products For BCL7A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL7A
Clone Products
- Applied Biological Materials (abm): Clones for BCL7A - Select products 50% OFF >
- * BCL7A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG200442
- MG202275
- MR200442
- MR200442L3
- MR200442L4
- MR202275
- MR202275L3
- MR202275L4
- RC210489
- RC210489L1
- RC210489L2
- RC210489L3
- RC210489L4
- RC223737
- RC223737L3
- RC223737L4
- RG210489
- RG223737
- MR200442L3V
- MR200442L4V
- MR202275L3V
- MR202275L4V
- RC210489L1V
- RC210489L2V
- RC210489L3V
- RC210489L4V
- RC223737L3V
- RC223737L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BCL7A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BCL7A
Relevant External Links for BCL7A Gene
- GeneLoc Exon Structure for
- BCL7A
Expression for BCL7A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
This gene is overexpressed in Blymphocyte (45.8), Fetal gut (7.9), and Islet of Langerhans (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BCL7A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL7A
SOURCE GeneReport for Unigene cluster for BCL7A Gene:
Hs.530970Evidence on tissue expression from TISSUES for BCL7A Gene
- Nervous system(4.6)
- Kidney(4.3)
- Liver(4.2)
- Lymph node(2.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for BCL7A
-
OriGene qPCR primer pairs and template standards for BCL7A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL7A Gene
Orthologs for BCL7A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BCL7A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BCL7A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Bcl7a 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC690085 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | BCL7A 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BCL7A 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | BCL7A 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | gga-mir-762 31 |
|
OneToOne | |
| BCL7A 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | BCL7A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | bcl7a 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | bcl7a 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | BCL7-like 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C28H8.1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for BCL7A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for BCL7A Gene
- ENSEMBL:
- Gene Tree for BCL7A (if available)
- TreeFam:
- Gene Tree for BCL7A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BCL7A: view image
Paralogs for BCL7A Gene
Variants for BCL7A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL7A Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34821485 | - | p.Asn120Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2676551 | CNV | deletion | 23128226 |
| esv3630966 | CNV | loss | 21293372 |
| nsv1070557 | CNV | deletion | 25765185 |
| nsv1112622 | CNV | deletion | 24896259 |
| nsv472490 | CNV | novel sequence insertion | 20440878 |
| nsv473807 | CNV | novel sequence insertion | 20440878 |
| nsv473912 | CNV | novel sequence insertion | 20440878 |
| nsv473975 | CNV | novel sequence insertion | 20440878 |
| nsv475357 | CNV | novel sequence insertion | 20440878 |
| nsv475750 | CNV | novel sequence insertion | 20440878 |
| nsv478278 | CNV | novel sequence insertion | 20440878 |
| nsv479148 | CNV | novel sequence insertion | 20440878 |
| nsv479488 | CNV | novel sequence insertion | 20440878 |
| nsv479754 | CNV | novel sequence insertion | 20440878 |
| nsv479770 | CNV | novel sequence insertion | 20440878 |
| nsv479804 | CNV | novel sequence insertion | 20440878 |
| nsv480041 | CNV | novel sequence insertion | 20440878 |
| nsv480071 | CNV | novel sequence insertion | 20440878 |
| nsv480129 | CNV | novel sequence insertion | 20440878 |
| nsv480167 | CNV | novel sequence insertion | 20440878 |
| nsv480235 | CNV | novel sequence insertion | 20440878 |
| nsv480649 | CNV | novel sequence insertion | 20440878 |
| nsv480742 | CNV | novel sequence insertion | 20440878 |
| nsv481123 | CNV | novel sequence insertion | 20440878 |
| nsv481247 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BCL7A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- BCL7A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL7A Gene
Disorders for BCL7A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma |
|
|
| b-cell non-hodgkin lymphoma |
|
|
| burkitt lymphoma |
|
|
Search BCL7A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
BCL7A_HUMAN- Note=Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. {ECO:0000269 PubMed:8605326}.
Additional Disease Information for BCL7A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for BCL7A Gene
Publications for BCL7A Gene
- Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. (PMID: 8605326) Zani VJ … Dyer MJ (Blood 1996) 2 3 4 23
- Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PMID: 19336552) Morton LM … Hartge P (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
- The BCL7 gene family: deletion of BCL7B in Williams syndrome. (PMID: 9931421) Jadayel DM … Dyer MJ (Gene 1998) 2 3 23
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (PMID: 23644491) Kadoch C … Crabtree GR (Nature genetics 2013) 2 3
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
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