Aliases for BCL6B Gene

Aliases for BCL6B Gene

  • BCL6B Transcription Repressor 2 3 5
  • Zinc Finger Protein 62 2 3 4
  • BAZF 2 3 4
  • B-Cell CLL/Lymphoma 6, Member B (Zinc Finger Protein) 2 3
  • B-Cell CLL/Lymphoma 6 Member B Protein 3 4
  • Bcl6-Associated Zinc Finger Protein 3 4
  • B Cell CLL/Lymphoma 6B 2 3
  • ZBTB28 2 3
  • ZNF62 3 4
  • B-Cell CLL/Lymphoma 6, Member B 2
  • BCL6B, Transcription Repressor 2
  • BCL6B 5

External Ids for BCL6B Gene

Previous HGNC Symbols for BCL6B Gene

  • ZNF62

Previous GeneCards Identifiers for BCL6B Gene

  • GC17U990185
  • GC17P006871
  • GC17P007126
  • GC17P006867
  • GC17P006926

Summaries for BCL6B Gene

GeneCards Summary for BCL6B Gene

BCL6B (BCL6B Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6B include Lymphoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is BCL6.

UniProtKB/Swiss-Prot Summary for BCL6B Gene

  • Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Gene Wiki entry for BCL6B Gene

Additional gene information for BCL6B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BCL6B Gene

Genomics for BCL6B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BCL6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BCL6B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BCL6B

Top Transcription factor binding sites by QIAGEN in the BCL6B gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • POU3F2
  • Sox9
  • Spz1

Genomic Locations for BCL6B Gene

Genomic Locations for BCL6B Gene
chr17:7,023,050-7,030,290
(GRCh38/hg38)
Size:
7,241 bases
Orientation:
Plus strand
chr17:6,926,339-6,933,609
(GRCh37/hg19)
Size:
7,271 bases
Orientation:
Plus strand

Genomic View for BCL6B Gene

Genes around BCL6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCL6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCL6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL6B Gene

Proteins for BCL6B Gene

  • Protein details for BCL6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N143-BCL6B_HUMAN
    Recommended name:
    B-cell CLL/lymphoma 6 member B protein
    Protein Accession:
    Q8N143
    Secondary Accessions:
    • Q6PCB4

    Protein attributes for BCL6B Gene

    Size:
    479 amino acids
    Molecular mass:
    51531 Da
    Quaternary structure:
    • Associates with BCL6 through the BTB domain.

neXtProt entry for BCL6B Gene

Post-translational modifications for BCL6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL6B Gene

No data available for DME Specific Peptides for BCL6B Gene

Domains & Families for BCL6B Gene

Gene Families for BCL6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for BCL6B Gene

InterPro:
Blocks:
  • BTB/POZ domain
ProtoNet:

Suggested Antigen Peptide Sequences for BCL6B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ77701, highly similar to Homo sapiens B-cell CLL/lymphoma 6, member B (zinc finger protein)(BCL6B), mRNA (A8KA13_HUMAN)
  • Zinc finger protein 62 (BCL6B_HUMAN)
genes like me logo Genes that share domains with BCL6B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BCL6B Gene

Function for BCL6B Gene

Molecular function for BCL6B Gene

UniProtKB/Swiss-Prot Function:
Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development.

Phenotypes From GWAS Catalog for BCL6B Gene

Gene Ontology (GO) - Molecular Function for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA,IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with BCL6B: view
genes like me logo Genes that share phenotypes with BCL6B: view

Animal Models for BCL6B Gene

MGI Knock Outs for BCL6B:

Animal Model Products

CRISPR Products

miRNA for BCL6B Gene

miRTarBase miRNAs that target BCL6B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCL6B Gene

Localization for BCL6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BCL6B gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with BCL6B: view

Pathways & Interactions for BCL6B Gene

PathCards logo

SuperPathways for BCL6B Gene

No Data Available

Gene Ontology (GO) - Biological Process for BCL6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0001817 regulation of cytokine production IBA 21873635
GO:0002682 regulation of immune system process IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0042092 type 2 immune response IBA 21873635
genes like me logo Genes that share ontologies with BCL6B: view

No data available for Pathways by source and SIGNOR curated interactions for BCL6B Gene

Drugs & Compounds for BCL6B Gene

No Compound Related Data Available

Transcripts for BCL6B Gene

mRNA/cDNA for BCL6B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BCL6B

Alternative Splicing Database (ASD) splice patterns (SP) for BCL6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for BCL6B Gene

GeneLoc Exon Structure for
BCL6B

Expression for BCL6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BCL6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL6B Gene

This gene is overexpressed in Lung (x4.4).

Protein differential expression in normal tissues from HIPED for BCL6B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BCL6B Gene



Protein tissue co-expression partners for BCL6B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BCL6B

SOURCE GeneReport for Unigene cluster for BCL6B Gene:

Hs.22575

mRNA Expression by UniProt/SwissProt for BCL6B Gene:

Q8N143-BCL6B_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression found in heart and placenta.

Evidence on tissue expression from TISSUES for BCL6B Gene

  • Heart(2)
genes like me logo Genes that share expression patterns with BCL6B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BCL6B Gene

Orthologs for BCL6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL6B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BCL6B 30 31
  • 99.65 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BCL6B 30 31
  • 89.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BCL6B 30 31
  • 89.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Bcl6b 30 17 31
  • 86.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Bcl6b 30
  • 86.72 (n)
Oppossum
(Monodelphis domestica)
Mammalia BCL6B 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BCL6B 31
  • 43 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BCL6B 31
  • 39 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToMany
Species where no ortholog for BCL6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BCL6B Gene

ENSEMBL:
Gene Tree for BCL6B (if available)
TreeFam:
Gene Tree for BCL6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BCL6B: view image

Paralogs for BCL6B Gene

genes like me logo Genes that share paralogs with BCL6B: view

Variants for BCL6B Gene

Additional dbSNP identifiers (rs#s) for BCL6B Gene

Structural Variations from Database of Genomic Variants (DGV) for BCL6B Gene

Variant ID Type Subtype PubMed ID
esv1009485 CNV insertion 20482838
esv1378459 CNV insertion 17803354
esv2422288 CNV deletion 17116639
esv3302465 CNV tandem duplication 20981092
esv3302715 CNV tandem duplication 20981092
esv3362853 CNV insertion 20981092
esv3416608 CNV insertion 20981092
esv3451987 CNV insertion 20981092
esv987894 CNV insertion 20482838
nsv111719 CNV insertion 16902084
nsv112411 CNV insertion 16902084
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv827869 CNV gain 20364138
nsv952117 CNV deletion 24416366

Variation tolerance for BCL6B Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BCL6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BCL6B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BCL6B Gene

Disorders for BCL6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for BCL6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search BCL6B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BCL6B

genes like me logo Genes that share disorders with BCL6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCL6B Gene

Publications for BCL6B Gene

  1. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. (PMID: 9632807) Okabe S … Tokuhisa T (Molecular and cellular biology 1998) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene. (PMID: 11855826) Sakashita C … Miki T (Biochemical and biophysical research communications 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway. (PMID: 29393377) Gu Y … Zhou L (International journal of molecular medicine 2018) 3

Products for BCL6B Gene

Sources for BCL6B Gene