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Aliases for BCL6B Gene

Aliases for BCL6B Gene

  • B Cell CLL/Lymphoma 6B 2 3 5
  • Zinc Finger Protein 62 2 3 4
  • B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein) 2 3
  • Bcl6-Associated Zinc Finger Protein 3 4
  • ZNF62 3 4
  • BAZF 3 4
  • B-Cell CLL/Lymphoma 6 Member B Protein 3
  • B-Cell CLL/Lymphoma 6, Member B 2
  • ZBTB28 3

External Ids for BCL6B Gene

Previous HGNC Symbols for BCL6B Gene

  • ZNF62

Previous GeneCards Identifiers for BCL6B Gene

  • GC17U990185
  • GC17P006871
  • GC17P007126
  • GC17P006867
  • GC17P006926

Summaries for BCL6B Gene

GeneCards Summary for BCL6B Gene

BCL6B (B Cell CLL/Lymphoma 6B) is a Protein Coding gene. Diseases associated with BCL6B include Lymphoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is BCL6.

UniProtKB/Swiss-Prot for BCL6B Gene

  • Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Wiki entry for BCL6B Gene

Additional gene information for BCL6B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL6B Gene

Genomics for BCL6B Gene

GeneHancer (GH) Regulatory Elements for BCL6B Gene

Promoters and enhancers for BCL6B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.8 -5.3 -5306 13.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MIR497HG RNASEK BCL6B C17orf49 ENSG00000267047 MIR195 MIR497 DVL2 SNORD10 CNTROB
GH17J007130 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +109.2 109192 4 HDGF PKNOX1 FOXA2 SMAD1 ARID4B IRF4 ZNF143 ZNF207 ATF7 RUNX3 LOC105371512 DVL2 CLEC10A SLC16A11 ASGR1 BCL6B CNTROB KCTD11 SNORD10 EIF5A
GH17J006853 Promoter/Enhancer 1.6 Ensembl ENCODE 10.5 -168.4 -168359 2.7 ARID4B SIN3A DMAP1 ZBTB7B YY1 ETS1 ELK1 ZNF143 FOS NFKBIZ ALOX12P2 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 GC17M006868
GH17J007177 Promoter/Enhancer 1.4 Ensembl ENCODE 10.3 +154.8 154829 1.7 ATF1 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 ATF7 SP3 RXRA GC17P007176 ASGR1 ENSG00000262067 LOC105371508 SPEM1 SLC16A11 ACADVL DLG4 SLC16A13 CTDNEP1
GH17J007135 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 +114.6 114625 4.3 ELF3 ARID4B SIN3A RAD21 RARA ZNF121 ZSCAN5C ZNF143 BCLAF1 MIXL1 DVL2 MIR324 SNORD10 ENSG00000262089 KDM6B CNTROB SNORA48 WRAP53 SLC16A11 NEURL4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BCL6B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BCL6B gene promoter:
  • E2F-3a
  • E2F
  • E2F-1
  • E2F-2
  • Spz1
  • E2F-4
  • E2F-5
  • POU3F2
  • Nkx2-5
  • Sox9

Genomic Locations for BCL6B Gene

Genomic Locations for BCL6B Gene
chr17:7,023,020-7,030,290
(GRCh38/hg38)
Size:
7,271 bases
Orientation:
Plus strand
chr17:6,926,339-6,933,609
(GRCh37/hg19)
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for BCL6B Gene

Genes around BCL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6B Gene

Proteins for BCL6B Gene

  • Protein details for BCL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N143-BCL6B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Protein Accession:
    Q8N143
    Secondary Accessions:
    • Q6PCB4

    Protein attributes for BCL6B Gene

    Size:
    479 amino acids
    Molecular mass:
    51531 Da
    Quaternary structure:
    • Associates with BCL6 through the BTB domain.

neXtProt entry for BCL6B Gene

Post-translational modifications for BCL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6B Gene

No data available for DME Specific Peptides for BCL6B Gene

Domains & Families for BCL6B Gene

Gene Families for BCL6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BCL6B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BCL6B: view

No data available for UniProtKB/Swiss-Prot for BCL6B Gene

Function for BCL6B Gene

Molecular function for BCL6B Gene

UniProtKB/Swiss-Prot Function:
Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Phenotypes From GWAS Catalog for BCL6B Gene

Gene Ontology (GO) - Molecular Function for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with BCL6B: view
genes like me logo Genes that share phenotypes with BCL6B: view

Animal Models for BCL6B Gene

MGI Knock Outs for BCL6B:

Animal Model Products

CRISPR Products

miRNA for BCL6B Gene

miRTarBase miRNAs that target BCL6B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL6B Gene

Localization for BCL6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL6B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BCL6B: view

Pathways & Interactions for BCL6B Gene

SuperPathways for BCL6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0042092 type 2 immune response IBA --
GO:0042127 regulation of cell proliferation IBA --
GO:0045595 regulation of cell differentiation IBA --
GO:0050727 regulation of inflammatory response IBA --
genes like me logo Genes that share ontologies with BCL6B: view

No data available for Pathways by source and SIGNOR curated interactions for BCL6B Gene

Drugs & Compounds for BCL6B Gene

No Compound Related Data Available

Transcripts for BCL6B Gene

mRNA/cDNA for BCL6B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BCL6B Gene

B-cell CLL/lymphoma 6, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for BCL6B Gene

GeneLoc Exon Structure for
BCL6B
ECgene alternative splicing isoforms for
BCL6B

Expression for BCL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BCL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6B Gene

This gene is overexpressed in Lung (x4.4).

Protein differential expression in normal tissues from HIPED for BCL6B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL6B Gene



Protein tissue co-expression partners for BCL6B Gene

NURSA nuclear receptor signaling pathways regulating expression of BCL6B Gene:

BCL6B

SOURCE GeneReport for Unigene cluster for BCL6B Gene:

Hs.22575

mRNA Expression by UniProt/SwissProt for BCL6B Gene:

Q8N143-BCL6B_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression found in heart and placenta.
genes like me logo Genes that share expression patterns with BCL6B: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL6B Gene

Orthologs for BCL6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL6B 34 33
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BCL6B 34 33
  • 89.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BCL6B 34 33
  • 89.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl6b 16 34 33
  • 86.99 (n)
rat
(Rattus norvegicus)
Mammalia Bcl6b 33
  • 86.72 (n)
oppossum
(Monodelphis domestica)
Mammalia BCL6B 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL6B 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BCL6B 34
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for BCL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL6B Gene

ENSEMBL:
Gene Tree for BCL6B (if available)
TreeFam:
Gene Tree for BCL6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL6B: view image

Paralogs for BCL6B Gene

Paralogs for BCL6B Gene

genes like me logo Genes that share paralogs with BCL6B: view

Variants for BCL6B Gene

Sequence variations from dbSNP and Humsavar for BCL6B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000145965 -- 7,024,003(+) C/T intron_variant
rs1000880100 -- 7,028,267(+) C/A 3_prime_UTR_variant
rs1000944195 -- 7,022,245(+) G/A upstream_transcript_variant
rs1000978265 -- 7,022,055(+) T/G upstream_transcript_variant
rs1001311702 -- 7,023,242(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BCL6B Gene

Variant ID Type Subtype PubMed ID
nsv952117 CNV deletion 24416366
nsv827869 CNV gain 20364138
nsv574322 CNV loss 21841781
nsv457659 CNV loss 19166990
nsv112411 CNV insertion 16902084
nsv111719 CNV insertion 16902084
esv987894 CNV insertion 20482838
esv3451987 CNV insertion 20981092
esv3416608 CNV insertion 20981092
esv3362853 CNV insertion 20981092
esv3302715 CNV tandem duplication 20981092
esv3302465 CNV tandem duplication 20981092
esv2422288 CNV deletion 17116639
esv1378459 CNV insertion 17803354
esv1009485 CNV insertion 20482838

Variation tolerance for BCL6B Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL6B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL6B Gene

Disorders for BCL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL6B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BCL6B

genes like me logo Genes that share disorders with BCL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL6B Gene

Publications for BCL6B Gene

  1. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PMID: 9632807) Okabe S … Tokuhisa T (Molecular and cellular biology 1998) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. (PMID: 11855826) Sakashita C … Miki T (Biochemical and biophysical research communications 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for BCL6B Gene

Sources for BCL6B Gene

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